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Trichodiscoma

MedGen UID:
352818
•Concept ID:
C1704237
•
Neoplastic Process
Synonym: Spindle-Cell Predominant Trichodiscoma
SNOMED CT: Trichodiscoma (128683008); Trichodiscoma (254700008)
 
HPO: HP:0032228

Definition

A small benign fibrovascular tumor of the dermal part of the hair disk. Trichodiscoma is rather simple in appearance and consists of a dome-shaped fibrous tumor with a prominent vascular component that fills the papillary dermis under an atrophic epidermis. As in a normal hair disk, a hair follicle may be present at one edge of the papular lesion. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrichodiscoma

Conditions with this feature

Birt-Hogg-Dube syndrome 1
MedGen UID:
1051978
•Concept ID:
CN375946
•
Disease or Syndrome
Any Birt-Hogg-Dube (BHD) syndrome in which the cause of the disease is a variation in the FLCN gene.
See: Condition Record
Birt-Hogg-Dube syndrome 1

Professional guidelines

PubMed

Birt-Hogg-Dubé syndrome: a review of the literature and the differential diagnosis of firm facial papules.
Vincent A, Farley M, Chan E, James WD
J Am Acad Dermatol 2003 Oct;49(4):698-705. doi: 10.1067/s0190-9622(03)01582-2. PMID: 14512919

Recent clinical studies

Etiology

What is in a name-Perifollicular fibroma or fibrofolliculoma?
Haneke E, Happle R
J Cutan Pathol 2024 Feb;51(2):170-175. Epub 2023 Aug 30 doi: 10.1111/cup.14522. PMID: 37649357
Spindle Cell Predominant Trichodiscoma or Spindle Cell Lipoma With Adnexal Induction? A Study of 25 Cases, Revealing a Subset of Cases With RB1 Heterozygous Deletion in the Spindle Cell Stroma.
Michalova K, Kutzner H, Steiner P, Hadravsky L, Michal M Jr, Michal M, Kazakov DV
Am J Dermatopathol 2019 Sep;41(9):637-643. doi: 10.1097/DAD.0000000000001358. PMID: 30908293
Benign follicular tumors.
Tellechea O, Cardoso JC, Reis JP, Ramos L, Gameiro AR, Coutinho I, Baptista AP
An Bras Dermatol 2015 Nov-Dec;90(6):780-96; quiz 797-8. doi: 10.1590/abd1806-4841.20154114. PMID: 26734858Free PMC Article
Association between Birt Hogg Dube syndrome and cancer predisposition.
Palmirotta R, Savonarola A, Ludovici G, Donati P, Cavaliere F, DE Marchis ML, Ferroni P, Guadagni F
Anticancer Res 2010 Mar;30(3):751-7. PMID: 20392993
A case of Birt-Hogg-Dubé syndrome.
Kim EH, Jeong SY, Kim HJ, Kim YC
J Korean Med Sci 2008 Apr;23(2):332-5. doi: 10.3346/jkms.2008.23.2.332. PMID: 18437022Free PMC Article

Diagnosis

Spindle Cell/Pleomorphic Lipoma With Trichodiscoma-like Epithelial Hyperplasia Mimicking Atypical Fibroxanthoma/Pleomorphic Dermal Sarcoma.
Aghighi M, Andea AA, Patel RM, Fullen DR, Bresler SC
Am J Dermatopathol 2022 Oct 1;44(10):764-767. Epub 2022 Apr 27 doi: 10.1097/DAD.0000000000002206. PMID: 35503875
Concomitant fibrofolliculoma and trichodiscoma on the abdomen.
Riley J, Athalye L, Tran D, Fogelson S, Shitabata P
Cutis 2018 Oct;102(4):E30-E32. PMID: 30489570
Benign follicular tumors.
Tellechea O, Cardoso JC, Reis JP, Ramos L, Gameiro AR, Coutinho I, Baptista AP
An Bras Dermatol 2015 Nov-Dec;90(6):780-96; quiz 797-8. doi: 10.1590/abd1806-4841.20154114. PMID: 26734858Free PMC Article
Birt-Hogg-Dubé Syndrome.
Welsch MJ, Krunic A, Medenica MM
Int J Dermatol 2005 Aug;44(8):668-73. doi: 10.1111/j.1365-4632.2004.02095.x. PMID: 16101870
CD34-reactive trichodiscoma.
Chartier M, Reed ML, Mandavilli S, Fung M, Grant-Kels JM, Murphy M
J Cutan Pathol 2004 May;31(5):398-400. doi: 10.1111/j.0303-6987.2004.00202.x. PMID: 15059227

Prognosis

Spindle Cell Predominant Trichodiscoma or Spindle Cell Lipoma With Adnexal Induction? A Study of 25 Cases, Revealing a Subset of Cases With RB1 Heterozygous Deletion in the Spindle Cell Stroma.
Michalova K, Kutzner H, Steiner P, Hadravsky L, Michal M Jr, Michal M, Kazakov DV
Am J Dermatopathol 2019 Sep;41(9):637-643. doi: 10.1097/DAD.0000000000001358. PMID: 30908293
Dermatology clinics: what's new in dermatopathology: news in nonmelanocytic neoplasia.
Sidhu HK, Patel RV, Goldenberg G
Dermatol Clin 2012 Oct;30(4):623-41, vi. Epub 2012 Aug 13 doi: 10.1016/j.det.2012.06.009. PMID: 23021050
Review of renal oncocytosis (multiple oncocytic lesions) with focus on clinical and pathobiological aspects.
Kuroda N, Tanaka A, Ohe C, Mikami S, Nagashima Y, Sasaki T, Inoue K, Hes O, Michal M, Brunelli M, Martignoni G
Histol Histopathol 2012 Nov;27(11):1407-12. doi: 10.14670/HH-27.1407. PMID: 23018240
Trichodiscoma. A benign tumor related to haarscheibe (hair disk).
Pinkus H, Coskey R, Burgess GH
J Invest Dermatol 1974 Aug;63(2):212-8. doi: 10.1111/1523-1747.ep12679429. PMID: 4843452

Clinical prediction guides

Review of renal oncocytosis (multiple oncocytic lesions) with focus on clinical and pathobiological aspects.
Kuroda N, Tanaka A, Ohe C, Mikami S, Nagashima Y, Sasaki T, Inoue K, Hes O, Michal M, Brunelli M, Martignoni G
Histol Histopathol 2012 Nov;27(11):1407-12. doi: 10.14670/HH-27.1407. PMID: 23018240
Localized Birt-Hogg-Dubé syndrome with prominent perivascular fibromas.
Schulz T, Ebschner U, Hartschuh W
Am J Dermatopathol 2001 Apr;23(2):149-53. doi: 10.1097/00000372-200104000-00013. PMID: 11285413
Acrochordons are not a component of the Birt-Hogg-Dubé syndrome: does this syndrome exist? Case reports and review of the literature.
De la Torre C, Ocampo C, Doval IG, Losada A, Cruces MJ
Am J Dermatopathol 1999 Aug;21(4):369-74. doi: 10.1097/00000372-199908000-00011. PMID: 10446780

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