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Malignant Intracranial Germ Cell Tumor

MedGen UID:
277333
•Concept ID:
C1334592
•
Neoplastic Process
Synonym: Malignant Intracranial Germ Cell Neoplasm

Definition

A malignant germ cell tumor that affects the structures within the cranium. [from NCI]

Professional guidelines

PubMed

Management of malignant pineal germ cell tumors with residual mature teratoma.
Friedman JA, Lynch JJ, Buckner JC, Scheithauer BW, Raffel C
Neurosurgery 2001 Mar;48(3):518-22; discussion 522-3. doi: 10.1097/00006123-200103000-00011. PMID: 11270541

Recent clinical studies

Etiology

Malignant intracranial germinoma in Smith-Lemli-Opitz syndrome: cholesterol homeostasis possibly connecting morphogenesis and cancer development.
Oslejskova H, Horinova V, Sterba J, Pavelka Z, Babovic-Vuksanovic D, Dubska L, Valik D
J Pediatr Hematol Oncol 2008 Sep;30(9):689-91. doi: 10.1097/MPH.0b013e318180bbde. PMID: 18776762
Basal ganglia germinoma in children with associated ipsilateral cerebral and brain stem hemiatrophy.
Ozelame RV, Shroff M, Wood B, Bouffet E, Bartels U, Drake JM, Hawkins C, Blaser S
Pediatr Radiol 2006 Apr;36(4):325-30. Epub 2006 Feb 4 doi: 10.1007/s00247-005-0063-4. PMID: 16463029
Management of malignant pineal germ cell tumors with residual mature teratoma.
Friedman JA, Lynch JJ, Buckner JC, Scheithauer BW, Raffel C
Neurosurgery 2001 Mar;48(3):518-22; discussion 522-3. doi: 10.1097/00006123-200103000-00011. PMID: 11270541

Diagnosis

Malignant transformation of germinoma 14 years after onset: Favorable efficacy of oral etoposide.
Fukuoka K, Yanagisawa T, Suzuki T, Shirahata M, Adachi J, Mishima K, Fujimaki T, Matsutani M, Nishikawa R
Pediatr Int 2015 Jun;57(3):483-6. Epub 2015 Feb 24 doi: 10.1111/ped.12559. PMID: 25712128
Basal ganglia germinoma in children with associated ipsilateral cerebral and brain stem hemiatrophy.
Ozelame RV, Shroff M, Wood B, Bouffet E, Bartels U, Drake JM, Hawkins C, Blaser S
Pediatr Radiol 2006 Apr;36(4):325-30. Epub 2006 Feb 4 doi: 10.1007/s00247-005-0063-4. PMID: 16463029
Dendritic cells activate antitumor immunity for malignant intracranial germ cell tumor: a case report.
Osada T, Fujimaki T, Takamizawa M, Tsuno NH, Kirino T, Shibata Y
Jpn J Clin Oncol 2001 Aug;31(8):403-6. doi: 10.1093/jjco/hye076. PMID: 11574635
Management of malignant pineal germ cell tumors with residual mature teratoma.
Friedman JA, Lynch JJ, Buckner JC, Scheithauer BW, Raffel C
Neurosurgery 2001 Mar;48(3):518-22; discussion 522-3. doi: 10.1097/00006123-200103000-00011. PMID: 11270541

Therapy

Malignant transformation of germinoma 14 years after onset: Favorable efficacy of oral etoposide.
Fukuoka K, Yanagisawa T, Suzuki T, Shirahata M, Adachi J, Mishima K, Fujimaki T, Matsutani M, Nishikawa R
Pediatr Int 2015 Jun;57(3):483-6. Epub 2015 Feb 24 doi: 10.1111/ped.12559. PMID: 25712128

Prognosis

Malignant transformation of germinoma 14 years after onset: Favorable efficacy of oral etoposide.
Fukuoka K, Yanagisawa T, Suzuki T, Shirahata M, Adachi J, Mishima K, Fujimaki T, Matsutani M, Nishikawa R
Pediatr Int 2015 Jun;57(3):483-6. Epub 2015 Feb 24 doi: 10.1111/ped.12559. PMID: 25712128
Malignant intracranial germinoma in Smith-Lemli-Opitz syndrome: cholesterol homeostasis possibly connecting morphogenesis and cancer development.
Oslejskova H, Horinova V, Sterba J, Pavelka Z, Babovic-Vuksanovic D, Dubska L, Valik D
J Pediatr Hematol Oncol 2008 Sep;30(9):689-91. doi: 10.1097/MPH.0b013e318180bbde. PMID: 18776762
Basal ganglia germinoma in children with associated ipsilateral cerebral and brain stem hemiatrophy.
Ozelame RV, Shroff M, Wood B, Bouffet E, Bartels U, Drake JM, Hawkins C, Blaser S
Pediatr Radiol 2006 Apr;36(4):325-30. Epub 2006 Feb 4 doi: 10.1007/s00247-005-0063-4. PMID: 16463029
Management of malignant pineal germ cell tumors with residual mature teratoma.
Friedman JA, Lynch JJ, Buckner JC, Scheithauer BW, Raffel C
Neurosurgery 2001 Mar;48(3):518-22; discussion 522-3. doi: 10.1097/00006123-200103000-00011. PMID: 11270541

Clinical prediction guides

Management of malignant pineal germ cell tumors with residual mature teratoma.
Friedman JA, Lynch JJ, Buckner JC, Scheithauer BW, Raffel C
Neurosurgery 2001 Mar;48(3):518-22; discussion 522-3. doi: 10.1097/00006123-200103000-00011. PMID: 11270541

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