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Monomorphic Post-Transplant Lymphoproliferative Disorder

MedGen UID:
235334
•Concept ID:
C1334798
•
Neoplastic Process
Synonym: Monomorphic PTLD

Definition

A clonal lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a monotonous population of transformed lymphocytes or plasma cells. It includes two variants: monomorphic B-cell and monomorphic T/NK cell post-transplant lymphoproliferative disorders. [from NCI]

Professional guidelines

PubMed

An Effective Combination Therapy for the Treatment of Pediatric Monomorphic Post-transplant Lymphoproliferative Disorder With Plasmacytic Differentiation.
Dumbrava M, Galardy P, Feldman AL, Kuhn A, Khan S, Ferdjallah A, Kohorst MA
J Pediatr Hematol Oncol 2023 Jul 1;45(5):e624-e627. Epub 2023 Jan 26 doi: 10.1097/MPH.0000000000002629. PMID: 36719134

Recent clinical studies

Etiology

Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Post-transplant lymphoproliferative disorder presenting as T-prolymphocytic leukemia: a case report.
Kasinathan G, Kori AN, Azmie NM
J Med Case Rep 2019 Jul 22;13(1):223. doi: 10.1186/s13256-019-2164-y. PMID: 31327318Free PMC Article
EBV-negative monomorphic B-cell post-transplant lymphoproliferative disorders are pathologically distinct from EBV-positive cases and frequently contain TP53 mutations.
Courville EL, Yohe S, Chou D, Nardi V, Lazaryan A, Thakral B, Nelson AC, Ferry JA, Sohani AR
Mod Pathol 2016 Oct;29(10):1200-11. Epub 2016 Jul 22 doi: 10.1038/modpathol.2016.130. PMID: 27443517
Role of Epstein-Barr virus status and immunophenotypic studies in the evaluation of exfoliative cytology specimens from patients with post-transplant lymphoproliferative disorders.
Gibson SE, Picarsic J, Swerdlow SH, Pantanowitz L
Cancer Cytopathol 2016 Jun;124(6):425-35. Epub 2016 Mar 17 doi: 10.1002/cncy.21694. PMID: 26992116

Diagnosis

Post-transplant lymphoproliferative disorder myeloradiculopathy.
Coradine TLC, Guida LOC, Fraiman P, Santos AJ, Pedroso JL, Barsottini OGP
Pract Neurol 2023 Oct;23(5):408-410. Epub 2023 May 5 doi: 10.1136/pn-2023-003696. PMID: 37147122
Primary Cutaneous Monomorphic Post-transplant Lymphoproliferative Disorder Mimicking Squamous Cell Carcinoma In Situ.
Craddock AP, Gru AA, Mannschreck D, Wilson BB, Raghavan SS
Am J Dermatopathol 2021 Dec 1;43(12):e234-e236. doi: 10.1097/DAD.0000000000001950. PMID: 33899771
Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Post-transplant lymphoproliferative disorder presenting as T-prolymphocytic leukemia: a case report.
Kasinathan G, Kori AN, Azmie NM
J Med Case Rep 2019 Jul 22;13(1):223. doi: 10.1186/s13256-019-2164-y. PMID: 31327318Free PMC Article
EBV-negative monomorphic B-cell post-transplant lymphoproliferative disorders are pathologically distinct from EBV-positive cases and frequently contain TP53 mutations.
Courville EL, Yohe S, Chou D, Nardi V, Lazaryan A, Thakral B, Nelson AC, Ferry JA, Sohani AR
Mod Pathol 2016 Oct;29(10):1200-11. Epub 2016 Jul 22 doi: 10.1038/modpathol.2016.130. PMID: 27443517

Therapy

Primary Cutaneous Monomorphic Post-transplant Lymphoproliferative Disorder Mimicking Squamous Cell Carcinoma In Situ.
Craddock AP, Gru AA, Mannschreck D, Wilson BB, Raghavan SS
Am J Dermatopathol 2021 Dec 1;43(12):e234-e236. doi: 10.1097/DAD.0000000000001950. PMID: 33899771
Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Post-transplant lymphoproliferative disorder presenting as T-prolymphocytic leukemia: a case report.
Kasinathan G, Kori AN, Azmie NM
J Med Case Rep 2019 Jul 22;13(1):223. doi: 10.1186/s13256-019-2164-y. PMID: 31327318Free PMC Article
Decreased survival in hepatitis C patients with monomorphic post-transplant lymphoproliferative disorder after liver transplantation treated with frontline immunochemotherapy.
Alderuccio JP, Stefanovic A, Dammrich D, Chapman JR, Vega F, Selvaggi G, Tzakis A, Lossos IS
Leuk Lymphoma 2018 Sep;59(9):2096-2104. Epub 2017 Dec 18 doi: 10.1080/10428194.2017.1413187. PMID: 29252057
EBV-negative monomorphic B-cell post-transplant lymphoproliferative disorders are pathologically distinct from EBV-positive cases and frequently contain TP53 mutations.
Courville EL, Yohe S, Chou D, Nardi V, Lazaryan A, Thakral B, Nelson AC, Ferry JA, Sohani AR
Mod Pathol 2016 Oct;29(10):1200-11. Epub 2016 Jul 22 doi: 10.1038/modpathol.2016.130. PMID: 27443517

Prognosis

Gastric Burkitt's monomorphic post-transplant lymphoproliferative disorder after kidney transplantation: A case report.
Yoshimura Y, Suwabe T, Fujiki A, Kaji D, Asano-Mori Y, Oba Y, Mizuno H, Yamanouchi M, Tanaka K, Hasegawa E, Miki K, Yokoyama T, Namamura Y, Ishii Y, Yamashita S, Kono K, Kinowaki K, Takazawa Y, Sawa N, Ubara Y
Clin Nephrol 2024 May;101(5):250-256. doi: 10.5414/CN111321. PMID: 38329919
Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Post-transplant lymphoproliferative disorder presenting as T-prolymphocytic leukemia: a case report.
Kasinathan G, Kori AN, Azmie NM
J Med Case Rep 2019 Jul 22;13(1):223. doi: 10.1186/s13256-019-2164-y. PMID: 31327318Free PMC Article
EBV-negative monomorphic B-cell post-transplant lymphoproliferative disorders are pathologically distinct from EBV-positive cases and frequently contain TP53 mutations.
Courville EL, Yohe S, Chou D, Nardi V, Lazaryan A, Thakral B, Nelson AC, Ferry JA, Sohani AR
Mod Pathol 2016 Oct;29(10):1200-11. Epub 2016 Jul 22 doi: 10.1038/modpathol.2016.130. PMID: 27443517
Role of Epstein-Barr virus status and immunophenotypic studies in the evaluation of exfoliative cytology specimens from patients with post-transplant lymphoproliferative disorders.
Gibson SE, Picarsic J, Swerdlow SH, Pantanowitz L
Cancer Cytopathol 2016 Jun;124(6):425-35. Epub 2016 Mar 17 doi: 10.1002/cncy.21694. PMID: 26992116

Clinical prediction guides

Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363

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