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Testis refractory cancer

MedGen UID:
235122
•Concept ID:
C1377904
•
Neoplastic Process
Synonyms: Refractory Cancer of Testis; refractory cancer of testis; Refractory Cancer of the Testis; refractory cancer of the testis; Refractory Malignant Testicular Germ Cell Tumor; refractory malignant testicular germ cell tumor; refractory malignant testicular germ cell tumour; Refractory Testicular Cancer; refractory testicular cancer; refractory testicular carcinoma; testis refractory cancer
 
Monarch Initiative: MONDO:0004401

Definition

Malignant testicular germ cell tumor that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTestis refractory cancer

Professional guidelines

PubMed

Treatment of refractory testis cancer: salvage or savage chemotherapy?
Levine EG, Raghavan D
Eur J Cancer 1991;27(7):932-6. doi: 10.1016/0277-5379(91)90150-c. PMID: 1657079

Recent clinical studies

Etiology

Autologous T cell therapy for MAGE-A4(+) solid cancers in HLA-A*02(+) patients: a phase 1 trial.
Hong DS, Van Tine BA, Biswas S, McAlpine C, Johnson ML, Olszanski AJ, Clarke JM, Araujo D, Blumenschein GR Jr, Kebriaei P, Lin Q, Tipping AJ, Sanderson JP, Wang R, Trivedi T, Annareddy T, Bai J, Rafail S, Sun A, Fernandes L, Navenot JM, Bushman FD, Everett JK, Karadeniz D, Broad R, Isabelle M, Naidoo R, Bath N, Betts G, Wolchinsky Z, Batrakou DG, Van Winkle E, Elefant E, Ghobadi A, Cashen A, Grand'Maison A, McCarthy P, Fracasso PM, Norry E, Williams D, Druta M, Liebner DA, Odunsi K, Butler MO
Nat Med 2023 Jan;29(1):104-114. Epub 2023 Jan 9 doi: 10.1038/s41591-022-02128-z. PMID: 36624315Free PMC Article
Testicular involvement of acute lymphoblastic leukemia in children and adolescents: Diagnosis, biology, and management.
Nguyen HTK, Terao MA, Green DM, Pui CH, Inaba H
Cancer 2021 Sep 1;127(17):3067-3081. Epub 2021 May 25 doi: 10.1002/cncr.33609. PMID: 34031876Free PMC Article
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251
Testis cancer.
Khan O, Protheroe A
Postgrad Med J 2007 Oct;83(984):624-32. doi: 10.1136/pgmj.2007.057992. PMID: 17916870Free PMC Article

Diagnosis

How we treat NK/T-cell lymphomas.
Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
Testicular involvement of acute lymphoblastic leukemia in children and adolescents: Diagnosis, biology, and management.
Nguyen HTK, Terao MA, Green DM, Pui CH, Inaba H
Cancer 2021 Sep 1;127(17):3067-3081. Epub 2021 May 25 doi: 10.1002/cncr.33609. PMID: 34031876Free PMC Article
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251
Testis cancer.
Khan O, Protheroe A
Postgrad Med J 2007 Oct;83(984):624-32. doi: 10.1136/pgmj.2007.057992. PMID: 17916870Free PMC Article

Therapy

Management of testicular germ cell tumors.
Wee CE, Gilligan TD
Clin Adv Hematol Oncol 2023 Apr;21(4):179-188. PMID: 37039725
Autologous T cell therapy for MAGE-A4(+) solid cancers in HLA-A*02(+) patients: a phase 1 trial.
Hong DS, Van Tine BA, Biswas S, McAlpine C, Johnson ML, Olszanski AJ, Clarke JM, Araujo D, Blumenschein GR Jr, Kebriaei P, Lin Q, Tipping AJ, Sanderson JP, Wang R, Trivedi T, Annareddy T, Bai J, Rafail S, Sun A, Fernandes L, Navenot JM, Bushman FD, Everett JK, Karadeniz D, Broad R, Isabelle M, Naidoo R, Bath N, Betts G, Wolchinsky Z, Batrakou DG, Van Winkle E, Elefant E, Ghobadi A, Cashen A, Grand'Maison A, McCarthy P, Fracasso PM, Norry E, Williams D, Druta M, Liebner DA, Odunsi K, Butler MO
Nat Med 2023 Jan;29(1):104-114. Epub 2023 Jan 9 doi: 10.1038/s41591-022-02128-z. PMID: 36624315Free PMC Article
How we treat NK/T-cell lymphomas.
Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
Testicular involvement of acute lymphoblastic leukemia in children and adolescents: Diagnosis, biology, and management.
Nguyen HTK, Terao MA, Green DM, Pui CH, Inaba H
Cancer 2021 Sep 1;127(17):3067-3081. Epub 2021 May 25 doi: 10.1002/cncr.33609. PMID: 34031876Free PMC Article
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616

Prognosis

Extranodal natural killer/T-cell lymphoma: An overview on pathology and clinical management.
Tse E, Fox CP, Glover A, Yoon SE, Kim WS, Kwong YL
Semin Hematol 2022 Oct;59(4):198-209. Epub 2022 Nov 12 doi: 10.1053/j.seminhematol.2022.10.002. PMID: 36805888
How we treat NK/T-cell lymphomas.
Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
NUT carcinoma of the lung.
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251

Clinical prediction guides

How we treat NK/T-cell lymphomas.
Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
NUT carcinoma of the lung.
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
Chemotherapeutic and surgical strategies for germ cell tumors.
Einhorn LH
Chest Surg Clin N Am 2002 Nov;12(4):695-706. doi: 10.1016/s1052-3359(02)00029-7. PMID: 12471872
Testicular cancer: an oncological success story.
Einhorn EH
Clin Cancer Res 1997 Dec;3(12 Pt 2):2630-2. PMID: 10068265
Etoposide therapy for testicular cancer.
Loehrer PJ Sr
Cancer 1991 Jan 1;67(1 Suppl):220-4. doi: 10.1002/1097-0142(19910101)67:1+<220::aid-cncr2820671303>3.0.co;2-o. PMID: 1984823

Recent systematic reviews

The contemporary role of chemotherapy for advanced testis cancer: a systematic review of the literature.
Calabrò F, Albers P, Bokemeyer C, Martin C, Einhorn LH, Horwich A, Krege S, Schmoll HJ, Sternberg CN, Daugaard G
Eur Urol 2012 Jun;61(6):1212-21. Epub 2012 Mar 24 doi: 10.1016/j.eururo.2012.03.038. PMID: 22464311

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