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Decreased circulating myo-inositol concentration

MedGen UID:
1841975
•Concept ID:
C5826521
•
Finding
Synonym: Myoinositol low in blood
 
HPO: HP:0034610

Definition

Concentration of myo-inositol in the blood circulation below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating myo-inositol concentration

Recent clinical studies

Etiology

Myo-Inositol Enhances the Inhibitory Effect of Metformin on Gonadotropin Levels in Postmenopausal Women.
Krysiak R, Kowalcze K, Okopień B
Gynecol Obstet Invest 2022;87(6):373-380. Epub 2022 Dec 14 doi: 10.1159/000527365. PMID: 36516786
Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity after Kidney Transplantation.
Lepping RJ, Montgomery RN, Sharma P, Mahnken JD, Vidoni ED, Choi IY, Sarnak MJ, Brooks WM, Burns JM, Gupta A
J Am Soc Nephrol 2021 Jan;32(1):177-187. Epub 2020 Oct 16 doi: 10.1681/ASN.2020050584. PMID: 33067382Free PMC Article
Intralipid/Heparin Infusion Alters Brain Metabolites Assessed With 1H-MRS Spectroscopy in Young Healthy Men.
Karczewska-Kupczewska M, Nikolajuk A, Filarski R, Majewski R, Tarasów E
J Clin Endocrinol Metab 2018 Jul 1;103(7):2563-2570. doi: 10.1210/jc.2018-00107. PMID: 29860500
Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial.
Costantino D, Minozzi G, Minozzi E, Guaraldi C
Eur Rev Med Pharmacol Sci 2009 Mar-Apr;13(2):105-10. PMID: 19499845
Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome.
Iuorno MJ, Jakubowicz DJ, Baillargeon JP, Dillon P, Gunn RD, Allan G, Nestler JE
Endocr Pract 2002 Nov-Dec;8(6):417-23. doi: 10.4158/EP.8.6.417. PMID: 15251831

Diagnosis

Myo-Inositol Enhances the Inhibitory Effect of Metformin on Gonadotropin Levels in Postmenopausal Women.
Krysiak R, Kowalcze K, Okopień B
Gynecol Obstet Invest 2022;87(6):373-380. Epub 2022 Dec 14 doi: 10.1159/000527365. PMID: 36516786
Intralipid/Heparin Infusion Alters Brain Metabolites Assessed With 1H-MRS Spectroscopy in Young Healthy Men.
Karczewska-Kupczewska M, Nikolajuk A, Filarski R, Majewski R, Tarasów E
J Clin Endocrinol Metab 2018 Jul 1;103(7):2563-2570. doi: 10.1210/jc.2018-00107. PMID: 29860500
Cerebral Osmolytes and Plasma Osmolality in Pregnancy and Preeclampsia: A Proton Magnetic Resonance Spectroscopy Study.
Nelander M, Wikström AK, Weis J, Bergman L, Larsson A, Sundström-Poromaa I, Wikström J
Am J Hypertens 2018 Jun 11;31(7):847-853. doi: 10.1093/ajh/hpy019. PMID: 29415199
Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial.
Costantino D, Minozzi G, Minozzi E, Guaraldi C
Eur Rev Med Pharmacol Sci 2009 Mar-Apr;13(2):105-10. PMID: 19499845
Regulation of splanchnic perfusion.
Moreau R, Lebrec D
Best Pract Res Clin Gastroenterol 2001 Feb;15(1):15-20. doi: 10.1053/bega.2000.0153. PMID: 11355898

Therapy

Myo-Inositol Enhances the Inhibitory Effect of Metformin on Gonadotropin Levels in Postmenopausal Women.
Krysiak R, Kowalcze K, Okopień B
Gynecol Obstet Invest 2022;87(6):373-380. Epub 2022 Dec 14 doi: 10.1159/000527365. PMID: 36516786
Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity after Kidney Transplantation.
Lepping RJ, Montgomery RN, Sharma P, Mahnken JD, Vidoni ED, Choi IY, Sarnak MJ, Brooks WM, Burns JM, Gupta A
J Am Soc Nephrol 2021 Jan;32(1):177-187. Epub 2020 Oct 16 doi: 10.1681/ASN.2020050584. PMID: 33067382Free PMC Article
Intralipid/Heparin Infusion Alters Brain Metabolites Assessed With 1H-MRS Spectroscopy in Young Healthy Men.
Karczewska-Kupczewska M, Nikolajuk A, Filarski R, Majewski R, Tarasów E
J Clin Endocrinol Metab 2018 Jul 1;103(7):2563-2570. doi: 10.1210/jc.2018-00107. PMID: 29860500
Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial.
Costantino D, Minozzi G, Minozzi E, Guaraldi C
Eur Rev Med Pharmacol Sci 2009 Mar-Apr;13(2):105-10. PMID: 19499845
Regulation of splanchnic perfusion.
Moreau R, Lebrec D
Best Pract Res Clin Gastroenterol 2001 Feb;15(1):15-20. doi: 10.1053/bega.2000.0153. PMID: 11355898

Prognosis

Cerebral Osmolytes and Plasma Osmolality in Pregnancy and Preeclampsia: A Proton Magnetic Resonance Spectroscopy Study.
Nelander M, Wikström AK, Weis J, Bergman L, Larsson A, Sundström-Poromaa I, Wikström J
Am J Hypertens 2018 Jun 11;31(7):847-853. doi: 10.1093/ajh/hpy019. PMID: 29415199
Evaluation of phosphoinositide turnover on ischemic human brain with 1-[1-11C]-butyryl-2-palmitoyl-rac-glycerol using PET.
Matsumoto K, Imahori Y, Fujii R, Ohmori Y, Sekimoto T, Ueda S, Mineura K
J Nucl Med 1999 Oct;40(10):1590-4. PMID: 10520696

Clinical prediction guides

Myo-Inositol Enhances the Inhibitory Effect of Metformin on Gonadotropin Levels in Postmenopausal Women.
Krysiak R, Kowalcze K, Okopień B
Gynecol Obstet Invest 2022;87(6):373-380. Epub 2022 Dec 14 doi: 10.1159/000527365. PMID: 36516786
Intralipid/Heparin Infusion Alters Brain Metabolites Assessed With 1H-MRS Spectroscopy in Young Healthy Men.
Karczewska-Kupczewska M, Nikolajuk A, Filarski R, Majewski R, Tarasów E
J Clin Endocrinol Metab 2018 Jul 1;103(7):2563-2570. doi: 10.1210/jc.2018-00107. PMID: 29860500
Cerebral Osmolytes and Plasma Osmolality in Pregnancy and Preeclampsia: A Proton Magnetic Resonance Spectroscopy Study.
Nelander M, Wikström AK, Weis J, Bergman L, Larsson A, Sundström-Poromaa I, Wikström J
Am J Hypertens 2018 Jun 11;31(7):847-853. doi: 10.1093/ajh/hpy019. PMID: 29415199
A prospective cohort study on sustained effects of low-dose ecstasy use on the brain in new ecstasy users.
de Win MM, Reneman L, Jager G, Vlieger EJ, Olabarriaga SD, Lavini C, Bisschops I, Majoie CB, Booij J, den Heeten GJ, van den Brink W
Neuropsychopharmacology 2007 Feb;32(2):458-70. Epub 2006 Nov 1 doi: 10.1038/sj.npp.1301225. PMID: 17077812
Regulation of the aromatase activity of human placental cytotrophoblasts by insulin, insulin-like growth factor-I, and -II.
Nestler JE
J Steroid Biochem Mol Biol 1993 Mar;44(4-6):449-57. doi: 10.1016/0960-0760(93)90249-v. PMID: 8476759

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