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Adult yolk sac tumor

MedGen UID:
231046
•Concept ID:
C1332221
•
Neoplastic Process
Synonyms: Adult Endodermal Sinus Neoplasm; adult endodermal sinus neoplasm; Adult Endodermal Sinus Tumor; adult endodermal sinus tumor; adult endodermal sinus tumour; Adult Yolk Sac Neoplasm; adult yolk Sac neoplasm; Adult Yolk Sac Tumor; adult yolk sac tumor; adult yolk Sac tumor; adult yolk Sac tumour; yolk sac tumor of adults; yolk sac tumour of adults
 
Monarch Initiative: MONDO:0003404

Definition

A yolk sac tumor that occurs in an adult. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult yolk sac tumor

Professional guidelines

PubMed

The clinical features and prognostic outcomes of primary mediastinal yolk sac tumors: A retrospective analysis of 15 rare cases from multiple centers.
Qin L, Zhu M, Wang T, Wang H, Pan Q, He D
Medicine (Baltimore) 2021 Jul 23;100(29):e26480. doi: 10.1097/MD.0000000000026480. PMID: 34398004Free PMC Article
Primary Mediastinal Nonseminomas: A Population-Based Surveillance, Epidemiology, and End Results Analysis.
Yang X, Zhao K, Mei J, Wei S, Xia L, Pu Y, Liu L
J Surg Res 2021 Nov;267:25-36. Epub 2021 Jun 11 doi: 10.1016/j.jss.2021.04.022. PMID: 34126390
Evaluation and management of pediatric solid ovarian tumors.
Lazar EL, Stolar CJ
Semin Pediatr Surg 1998 Feb;7(1):29-34. doi: 10.1016/s1055-8586(98)70003-4. PMID: 9498265

Recent clinical studies

Etiology

Ovarian yolk sac tumor in a premenarchal girl.
Miletić AI, Habek D, Medić F, Prka M, Berić Lerotić S, Knežević F
Wien Med Wochenschr 2023 Mar;173(3-4):70-73. Epub 2023 Jan 13 doi: 10.1007/s10354-022-00996-1. PMID: 36637654
Adjuvant and post-surgical treatment in non-epithelial ovarian cancer.
El Helali A, Kwok GST, Tse KY
Best Pract Res Clin Obstet Gynaecol 2022 Jan;78:74-85. Epub 2021 Aug 4 doi: 10.1016/j.bpobgyn.2021.06.001. PMID: 34493450
Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature.
Young RH, Wong A, Stall JN
Am J Surg Pathol 2022 Mar 1;46(3):309-325. doi: 10.1097/PAS.0000000000001793. PMID: 34469331
Pediatric vulvar malignancies: rare but important to know.
Strickland AL, Fadare O
Semin Diagn Pathol 2021 Jan;38(1):99-109. Epub 2020 Sep 5 doi: 10.1053/j.semdp.2020.09.001. PMID: 32943238
Pineal tumors.
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982

Diagnosis

Pure post-pubertal yolk sac tumor of the testis: An extremely rare and aggressive entity.
Patel S, Satturwar S, Khan W, Ashman D, Quiroga-Garza GM
Ann Diagn Pathol 2023 Apr;63:152086. Epub 2022 Dec 23 doi: 10.1016/j.anndiagpath.2022.152086. PMID: 36580878
Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature.
Young RH, Wong A, Stall JN
Am J Surg Pathol 2022 Mar 1;46(3):309-325. doi: 10.1097/PAS.0000000000001793. PMID: 34469331
Pregnancy and Delivery After Ovarian Yolk Sac Tumor: A Case Report.
Alrjoub MM, Sindiani A, Alshriedeh O, Amarin Z
Am J Case Rep 2021 Aug 19;22:e932091. doi: 10.12659/AJCR.932091. PMID: 34408122Free PMC Article
A yolk sac tumor of the pancreas and derived xenograft model effectively responded to VIP chemotherapy.
Yonemaru J, Takahashi M, Nara S, Ichikawa H, Ishigamori R, Imai T, Hiraoka N
Pancreatology 2020 Apr;20(3):551-557. Epub 2019 Dec 31 doi: 10.1016/j.pan.2019.12.021. PMID: 31917123
Pineal tumors.
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982

Therapy

Pregnancy and Delivery After Ovarian Yolk Sac Tumor: A Case Report.
Alrjoub MM, Sindiani A, Alshriedeh O, Amarin Z
Am J Case Rep 2021 Aug 19;22:e932091. doi: 10.12659/AJCR.932091. PMID: 34408122Free PMC Article
A yolk sac tumor of the pancreas and derived xenograft model effectively responded to VIP chemotherapy.
Yonemaru J, Takahashi M, Nara S, Ichikawa H, Ishigamori R, Imai T, Hiraoka N
Pancreatology 2020 Apr;20(3):551-557. Epub 2019 Dec 31 doi: 10.1016/j.pan.2019.12.021. PMID: 31917123
Yolk sac tumor of endometrium: A case report and literature review.
Lin SW, Hsieh SW, Huang SH, Liang HS, Huang CY
Taiwan J Obstet Gynecol 2019 Nov;58(6):846-848. doi: 10.1016/j.tjog.2019.09.020. PMID: 31759539
Ovarian yolk sac tumor in postmenopausal females: A case series and a literature review.
Wang Y, Yang J, Yu M, Cao D, Zhang Y, Zong X, Shen K
Medicine (Baltimore) 2018 Aug;97(33):e11838. doi: 10.1097/MD.0000000000011838. PMID: 30113473Free PMC Article
Ovarian yolk sac tumor associated with endometrioid carcinoma and mucinous cystadenoma of the ovary.
Lopez JM, Malpica A, Deavers MT, Ayala AG
Ann Diagn Pathol 2003 Oct;7(5):300-5. doi: 10.1016/s1092-9134(03)00081-9. PMID: 14571433

Prognosis

Pediatric vulvar malignancies: rare but important to know.
Strickland AL, Fadare O
Semin Diagn Pathol 2021 Jan;38(1):99-109. Epub 2020 Sep 5 doi: 10.1053/j.semdp.2020.09.001. PMID: 32943238
Ovarian yolk sac tumor in postmenopausal females: A case series and a literature review.
Wang Y, Yang J, Yu M, Cao D, Zhang Y, Zong X, Shen K
Medicine (Baltimore) 2018 Aug;97(33):e11838. doi: 10.1097/MD.0000000000011838. PMID: 30113473Free PMC Article
Primary yolk sac tumor of seminal vesicle: a case report and literature review.
Yao XD, Hong YP, Ye DW, Wang CF
World J Surg Oncol 2012 Sep 14;10:189. doi: 10.1186/1477-7819-10-189. PMID: 22978485Free PMC Article
Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653
Pineal tumors.
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982

Clinical prediction guides

How and where to expect endosalpingiosis intraoperatively.
Burla L, Kalaitzopoulos DR, Mrozek A, Eberhard M, Samartzis N
Fertil Steril 2022 Feb;117(2):461-462. Epub 2022 Jan 2 doi: 10.1016/j.fertnstert.2021.11.016. PMID: 34986982
Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature.
Young RH, Wong A, Stall JN
Am J Surg Pathol 2022 Mar 1;46(3):309-325. doi: 10.1097/PAS.0000000000001793. PMID: 34469331
Juvenile Granulosa Cell Tumors of the Ovary.
Ye Y, Lv C, Xu S, Chen Y, Qian R, Wang P, Wang S
Am J Clin Pathol 2020 Oct 13;154(5):635-644. doi: 10.1093/ajcp/aqaa081. PMID: 32561911
Yolk Sac Tumor in Extragonadal Pelvic Sites: Still a Diagnostic Challenge.
Ravishankar S, Malpica A, Ramalingam P, Euscher ED
Am J Surg Pathol 2017 Jan;41(1):1-11. doi: 10.1097/PAS.0000000000000722. PMID: 27631522
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Recent systematic reviews

Primary yolk sac tumor of the endometrium: a case report and review of the literatures.
Lu T, Qi L, Ma Y, Lu G, Zhang X, Liu P
Arch Gynecol Obstet 2019 Nov;300(5):1177-1187. Epub 2019 Sep 23 doi: 10.1007/s00404-019-05309-3. PMID: 31549219

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