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Epstein-Barr virus-associated gastric carcinoma

MedGen UID:
896878
•Concept ID:
C4274414
•
Neoplastic Process
Synonyms: Carcinoma of stomach due to Epstein-Barr virus disease; EBV-Associated Gastric Carcinoma; EBV-associated gastric carcinoma; EBV-Related Gastric Carcinoma; EBVaGC; Epstein-Barr virus associated gastric carcinoma; Epstein-Barr Virus-Associated Gastric Carcinoma; Epstein-Barr Virus-Related Gastric Carcinoma; Gastric carcinoma due to Epstein-Barr virus disease
SNOMED CT: Epstein-Barr virus associated gastric carcinoma (716586009); Carcinoma of stomach due to Epstein-Barr virus disease (716586009); Gastric carcinoma due to Epstein-Barr virus disease (716586009)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0017784
Orphanet: ORPHA313920

Definition

A rare form of gastric carcinoma characterized by a latent EBV infection in gastric carcinoma cells, diffuse-type histology, a proximal location (in the body and cardia of the stomach) and a relatively favorable prognosis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpstein-Barr virus-associated gastric carcinoma

Professional guidelines

PubMed

The importance of Epstein-Barr virus infection in the systemic treatment of patients with gastric cancer.
Pikuła A, Kwietniewska M, Rawicz-Pruszyński K, Ciseł B, Skórzewska M, Gęca K, Franciszkiewicz-Pietrzak K, Kurylcio A, Mielko J, Polkowski WP
Semin Oncol 2020 Apr-Jun;47(2-3):127-137. Epub 2020 May 6 doi: 10.1053/j.seminoncol.2020.04.001. PMID: 32402473
Prospective observation: Clinical utility of plasma Epstein-Barr virus DNA load in EBV-associated gastric carcinoma patients.
Qiu MZ, He CY, Lu SX, Guan WL, Wang F, Wang XJ, Jin Y, Wang FH, Li YH, Shao JY, Zhou ZW, Yun JP, Xu RH
Int J Cancer 2020 Jan 1;146(1):272-280. Epub 2019 Jun 19 doi: 10.1002/ijc.32490. PMID: 31162842
Clinical utility of circulating cell-free Epstein-Barr virus DNA in patients with gastric cancer.
Shoda K, Ichikawa D, Fujita Y, Masuda K, Hiramoto H, Hamada J, Arita T, Konishi H, Kosuga T, Komatsu S, Shiozaki A, Okamoto K, Imoto I, Otsuji E
Oncotarget 2017 Apr 25;8(17):28796-28804. doi: 10.18632/oncotarget.15675. PMID: 28430637Free PMC Article

Recent clinical studies

Etiology

Prognostic Value of Tumor-Infiltrating Lymphocytes and Tertiary Lymphoid Structures in Epstein-Barr Virus-Associated and -Negative Gastric Carcinoma.
Cheng N, Li P, Cheng H, Zhao X, Dong M, Zhang Y, Zhao P, Chen J, Shao C
Front Immunol 2021;12:692859. Epub 2021 Jul 1 doi: 10.3389/fimmu.2021.692859. PMID: 34276684Free PMC Article
Risk for lymph node metastasis in Epstein-Barr virus-associated gastric carcinoma with submucosal invasion.
Tsuji Y, Ushiku T, Shinozaki T, Yamashita H, Seto Y, Fukayama M, Fujishiro M, Oda I, Katai H, Taniguchi H, Hasatani K, Kaizaki Y, Oga A, Nishikawa J, Akasaka R, Endo M, Sugai T, Matsumoto T, Koike K
Dig Endosc 2021 May;33(4):592-597. Epub 2020 Oct 19 doi: 10.1111/den.13823. PMID: 32852875
Clinicopathological features of Epstein-Barr virus-associated gastric carcinoma: A systematic review and meta-analysis.
Qiao YW, Zhao XQ, Liu J, Yang WJ
J BUON 2019 May-Jun;24(3):1092-1099. PMID: 31424666
Clinicopathological and molecular characteristics of Epstein-Barr virus-associated gastric carcinoma: a meta-analysis.
Lee JH, Kim SH, Han SH, An JS, Lee ES, Kim YS
J Gastroenterol Hepatol 2009 Mar;24(3):354-65. doi: 10.1111/j.1440-1746.2009.05775.x. PMID: 19335785
Endoscopic and pathologic features of Epstein-Barr virus-associated gastric carcinoma.
Yanai H, Nishikawa J, Mizugaki Y, Shimizu N, Takada K, Matsusaki K, Toda T, Matsumoto Y, Tada M, Okita K
Gastrointest Endosc 1997 Mar;45(3):236-42. doi: 10.1016/s0016-5107(97)70265-7. PMID: 9087829

Diagnosis

MC180295 Inhibited Epstein-Barr Virus-Associated Gastric Carcinoma Cell Growth by Suppressing DNA Repair and the Cell Cycle.
Fujii T, Nishikawa J, Fukuda S, Kubota N, Nojima J, Fujisawa K, Ogawa R, Goto A, Hamabe K, Hashimoto S, Wai AP, Iizasa H, Yoshiyama H, Sakai K, Suehiro Y, Yamasaki T, Takami T
Int J Mol Sci 2022 Sep 13;23(18) doi: 10.3390/ijms231810597. PMID: 36142506Free PMC Article
Prognostic Value of Tumor-Infiltrating Lymphocytes and Tertiary Lymphoid Structures in Epstein-Barr Virus-Associated and -Negative Gastric Carcinoma.
Cheng N, Li P, Cheng H, Zhao X, Dong M, Zhang Y, Zhao P, Chen J, Shao C
Front Immunol 2021;12:692859. Epub 2021 Jul 1 doi: 10.3389/fimmu.2021.692859. PMID: 34276684Free PMC Article
Expression and prognostic roles of PIK3CA, JAK2, PD-L1, and PD-L2 in Epstein-Barr virus-associated gastric carcinoma.
Dong M, Wang HY, Zhao XX, Chen JN, Zhang YW, Huang Y, Xue L, Li HG, Du H, Wu XY, Shao CK
Hum Pathol 2016 Jul;53:25-34. Epub 2016 Mar 4 doi: 10.1016/j.humpath.2016.02.007. PMID: 26980034
In Epstein-Barr virus-associated gastric carcinoma a high density of CD66b-positive tumor-associated neutrophils is associated with intestinal-type histology and low frequency of lymph node metastasis.
Abe H, Morikawa T, Saito R, Yamashita H, Seto Y, Fukayama M
Virchows Arch 2016 May;468(5):539-48. Epub 2016 Feb 25 doi: 10.1007/s00428-016-1915-z. PMID: 26915031
Epstein-Barr virus associated gastric carcinoma: epidemiological and clinicopathological features.
Akiba S, Koriyama C, Herrera-Goepfert R, Eizuru Y
Cancer Sci 2008 Feb;99(2):195-201. doi: 10.1111/j.1349-7006.2007.00674.x. PMID: 18271915

Therapy

Clinicopathological features of Epstein-Barr virus-associated gastric carcinoma: A systematic review and meta-analysis.
Qiao YW, Zhao XQ, Liu J, Yang WJ
J BUON 2019 May-Jun;24(3):1092-1099. PMID: 31424666
Epstein-Barr virus-associated gastric carcinoma.
Fukayama M, Ushiku T
Pathol Res Pract 2011 Sep 15;207(9):529-37. Epub 2011 Sep 23 doi: 10.1016/j.prp.2011.07.004. PMID: 21944426
Ganciclovir augments the lytic induction and apoptosis induced by chemotherapeutic agents in an Epstein-Barr virus-infected gastric carcinoma cell line.
Ji Jung E, Mie Lee Y, Lan Lee B, Soo Chang M, Ho Kim W
Anticancer Drugs 2007 Jan;18(1):79-85. doi: 10.1097/CAD.0b013e3280101006. PMID: 17159505

Prognosis

Expression of MAP9 in Epstein-Barr virus-associated gastric carcinoma.
Xiao H, Sun J, Huang W, Liu W, Zhang Y, Wang H, Luo B
Virus Res 2021 Feb;293:198253. Epub 2020 Dec 10 doi: 10.1016/j.virusres.2020.198253. PMID: 33309912
Update on Epstein-Barr virus and gastric cancer (review).
Shinozaki-Ushiku A, Kunita A, Fukayama M
Int J Oncol 2015 Apr;46(4):1421-34. Epub 2015 Jan 28 doi: 10.3892/ijo.2015.2856. PMID: 25633561
Epigenetic dysregulation in Epstein-Barr virus-associated gastric carcinoma: disease and treatments.
Yau TO, Tang CM, Yu J
World J Gastroenterol 2014 Jun 7;20(21):6448-56. doi: 10.3748/wjg.v20.i21.6448. PMID: 24914366Free PMC Article
Clinicopathological and molecular characteristics of Epstein-Barr virus-associated gastric carcinoma: a meta-analysis.
Lee JH, Kim SH, Han SH, An JS, Lee ES, Kim YS
J Gastroenterol Hepatol 2009 Mar;24(3):354-65. doi: 10.1111/j.1440-1746.2009.05775.x. PMID: 19335785
Epstein-Barr virus associated gastric carcinoma: epidemiological and clinicopathological features.
Akiba S, Koriyama C, Herrera-Goepfert R, Eizuru Y
Cancer Sci 2008 Feb;99(2):195-201. doi: 10.1111/j.1349-7006.2007.00674.x. PMID: 18271915

Clinical prediction guides

MC180295 Inhibited Epstein-Barr Virus-Associated Gastric Carcinoma Cell Growth by Suppressing DNA Repair and the Cell Cycle.
Fujii T, Nishikawa J, Fukuda S, Kubota N, Nojima J, Fujisawa K, Ogawa R, Goto A, Hamabe K, Hashimoto S, Wai AP, Iizasa H, Yoshiyama H, Sakai K, Suehiro Y, Yamasaki T, Takami T
Int J Mol Sci 2022 Sep 13;23(18) doi: 10.3390/ijms231810597. PMID: 36142506Free PMC Article
Virus-host interactions in carcinogenesis of Epstein-Barr virus-associated gastric carcinoma: Potential roles of lost ARID1A expression in its early stage.
Abe H, Kunita A, Otake Y, Kanda T, Kaneda A, Ushiku T, Fukayama M
PLoS One 2021;16(9):e0256440. Epub 2021 Sep 1 doi: 10.1371/journal.pone.0256440. PMID: 34469459Free PMC Article
The implication of tumor-infiltrating lymphocytes in Epstein-Barr virus-associated gastric carcinoma.
Gong LP, Chen JN, Xiao L, He Q, Feng ZY, Zhang ZG, Liu JP, Wei HB, Shao CK
Hum Pathol 2019 Mar;85:82-91. Epub 2018 Nov 15 doi: 10.1016/j.humpath.2018.11.002. PMID: 30448221
Radiation-induced Epstein-Barr virus reactivation in gastric cancer cells with latent EBV infection.
Nandakumar A, Uwatoko F, Yamamoto M, Tomita K, Majima HJ, Akiba S, Koriyama C
Tumour Biol 2017 Jul;39(7):1010428317717718. doi: 10.1177/1010428317717718. PMID: 28675108
Epstein-Barr virus associated gastric carcinoma: epidemiological and clinicopathological features.
Akiba S, Koriyama C, Herrera-Goepfert R, Eizuru Y
Cancer Sci 2008 Feb;99(2):195-201. doi: 10.1111/j.1349-7006.2007.00674.x. PMID: 18271915

Recent systematic reviews

Clinicopathological features of Epstein-Barr virus-associated gastric carcinoma: A systematic review and meta-analysis.
Qiao YW, Zhao XQ, Liu J, Yang WJ
J BUON 2019 May-Jun;24(3):1092-1099. PMID: 31424666

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