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Peripheral edema

MedGen UID:
39321
Concept ID:
C0085649
Pathologic Function
Synonyms: Edema of extremities; Edema of the extremities; Edema, peripheral
SNOMED CT: Peripheral edema (82014009); Edema of extremity (424372002); Peripheral edema (271809000)
 
HPO: HP:0012398

Definition

An abnormal accumulation of interstitial fluid in the soft tissues of the limbs. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Peripheral edema

Conditions with this feature

Lethal congenital glycogen storage disease of heart
MedGen UID:
337919
Concept ID:
C1849813
Disease or Syndrome
A rare glycogen storage disease with fetal or neonatal onset of severe cardiomyopathy with non-lysosomal glycogen accumulation and fatal outcome in infancy. Patients present with massive cardiomegaly, severe cardiac and respiratory complications and failure to thrive. Non-specific facial dysmorphism, bilateral cataracts, macroglossia, hydrocephalus, enlarged kidneys and skeletal muscle involvement have been reported in some cases.

Professional guidelines

PubMed

Patel H, Skok C, DeMarco A
Am Fam Physician 2022 Nov;106(5):557-564. PMID: 36379502
Raetz J, Wilson M, Collins K
Am Fam Physician 2019 Jun 1;99(11):682-688. PMID: 31150188
Kodner C
Am Fam Physician 2016 Mar 15;93(6):479-85. PMID: 26977832

Recent clinical studies

Etiology

Liang L, Kung JY, Mitchelmore B, Cave A, Banh HL
J Clin Hypertens (Greenwich) 2022 May;24(5):536-554. Epub 2022 Mar 2 doi: 10.1111/jch.14436. PMID: 35234349Free PMC Article
Raetz J, Wilson M, Collins K
Am Fam Physician 2019 Jun 1;99(11):682-688. PMID: 31150188
Baba M, Matsui N, Kuroha M, Wasaki Y, Ohwada S
J Diabetes Investig 2019 Sep;10(5):1299-1306. Epub 2019 Feb 28 doi: 10.1111/jdi.13013. PMID: 30672128Free PMC Article
Montani D, Günther S, Dorfmüller P, Perros F, Girerd B, Garcia G, Jaïs X, Savale L, Artaud-Macari E, Price LC, Humbert M, Simonneau G, Sitbon O
Orphanet J Rare Dis 2013 Jul 6;8:97. doi: 10.1186/1750-1172-8-97. PMID: 23829793Free PMC Article
Makani H, Bangalore S, Romero J, Htyte N, Berrios RS, Makwana H, Messerli FH
J Hypertens 2011 Jul;29(7):1270-80. doi: 10.1097/HJH.0b013e3283472643. PMID: 21558959

Diagnosis

Patel H, Skok C, DeMarco A
Am Fam Physician 2022 Nov;106(5):557-564. PMID: 36379502
Chen J, Aronowitz P
Med Clin North Am 2022 May;106(3):447-458. Epub 2022 Apr 4 doi: 10.1016/j.mcna.2021.12.002. PMID: 35491065
Raetz J, Wilson M, Collins K
Am Fam Physician 2019 Jun 1;99(11):682-688. PMID: 31150188
Kodner C
Am Fam Physician 2016 Mar 15;93(6):479-85. PMID: 26977832
King M, Kingery J, Casey B
Am Fam Physician 2012 Jun 15;85(12):1161-8. PMID: 22962896

Therapy

Chen H, Wu S, Tang M, Zhao R, Zhang Q, Dai Z, Gao Y, Yang S, Li Z, Du Y, Yang A, Zhong L, Lu L, Xu L, Shen X, Liu S, Zhong J, Li X, Lu H, Xiong H, Shen Y, Chen H, Gong S, Xue H, Ge Z
N Engl J Med 2023 Nov 2;389(18):1649-1659. doi: 10.1056/NEJMoa2303706. PMID: 37913505
Dull RO, Hahn RG
Crit Care 2023 May 27;27(1):206. doi: 10.1186/s13054-023-04496-5. PMID: 37245039Free PMC Article
Liang L, Kung JY, Mitchelmore B, Cave A, Banh HL
J Clin Hypertens (Greenwich) 2022 May;24(5):536-554. Epub 2022 Mar 2 doi: 10.1111/jch.14436. PMID: 35234349Free PMC Article
Raetz J, Wilson M, Collins K
Am Fam Physician 2019 Jun 1;99(11):682-688. PMID: 31150188
Kodner C
Am Fam Physician 2016 Mar 15;93(6):479-85. PMID: 26977832

Prognosis

Chen J, Aronowitz P
Med Clin North Am 2022 May;106(3):447-458. Epub 2022 Apr 4 doi: 10.1016/j.mcna.2021.12.002. PMID: 35491065
Tam CS, Opat S, D'Sa S, Jurczak W, Lee HP, Cull G, Owen RG, Marlton P, Wahlin BE, Sanz RG, McCarthy H, Mulligan S, Tedeschi A, Castillo JJ, Czyz J, Fernández de Larrea C, Belada D, Libby E, Matous JV, Motta M, Siddiqi T, Tani M, Trneny M, Minnema MC, Buske C, Leblond V, Trotman J, Chan WY, Schneider J, Ro S, Cohen A, Huang J, Dimopoulos M
Blood 2020 Oct 29;136(18):2038-2050. doi: 10.1182/blood.2020006844. PMID: 32731259Free PMC Article
Sibaud V, Beylot-Barry M, Protin C, Vigarios E, Recher C, Ysebaert L
Am J Clin Dermatol 2020 Dec;21(6):799-812. doi: 10.1007/s40257-020-00535-x. PMID: 32613545
Kodner C
Am Fam Physician 2016 Mar 15;93(6):479-85. PMID: 26977832
Khanna R
Mo Med 2011 Jan-Feb;108(1):33-6. PMID: 21462608Free PMC Article

Clinical prediction guides

Patel H, Skok C, DeMarco A
Am Fam Physician 2022 Nov;106(5):557-564. PMID: 36379502
Pandhi P, Ter Maaten JM, Anker SD, Ng LL, Metra M, Samani NJ, Lang CC, Dickstein K, de Boer RA, van Veldhuisen DJ, Voors AA, Sama IE
JACC Heart Fail 2022 Sep;10(9):623-632. doi: 10.1016/j.jchf.2022.05.013. PMID: 36049813
Francque SM, Bedossa P, Ratziu V, Anstee QM, Bugianesi E, Sanyal AJ, Loomba R, Harrison SA, Balabanska R, Mateva L, Lanthier N, Alkhouri N, Moreno C, Schattenberg JM, Stefanova-Petrova D, Vonghia L, Rouzier R, Guillaume M, Hodge A, Romero-Gómez M, Huot-Marchand P, Baudin M, Richard MP, Abitbol JL, Broqua P, Junien JL, Abdelmalek MF; NATIVE Study Group
N Engl J Med 2021 Oct 21;385(17):1547-1558. doi: 10.1056/NEJMoa2036205. PMID: 34670042
Wolf J, Seto T, Han JY, Reguart N, Garon EB, Groen HJM, Tan DSW, Hida T, de Jonge M, Orlov SV, Smit EF, Souquet PJ, Vansteenkiste J, Hochmair M, Felip E, Nishio M, Thomas M, Ohashi K, Toyozawa R, Overbeck TR, de Marinis F, Kim TM, Laack E, Robeva A, Le Mouhaer S, Waldron-Lynch M, Sankaran B, Balbin OA, Cui X, Giovannini M, Akimov M, Heist RS; GEOMETRY mono-1 Investigators
N Engl J Med 2020 Sep 3;383(10):944-957. doi: 10.1056/NEJMoa2002787. PMID: 32877583
Paik PK, Felip E, Veillon R, Sakai H, Cortot AB, Garassino MC, Mazieres J, Viteri S, Senellart H, Van Meerbeeck J, Raskin J, Reinmuth N, Conte P, Kowalski D, Cho BC, Patel JD, Horn L, Griesinger F, Han JY, Kim YC, Chang GC, Tsai CL, Yang JC, Chen YM, Smit EF, van der Wekken AJ, Kato T, Juraeva D, Stroh C, Bruns R, Straub J, Johne A, Scheele J, Heymach JV, Le X
N Engl J Med 2020 Sep 3;383(10):931-943. Epub 2020 May 29 doi: 10.1056/NEJMoa2004407. PMID: 32469185Free PMC Article

Recent systematic reviews

Santosa D, Rizky D, Tandarto K, Kartiyani I, Yunarvika V, Ardini DNE, Setiawan B, Pangarsa EA, Suharti C
Asian Pac J Cancer Prev 2023 Dec 1;24(12):4025-4033. doi: 10.31557/APJCP.2023.24.12.4025. PMID: 38156834Free PMC Article
Mostafa S, Shabana H, Khalil F, Mancy IME, Zedan HA, Elmoursi A, Ramadan IG, Mohamed SED, Kassem A, Kamel IS
High Blood Press Cardiovasc Prev 2022 Nov;29(6):565-576. Epub 2022 Oct 26 doi: 10.1007/s40292-022-00544-3. PMID: 36287359
Liang L, Kung JY, Mitchelmore B, Cave A, Banh HL
J Clin Hypertens (Greenwich) 2022 May;24(5):536-554. Epub 2022 Mar 2 doi: 10.1111/jch.14436. PMID: 35234349Free PMC Article
Elliott WJ, Bistrika EA
Expert Opin Drug Saf 2018 Feb;17(2):207-216. Epub 2017 Oct 31 doi: 10.1080/14740338.2018.1397129. PMID: 29065722
Yang Y, Liu YH, Sun X, Yu MW, Yang L, Cheng PY, Yang GW, Wang XM
Curr Med Res Opin 2017 Sep;33(9):1663-1675. Epub 2017 Jul 20 doi: 10.1080/03007995.2017.1349657. PMID: 28665153

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