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Widely Invasive Thymoma

MedGen UID:
328168
•Concept ID:
C1710673
•
Neoplastic Process

Definition

A thymoma that spreads by direct extension into adjacent tissues (lung, pericardium, or large vessels). This type of thymoma usually appears invasive at the time of excision. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWidely Invasive Thymoma

Professional guidelines

PubMed

Metformin treatment exerts antiinvasive and antimetastatic effects in human endometrial carcinoma cells.
Tan BK, Adya R, Chen J, Lehnert H, Sant Cassia LJ, Randeva HS
J Clin Endocrinol Metab 2011 Mar;96(3):808-16. Epub 2010 Dec 29 doi: 10.1210/jc.2010-1803. PMID: 21190977
Natural history and treatment of malignant thymoma.
Cowen D, Hannoun-Levi JM, Resbeut M, Alzieu C
Oncology (Williston Park) 1998 Jul;12(7):1001-5; discussion 1006. PMID: 9684271

Recent clinical studies

Etiology

Perioperative outcomes of minimally invasive surgery for large malignant thymic epithelial tumors and for total thymectomy.
Inoue M, Yamamoto H, Okada Y, Sato T, Sato Y, Suzuki K, Yoshino I, Chida M; Japanese Association of Chest Surgery
Surg Today 2023 Sep;53(9):1089-1099. Epub 2023 Mar 3 doi: 10.1007/s00595-023-02667-z. PMID: 36867230
Phase II study of S-1 in patients with previously-treated invasive thymoma and thymic carcinoma: North Japan lung cancer study group trial 1203.
Tsukita Y, Inoue A, Sugawara S, Kuyama S, Nakagawa T, Harada D, Tanaka H, Watanabe K, Mori Y, Harada T, Hino T, Fujii M, Ichinose M
Lung Cancer 2020 Jan;139:89-93. Epub 2019 Oct 18 doi: 10.1016/j.lungcan.2019.10.016. PMID: 31751805
Thoracoscopic thymectomy is a feasible and less invasive alternative for the surgical treatment of large thymomas.
Odaka M, Tsukamoto Y, Shibasaki T, Katou D, Mori S, Asano H, Yamashita M, Morikawa T
Interact Cardiovasc Thorac Surg 2017 Jul 1;25(1):103-108. doi: 10.1093/icvts/ivx048. PMID: 28369483
Therapy for thymic epithelial tumors.
Kondo K
Gen Thorac Cardiovasc Surg 2014 Aug;62(8):468-74. Epub 2014 Jun 10 doi: 10.1007/s11748-014-0420-z. PMID: 24913632
Natural history and treatment of malignant thymoma.
Cowen D, Hannoun-Levi JM, Resbeut M, Alzieu C
Oncology (Williston Park) 1998 Jul;12(7):1001-5; discussion 1006. PMID: 9684271

Diagnosis

Pulmonologist-led ultrasound guided lung biopsy safety and efficacy: a 4-year experience from a tertiary centre in Northern Malaysia.
Ismail IN, Alaga A
Med J Malaysia 2023 Nov;78(6):751-755. PMID: 38031216
Coincidence of Thyroid Transcription Factor-1-Positive Thymoma and Pulmonary Adenocarcinoma.
Kataoka Y, Fujita T, Hanaoka J
Ann Thorac Surg 2022 Jul;114(1):e47-e50. Epub 2021 Oct 6 doi: 10.1016/j.athoracsur.2021.08.070. PMID: 34624262
Thoracoscopic thymectomy is a feasible and less invasive alternative for the surgical treatment of large thymomas.
Odaka M, Tsukamoto Y, Shibasaki T, Katou D, Mori S, Asano H, Yamashita M, Morikawa T
Interact Cardiovasc Thorac Surg 2017 Jul 1;25(1):103-108. doi: 10.1093/icvts/ivx048. PMID: 28369483
Clinical and pathologic predictors of survival in patients with thymoma.
Wilkins KB, Sheikh E, Green R, Patel M, George S, Takano M, Diener-West M, Welsh J, Howard S, Askin F, Bulkley GB
Ann Surg 1999 Oct;230(4):562-72; discussion 572-4. doi: 10.1097/00000658-199910000-00012. PMID: 10522726Free PMC Article
Anemia in cancer.
Zucker S
Cancer Invest 1985;3(3):249-60. doi: 10.3109/07357908509039786. PMID: 3891030

Therapy

Pulmonologist-led ultrasound guided lung biopsy safety and efficacy: a 4-year experience from a tertiary centre in Northern Malaysia.
Ismail IN, Alaga A
Med J Malaysia 2023 Nov;78(6):751-755. PMID: 38031216
Phase II study of S-1 in patients with previously-treated invasive thymoma and thymic carcinoma: North Japan lung cancer study group trial 1203.
Tsukita Y, Inoue A, Sugawara S, Kuyama S, Nakagawa T, Harada D, Tanaka H, Watanabe K, Mori Y, Harada T, Hino T, Fujii M, Ichinose M
Lung Cancer 2020 Jan;139:89-93. Epub 2019 Oct 18 doi: 10.1016/j.lungcan.2019.10.016. PMID: 31751805
Natural history and treatment of malignant thymoma.
Cowen D, Hannoun-Levi JM, Resbeut M, Alzieu C
Oncology (Williston Park) 1998 Jul;12(7):1001-5; discussion 1006. PMID: 9684271
Dramatic response of recurrent invasive thymoma to high doses of corticosteroids.
Kirkove C, Berghmans J, Noel H, van de Merckt J
Clin Oncol (R Coll Radiol) 1992 Jan;4(1):64-6. doi: 10.1016/s0936-6555(05)80783-6. PMID: 1736985
Cardiac torsion after lobectomy with partial pericardectomy.
Ohri SK, Siddiqui AA, Townsend ER
Ann Thorac Surg 1992 Apr;53(4):703-5. doi: 10.1016/0003-4975(92)90341-z. PMID: 1554288

Prognosis

Phase II study of S-1 in patients with previously-treated invasive thymoma and thymic carcinoma: North Japan lung cancer study group trial 1203.
Tsukita Y, Inoue A, Sugawara S, Kuyama S, Nakagawa T, Harada D, Tanaka H, Watanabe K, Mori Y, Harada T, Hino T, Fujii M, Ichinose M
Lung Cancer 2020 Jan;139:89-93. Epub 2019 Oct 18 doi: 10.1016/j.lungcan.2019.10.016. PMID: 31751805
Thoracoscopic thymectomy is a feasible and less invasive alternative for the surgical treatment of large thymomas.
Odaka M, Tsukamoto Y, Shibasaki T, Katou D, Mori S, Asano H, Yamashita M, Morikawa T
Interact Cardiovasc Thorac Surg 2017 Jul 1;25(1):103-108. doi: 10.1093/icvts/ivx048. PMID: 28369483
Therapy for thymic epithelial tumors.
Kondo K
Gen Thorac Cardiovasc Surg 2014 Aug;62(8):468-74. Epub 2014 Jun 10 doi: 10.1007/s11748-014-0420-z. PMID: 24913632
Clinical and pathologic predictors of survival in patients with thymoma.
Wilkins KB, Sheikh E, Green R, Patel M, George S, Takano M, Diener-West M, Welsh J, Howard S, Askin F, Bulkley GB
Ann Surg 1999 Oct;230(4):562-72; discussion 572-4. doi: 10.1097/00000658-199910000-00012. PMID: 10522726Free PMC Article
Anemia in cancer.
Zucker S
Cancer Invest 1985;3(3):249-60. doi: 10.3109/07357908509039786. PMID: 3891030

Clinical prediction guides

Perioperative outcomes of minimally invasive surgery for large malignant thymic epithelial tumors and for total thymectomy.
Inoue M, Yamamoto H, Okada Y, Sato T, Sato Y, Suzuki K, Yoshino I, Chida M; Japanese Association of Chest Surgery
Surg Today 2023 Sep;53(9):1089-1099. Epub 2023 Mar 3 doi: 10.1007/s00595-023-02667-z. PMID: 36867230
Phase II study of S-1 in patients with previously-treated invasive thymoma and thymic carcinoma: North Japan lung cancer study group trial 1203.
Tsukita Y, Inoue A, Sugawara S, Kuyama S, Nakagawa T, Harada D, Tanaka H, Watanabe K, Mori Y, Harada T, Hino T, Fujii M, Ichinose M
Lung Cancer 2020 Jan;139:89-93. Epub 2019 Oct 18 doi: 10.1016/j.lungcan.2019.10.016. PMID: 31751805
Therapy for thymic epithelial tumors.
Kondo K
Gen Thorac Cardiovasc Surg 2014 Aug;62(8):468-74. Epub 2014 Jun 10 doi: 10.1007/s11748-014-0420-z. PMID: 24913632
Clinical and pathologic predictors of survival in patients with thymoma.
Wilkins KB, Sheikh E, Green R, Patel M, George S, Takano M, Diener-West M, Welsh J, Howard S, Askin F, Bulkley GB
Ann Surg 1999 Oct;230(4):562-72; discussion 572-4. doi: 10.1097/00000658-199910000-00012. PMID: 10522726Free PMC Article
Expression of E-cadherin and alpha- and beta-catenins in thymoma.
Pan CC, Ho DM, Chen WY, Chiang H, Fahn HJ, Wang LS
J Pathol 1998 Feb;184(2):207-11. doi: 10.1002/(SICI)1096-9896(199802)184:2<207::AID-PATH967>3.0.CO;2-X. PMID: 9602713

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