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Grade 3b Malignant Neoplasm

MedGen UID:
232564
•Concept ID:
C1333851
•
Neoplastic Process

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3b Malignant Neoplasm

Professional guidelines

PubMed

Lisocabtagene maraleucel in the treatment of relapsed/refractory large B-cell lymphoma.
St-Pierre F, Gordon LI
Future Oncol 2023 Jan;19(1):19-28. Epub 2023 Jan 18 doi: 10.2217/fon-2022-0774. PMID: 36651471
Primary treatment of light-chain amyloidosis with bortezomib, lenalidomide, and dexamethasone.
Kastritis E, Dialoupi I, Gavriatopoulou M, Roussou M, Kanellias N, Fotiou D, Ntanasis-Stathopoulos I, Papadopoulou E, Ziogas DC, Stamatelopoulos K, Manios E, Ntalianis A, Eleutherakis-Papaiakovou E, Papanikolaou A, Migkou M, Papanota AM, Gakiopoulou H, Psimenou E, Tselegkidi MI, Tsitsilonis O, Kostopoulos I, Terpos E, Dimopoulos MA
Blood Adv 2019 Oct 22;3(20):3002-3009. doi: 10.1182/bloodadvances.2019000147. PMID: 31648323Free PMC Article
Ureteroscopic and percutaneous management of upper tract urothelial carcinoma (UTUC): systematic review.
Cutress ML, Stewart GD, Zakikhani P, Phipps S, Thomas BG, Tolley DA
BJU Int 2012 Sep;110(5):614-28. Epub 2012 Apr 3 doi: 10.1111/j.1464-410X.2012.11068.x. PMID: 22471401

Recent clinical studies

Etiology

Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial.
Luke JJ, Rutkowski P, Queirolo P, Del Vecchio M, Mackiewicz J, Chiarion-Sileni V, de la Cruz Merino L, Khattak MA, Schadendorf D, Long GV, Ascierto PA, Mandala M, De Galitiis F, Haydon A, Dummer R, Grob JJ, Robert C, Carlino MS, Mohr P, Poklepovic A, Sondak VK, Scolyer RA, Kirkwood JM, Chen K, Diede SJ, Ahsan S, Ibrahim N, Eggermont AMM; KEYNOTE-716 Investigators
Lancet 2022 Apr 30;399(10336):1718-1729. Epub 2022 Apr 1 doi: 10.1016/S0140-6736(22)00562-1. PMID: 35367007
Feasibility, Biodistribution, and Preliminary Dosimetry in Peptide-Targeted Radionuclide Therapy of Diverse Adenocarcinomas Using (177)Lu-FAP-2286: First-in-Humans Results.
Baum RP, Schuchardt C, Singh A, Chantadisai M, Robiller FC, Zhang J, Mueller D, Eismant A, Almaguel F, Zboralski D, Osterkamp F, Hoehne A, Reineke U, Smerling C, Kulkarni HR
J Nucl Med 2022 Mar;63(3):415-423. Epub 2021 Jun 24 doi: 10.2967/jnumed.120.259192. PMID: 34168013Free PMC Article
Full population results from the core phase of CompLEEment-1, a phase 3b study of ribociclib plus letrozole as first-line therapy for advanced breast cancer in an expanded population.
De Laurentiis M, Borstnar S, Campone M, Warner E, Bofill JS, Jacot W, Dent S, Martin M, Ring A, Cottu P, Lu J, Ciruelos E, Azim HA, Chatterjee S, Zhou K, Wu J, Menon-Singh L, Zamagni C
Breast Cancer Res Treat 2021 Oct;189(3):689-699. Epub 2021 Aug 19 doi: 10.1007/s10549-021-06334-0. PMID: 34414532Free PMC Article
Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial.
Morschhauser F, Tilly H, Chaidos A, McKay P, Phillips T, Assouline S, Batlevi CL, Campbell P, Ribrag V, Damaj GL, Dickinson M, Jurczak W, Kazmierczak M, Opat S, Radford J, Schmitt A, Yang J, Whalen J, Agarwal S, Adib D, Salles G
Lancet Oncol 2020 Nov;21(11):1433-1442. Epub 2020 Oct 6 doi: 10.1016/S1470-2045(20)30441-1. PMID: 33035457Free PMC Article
Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study.
Abramson JS, Palomba ML, Gordon LI, Lunning MA, Wang M, Arnason J, Mehta A, Purev E, Maloney DG, Andreadis C, Sehgal A, Solomon SR, Ghosh N, Albertson TM, Garcia J, Kostic A, Mallaney M, Ogasawara K, Newhall K, Kim Y, Li D, Siddiqi T
Lancet 2020 Sep 19;396(10254):839-852. Epub 2020 Sep 1 doi: 10.1016/S0140-6736(20)31366-0. PMID: 32888407

Diagnosis

Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial.
Luke JJ, Rutkowski P, Queirolo P, Del Vecchio M, Mackiewicz J, Chiarion-Sileni V, de la Cruz Merino L, Khattak MA, Schadendorf D, Long GV, Ascierto PA, Mandala M, De Galitiis F, Haydon A, Dummer R, Grob JJ, Robert C, Carlino MS, Mohr P, Poklepovic A, Sondak VK, Scolyer RA, Kirkwood JM, Chen K, Diede SJ, Ahsan S, Ibrahim N, Eggermont AMM; KEYNOTE-716 Investigators
Lancet 2022 Apr 30;399(10336):1718-1729. Epub 2022 Apr 1 doi: 10.1016/S0140-6736(22)00562-1. PMID: 35367007
Feasibility, Biodistribution, and Preliminary Dosimetry in Peptide-Targeted Radionuclide Therapy of Diverse Adenocarcinomas Using (177)Lu-FAP-2286: First-in-Humans Results.
Baum RP, Schuchardt C, Singh A, Chantadisai M, Robiller FC, Zhang J, Mueller D, Eismant A, Almaguel F, Zboralski D, Osterkamp F, Hoehne A, Reineke U, Smerling C, Kulkarni HR
J Nucl Med 2022 Mar;63(3):415-423. Epub 2021 Jun 24 doi: 10.2967/jnumed.120.259192. PMID: 34168013Free PMC Article
The diagnostic and therapeutic challenges of Grade 3B follicular lymphoma.
Barraclough A, Bishton M, Cheah CY, Villa D, Hawkes EA
Br J Haematol 2021 Oct;195(1):15-24. Epub 2021 Mar 11 doi: 10.1111/bjh.17404. PMID: 33704790
Follicular lymphoma grade 3: review and updates.
Vaidyanathan G, Czuczman MS
Clin Lymphoma Myeloma Leuk 2014 Dec;14(6):431-5. Epub 2014 Jun 12 doi: 10.1016/j.clml.2014.04.008. PMID: 25066038
Pathology of follicular lymphoma.
Takata K, Miyata-Takata T, Sato Y, Yoshino T
J Clin Exp Hematop 2014;54(1):3-9. doi: 10.3960/jslrt.54.3. PMID: 24942941

Therapy

Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial.
Luke JJ, Rutkowski P, Queirolo P, Del Vecchio M, Mackiewicz J, Chiarion-Sileni V, de la Cruz Merino L, Khattak MA, Schadendorf D, Long GV, Ascierto PA, Mandala M, De Galitiis F, Haydon A, Dummer R, Grob JJ, Robert C, Carlino MS, Mohr P, Poklepovic A, Sondak VK, Scolyer RA, Kirkwood JM, Chen K, Diede SJ, Ahsan S, Ibrahim N, Eggermont AMM; KEYNOTE-716 Investigators
Lancet 2022 Apr 30;399(10336):1718-1729. Epub 2022 Apr 1 doi: 10.1016/S0140-6736(22)00562-1. PMID: 35367007
Feasibility, Biodistribution, and Preliminary Dosimetry in Peptide-Targeted Radionuclide Therapy of Diverse Adenocarcinomas Using (177)Lu-FAP-2286: First-in-Humans Results.
Baum RP, Schuchardt C, Singh A, Chantadisai M, Robiller FC, Zhang J, Mueller D, Eismant A, Almaguel F, Zboralski D, Osterkamp F, Hoehne A, Reineke U, Smerling C, Kulkarni HR
J Nucl Med 2022 Mar;63(3):415-423. Epub 2021 Jun 24 doi: 10.2967/jnumed.120.259192. PMID: 34168013Free PMC Article
Full population results from the core phase of CompLEEment-1, a phase 3b study of ribociclib plus letrozole as first-line therapy for advanced breast cancer in an expanded population.
De Laurentiis M, Borstnar S, Campone M, Warner E, Bofill JS, Jacot W, Dent S, Martin M, Ring A, Cottu P, Lu J, Ciruelos E, Azim HA, Chatterjee S, Zhou K, Wu J, Menon-Singh L, Zamagni C
Breast Cancer Res Treat 2021 Oct;189(3):689-699. Epub 2021 Aug 19 doi: 10.1007/s10549-021-06334-0. PMID: 34414532Free PMC Article
Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial.
Morschhauser F, Tilly H, Chaidos A, McKay P, Phillips T, Assouline S, Batlevi CL, Campbell P, Ribrag V, Damaj GL, Dickinson M, Jurczak W, Kazmierczak M, Opat S, Radford J, Schmitt A, Yang J, Whalen J, Agarwal S, Adib D, Salles G
Lancet Oncol 2020 Nov;21(11):1433-1442. Epub 2020 Oct 6 doi: 10.1016/S1470-2045(20)30441-1. PMID: 33035457Free PMC Article
Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study.
Abramson JS, Palomba ML, Gordon LI, Lunning MA, Wang M, Arnason J, Mehta A, Purev E, Maloney DG, Andreadis C, Sehgal A, Solomon SR, Ghosh N, Albertson TM, Garcia J, Kostic A, Mallaney M, Ogasawara K, Newhall K, Kim Y, Li D, Siddiqi T
Lancet 2020 Sep 19;396(10254):839-852. Epub 2020 Sep 1 doi: 10.1016/S0140-6736(20)31366-0. PMID: 32888407

Prognosis

Ruxolitinib versus best available therapy in inadequately controlled polycythaemia vera without splenomegaly (RESPONSE-2): 5-year follow up of a randomised, phase 3b study.
Passamonti F, Palandri F, Saydam G, Callum J, Devos T, Guglielmelli P, Vannucchi AM, Zor E, Zuurman M, Gilotti G, Zhang Y, Griesshammer M
Lancet Haematol 2022 Jul;9(7):e480-e492. Epub 2022 May 18 doi: 10.1016/S2352-3026(22)00102-8. PMID: 35597252
The diagnostic and therapeutic challenges of Grade 3B follicular lymphoma.
Barraclough A, Bishton M, Cheah CY, Villa D, Hawkes EA
Br J Haematol 2021 Oct;195(1):15-24. Epub 2021 Mar 11 doi: 10.1111/bjh.17404. PMID: 33704790
Follicular lymphoma grade 3: review and updates.
Vaidyanathan G, Czuczman MS
Clin Lymphoma Myeloma Leuk 2014 Dec;14(6):431-5. Epub 2014 Jun 12 doi: 10.1016/j.clml.2014.04.008. PMID: 25066038
Pathology of follicular lymphoma.
Takata K, Miyata-Takata T, Sato Y, Yoshino T
J Clin Exp Hematop 2014;54(1):3-9. doi: 10.3960/jslrt.54.3. PMID: 24942941
Follicular lymphomas.
Vitolo U, Ferreri AJ, Montoto S
Crit Rev Oncol Hematol 2008 Jun;66(3):248-61. Epub 2008 Mar 21 doi: 10.1016/j.critrevonc.2008.01.014. PMID: 18359244

Clinical prediction guides

Feasibility, Biodistribution, and Preliminary Dosimetry in Peptide-Targeted Radionuclide Therapy of Diverse Adenocarcinomas Using (177)Lu-FAP-2286: First-in-Humans Results.
Baum RP, Schuchardt C, Singh A, Chantadisai M, Robiller FC, Zhang J, Mueller D, Eismant A, Almaguel F, Zboralski D, Osterkamp F, Hoehne A, Reineke U, Smerling C, Kulkarni HR
J Nucl Med 2022 Mar;63(3):415-423. Epub 2021 Jun 24 doi: 10.2967/jnumed.120.259192. PMID: 34168013Free PMC Article
High-grade Follicular Lymphomas Exhibit Clinicopathologic, Cytogenetic, and Molecular Diversity Extending Beyond Grades 3A and 3B.
Laurent C, Adélaïde J, Guille A, Tesson B, Gat E, Evrard S, Escudié F, Syrykh C, Canioni D, Fabiani B, Meignin V, Chassagne-Clement C, Dartigues P, Traverse-Glehen A, Parrens M, Huet S, Copie-Bergman C, Salles G, Birnbaum D, Brousset P, Morschhauser F, Xerri L; Lymphoma Study Association (LYSA)
Am J Surg Pathol 2021 Oct 1;45(10):1324-1336. doi: 10.1097/PAS.0000000000001726. PMID: 34334687
Methylomic Signatures of High Grade Serous Ovarian Cancer.
Cardenas H, Fang F, Jiang G, Perkins SM, Zhang C, Emerson RE, Hutchins G, Keer HN, Liu Y, Matei D, Nephew K
Epigenetics 2021 Nov;16(11):1201-1216. Epub 2020 Dec 8 doi: 10.1080/15592294.2020.1853402. PMID: 33289590Free PMC Article
Cervical, Ovarian and Endometrial Tumor Markers: Potential Clinical Value.
Malhone C, Longatto-Filho A
Semin Ultrasound CT MR 2019 Aug;40(4):350-357. Epub 2019 Mar 5 doi: 10.1053/j.sult.2019.03.003. PMID: 31375174
Follicular lymphomas.
Vitolo U, Ferreri AJ, Montoto S
Crit Rev Oncol Hematol 2008 Jun;66(3):248-61. Epub 2008 Mar 21 doi: 10.1016/j.critrevonc.2008.01.014. PMID: 18359244

Recent systematic reviews

Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review.
Silva A, Cerqueira MC, Rosa B, Sobral C, Pinto-Ribeiro F, Costa MF, Baltazar F, Afonso J
Int J Mol Sci 2023 Mar 7;24(6) doi: 10.3390/ijms24065141. PMID: 36982217Free PMC Article
Diagnostic value of Knosp grade and modified Knosp grade for cavernous sinus invasion in pituitary adenomas: a systematic review and meta-analysis.
Fang Y, Pei Z, Chen H, Wang R, Feng M, Wei L, Li J, Zhang H, Wang S
Pituitary 2021 Jun;24(3):457-464. Epub 2021 Jan 25 doi: 10.1007/s11102-020-01122-3. PMID: 33491163
Results and outcomes after endoscopic treatment of upper urinary tract carcinoma: the Austrian experience.
Fajkovic H, Klatte T, Nagele U, Dunzinger M, Zigeuner R, Hübner W, Remzi M
World J Urol 2013 Feb;31(1):37-44. Epub 2012 Sep 27 doi: 10.1007/s00345-012-0948-4. PMID: 23014836
Ureteroscopic and percutaneous management of upper tract urothelial carcinoma (UTUC): systematic review.
Cutress ML, Stewart GD, Zakikhani P, Phipps S, Thomas BG, Tolley DA
BJU Int 2012 Sep;110(5):614-28. Epub 2012 Apr 3 doi: 10.1111/j.1464-410X.2012.11068.x. PMID: 22471401
Breast cancer (non-metastatic).
Stebbing J, Delaney G, Thompson A
BMJ Clin Evid 2011 Feb 8;2011 PMID: 21718560Free PMC Article

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