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EBV-Related Malignant Neoplasm

MedGen UID:
234226
•Concept ID:
C1333432
•
Neoplastic Process
Synonyms: EBV Related Malignancy; EBV-Related Malignancy; Epstein-Barr Virus Related Malignancy; Epstein-Barr Virus-Related Malignancy; Epstein-Barr Virus-Related Malignant Neoplasm

Definition

A malignant neoplasm that develops in a patient infected with Epstein-Barr virus (EBV) and in which there is a well-documented association between the malignancy and EBV. Representative examples include EBV-related lymphomas and carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEBV-Related Malignant Neoplasm

Professional guidelines

PubMed

Utility of clinical metagenomics in diagnosing malignancies in a cohort of patients with Epstein-Barr virus positivity.
Song J, Zhu K, Wang X, Yang Q, Yu S, Zhang Y, Fu Z, Wang H, Zhao Y, Lin K, Yuan G, Guo J, Shi Y, Liu C, Ai J, Zhang H, Zhang W
Front Cell Infect Microbiol 2023;13:1211732. Epub 2023 Aug 22 doi: 10.3389/fcimb.2023.1211732. PMID: 37674580Free PMC Article
Immunotherapy for the treatment of advanced nasopharyngeal carcinoma: a promising new era.
Wang S, Chen S, Zhong Q, Liu Y
J Cancer Res Clin Oncol 2023 May;149(5):2071-2079. Epub 2022 Jul 25 doi: 10.1007/s00432-022-04214-8. PMID: 35876949
The appropriate use of circulating EBV-DNA in nasopharyngeal carcinoma: Comprehensive clinical practice guidelines evaluation.
Trevisiol C, Gion M, Vaona A, Fabricio ASC, Roca E, Licitra L, Alfieri S, Bossi P
Oral Oncol 2021 Mar;114:105128. Epub 2021 Jan 11 doi: 10.1016/j.oraloncology.2020.105128. PMID: 33444925

Recent clinical studies

Etiology

Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies.
Argirion I, Pfeiffer RM, Proietti C, Coghill AE, Yu KJ, Middeldorp JM, Sarathkumara YD, Hsu WL, Chien YC, Lou PJ, Wang CP, Rothman N, Lan Q, Chen CJ, Mbulaiteye SM, Jarrett RF, Glimelius I, Smedby KE, Hjalgrim H, Hildesheim A, Doolan DL, Liu Z
Cancer Epidemiol Biomarkers Prev 2023 May 1;32(5):687-696. doi: 10.1158/1055-9965.EPI-22-0452. PMID: 36788424Free PMC Article
What we should know about natural killer/T-cell lymphomas.
Xiong J, Zhao W
Hematol Oncol 2019 Jun;37 Suppl 1:75-81. doi: 10.1002/hon.2588. PMID: 31187536
Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point.
Linke-Serinsöz E, Fend F, Quintanilla-Martinez L
Semin Diagn Pathol 2017 Jul;34(4):352-363. Epub 2017 Apr 7 doi: 10.1053/j.semdp.2017.04.003. PMID: 28506687
EBV-Related Malignancies, Outcomes and Novel Prevention Strategies.
Ozoya OO, Sokol L, Dalia S
Infect Disord Drug Targets 2016;16(1):4-21. doi: 10.2174/1871526516666160407113536. PMID: 27052336
Angiocentric and intravascular lymphomas.
Tomasini D, Berti E
G Ital Dermatol Venereol 2015 Feb;150(1):95-113. Epub 2014 Dec 22 PMID: 25531150

Diagnosis

EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma.
Yuan L, Li S, Chen Q, Xia T, Luo D, Li L, Liu S, Guo S, Liu L, Du C, Jia G, Li X, Lu Z, Yang Z, Liu H, Mai H, Tang L
Cell Death Differ 2022 Aug;29(8):1513-1527. Epub 2022 Feb 1 doi: 10.1038/s41418-022-00939-8. PMID: 35105963Free PMC Article
Haemophagocytic lymphohistiocytosis and Epstein-Barr virus: a complex relationship with diverse origins, expression and outcomes.
El-Mallawany NK, Curry CV, Allen CE
Br J Haematol 2022 Jan;196(1):31-44. Epub 2021 Jun 24 doi: 10.1111/bjh.17638. PMID: 34169507
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
What we should know about natural killer/T-cell lymphomas.
Xiong J, Zhao W
Hematol Oncol 2019 Jun;37 Suppl 1:75-81. doi: 10.1002/hon.2588. PMID: 31187536
Angiocentric and intravascular lymphomas.
Tomasini D, Berti E
G Ital Dermatol Venereol 2015 Feb;150(1):95-113. Epub 2014 Dec 22 PMID: 25531150

Therapy

Clinical efficacy and biomarker analysis of dual PD-1/CTLA-4 blockade in recurrent/metastatic EBV-associated nasopharyngeal carcinoma.
Lim DW, Kao HF, Suteja L, Li CH, Quah HS, Tan DS, Tan SH, Tan EH, Tan WL, Lee JN, Wee FY, Jain A, Goh BC, Chua MLK, Liao BC, Ng QS, Hong RL, Ang MK, Yeong JP, Iyer NG
Nat Commun 2023 May 15;14(1):2781. doi: 10.1038/s41467-023-38407-7. PMID: 37188668Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
NK/T-cell lymphomas.
Tse E, Kwong YL
Best Pract Res Clin Haematol 2019 Sep;32(3):253-261. Epub 2019 Jun 12 doi: 10.1016/j.beha.2019.06.005. PMID: 31585625
Novel Therapeutics for Epstein⁻Barr Virus.
Andrei G, Trompet E, Snoeck R
Molecules 2019 Mar 12;24(5) doi: 10.3390/molecules24050997. PMID: 30871092Free PMC Article

Prognosis

Clinical efficacy and biomarker analysis of dual PD-1/CTLA-4 blockade in recurrent/metastatic EBV-associated nasopharyngeal carcinoma.
Lim DW, Kao HF, Suteja L, Li CH, Quah HS, Tan DS, Tan SH, Tan EH, Tan WL, Lee JN, Wee FY, Jain A, Goh BC, Chua MLK, Liao BC, Ng QS, Hong RL, Ang MK, Yeong JP, Iyer NG
Nat Commun 2023 May 15;14(1):2781. doi: 10.1038/s41467-023-38407-7. PMID: 37188668Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
What we should know about natural killer/T-cell lymphomas.
Xiong J, Zhao W
Hematol Oncol 2019 Jun;37 Suppl 1:75-81. doi: 10.1002/hon.2588. PMID: 31187536
Primary CNS lymphoma in HIV infection.
Brandsma D, Bromberg JEC
Handb Clin Neurol 2018;152:177-186. doi: 10.1016/B978-0-444-63849-6.00014-1. PMID: 29604975
EBV-Related Malignancies, Outcomes and Novel Prevention Strategies.
Ozoya OO, Sokol L, Dalia S
Infect Disord Drug Targets 2016;16(1):4-21. doi: 10.2174/1871526516666160407113536. PMID: 27052336

Clinical prediction guides

Clinical efficacy and biomarker analysis of dual PD-1/CTLA-4 blockade in recurrent/metastatic EBV-associated nasopharyngeal carcinoma.
Lim DW, Kao HF, Suteja L, Li CH, Quah HS, Tan DS, Tan SH, Tan EH, Tan WL, Lee JN, Wee FY, Jain A, Goh BC, Chua MLK, Liao BC, Ng QS, Hong RL, Ang MK, Yeong JP, Iyer NG
Nat Commun 2023 May 15;14(1):2781. doi: 10.1038/s41467-023-38407-7. PMID: 37188668Free PMC Article
Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies.
Argirion I, Pfeiffer RM, Proietti C, Coghill AE, Yu KJ, Middeldorp JM, Sarathkumara YD, Hsu WL, Chien YC, Lou PJ, Wang CP, Rothman N, Lan Q, Chen CJ, Mbulaiteye SM, Jarrett RF, Glimelius I, Smedby KE, Hjalgrim H, Hildesheim A, Doolan DL, Liu Z
Cancer Epidemiol Biomarkers Prev 2023 May 1;32(5):687-696. doi: 10.1158/1055-9965.EPI-22-0452. PMID: 36788424Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
What we should know about natural killer/T-cell lymphomas.
Xiong J, Zhao W
Hematol Oncol 2019 Jun;37 Suppl 1:75-81. doi: 10.1002/hon.2588. PMID: 31187536

Recent systematic reviews

EBV Positivity and Programmed Death-ligand 1 Expression in Diffuse Large B-cell Lymphoma: A Systematic Review.
Barzyk GA, Sheriff V
Anticancer Res 2020 Nov;40(11):5951-5968. doi: 10.21873/anticanres.14616. PMID: 33109533

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