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Low tension glaucoma

MedGen UID:
56263
•Concept ID:
C0152136
•
Disease or Syndrome
Synonyms: Glaucoma, Low Tension; Glaucoma, Normal Tension; Low Tension Glaucoma; Low Tension Glaucomas; Normal Tension Glaucoma; Normal Tension Glaucomas
SNOMED CT: Normal pressure glaucoma (50485007); LTG - Low tension glaucoma (50485007); Normal tension glaucoma (50485007); Low tension glaucoma (50485007)
 
Monarch Initiative: MONDO:0006837

Definition

A form of glaucoma in which chronic optic nerve damage and loss of vision normally attributable to buildup of intraocular pressure occurs despite prevailing conditions of normal intraocular pressure. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow tension glaucoma

Professional guidelines

PubMed

Normal-tension Glaucoma Management: A Survey of Glaucoma Sub-specialists in Korea.
Han YS, Ha A, Kim YK, Jeoung JW, Park KH
Korean J Ophthalmol 2020 Dec;34(6):425-431. Epub 2020 Dec 3 doi: 10.3341/kjo.2020.0061. PMID: 33307601Free PMC Article
Comparison of the Progression of High- and Low-tension Glaucoma as Determined by Two Different Criteria.
Lee JY, Sung KR, Lee JY
Korean J Ophthalmol 2016 Feb;30(1):40-7. Epub 2016 Jan 21 doi: 10.3341/kjo.2016.30.1.40. PMID: 26865802Free PMC Article
Calcium channel blockers in the management of low-tension and open-angle glaucoma.
Netland PA, Chaturvedi N, Dreyer EB
Am J Ophthalmol 1993 May 15;115(5):608-13. doi: 10.1016/s0002-9394(14)71458-8. PMID: 8488913

Recent clinical studies

Etiology

Familial normal tension glaucoma genetics.
Fox AR, Fingert JH
Prog Retin Eye Res 2023 Sep;96:101191. Epub 2023 Jun 22 doi: 10.1016/j.preteyeres.2023.101191. PMID: 37353142
Normal-tension glaucoma: Current concepts and approaches-A review.
Leung DYL, Tham CC
Clin Exp Ophthalmol 2022 Mar;50(2):247-259. Epub 2022 Feb 7 doi: 10.1111/ceo.14043. PMID: 35040248
Is "normal tension glaucoma" glaucoma?
Fan N, Tan J, Liu X
Med Hypotheses 2019 Dec;133:109405. Epub 2019 Sep 24 doi: 10.1016/j.mehy.2019.109405. PMID: 31563827
Normal tension glaucoma: review of current understanding and mechanisms of the pathogenesis.
Killer HE, Pircher A
Eye (Lond) 2018 May;32(5):924-930. Epub 2018 Feb 19 doi: 10.1038/s41433-018-0042-2. PMID: 29456252Free PMC Article
Normal-tension glaucoma: an update.
Esporcatte BL, Tavares IM
Arq Bras Oftalmol 2016 Jul-Aug;79(4):270-6. doi: 10.5935/0004-2749.20160077. PMID: 27626157

Diagnosis

Familial normal tension glaucoma genetics.
Fox AR, Fingert JH
Prog Retin Eye Res 2023 Sep;96:101191. Epub 2023 Jun 22 doi: 10.1016/j.preteyeres.2023.101191. PMID: 37353142
Normal-tension glaucoma: Current concepts and approaches-A review.
Leung DYL, Tham CC
Clin Exp Ophthalmol 2022 Mar;50(2):247-259. Epub 2022 Feb 7 doi: 10.1111/ceo.14043. PMID: 35040248
Normal tension glaucoma: review of current understanding and mechanisms of the pathogenesis.
Killer HE, Pircher A
Eye (Lond) 2018 May;32(5):924-930. Epub 2018 Feb 19 doi: 10.1038/s41433-018-0042-2. PMID: 29456252Free PMC Article
Normal-tension glaucoma: an update.
Esporcatte BL, Tavares IM
Arq Bras Oftalmol 2016 Jul-Aug;79(4):270-6. doi: 10.5935/0004-2749.20160077. PMID: 27626157
Low-tension glaucoma.
Chumbley LC, Brubaker RF
Am J Ophthalmol 1976 Jun;81(6):761-7. doi: 10.1016/0002-9394(76)90359-7. PMID: 937430

Therapy

Normal-tension glaucoma is associated with cognitive impairment.
Mullany S, Xiao L, Qassim A, Marshall H, Gharahkhani P, MacGregor S, Hassall MM, Siggs OM, Souzeau E, Craig JE
Br J Ophthalmol 2022 Jul;106(7):952-956. Epub 2021 Mar 29 doi: 10.1136/bjophthalmol-2020-317461. PMID: 33781990Free PMC Article
Is "normal tension glaucoma" glaucoma?
Fan N, Tan J, Liu X
Med Hypotheses 2019 Dec;133:109405. Epub 2019 Sep 24 doi: 10.1016/j.mehy.2019.109405. PMID: 31563827
Management of normal tension glaucoma.
Gittinger JW Jr
Surv Ophthalmol 2019 Jan-Feb;64(1):101. doi: 10.1016/j.survophthal.2018.10.001. PMID: 30514477
Intraocular pressure-independent management of normal tension glaucoma.
Adeghate J, Rahmatnejad K, Waisbourd M, Katz LJ
Surv Ophthalmol 2019 Jan-Feb;64(1):101-110. Epub 2018 Oct 6 doi: 10.1016/j.survophthal.2018.08.005. PMID: 30300625
Low-tension glaucoma.
Alexander LJ, Fingeret M, Jennings B, Thimons JJ
Optom Clin 1991;1(1):255-65. PMID: 1686844

Prognosis

Normal-tension glaucoma: Current concepts and approaches-A review.
Leung DYL, Tham CC
Clin Exp Ophthalmol 2022 Mar;50(2):247-259. Epub 2022 Feb 7 doi: 10.1111/ceo.14043. PMID: 35040248
Glaucoma conversion of the contralateral eye in unilateral normal-tension glaucoma patients: a 5-year follow-up study.
Kim JS, Choi HJ, Park KH
Br J Ophthalmol 2021 Oct;105(10):1383-1389. Epub 2020 Sep 5 doi: 10.1136/bjophthalmol-2020-316371. PMID: 32892166
TBK1 gene duplication and normal-tension glaucoma.
Ritch R, Darbro B, Menon G, Khanna CL, Solivan-Timpe F, Roos BR, Sarfarzi M, Kawase K, Yamamoto T, Robin AL, Lotery AJ, Fingert JH
JAMA Ophthalmol 2014 May;132(5):544-8. doi: 10.1001/jamaophthalmol.2014.104. PMID: 24699864Free PMC Article
Low-tension glaucoma.
Chumbley LC, Brubaker RF
Am J Ophthalmol 1976 Jun;81(6):761-7. doi: 10.1016/0002-9394(76)90359-7. PMID: 937430
Shock and low-tension glaucoma.
Schwartz B
N Engl J Med 1973 Feb 22;288(8):417-8. doi: 10.1056/NEJM197302222880813. PMID: 4684047

Clinical prediction guides

Retinal vessel architecture and geometry are not impaired in normal-tension glaucoma.
Leveque AS, Bouisse M, Labarere J, Trucco E, Hogg S, MacGillivray T, Aptel F, Chiquet C
Sci Rep 2023 Apr 25;13(1):6713. doi: 10.1038/s41598-023-33361-2. PMID: 37185916Free PMC Article
Co-occurrence of chronic kidney disease and glaucoma: Epidemiology and etiological mechanisms.
Liu W, Guo R, Huang D, Ji J, Gansevoort RT, Snieder H, Jansonius NM
Surv Ophthalmol 2023 Jan-Feb;68(1):1-16. Epub 2022 Sep 9 doi: 10.1016/j.survophthal.2022.09.001. PMID: 36088997
Normal-tension glaucoma: Current concepts and approaches-A review.
Leung DYL, Tham CC
Clin Exp Ophthalmol 2022 Mar;50(2):247-259. Epub 2022 Feb 7 doi: 10.1111/ceo.14043. PMID: 35040248
Normal-tension glaucoma is associated with cognitive impairment.
Mullany S, Xiao L, Qassim A, Marshall H, Gharahkhani P, MacGregor S, Hassall MM, Siggs OM, Souzeau E, Craig JE
Br J Ophthalmol 2022 Jul;106(7):952-956. Epub 2021 Mar 29 doi: 10.1136/bjophthalmol-2020-317461. PMID: 33781990Free PMC Article
Cognitive functions and normal tension glaucoma.
Daveckaite A, Grusauskiene E, Petrikonis K, Vaitkus A, Siaudvytyte L, Januleviciene I
Indian J Ophthalmol 2017 Oct;65(10):974-978. doi: 10.4103/ijo.IJO_756_16. PMID: 29044063Free PMC Article

Recent systematic reviews

Association of Gene Polymorphisms with Normal Tension Glaucoma: A Systematic Review and Meta-Analysis.
Pan L, Wu J, Wang N
Genes (Basel) 2024 Apr 14;15(4) doi: 10.3390/genes15040491. PMID: 38674425Free PMC Article
Is Glaucoma a Two-Pressure-Related Optic Neuropathy? A Systematic Review and Meta-Analysis.
Hoang TT, Anh BV, Subramanian P
Turk J Ophthalmol 2024 Apr 19;54(2):83-89. doi: 10.4274/tjo.galenos.2024.66267. PMID: 38645613Free PMC Article
Corneal Biomechanics in Primary Open Angle Glaucoma and Ocular Hypertension: A Systematic Review and Meta-analysis.
Liu MX, Zhou M, Li DL, Dong XX, Liang G, Pan CW
J Glaucoma 2023 Mar 1;32(3):e24-e32. Epub 2022 Dec 30 doi: 10.1097/IJG.0000000000002170. PMID: 36583701
Prevalence of Normal-Tension Glaucoma in the Chinese Population: A Systematic Review and Meta-Analysis.
Zhao J, Solano MM, Oldenburg CE, Liu T, Wang Y, Wang N, Lin SC
Am J Ophthalmol 2019 Mar;199:101-110. Epub 2018 Oct 21 doi: 10.1016/j.ajo.2018.10.017. PMID: 30352196
Association of WDR36 polymorphisms with primary open angle glaucoma: A systematic review and meta-analysis.
Liu K, He W, Zhao J, Zeng Y, Cheng H
Medicine (Baltimore) 2017 Jun;96(26):e7291. doi: 10.1097/MD.0000000000007291. PMID: 28658128Free PMC Article

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