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Germ cell tumor

MedGen UID:
60030
Concept ID:
C0205851
Neoplastic Process
Synonyms: Germ Cell Neoplasms; Germ Cell Tumor; Germ Cell Tumors; Neoplasms, Germ Cell; Tumor, Germ Cell; Tumors, Germ Cell
SNOMED CT: Germ cell neoplasm (115233005); Germ cell tumor (402878003); Germ cell neoplasm (402878003); Germ cell tumor (28307001)
 
Monarch Initiative: MONDO:0005040

Definition

A benign or malignant, gonadal or extragonadal neoplasm that originates from germ cells. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumor. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Frappaz D, Dhall G, Murray MJ, Goldman S, Faure Conter C, Allen J, Kortmann RD, Haas-Kogen D, Morana G, Finlay J, Nicholson JC, Bartels U, Souweidane M, Schönberger S, Vasiljevic A, Robertson P, Albanese A, Alapetite C, Czech T, Lau CC, Wen P, Schiff D, Shaw D, Calaminus G, Bouffet E
Neuro Oncol 2022 Apr 1;24(4):516-527. doi: 10.1093/neuonc/noab252. PMID: 34724065Free PMC Article
Patti G, Ibba A, Morana G, Napoli F, Fava D, di Iorgi N, Maghnie M
Best Pract Res Clin Endocrinol Metab 2020 Sep;34(5):101440. Epub 2020 Jun 29 doi: 10.1016/j.beem.2020.101440. PMID: 32646670
Oing C, Giannatempo P, Honecker F, Oechsle K, Bokemeyer C, Beyer J
Cancer Treat Rev 2018 Dec;71:102-107. Epub 2018 Oct 22 doi: 10.1016/j.ctrv.2018.10.007. PMID: 30415106

Recent clinical studies

Etiology

Ramalingam P
Semin Diagn Pathol 2023 Jan;40(1):22-36. Epub 2022 Jul 29 doi: 10.1053/j.semdp.2022.07.004. PMID: 36088223
Frappaz D, Dhall G, Murray MJ, Goldman S, Faure Conter C, Allen J, Kortmann RD, Haas-Kogen D, Morana G, Finlay J, Nicholson JC, Bartels U, Souweidane M, Schönberger S, Vasiljevic A, Robertson P, Albanese A, Alapetite C, Czech T, Lau CC, Wen P, Schiff D, Shaw D, Calaminus G, Bouffet E
Neuro Oncol 2022 Apr 1;24(4):516-527. doi: 10.1093/neuonc/noab252. PMID: 34724065Free PMC Article
Farazdaghi A, Vaughn DJ, Singhal S
Ann Thorac Cardiovasc Surg 2019 Dec 20;25(6):289-295. Epub 2019 Nov 13 doi: 10.5761/atcs.ra.19-00070. PMID: 31723083Free PMC Article
Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171
Mukherjee S, Ibrahimi S, John S, Adnan MM, Scordino T, Khalil MO, Cherry M
Ann Hematol 2017 Sep;96(9):1435-1439. Epub 2017 Jun 3 doi: 10.1007/s00277-017-3037-3. PMID: 28578457

Diagnosis

Ramalingam P
Semin Diagn Pathol 2023 Jan;40(1):22-36. Epub 2022 Jul 29 doi: 10.1053/j.semdp.2022.07.004. PMID: 36088223
Al-Obaidy KI, Magers MJ, Idrees MT
Surg Pathol Clin 2022 Dec;15(4):745-757. doi: 10.1016/j.path.2022.07.010. PMID: 36344187
Lafin JT, Amatruda JF, Bagrodia A
Methods Mol Biol 2021;2195:65-76. doi: 10.1007/978-1-0716-0860-9_5. PMID: 32852757
Marshall C, Enzerra M, Rahnemai-Azar AA, Ramaiya NH
Abdom Radiol (NY) 2019 Mar;44(3):1083-1090. doi: 10.1007/s00261-018-1846-z. PMID: 30539249
Mukherjee S, Ibrahimi S, John S, Adnan MM, Scordino T, Khalil MO, Cherry M
Ann Hematol 2017 Sep;96(9):1435-1439. Epub 2017 Jun 3 doi: 10.1007/s00277-017-3037-3. PMID: 28578457

Therapy

Daneshmand S, Cary C, Masterson T, Einhorn L, Adra N, Boorjian SA, Kollmannsberger C, Schuckman A, So A, Black P, Bagrodia A, Skinner E, Alemozaffar M, Brand T, Eggener S, Pierorazio P, Stratton K, Nappi L, Nichols C, Luo C, Li M, Hu B
J Clin Oncol 2023 Jun 1;41(16):3009-3018. Epub 2023 Mar 13 doi: 10.1200/JCO.22.00624. PMID: 36913642
Abughanimeh O, Teply BA
Curr Oncol Rep 2021 Jul 16;23(9):101. doi: 10.1007/s11912-021-01093-z. PMID: 34269906
Brown DW, Lan Q, Rothman N, Pluta J, Almstrup K, Dalgaard MD, Greene MH, Grotmol T, Loveday C, Schwartz SM, Turnbull C, Wiklund F, Kanetsky PA, Nathanson KL, McGlynn KA, Machiela MJ; Testicular Cancer Consortium
Cancer Epidemiol Biomarkers Prev 2021 Jun;30(6):1275-1278. Epub 2021 Mar 18 doi: 10.1158/1055-9965.EPI-20-1775. PMID: 33737296Free PMC Article
Farazdaghi A, Vaughn DJ, Singhal S
Ann Thorac Cardiovasc Surg 2019 Dec 20;25(6):289-295. Epub 2019 Nov 13 doi: 10.5761/atcs.ra.19-00070. PMID: 31723083Free PMC Article
Feldman DR, Sheinfeld J, Bajorin DF, Fischer P, Turkula S, Ishill N, Patil S, Bains M, Reich LM, Bosl GJ, Motzer RJ
J Clin Oncol 2010 Apr 1;28(10):1706-13. Epub 2010 Mar 1 doi: 10.1200/JCO.2009.25.1561. PMID: 20194867Free PMC Article

Prognosis

Kawakubo N, Okubo Y, Yotsukura M, Yoshida Y, Nakagawa K, Yonemori K, Watanabe H, Yatabe Y, Watanabe SI
J Surg Res 2022 Apr;272:61-68. Epub 2021 Dec 20 doi: 10.1016/j.jss.2021.11.002. PMID: 34936913
Oing C, Seidel C, Bokemeyer C
Expert Rev Anticancer Ther 2018 Apr;18(4):389-397. Epub 2018 Mar 12 doi: 10.1080/14737140.2018.1450630. PMID: 29516750
Ceppa DP
Thorac Surg Clin 2016 Feb;26(1):49-54. doi: 10.1016/j.thorsurg.2015.09.007. PMID: 26611510
Stevenson SM, Lowrance WT
Urol Clin North Am 2015 Aug;42(3):269-75. Epub 2015 Jun 11 doi: 10.1016/j.ucl.2015.04.001. PMID: 26216814
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320

Clinical prediction guides

Langan RC, Puente MEE
Am Fam Physician 2022 Aug;106(2):184-189. PMID: 35977130
Brown DW, Lan Q, Rothman N, Pluta J, Almstrup K, Dalgaard MD, Greene MH, Grotmol T, Loveday C, Schwartz SM, Turnbull C, Wiklund F, Kanetsky PA, Nathanson KL, McGlynn KA, Machiela MJ; Testicular Cancer Consortium
Cancer Epidemiol Biomarkers Prev 2021 Jun;30(6):1275-1278. Epub 2021 Mar 18 doi: 10.1158/1055-9965.EPI-20-1775. PMID: 33737296Free PMC Article
Francis F, Zhou M
Methods Mol Biol 2021;2195:13-29. doi: 10.1007/978-1-0716-0860-9_2. PMID: 32852754
Woldu SL, Amatruda JF, Bagrodia A
Curr Opin Urol 2017 Jan;27(1):41-47. doi: 10.1097/MOU.0000000000000347. PMID: 27584029Free PMC Article
Oliver T, Mead G
Curr Opin Oncol 1993 May;5(3):559-67. doi: 10.1097/00001622-199305000-00018. PMID: 8388258

Recent systematic reviews

Nijsten K, Jansen LAW, Limpens J, Finken MJJ, Koot MH, Grooten IJ, Roseboom TJ, Painter RC
Am J Obstet Gynecol 2022 Sep;227(3):414-429.e17. Epub 2022 Mar 30 doi: 10.1016/j.ajog.2022.03.052. PMID: 35367190
Liu Q, Lian Q, Lv H, Zhang X, Zhou F
Mol Diagn Ther 2021 May;25(3):273-281. Epub 2021 Apr 22 doi: 10.1007/s40291-021-00521-x. PMID: 33886084
Gupta M, Cheaib JG, Patel HD, Sharma R, Zhang A, Bass EB, Pierorazio PM
J Urol 2020 Jul;204(1):33-41. Epub 2020 Jan 22 doi: 10.1097/JU.0000000000000758. PMID: 31967523
Ghasemiesfe M, Barrow B, Leonard S, Keyhani S, Korenstein D
JAMA Netw Open 2019 Nov 1;2(11):e1916318. doi: 10.1001/jamanetworkopen.2019.16318. PMID: 31774524Free PMC Article
Chovanec M, Abu Zaid M, Hanna N, El-Kouri N, Einhorn LH, Albany C
Ann Oncol 2017 Nov 1;28(11):2670-2679. doi: 10.1093/annonc/mdx360. PMID: 29045502Free PMC Article

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