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Non-Neoplastic Breast Disorder

MedGen UID:
233231
•Concept ID:
C1334998
•
Disease or Syndrome
Synonyms: Non-Neoplastic Breast Disease; Non-Neoplastic Disease of Breast; Non-Neoplastic Disease of the Breast

Definition

A non-neoplastic disorder that affects the breast. Representative examples include fibrocystic disease, gynecomastia, mastitis, and adenosis. [from NCI]

Professional guidelines

PubMed

Cost in the United States of FDA-approved small molecule protein kinase inhibitors used in the treatment of neoplastic and non-neoplastic diseases.
Roskoski R Jr
Pharmacol Res 2024 Jan;199:107036. Epub 2023 Dec 12 doi: 10.1016/j.phrs.2023.107036. PMID: 38096958
Oral contraceptives, menopausal hormone replacement treatment and breast cancer risk.
Levi F, Lucchini F, Pasche C, La Vecchia C
Eur J Cancer Prev 1996 Aug;5(4):259-66. doi: 10.1097/00008469-199608000-00006. PMID: 8894563
Hormone replacement treatment and breast cancer risk: a cooperative Italian study.
La Vecchia C, Negri E, Franceschi S, Favero A, Nanni O, Filiberti R, Conti E, Montella M, Veronesi A, Ferraroni M
Br J Cancer 1995 Jul;72(1):244-8. doi: 10.1038/bjc.1995.310. PMID: 7599060Free PMC Article

Recent clinical studies

Etiology

INFLUENCE OF IONIZING RADIATION ON THE DEVELOPMENT OF BREAST CANCER.
Bazyka DA, Lytvynenko OO, Litvinenko OO
Probl Radiac Med Radiobiol 2023 Dec;28:22-48. doi: 10.33145/2304-8336-2023-28-22-48. PMID: 38155113
Metabolic pathways in obesity-related breast cancer.
Brown KA
Nat Rev Endocrinol 2021 Jun;17(6):350-363. Epub 2021 Apr 29 doi: 10.1038/s41574-021-00487-0. PMID: 33927368Free PMC Article
Mediterranean Diet and Breast Cancer Risk.
Turati F, Carioli G, Bravi F, Ferraroni M, Serraino D, Montella M, Giacosa A, Toffolutti F, Negri E, Levi F, La Vecchia C
Nutrients 2018 Mar 8;10(3) doi: 10.3390/nu10030326. PMID: 29518016Free PMC Article
How to approach breast lesions in children and adolescents.
Gao Y, Saksena MA, Brachtel EF, terMeulen DC, Rafferty EA
Eur J Radiol 2015 Jul;84(7):1350-64. Epub 2015 Apr 27 doi: 10.1016/j.ejrad.2015.04.011. PMID: 25958188
Antiestrogens--tamoxifen, SERMs and beyond.
Dhingra K
Invest New Drugs 1999;17(3):285-311. doi: 10.1023/a:1006348907994. PMID: 10665480

Diagnosis

Lipocalin-2: Structure, function, distribution and role in metabolic disorders.
Jaberi SA, Cohen A, D'Souza C, Abdulrazzaq YM, Ojha S, Bastaki S, Adeghate EA
Biomed Pharmacother 2021 Oct;142:112002. Epub 2021 Aug 27 doi: 10.1016/j.biopha.2021.112002. PMID: 34463264
"The unusual suspects"-Mammographic, sonographic, and histopathologic appearance of atypical breast masses.
Naeem M, Zulfiqar M, Ballard DH, Billadello L, Cao G, Winter A, Lowdermilk M
Clin Imaging 2020 Oct;66:111-120. Epub 2020 May 3 doi: 10.1016/j.clinimag.2020.04.039. PMID: 32470708Free PMC Article
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
How to approach breast lesions in children and adolescents.
Gao Y, Saksena MA, Brachtel EF, terMeulen DC, Rafferty EA
Eur J Radiol 2015 Jul;84(7):1350-64. Epub 2015 Apr 27 doi: 10.1016/j.ejrad.2015.04.011. PMID: 25958188
MicroRNAs as biomarkers in pituitary tumors.
Di Ieva A, Butz H, Niamah M, Rotondo F, De Rosa S, Sav A, Yousef GM, Kovacs K, Cusimano MD
Neurosurgery 2014 Aug;75(2):181-9; discussion 188-9. doi: 10.1227/NEU.0000000000000369. PMID: 24739366

Therapy

The Spectrum of Non-neoplastic Changes Associated With Breast Implants: Histopathology, Imaging, and Clinical Significance.
Marques-Piubelli ML, Lyapichev KA, Fnu A, Adrada B, Stewart J, Hunt KK, Clemens MW, Iyer S, Wu Y, El Hussein S, Xu J, Ok CY, Li S, Pierson DM, Ferrufino-Schmidt MC, Nahmod KA, Yoga A, Hunsicker L, Evans MG, Resetkova E, Qiu L, Khanlari M, Garces SA, Bueso-Ramos CE, Medeiros LJ, Miranda RN
Am J Surg Pathol 2024 Jun 1;48(6):e43-e64. Epub 2024 Mar 4 doi: 10.1097/PAS.0000000000002198. PMID: 38451836
Mechanism-Based Sonodynamic-Chemo Combinations against Triple-Negative Breast Cancer.
Feng X, Wu C, Yang W, Wu J, Wang P
Int J Mol Sci 2022 Jul 20;23(14) doi: 10.3390/ijms23147981. PMID: 35887326Free PMC Article
Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update.
Roskoski R Jr
Pharmacol Res 2020 Feb;152:104609. Epub 2019 Dec 17 doi: 10.1016/j.phrs.2019.104609. PMID: 31862477
Farnesyltransferase inhibitors: mechanism and applications.
Prendergast GC, Rane N
Expert Opin Investig Drugs 2001 Dec;10(12):2105-16. doi: 10.1517/13543784.10.12.2105. PMID: 11772308
Antiestrogens--tamoxifen, SERMs and beyond.
Dhingra K
Invest New Drugs 1999;17(3):285-311. doi: 10.1023/a:1006348907994. PMID: 10665480

Prognosis

The Spectrum of Non-neoplastic Changes Associated With Breast Implants: Histopathology, Imaging, and Clinical Significance.
Marques-Piubelli ML, Lyapichev KA, Fnu A, Adrada B, Stewart J, Hunt KK, Clemens MW, Iyer S, Wu Y, El Hussein S, Xu J, Ok CY, Li S, Pierson DM, Ferrufino-Schmidt MC, Nahmod KA, Yoga A, Hunsicker L, Evans MG, Resetkova E, Qiu L, Khanlari M, Garces SA, Bueso-Ramos CE, Medeiros LJ, Miranda RN
Am J Surg Pathol 2024 Jun 1;48(6):e43-e64. Epub 2024 Mar 4 doi: 10.1097/PAS.0000000000002198. PMID: 38451836
Rosai-Dorfman disease of the breast: a clinicoradiologic and pathologic study.
Wang Q, Bradley K, Zhang M, Li S, Li X
Hum Pathol 2023 Nov;141:30-42. Epub 2023 Sep 9 doi: 10.1016/j.humpath.2023.08.009. PMID: 37673345
microRNA-140: A miRNA with diverse roles in human diseases.
Ghafouri-Fard S, Bahroudi Z, Shoorei H, Abak A, Ahin M, Taheri M
Biomed Pharmacother 2021 Mar;135:111256. Epub 2021 Feb 1 doi: 10.1016/j.biopha.2021.111256. PMID: 33434855
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
MicroRNAs as biomarkers in pituitary tumors.
Di Ieva A, Butz H, Niamah M, Rotondo F, De Rosa S, Sav A, Yousef GM, Kovacs K, Cusimano MD
Neurosurgery 2014 Aug;75(2):181-9; discussion 188-9. doi: 10.1227/NEU.0000000000000369. PMID: 24739366

Clinical prediction guides

The Spectrum of Non-neoplastic Changes Associated With Breast Implants: Histopathology, Imaging, and Clinical Significance.
Marques-Piubelli ML, Lyapichev KA, Fnu A, Adrada B, Stewart J, Hunt KK, Clemens MW, Iyer S, Wu Y, El Hussein S, Xu J, Ok CY, Li S, Pierson DM, Ferrufino-Schmidt MC, Nahmod KA, Yoga A, Hunsicker L, Evans MG, Resetkova E, Qiu L, Khanlari M, Garces SA, Bueso-Ramos CE, Medeiros LJ, Miranda RN
Am J Surg Pathol 2024 Jun 1;48(6):e43-e64. Epub 2024 Mar 4 doi: 10.1097/PAS.0000000000002198. PMID: 38451836
microRNA-140: A miRNA with diverse roles in human diseases.
Ghafouri-Fard S, Bahroudi Z, Shoorei H, Abak A, Ahin M, Taheri M
Biomed Pharmacother 2021 Mar;135:111256. Epub 2021 Feb 1 doi: 10.1016/j.biopha.2021.111256. PMID: 33434855
Mediterranean Diet and Breast Cancer Risk.
Turati F, Carioli G, Bravi F, Ferraroni M, Serraino D, Montella M, Giacosa A, Toffolutti F, Negri E, Levi F, La Vecchia C
Nutrients 2018 Mar 8;10(3) doi: 10.3390/nu10030326. PMID: 29518016Free PMC Article
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
MicroRNAs as biomarkers in pituitary tumors.
Di Ieva A, Butz H, Niamah M, Rotondo F, De Rosa S, Sav A, Yousef GM, Kovacs K, Cusimano MD
Neurosurgery 2014 Aug;75(2):181-9; discussion 188-9. doi: 10.1227/NEU.0000000000000369. PMID: 24739366

Recent systematic reviews

Ki-67 assessment of pancreatic neuroendocrine neoplasms: Systematic review and meta-analysis of manual vs. digital pathology scoring.
Luchini C, Pantanowitz L, Adsay V, Asa SL, Antonini P, Girolami I, Veronese N, Nottegar A, Cingarlini S, Landoni L, Brosens LA, Verschuur AV, Mattiolo P, Pea A, Mafficini A, Milella M, Niazi MK, Gurcan MN, Eccher A, Cree IA, Scarpa A
Mod Pathol 2022 Jun;35(6):712-720. Epub 2022 Mar 5 doi: 10.1038/s41379-022-01055-1. PMID: 35249100Free PMC Article

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