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Anaplastic Diencephalic Astrocytoma

MedGen UID:
231068
•Concept ID:
C1332281
•
Neoplastic Process
Synonyms: Anaplastic Astrocytoma of Diencephalon; Anaplastic Astrocytoma of the Diencephalon; Diencephalic Anaplastic Astrocytoma; Grade 3 Astrocytic Neoplasm of Diencephalon; Grade 3 Astrocytic Neoplasm of the Diencephalon; Grade 3 Astrocytic Tumor of Diencephalon; Grade 3 Astrocytic Tumor of the Diencephalon; Grade 3 Astrocytoma of Diencephalon; Grade 3 Astrocytoma of the Diencephalon; Grade 3 Diencephalic Astrocytic Neoplasm; Grade 3 Diencephalic Astrocytic Tumor; Grade 3 Diencephalic Astrocytoma; Grade III Astrocytic Neoplasm of Diencephalon; Grade III Astrocytic Neoplasm of the Diencephalon; Grade III Astrocytic Tumor of Diencephalon; Grade III Astrocytic Tumor of the Diencephalon; Grade III Astrocytoma of Diencephalon; Grade III Astrocytoma of the Diencephalon; Grade III Diencephalic Astrocytic Neoplasm; Grade III Diencephalic Astrocytic Tumor; Grade III Diencephalic Astrocytoma; Undifferentiated Astrocytoma of Diencephalon; Undifferentiated Astrocytoma of the Diencephalon; Undifferentiated Diencephalic Astrocytoma

Definition

An anaplastic astrocytoma that occurs in the diencephalon. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic Diencephalic Astrocytoma

Professional guidelines

PubMed

Selection of a management strategy for pediatric brainstem tumors.
Halperin EC, Wehn SM, Scott JW, Djang W, Oakes WJ, Friedman HS
Med Pediatr Oncol 1989;17(2):117-26. doi: 10.1002/mpo.2950170209. PMID: 2704333

Recent clinical studies

Etiology

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma.
Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, Schmieder K, Wesseling P, Mawrin C, Hasselblatt M, Louis DN, Korshunov A, Pfister S, Hartmann C, Paulus W, Reifenberger G, von Deimling A
Acta Neuropathol 2011 Mar;121(3):397-405. Epub 2011 Jan 29 doi: 10.1007/s00401-011-0802-6. PMID: 21274720
Selection of a management strategy for pediatric brainstem tumors.
Halperin EC, Wehn SM, Scott JW, Djang W, Oakes WJ, Friedman HS
Med Pediatr Oncol 1989;17(2):117-26. doi: 10.1002/mpo.2950170209. PMID: 2704333
Vascular bundles and wickerworks in childhood brain tumors.
Sato K, Rorke LB
Pediatr Neurosci 1989;15(3):105-10. doi: 10.1159/000120454. PMID: 2702345

Diagnosis

An infant with hyperalertness, hyperkinesis, and failure to thrive: a rare diencephalic syndrome due to hypothalamic anaplastic astrocytoma.
Stival A, Lucchesi M, Farina S, Buccoliero AM, Castiglione F, Genitori L, de Martino M, Sardi I
BMC Cancer 2015 Sep 4;15:616. doi: 10.1186/s12885-015-1626-x. PMID: 26337554Free PMC Article
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma.
Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, Schmieder K, Wesseling P, Mawrin C, Hasselblatt M, Louis DN, Korshunov A, Pfister S, Hartmann C, Paulus W, Reifenberger G, von Deimling A
Acta Neuropathol 2011 Mar;121(3):397-405. Epub 2011 Jan 29 doi: 10.1007/s00401-011-0802-6. PMID: 21274720
von Recklinghausen's disease with diencephalic syndrome in an adult. Case report.
Tanabe M, Watanabe T, Hori T
J Neurosurg 1994 Mar;80(3):556-8. doi: 10.3171/jns.1994.80.3.0556. PMID: 8113871
Selection of a management strategy for pediatric brainstem tumors.
Halperin EC, Wehn SM, Scott JW, Djang W, Oakes WJ, Friedman HS
Med Pediatr Oncol 1989;17(2):117-26. doi: 10.1002/mpo.2950170209. PMID: 2704333

Prognosis

An infant with hyperalertness, hyperkinesis, and failure to thrive: a rare diencephalic syndrome due to hypothalamic anaplastic astrocytoma.
Stival A, Lucchesi M, Farina S, Buccoliero AM, Castiglione F, Genitori L, de Martino M, Sardi I
BMC Cancer 2015 Sep 4;15:616. doi: 10.1186/s12885-015-1626-x. PMID: 26337554Free PMC Article
Selection of a management strategy for pediatric brainstem tumors.
Halperin EC, Wehn SM, Scott JW, Djang W, Oakes WJ, Friedman HS
Med Pediatr Oncol 1989;17(2):117-26. doi: 10.1002/mpo.2950170209. PMID: 2704333

Clinical prediction guides

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma.
Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, Schmieder K, Wesseling P, Mawrin C, Hasselblatt M, Louis DN, Korshunov A, Pfister S, Hartmann C, Paulus W, Reifenberger G, von Deimling A
Acta Neuropathol 2011 Mar;121(3):397-405. Epub 2011 Jan 29 doi: 10.1007/s00401-011-0802-6. PMID: 21274720
Congenital anaplastic astrocytoma differentiated into pilocytic astrocytoma: an autopsy case.
Arai Y, Tsuchida T, Tanioka F, Sugimura H, Watanabe C, Hongo T, Tsutsui Y
Neuropathology 2008 Aug;28(4):433-9. Epub 2008 Feb 16 doi: 10.1111/j.1440-1789.2008.00866.x. PMID: 18282169
Selection of a management strategy for pediatric brainstem tumors.
Halperin EC, Wehn SM, Scott JW, Djang W, Oakes WJ, Friedman HS
Med Pediatr Oncol 1989;17(2):117-26. doi: 10.1002/mpo.2950170209. PMID: 2704333

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