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Malignant cardiac germ cell tumor

MedGen UID:
233143
•Concept ID:
C1334566
•
Neoplastic Process
Synonyms: Malignant Cardiac Germ Cell Neoplasm; malignant Cardiac germ cell neoplasm; Malignant Cardiac Germ Cell Tumor; malignant cardiac germ cell tumor; malignant Cardiac germ cell tumor; malignant Cardiac germ cell tumour; Malignant germ cell neoplasm of heart; Malignant Germ Cell Neoplasm of Heart; malignant germ cell neoplasm of heart; Malignant Germ Cell Neoplasm of the Heart; malignant germ cell neoplasm of the heart; Malignant Germ Cell Tumor of Heart; malignant germ cell tumor of heart; Malignant Germ Cell Tumor of the Heart; malignant germ cell tumor of the heart; malignant germ cell tumour of heart; malignant germ cell tumour of the heart; Malignant Heart Germ Cell Neoplasm; malignant heart germ cell neoplasm; Malignant Heart Germ Cell Tumor; malignant heart germ cell tumor; malignant heart germ cell tumour
SNOMED CT: Malignant germ cell neoplasm of heart (866080006)
 
Monarch Initiative: MONDO:0001991

Definition

A rare malignant germ cell tumor that arises within the myocardium or cardiac chambers. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant cardiac germ cell tumor

Professional guidelines

PubMed

Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants.
Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Carcinoid Heart Disease: Pathophysiology, Pathology, Clinical Manifestations, and Management.
Jin C, Sharma AN, Thevakumar B, Majid M, Al Chalaby S, Takahashi N, Tanious A, Arockiam AD, Beri N, Amsterdam EA
Cardiology 2021;146(1):65-73. Epub 2020 Oct 16 doi: 10.1159/000507847. PMID: 33070143
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Recent clinical studies

Etiology

Epidemiology of Cancer.
Schwartz SM
Clin Chem 2024 Jan 4;70(1):140-149. doi: 10.1093/clinchem/hvad202. PMID: 38175589
Systemic Photoprotection in Melanoma and Non-Melanoma Skin Cancer.
Hyeraci M, Papanikolau ES, Grimaldi M, Ricci F, Pallotta S, Monetta R, Minafò YA, Di Lella G, Galdo G, Abeni D, Fania L, Dellambra E
Biomolecules 2023 Jul 2;13(7) doi: 10.3390/biom13071067. PMID: 37509103Free PMC Article
Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants.
Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Scrotal Masses.
Langan RC, Puente MEE
Am Fam Physician 2022 Aug;106(2):184-189. PMID: 35977130
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082

Diagnosis

What do we know about carcinoid heart disease in the present era?
Pęczkowska M, Konsek-Komorowska SJ, Kolasińska-Ćwikła AD, Konka M, Michałowska I, Ćwikła JB
Kardiol Pol 2022;80(10):990-1001. Epub 2022 Sep 22 doi: 10.33963/KP.a2022.0222. PMID: 36136036
Scrotal Masses.
Langan RC, Puente MEE
Am Fam Physician 2022 Aug;106(2):184-189. PMID: 35977130
Cardiovascular disease and malignant melanoma.
Wang CY, Zoungas S, Voskoboynik M, Mar V
Melanoma Res 2022 Jun 1;32(3):135-141. Epub 2022 Mar 29 doi: 10.1097/CMR.0000000000000817. PMID: 35377865
Cardiac paragangliomas.
Wang JG, Han J, Jiang T, Li YJ
J Card Surg 2015 Jan;30(1):55-60. Epub 2014 Oct 20 doi: 10.1111/jocs.12455. PMID: 25331372
Neonatal liver tumours.
von Schweinitz D
Semin Neonatol 2003 Oct;8(5):403-10. doi: 10.1016/S1084-2756(03)00092-7. PMID: 15001128

Therapy

Cardiovascular disease and malignant melanoma.
Wang CY, Zoungas S, Voskoboynik M, Mar V
Melanoma Res 2022 Jun 1;32(3):135-141. Epub 2022 Mar 29 doi: 10.1097/CMR.0000000000000817. PMID: 35377865
Carcinoid-syndrome: recent advances, current status and controversies.
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Carcinoid heart disease.
Palaniswamy C, Frishman WH, Aronow WS
Cardiol Rev 2012 Jul-Aug;20(4):167-76. doi: 10.1097/CRD.0b013e31824c866e. PMID: 22314145
Carcinoid heart disease.
Bernheim AM, Connolly HM, Hobday TJ, Abel MD, Pellikka PA
Prog Cardiovasc Dis 2007 May-Jun;49(6):439-51. doi: 10.1016/j.pcad.2006.12.002. PMID: 17498524
Carcinoid tumors.
Boushey RP, Dackiw AP
Curr Treat Options Oncol 2002 Aug;3(4):319-26. doi: 10.1007/s11864-002-0031-2. PMID: 12074768

Prognosis

Cardiovascular disease and malignant melanoma.
Wang CY, Zoungas S, Voskoboynik M, Mar V
Melanoma Res 2022 Jun 1;32(3):135-141. Epub 2022 Mar 29 doi: 10.1097/CMR.0000000000000817. PMID: 35377865
Fetal intrapericardial teratomas.
Yuan SM, Lin H
Turk J Pediatr 2019;61(2):153-158. doi: 10.24953/turkjped.2019.02.001. PMID: 31951327
Carcinoid-syndrome: recent advances, current status and controversies.
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Cardiac paraganglioma.
El-Ashry AA, Cerfolio RJ, Singh SP, McGiffin D
J Card Surg 2015 Feb;30(2):135-9. Epub 2014 Dec 22 doi: 10.1111/jocs.12479. PMID: 25533017
Cardiac tumors.
Petris AO, Alexandrescu DM, Costache II
Rev Med Chir Soc Med Nat Iasi 2014 Apr-Jun;118(2):289-92. PMID: 25076689

Clinical prediction guides

Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants.
Taïeb D, Wanna GB, Ahmad M, Lussey-Lepoutre C, Perrier ND, Nölting S, Amar L, Timmers HJLM, Schwam ZG, Estrera AL, Lim M, Pollom EL, Vitzthum L, Bourdeau I, Casey RT, Castinetti F, Clifton-Bligh R, Corssmit EPM, de Krijger RR, Del Rivero J, Eisenhofer G, Ghayee HK, Gimenez-Roqueplo AP, Grossman A, Imperiale A, Jansen JC, Jha A, Kerstens MN, Kunst HPM, Liu JK, Maher ER, Marchioni D, Mercado-Asis LB, Mete O, Naruse M, Nilubol N, Pandit-Taskar N, Sebag F, Tanabe A, Widimsky J, Meuter L, Lenders JWM, Pacak K
Lancet Diabetes Endocrinol 2023 May;11(5):345-361. Epub 2023 Mar 31 doi: 10.1016/S2213-8587(23)00038-4. PMID: 37011647Free PMC Article
Scrotal Masses.
Langan RC, Puente MEE
Am Fam Physician 2022 Aug;106(2):184-189. PMID: 35977130
Cardiovascular disease and malignant melanoma.
Wang CY, Zoungas S, Voskoboynik M, Mar V
Melanoma Res 2022 Jun 1;32(3):135-141. Epub 2022 Mar 29 doi: 10.1097/CMR.0000000000000817. PMID: 35377865
Fetal intrapericardial teratomas.
Yuan SM, Lin H
Turk J Pediatr 2019;61(2):153-158. doi: 10.24953/turkjped.2019.02.001. PMID: 31951327
Carcinoid heart disease.
Bernheim AM, Connolly HM, Hobday TJ, Abel MD, Pellikka PA
Prog Cardiovasc Dis 2007 May-Jun;49(6):439-51. doi: 10.1016/j.pcad.2006.12.002. PMID: 17498524

Recent systematic reviews

Awake craniotomy during pregnancy: A systematic review of the published literature.
Mofatteh M, Mashayekhi MS, Arfaie S, Wei H, Kazerouni A, Skandalakis GP, Pour-Rashidi A, Baiad A, Elkaim L, Lam J, Palmisciano P, Su X, Liao X, Das S, Ashkan K, Cohen-Gadol AA
Neurosurg Rev 2023 Nov 1;46(1):290. doi: 10.1007/s10143-023-02187-x. PMID: 37910275Free PMC Article
Association between genetically determined telomere length and health-related outcomes: A systematic review and meta-analysis of Mendelian randomization studies.
Chen B, Yan Y, Wang H, Xu J
Aging Cell 2023 Jul;22(7):e13874. Epub 2023 May 26 doi: 10.1111/acel.13874. PMID: 37232505Free PMC Article
A Systematic Review and Meta-Analysis of Prevalence and Outcomes of Cardiac Metastasis of Neuroendocrine Malignancies.
Hamza M, Manasrah N, Patel NN, Sattar Y, Patel B
Am J Cardiol 2023 May 1;194:86-92. Epub 2023 Mar 29 doi: 10.1016/j.amjcard.2023.02.011. PMID: 36996525
Antitumor effects of oleandrin in different types of cancers: Systematic review.
Francischini CRD, Mendonça CR, Barcelos KA, Silva MAM, Botelho AFM
Toxicon 2022 Sep;216:15-27. Epub 2022 Jun 27 doi: 10.1016/j.toxicon.2022.06.010. PMID: 35772506
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

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