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Corneal Endothelial Cell Loss

MedGen UID:
404624
•Concept ID:
C2717756
•
Finding
Synonyms: Corneal Endothelial Cell Damage; Endothelial Cell Loss, Corneal

Definition

A decrease in corneal endothelial cell density. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCorneal Endothelial Cell Loss

Professional guidelines

PubMed

A prospective evaluation of photorefractive intrastromal cross-linking for the treatment of low-grade myopia.
Fredriksson A, Näslund S, Behndig A
Acta Ophthalmol 2020 Mar;98(2):201-206. Epub 2019 Jul 12 doi: 10.1111/aos.14190. PMID: 31301105

Recent clinical studies

Etiology

Preserflo MicroShunt: Efficacy and Endothelial Cell Density.
Anton Steindor F, Trigaux C, Holtmann C, Spaniol K, Geerling G, Borrelli M
J Glaucoma 2023 Dec 1;32(12):1018-1021. Epub 2023 Oct 17 doi: 10.1097/IJG.0000000000002325. PMID: 38200660
Corneal endothelial cell damage after scleral fixation of intraocular lens surgery.
Jo YJ, Lee JS, Byon IS, Lee JE, Park SW
Jpn J Ophthalmol 2022 Jan;66(1):68-73. Epub 2021 Nov 9 doi: 10.1007/s10384-021-00884-y. PMID: 34751858
Corneal Endothelial Cell Loss After Endocapsular and Supracapsular Phacoemulsification: The PERCEPOLIS Randomized Clinical Trial.
Perone JM, Ghetemme C, Zevering Y, Zaidi M, Ouamara N, Goetz C, Lhuillier L
Cornea 2022 Jun 1;41(6):714-721. Epub 2021 Nov 2 doi: 10.1097/ICO.0000000000002822. PMID: 34732666
Corneal endothelial cell loss after trabeculectomy and phacoemulsification in one or two steps: a prospective study.
Soro-Martínez MI, Miralles de Imperial-Ollero JA, Pastor-Montoro M, Arcos-Villegas G, Sobrado-Calvo P, Ruiz-Gómez JM, Miralles de Imperial-Mora-Figueroa J, Villegas-Pérez MP
Eye (Lond) 2021 Nov;35(11):2999-3006. Epub 2021 Jan 7 doi: 10.1038/s41433-020-01331-x. PMID: 33414526Free PMC Article
Corneal Endothelial Cell Loss after Baerveldt Glaucoma Implant Surgery.
Hau S, Bunce C, Barton K
Ophthalmol Glaucoma 2021 Jan-Feb;4(1):20-31. Epub 2020 Jul 4 doi: 10.1016/j.ogla.2020.06.012. PMID: 32830103

Diagnosis

Preserflo MicroShunt: Efficacy and Endothelial Cell Density.
Anton Steindor F, Trigaux C, Holtmann C, Spaniol K, Geerling G, Borrelli M
J Glaucoma 2023 Dec 1;32(12):1018-1021. Epub 2023 Oct 17 doi: 10.1097/IJG.0000000000002325. PMID: 38200660
Corneal endothelial cell damage after scleral fixation of intraocular lens surgery.
Jo YJ, Lee JS, Byon IS, Lee JE, Park SW
Jpn J Ophthalmol 2022 Jan;66(1):68-73. Epub 2021 Nov 9 doi: 10.1007/s10384-021-00884-y. PMID: 34751858
Corneal Endothelial Cell Loss After Endocapsular and Supracapsular Phacoemulsification: The PERCEPOLIS Randomized Clinical Trial.
Perone JM, Ghetemme C, Zevering Y, Zaidi M, Ouamara N, Goetz C, Lhuillier L
Cornea 2022 Jun 1;41(6):714-721. Epub 2021 Nov 2 doi: 10.1097/ICO.0000000000002822. PMID: 34732666
Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1).
Medeiros FA, Walters TR, Kolko M, Coote M, Bejanian M, Goodkin ML, Guo Q, Zhang J, Robinson MR, Weinreb RN; ARTEMIS 1 Study Group
Ophthalmology 2020 Dec;127(12):1627-1641. Epub 2020 Jun 13 doi: 10.1016/j.ophtha.2020.06.018. PMID: 32544560
Effect of trabeculectomy on corneal endothelial cell loss.
Hirooka K, Nitta E, Ukegawa K, Sato S, Kiuchi Y
Br J Ophthalmol 2020 Mar;104(3):376-380. Epub 2019 Jun 14 doi: 10.1136/bjophthalmol-2018-313417. PMID: 31201168

Therapy

Corneal Endothelial Cell Loss after Baerveldt Glaucoma Implant Surgery.
Hau S, Bunce C, Barton K
Ophthalmol Glaucoma 2021 Jan-Feb;4(1):20-31. Epub 2020 Jul 4 doi: 10.1016/j.ogla.2020.06.012. PMID: 32830103
Cannabis and the Cornea.
Nguyen AX, Wu AY
Ocul Immunol Inflamm 2021 Jul 4;29(5):1023-1028. Epub 2020 Mar 11 doi: 10.1080/09273948.2020.1726969. PMID: 32159404Free PMC Article
Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1).
Medeiros FA, Walters TR, Kolko M, Coote M, Bejanian M, Goodkin ML, Guo Q, Zhang J, Robinson MR, Weinreb RN; ARTEMIS 1 Study Group
Ophthalmology 2020 Dec;127(12):1627-1641. Epub 2020 Jun 13 doi: 10.1016/j.ophtha.2020.06.018. PMID: 32544560
Glaucoma-associated corneal endothelial cell damage: A review.
Janson BJ, Alward WL, Kwon YH, Bettis DI, Fingert JH, Provencher LM, Goins KM, Wagoner MD, Greiner MA
Surv Ophthalmol 2018 Jul-Aug;63(4):500-506. Epub 2017 Nov 14 doi: 10.1016/j.survophthal.2017.11.002. PMID: 29146208
Progress in corneal wound healing.
Ljubimov AV, Saghizadeh M
Prog Retin Eye Res 2015 Nov;49:17-45. Epub 2015 Jul 18 doi: 10.1016/j.preteyeres.2015.07.002. PMID: 26197361Free PMC Article

Prognosis

Endothelial Keratoplasty Update 2020.
Price MO, Feng MT, Price FW Jr
Cornea 2021 May 1;40(5):541-547. doi: 10.1097/ICO.0000000000002565. PMID: 33252380
Corneal Endothelial Cell Loss after Baerveldt Glaucoma Implant Surgery.
Hau S, Bunce C, Barton K
Ophthalmol Glaucoma 2021 Jan-Feb;4(1):20-31. Epub 2020 Jul 4 doi: 10.1016/j.ogla.2020.06.012. PMID: 32830103
Long-Term Maintenance of Corneal Endothelial Cell Density After Corneal Transplantation.
Kayukawa K, Kitazawa K, Wakimasu K, Patel SV, Bush J, Sotozono C, Kinoshita S
Cornea 2020 Dec;39(12):1510-1515. doi: 10.1097/ICO.0000000000002386. PMID: 32482965
Effect of trabeculectomy on corneal endothelial cell loss.
Hirooka K, Nitta E, Ukegawa K, Sato S, Kiuchi Y
Br J Ophthalmol 2020 Mar;104(3):376-380. Epub 2019 Jun 14 doi: 10.1136/bjophthalmol-2018-313417. PMID: 31201168
Progress in corneal wound healing.
Ljubimov AV, Saghizadeh M
Prog Retin Eye Res 2015 Nov;49:17-45. Epub 2015 Jul 18 doi: 10.1016/j.preteyeres.2015.07.002. PMID: 26197361Free PMC Article

Clinical prediction guides

Preserflo MicroShunt: Efficacy and Endothelial Cell Density.
Anton Steindor F, Trigaux C, Holtmann C, Spaniol K, Geerling G, Borrelli M
J Glaucoma 2023 Dec 1;32(12):1018-1021. Epub 2023 Oct 17 doi: 10.1097/IJG.0000000000002325. PMID: 38200660
Endothelial Keratoplasty Update 2020.
Price MO, Feng MT, Price FW Jr
Cornea 2021 May 1;40(5):541-547. doi: 10.1097/ICO.0000000000002565. PMID: 33252380
Cannabis and the Cornea.
Nguyen AX, Wu AY
Ocul Immunol Inflamm 2021 Jul 4;29(5):1023-1028. Epub 2020 Mar 11 doi: 10.1080/09273948.2020.1726969. PMID: 32159404Free PMC Article
Effect of trabeculectomy on corneal endothelial cell loss.
Hirooka K, Nitta E, Ukegawa K, Sato S, Kiuchi Y
Br J Ophthalmol 2020 Mar;104(3):376-380. Epub 2019 Jun 14 doi: 10.1136/bjophthalmol-2018-313417. PMID: 31201168
Progress in corneal wound healing.
Ljubimov AV, Saghizadeh M
Prog Retin Eye Res 2015 Nov;49:17-45. Epub 2015 Jul 18 doi: 10.1016/j.preteyeres.2015.07.002. PMID: 26197361Free PMC Article

Recent systematic reviews

Corneal Endothelial Cell Density Loss after Glaucoma Surgery Alone or in Combination with Cataract Surgery: A Systematic Review and Meta-analysis.
Fang CEH, Mathew RG, Khaw PT, Henein C
Ophthalmology 2022 Aug;129(8):841-855. Epub 2022 Mar 22 doi: 10.1016/j.ophtha.2022.03.015. PMID: 35331751
Ab interno supraciliary microstent surgery for open-angle glaucoma.
Sandhu A, Jayaram H, Hu K, Bunce C, Gazzard G
Cochrane Database Syst Rev 2021 May 28;5(5):CD012802. doi: 10.1002/14651858.CD012802.pub2. PMID: 34049422Free PMC Article
Systematic Review and Meta-Analysis of Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty Versus Descemet Stripping Endothelial Keratoplasty/Descemet Stripping Automated Endothelial Keratoplasty.
Singh A, Zarei-Ghanavati M, Avadhanam V, Liu C
Cornea 2017 Nov;36(11):1437-1443. doi: 10.1097/ICO.0000000000001320. PMID: 28834814
Efficacy of Corneal Collagen Cross-Linking for the Treatment of Keratoconus: A Systematic Review and Meta-Analysis.
Meiri Z, Keren S, Rosenblatt A, Sarig T, Shenhav L, Varssano D
Cornea 2016 Mar;35(3):417-28. doi: 10.1097/ICO.0000000000000723. PMID: 26751990
Meta-analysis to Compare the Safety and Efficacy of Manual Small Incision Cataract Surgery and Phacoemulsification.
Gogate P, Optom JJ, Deshpande S, Naidoo K
Middle East Afr J Ophthalmol 2015 Jul-Sep;22(3):362-9. doi: 10.4103/0974-9233.159763. PMID: 26180478Free PMC Article

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