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Treponemal infection

MedGen UID:
21253
•Concept ID:
C0040843
•
Disease or Syndrome
Synonyms: Infection, Treponemal; Infections, Treponemal; Treponemal Infection; Treponemal Infections
SNOMED CT: Treponemal infection (76272004); Treponemal disease (76272004)

Definition

A sexually transmitted infection caused by the Gram-negative spirochete Treponema pallidum. It is manifested as syphilis. [from NCI]

Professional guidelines

PubMed

Placental Syphilis: A Comprehensive Review of Routine Histomorphology, HIV Co-infection, Penicillin Treatment, Immunohistochemistry, and Polymerase Chain Reaction.
Marais YA, Mason D, Barnard A, Saaiman CR, Els HC, Kluge J, Glass AJ, Wright CA, Schubert PT
Fetal Pediatr Pathol 2023 Dec;42(6):870-890. Epub 2023 Sep 5 doi: 10.1080/15513815.2023.2253309. PMID: 37668986
A paleoepidemiological approach to the challenging differential diagnosis of an isolated 1500-year-old anomalous molar from Panamá.
Smith-Guzmán NE
Int J Paleopathol 2022 Dec;39:1-13. Epub 2022 Aug 24 doi: 10.1016/j.ijpp.2022.07.002. PMID: 36029689
Otosyphilis: a practical guide to diagnosis and treatment.
Guttenplan M, Hendrix RA
Trans Pa Acad Ophthalmol Otolaryngol 1989;41:834-8. PMID: 2698522

Recent clinical studies

Etiology

Syphilis in pregnancy: an ongoing public health threat.
Eppes CS, Stafford I, Rac M
Am J Obstet Gynecol 2022 Dec;227(6):822-838. Epub 2022 Aug 3 doi: 10.1016/j.ajog.2022.07.041. PMID: 35932881
A Comparative Study of the Epidemiology of Treponemal Infection in the Volta and Oti Regions of Ghana: A Five-Year Multisite Parallel Population-Based Analysis vis-à-vis the Sentinel Survey.
Lokpo SY, Owusu-Dabo E, Deku JG, Orish VN, Kye-Duodu G, Ussher FA, Boakye T, Adigbli D, Ameke LS, Fianko WK, Adedze-Kpodo R, Letsa HK, Tashie W, Gbormittah NS, Kpene GE, Osei-Yeboah J
Biomed Res Int 2021;2021:4462389. Epub 2021 Nov 9 doi: 10.1155/2021/4462389. PMID: 34796232Free PMC Article
Yaws, a non-venereal treponemal infection. Still endemic in some parts of the world.
Prescrire Int 2012 Sep;21(130):217-9. PMID: 23016260
Treponemal infection rates, risk factors and pregnancy outcome in a rural area of Senegal.
Lagarde E, Guyavarch E, Piau JP, Gueye-Ndiaye A, Seck K, Enel C, Pison G, Ndoye I, Mboup S; MECORA group
Int J STD AIDS 2003 Mar;14(3):208-15. doi: 10.1258/095646203762869241. PMID: 12665446
Syphilis and drugs of abuse.
Paradise LJ, Friedman H
Adv Exp Med Biol 1993;335:81-7. doi: 10.1007/978-1-4615-2980-4_12. PMID: 8237612

Diagnosis

Placental Syphilis: A Comprehensive Review of Routine Histomorphology, HIV Co-infection, Penicillin Treatment, Immunohistochemistry, and Polymerase Chain Reaction.
Marais YA, Mason D, Barnard A, Saaiman CR, Els HC, Kluge J, Glass AJ, Wright CA, Schubert PT
Fetal Pediatr Pathol 2023 Dec;42(6):870-890. Epub 2023 Sep 5 doi: 10.1080/15513815.2023.2253309. PMID: 37668986
Syphilis in pregnancy: an ongoing public health threat.
Eppes CS, Stafford I, Rac M
Am J Obstet Gynecol 2022 Dec;227(6):822-838. Epub 2022 Aug 3 doi: 10.1016/j.ajog.2022.07.041. PMID: 35932881
Yaws.
Marks M, Lebari D, Solomon AW, Higgins SP
Int J STD AIDS 2015 Sep;26(10):696-703. Epub 2014 Sep 4 doi: 10.1177/0956462414549036. PMID: 25193248Free PMC Article
Diagnosis of treponemal co-infection in HIV-infected West Africans.
Mamoojee Y, Tan G, Gittins S, Sarfo S, Stephenson L, Carrington D, Bedu-Addo G, Phillips R, Appiah LT, Chadwick D
Trop Med Int Health 2012 Dec;17(12):1521-6. Epub 2012 Sep 20 doi: 10.1111/j.1365-3156.2012.03090.x. PMID: 22994205
The origin and antiquity of syphilis revisited: an appraisal of Old World pre-Columbian evidence for treponemal infection.
Harper KN, Zuckerman MK, Harper ML, Kingston JD, Armelagos GJ
Am J Phys Anthropol 2011;146 Suppl 53:99-133. doi: 10.1002/ajpa.21613. PMID: 22101689

Therapy

Placental Syphilis: A Comprehensive Review of Routine Histomorphology, HIV Co-infection, Penicillin Treatment, Immunohistochemistry, and Polymerase Chain Reaction.
Marais YA, Mason D, Barnard A, Saaiman CR, Els HC, Kluge J, Glass AJ, Wright CA, Schubert PT
Fetal Pediatr Pathol 2023 Dec;42(6):870-890. Epub 2023 Sep 5 doi: 10.1080/15513815.2023.2253309. PMID: 37668986
Syphilis in pregnancy: an ongoing public health threat.
Eppes CS, Stafford I, Rac M
Am J Obstet Gynecol 2022 Dec;227(6):822-838. Epub 2022 Aug 3 doi: 10.1016/j.ajog.2022.07.041. PMID: 35932881
Yaws.
Marks M, Lebari D, Solomon AW, Higgins SP
Int J STD AIDS 2015 Sep;26(10):696-703. Epub 2014 Sep 4 doi: 10.1177/0956462414549036. PMID: 25193248Free PMC Article
Treponemal infection rates, risk factors and pregnancy outcome in a rural area of Senegal.
Lagarde E, Guyavarch E, Piau JP, Gueye-Ndiaye A, Seck K, Enel C, Pison G, Ndoye I, Mboup S; MECORA group
Int J STD AIDS 2003 Mar;14(3):208-15. doi: 10.1258/095646203762869241. PMID: 12665446
Tropical myeloneuropathies: the hidden endemias.
Román GC, Spencer PS, Schoenberg BS
Neurology 1985 Aug;35(8):1158-70. doi: 10.1212/wnl.35.8.1158. PMID: 2991814

Prognosis

Diagnosis of treponemal co-infection in HIV-infected West Africans.
Mamoojee Y, Tan G, Gittins S, Sarfo S, Stephenson L, Carrington D, Bedu-Addo G, Phillips R, Appiah LT, Chadwick D
Trop Med Int Health 2012 Dec;17(12):1521-6. Epub 2012 Sep 20 doi: 10.1111/j.1365-3156.2012.03090.x. PMID: 22994205
Treponemal infection and the outcome of pregnancy in a rural area of The Gambia, west Africa.
Greenwood AM, D'Alessandro U, Sisay F, Greenwood BM
J Infect Dis 1992 Oct;166(4):842-6. doi: 10.1093/infdis/166.4.842. PMID: 1527421
Syphilis in pregnant women in Mozambique.
Liljestrand J, Bergström S, Nieuwenhuis F, Hederstedt B
Genitourin Med 1985 Dec;61(6):355-8. doi: 10.1136/sti.61.6.355. PMID: 3910543Free PMC Article
Syphilis in patients with Hansen's disease.
Murray KA
Int J Lepr Other Mycobact Dis 1982 Jun;50(2):152-8. PMID: 6749704
Prognosis of idiopathic cardiomegaly in Jamaica with reference to the coronary arteries and other factors.
Stuart KL, Bras G
Br Heart J 1971;33(Suppl):Suppl:187-93. doi: 10.1136/hrt.33.suppl.187. PMID: 4102089Free PMC Article

Clinical prediction guides

Placental Syphilis: A Comprehensive Review of Routine Histomorphology, HIV Co-infection, Penicillin Treatment, Immunohistochemistry, and Polymerase Chain Reaction.
Marais YA, Mason D, Barnard A, Saaiman CR, Els HC, Kluge J, Glass AJ, Wright CA, Schubert PT
Fetal Pediatr Pathol 2023 Dec;42(6):870-890. Epub 2023 Sep 5 doi: 10.1080/15513815.2023.2253309. PMID: 37668986
The dark art of syphilis serology - an analysis of testing algorithms at a UK reference laboratory.
Scobie A, Brown CS, French P, Donati M, Muir P, Templeton K, Higgins SP, Patel H, Alexander S, Fifer H
J Med Microbiol 2022 Apr;71(4) doi: 10.1099/jmm.0.001479. PMID: 35451942
Treponema pallidum infection in the wild baboons of East Africa: distribution and genetic characterization of the strains responsible.
Harper KN, Fyumagwa RD, Hoare R, Wambura PN, Coppenhaver DH, Sapolsky RM, Alberts SC, Tung J, Rogers J, Kilewo M, Batamuzi EK, Leendertz FH, Armelagos GJ, Knauf S
PLoS One 2012;7(12):e50882. Epub 2012 Dec 20 doi: 10.1371/journal.pone.0050882. PMID: 23284649Free PMC Article
An assessment of health and disease in the prehistoric inhabitants of the Mariana Islands.
Pietrusewsky M, Douglas MT, Ikehara-Quebral RM
Am J Phys Anthropol 1997 Nov;104(3):315-42. doi: 10.1002/(SICI)1096-8644(199711)104:3<315::AID-AJPA4>3.0.CO;2-U. PMID: 9408539
Syphilis in pregnant women in Mozambique.
Liljestrand J, Bergström S, Nieuwenhuis F, Hederstedt B
Genitourin Med 1985 Dec;61(6):355-8. doi: 10.1136/sti.61.6.355. PMID: 3910543Free PMC Article

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