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Central nervous system endodermal sinus tumor

MedGen UID:
234604
•Concept ID:
C1377613
•
Neoplastic Process
Synonyms: central nervous system endodermal sinus tumor; Childhood Central Nervous System Endodermal Sinus Neoplasm; childhood central nervous system endodermal sinus neoplasm; Childhood Central Nervous System Endodermal Sinus Tumor; childhood central nervous system endodermal sinus tumor; childhood central nervous system endodermal sinus tumour; Childhood Central Nervous System Yolk Sac Neoplasm; Childhood Central Nervous System Yolk Sac Tumor; paediatric central nervous system endodermal sinus neoplasm; Pediatric Central Nervous System Endodermal Sinus Neoplasm; pediatric central nervous system endodermal sinus neoplasm; Pediatric Central Nervous System Endodermal Sinus Tumor; Pediatric Central Nervous System Yolk Sac Neoplasm; Pediatric Central Nervous System Yolk Sac Tumor
 
Monarch Initiative: MONDO:0003401

Definition

A yolk sac tumor that arises from the central nervous system and occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral nervous system endodermal sinus tumor

Professional guidelines

PubMed

Salivary evaluation of pediatric patients with cancer, before and after antineoplasic treatment.
Guerra RN, Oliveira-Junior JJ, Mouchrek-Filho JC, Liberio SA, Lima MV, Paim DB, Brito CX, Mendonça C, Nascimento FR, Pereira AL
J Oral Pathol Med 2012 Aug;41(7):527-32. Epub 2012 Jun 12 doi: 10.1111/j.1600-0714.2012.01165.x. PMID: 22687139
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765
Pineal region masses: differential diagnosis.
Smirniotopoulos JG, Rushing EJ, Mena H
Radiographics 1992 May;12(3):577-96. doi: 10.1148/radiographics.12.3.1609147. PMID: 1609147

Recent clinical studies

Etiology

Clinical characteristics and prognostic factors of male yolk sac tumor: a Surveillance, Epidemiology, and End Results program study.
Geng R, Zheng Z, Lin Y, Li Y, Ge G, Zhang J, Wang C, Dai X, Ye Q, Zhen J, Zhang Y, Fu C, Li Y
World J Urol 2021 Apr;39(4):1211-1217. Epub 2020 Jun 19 doi: 10.1007/s00345-020-03311-y. PMID: 32562046
Experience with pineal region tumors.
Kang JK, Jeun SS, Hong YK, Park CK, Son BC, Lee IW, Kim MC
Childs Nerv Syst 1998 Jan-Feb;14(1-2):63-8. doi: 10.1007/s003810050177. PMID: 9548344
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765
Non-midline endodermal sinus tumor in the head and neck region: a case report.
Kebudi R, Ayan I, Darendeliler E, Ağaoğlu L, Kinay M, Olgaç V, Bilge N
Med Pediatr Oncol 1993;21(9):685-9. doi: 10.1002/mpo.2950210915. PMID: 8413005
Pineal tumors.
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982

Diagnosis

Clinical characteristics and prognostic factors of male yolk sac tumor: a Surveillance, Epidemiology, and End Results program study.
Geng R, Zheng Z, Lin Y, Li Y, Ge G, Zhang J, Wang C, Dai X, Ye Q, Zhen J, Zhang Y, Fu C, Li Y
World J Urol 2021 Apr;39(4):1211-1217. Epub 2020 Jun 19 doi: 10.1007/s00345-020-03311-y. PMID: 32562046
Non-midline endodermal sinus tumor in the head and neck region: a case report.
Kebudi R, Ayan I, Darendeliler E, Ağaoğlu L, Kinay M, Olgaç V, Bilge N
Med Pediatr Oncol 1993;21(9):685-9. doi: 10.1002/mpo.2950210915. PMID: 8413005
Pineal region masses: differential diagnosis.
Smirniotopoulos JG, Rushing EJ, Mena H
Radiographics 1992 May;12(3):577-96. doi: 10.1148/radiographics.12.3.1609147. PMID: 1609147
Pineal tumors.
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982
Endodermal sinus tumor: a clinical and pathological correlation.
Olsen MM, Raffensperger JG, Gonzalez-Crussi F, Luck SR, Kaplan WE, Morgan ER
J Pediatr Surg 1982 Dec;17(6):832-40. doi: 10.1016/s0022-3468(82)80452-1. PMID: 7161670

Therapy

Intracranial endodermal sinus tumors associated with growth hormone replacement therapy in a girl.
Tang Z, Shi X, Singh Khatri Chhetri KI, Qi X
J Neurosurg Pediatr 2012 Jan;9(1):49-53. doi: 10.3171/2011.10.PEDS1195. PMID: 22208321
Treatment of endodermal sinus tumor in children using a regimen that lacks bleomycin.
Frazier AL, Grier HE, Green DM
Med Pediatr Oncol 1996 Aug;27(2):69-73. doi: 10.1002/(SICI)1096-911X(199608)27:2<69::AID-MPO1>3.0.CO;2-R. PMID: 8649322
Radiation therapy for primary intracranial germ-cell tumors.
Wolden SL, Wara WM, Larson DA, Prados MD, Edwards MS, Sneed PK
Int J Radiat Oncol Biol Phys 1995 Jul 15;32(4):943-9. doi: 10.1016/0360-3016(95)00067-9. PMID: 7607968
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765
Chemotherapy trials in recurrent primary intracranial germ cell tumors.
Allen JC, Bosl G, Walker R
J Neurooncol 1985;3(2):147-52. doi: 10.1007/BF02228891. PMID: 3897472

Prognosis

Clinical characteristics and prognostic factors of male yolk sac tumor: a Surveillance, Epidemiology, and End Results program study.
Geng R, Zheng Z, Lin Y, Li Y, Ge G, Zhang J, Wang C, Dai X, Ye Q, Zhen J, Zhang Y, Fu C, Li Y
World J Urol 2021 Apr;39(4):1211-1217. Epub 2020 Jun 19 doi: 10.1007/s00345-020-03311-y. PMID: 32562046
Experience with pineal region tumors.
Kang JK, Jeun SS, Hong YK, Park CK, Son BC, Lee IW, Kim MC
Childs Nerv Syst 1998 Jan-Feb;14(1-2):63-8. doi: 10.1007/s003810050177. PMID: 9548344
Non-midline endodermal sinus tumor in the head and neck region: a case report.
Kebudi R, Ayan I, Darendeliler E, Ağaoğlu L, Kinay M, Olgaç V, Bilge N
Med Pediatr Oncol 1993;21(9):685-9. doi: 10.1002/mpo.2950210915. PMID: 8413005
Pineal tumors.
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982
Germ cell tumors of the thalamus and the basal ganglia.
Tamaki N, Lin T, Shirataki K, Hosoda K, Kurata H, Matsumoto S, Ito H
Childs Nerv Syst 1990 Jan;6(1):3-7. doi: 10.1007/BF00262257. PMID: 2178773

Clinical prediction guides

Clinical and Radiologic Features of Pediatric Basal Ganglia Germ Cell Tumors.
Zhang S, Liang G, Ju Y, You C
World Neurosurg 2016 Nov;95:516-524.e1. Epub 2016 Aug 24 doi: 10.1016/j.wneu.2016.08.072. PMID: 27567571
Salivary evaluation of pediatric patients with cancer, before and after antineoplasic treatment.
Guerra RN, Oliveira-Junior JJ, Mouchrek-Filho JC, Liberio SA, Lima MV, Paim DB, Brito CX, Mendonça C, Nascimento FR, Pereira AL
J Oral Pathol Med 2012 Aug;41(7):527-32. Epub 2012 Jun 12 doi: 10.1111/j.1600-0714.2012.01165.x. PMID: 22687139
Nestin expression in central nervous system germ cell tumors.
Sakurada K, Saino M, Mouri W, Sato A, Kitanaka C, Kayama T
Neurosurg Rev 2008 Apr;31(2):173-6; discussion 176-7. Epub 2007 Dec 19 doi: 10.1007/s10143-007-0115-3. PMID: 18092184
Chemotherapy trials in recurrent primary intracranial germ cell tumors.
Allen JC, Bosl G, Walker R
J Neurooncol 1985;3(2):147-52. doi: 10.1007/BF02228891. PMID: 3897472
Primary pineal endodermal sinus tumor with elevated serum and CSF alphafetoprotein levels. Case report.
Arita N, Bitoh S, Ushio Y, Hayakawa T, Hasegawa H, Fujiwara M, Ozaki K, Par-khen L, Mori T
J Neurosurg 1980 Aug;53(2):244-8. doi: 10.3171/jns.1980.53.2.0244. PMID: 6159459

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