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Non-Neoplastic Liver and Intrahepatic Bile Duct Disorder

MedGen UID:
317957
•Concept ID:
C1709250
•
Disease or Syndrome
Synonyms: Non-Neoplastic Hepatic Disease; Non-Neoplastic Hepatic Disorder

Definition

A non-neoplastic disorder that affects the liver parenchyma and the intrahepatic bile ducts. Representative examples include hepatitis, cirrhosis, and cholangitis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Neoplastic Liver and Intrahepatic Bile Duct Disorder

Professional guidelines

PubMed

Hepatic Cysts: Reappraisal of the Classification, Terminology, Differential Diagnosis, and Clinicopathologic Characteristics in 258 Cases.
Armutlu A, Quigley B, Choi H, Basturk O, Akkas G, Pehlivanoglu B, Memis B, Jang KT, Erkan M, Erkan B, Balci S, Saka B, Bagci P, Farris AB, Kooby DA, Martin D, Kalb B, Maithel SK, Sarmiento J, Reid MD, Adsay NV
Am J Surg Pathol 2022 Sep 1;46(9):1219-1233. Epub 2022 Jul 4 doi: 10.1097/PAS.0000000000001930. PMID: 35778790
Current knowledge and management of portal vein thrombosis in cirrhosis.
Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
Major Hepatic Complications in Ursodeoxycholic Acid-Treated Patients With Primary Biliary Cholangitis: Risk Factors and Time Trends in Incidence and Outcome.
Harms MH, Lammers WJ, Thorburn D, Corpechot C, Invernizzi P, Janssen HLA, Battezzati PM, Nevens F, Lindor KD, Floreani A, Ponsioen CY, Mayo MJ, Dalekos GN, Bruns T, Parés A, Mason AL, Verhelst X, Kowdley KV, Goet JC, Hirschfield GM, Hansen BE, van Buuren HR; Global PBC Study Group
Am J Gastroenterol 2018 Feb;113(2):254-264. Epub 2017 Dec 12 doi: 10.1038/ajg.2017.440. PMID: 29231188

Recent clinical studies

Etiology

Clinical outcomes and prognostic factors in non-cirrhotic non-neoplastic patients with portal vein thrombosis: A single-centre experience.
Gioia S, Riggio O, Nardelli S, Ridola L, Marzano C
Dig Liver Dis 2023 Nov;55(11):1487-1495. Epub 2023 May 23 doi: 10.1016/j.dld.2023.05.007. PMID: 37230857
Roles of Yes-associated protein and transcriptional coactivator with PDZ-binding motif in non-neoplastic liver diseases.
Chen D, Zhang H, Zhang X, Sun X, Qin Q, Hou Y, Jia M, Chen Y
Biomed Pharmacother 2022 Jul;151:113166. Epub 2022 May 24 doi: 10.1016/j.biopha.2022.113166. PMID: 35609372
Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis.
Goeppert B, Stichel D, Toth R, Fritzsche S, Loeffler MA, Schlitter AM, Neumann O, Assenov Y, Vogel MN, Mehrabi A, Hoffmann K, Köhler B, Springfeld C, Weichenhan D, Plass C, Esposito I, Schirmacher P, von Deimling A, Roessler S
Gut 2022 Feb;71(2):391-401. Epub 2021 Jan 19 doi: 10.1136/gutjnl-2020-322983. PMID: 33468537Free PMC Article
Current knowledge and management of portal vein thrombosis in cirrhosis.
Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
Alcohol use disorder and the gut.
Haber PS, Kortt NC
Addiction 2021 Mar;116(3):658-667. Epub 2020 Jul 7 doi: 10.1111/add.15147. PMID: 32511812

Diagnosis

Current knowledge and management of portal vein thrombosis in cirrhosis.
Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
Neuropilins and liver.
Elpek GÖ
World J Gastroenterol 2015 Jun 21;21(23):7065-73. doi: 10.3748/wjg.v21.i23.7065. PMID: 26109793Free PMC Article
Keratins in health and disease.
Toivola DM, Boor P, Alam C, Strnad P
Curr Opin Cell Biol 2015 Feb;32:73-81. Epub 2015 Jan 17 doi: 10.1016/j.ceb.2014.12.008. PMID: 25599598
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article

Therapy

Clinical outcomes and prognostic factors in non-cirrhotic non-neoplastic patients with portal vein thrombosis: A single-centre experience.
Gioia S, Riggio O, Nardelli S, Ridola L, Marzano C
Dig Liver Dis 2023 Nov;55(11):1487-1495. Epub 2023 May 23 doi: 10.1016/j.dld.2023.05.007. PMID: 37230857
Development of Non-alcoholic Steatohepatitis and Nodular Regenerative Hyperplasia in C57BL/6J Mice Fed a Fructose-containing Western Diet.
Inoue KI, Yamagishi H, Jojima T, Inoue T, Toyoda S
Anticancer Res 2022 Jan;42(1):609-617. doi: 10.21873/anticanres.15518. PMID: 34969770
Alcohol drinking and risks of liver cancer and non-neoplastic chronic liver diseases in China: a 10-year prospective study of 0.5 million adults.
Im PK, Millwood IY, Kartsonaki C, Guo Y, Chen Y, Turnbull I, Yu C, Du H, Pei P, Lv J, Walters RG, Li L, Yang L, Chen Z; China Kadoorie Biobank (CKB) collaborative group
BMC Med 2021 Sep 17;19(1):216. doi: 10.1186/s12916-021-02079-1. PMID: 34530818Free PMC Article
Unique T-Cell Populations Define Immune-Inflamed Hepatocellular Carcinoma.
Di Blasi D, Boldanova T, Mori L, Terracciano L, Heim MH, De Libero G
Cell Mol Gastroenterol Hepatol 2020;9(2):195-218. Epub 2019 Aug 22 doi: 10.1016/j.jcmgh.2019.08.004. PMID: 31445190Free PMC Article
Targeted therapies in hepatocellular carcinoma.
Bronte F, Bronte G, Cusenza S, Fiorentino E, Rolfo C, Cicero G, Bronte E, Di Marco V, Firenze A, Angarano G, Fontana T, Russo A
Curr Med Chem 2014;21(8):966-74. doi: 10.2174/09298673113209990234. PMID: 23992323

Prognosis

Clinical outcomes and prognostic factors in non-cirrhotic non-neoplastic patients with portal vein thrombosis: A single-centre experience.
Gioia S, Riggio O, Nardelli S, Ridola L, Marzano C
Dig Liver Dis 2023 Nov;55(11):1487-1495. Epub 2023 May 23 doi: 10.1016/j.dld.2023.05.007. PMID: 37230857
Current knowledge and management of portal vein thrombosis in cirrhosis.
Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
NQO1 as a Marker of Chemosensitivity and Prognosis for Colorectal Liver Metastasis.
Hirose Y, Sakata J, Kobayashi T, Miura K, Yuza K, Nakano M, Ichikawa H, Nagahashi M, Shimada Y, Kameyama H, Wakai T
Anticancer Res 2021 Mar;41(3):1563-1570. doi: 10.21873/anticanres.14916. PMID: 33788750
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article

Clinical prediction guides

Clinical outcomes and prognostic factors in non-cirrhotic non-neoplastic patients with portal vein thrombosis: A single-centre experience.
Gioia S, Riggio O, Nardelli S, Ridola L, Marzano C
Dig Liver Dis 2023 Nov;55(11):1487-1495. Epub 2023 May 23 doi: 10.1016/j.dld.2023.05.007. PMID: 37230857
Regression of portal hypertension: underlying mechanisms and therapeutic strategies.
Selicean S, Wang C, Guixé-Muntet S, Stefanescu H, Kawada N, Gracia-Sancho J
Hepatol Int 2021 Feb;15(1):36-50. Epub 2021 Feb 5 doi: 10.1007/s12072-021-10135-4. PMID: 33544313Free PMC Article
Unique T-Cell Populations Define Immune-Inflamed Hepatocellular Carcinoma.
Di Blasi D, Boldanova T, Mori L, Terracciano L, Heim MH, De Libero G
Cell Mol Gastroenterol Hepatol 2020;9(2):195-218. Epub 2019 Aug 22 doi: 10.1016/j.jcmgh.2019.08.004. PMID: 31445190Free PMC Article
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article

Recent systematic reviews

Clinical features, natural history and outcomes of pseudolymphoma of liver: A case-series and systematic review.
Jiang W, Wu D, Li Q, Liu CH, Zeng Q, Chen E, Lu C, Tang H
Asian J Surg 2023 Feb;46(2):841-849. Epub 2022 Sep 16 doi: 10.1016/j.asjsur.2022.08.113. PMID: 36123208
Therapeutic approaches for portal biliopathy: A systematic review.
Franceschet I, Zanetto A, Ferrarese A, Burra P, Senzolo M
World J Gastroenterol 2016 Dec 7;22(45):9909-9920. doi: 10.3748/wjg.v22.i45.9909. PMID: 28018098Free PMC Article
Relationship between RUNX3 methylation and hepatocellular carcinoma in Asian populations: a systematic review.
Lu XX, Zhu LQ, Pang F, Sun W, Ou C, Li Y, Cao J, Hu YL
Genet Mol Res 2014 Jul 7;13(3):5182-9. doi: 10.4238/2014.July.7.11. PMID: 25061743

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