U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant neoplasm of endocrine gland

MedGen UID:
56319
•Concept ID:
C0153658
•
Neoplastic Process
Synonyms: Endocrine Cancer; Malignant endocrine neoplasm
SNOMED CT: Malignant neoplasm of endocrine gland (371982006); Malignant tumor of endocrine gland (371982006)
 
Monarch Initiative: MONDO:0021069

Definition

A malignant neoplasm affecting the endocrine glands. Representative examples include thyroid gland carcinoma, parathyroid gland carcinoma, pituitary gland carcinoma, and adrenal cortex carcinoma. [from NCI]

Professional guidelines

PubMed

European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Jul 20;189(1):G1-G42. doi: 10.1093/ejendo/lvad066. PMID: 37318239
Contemporary Thyroid Nodule Evaluation and Management.
Grani G, Sponziello M, Pecce V, Ramundo V, Durante C
J Clin Endocrinol Metab 2020 Sep 1;105(9):2869-83. doi: 10.1210/clinem/dgaa322. PMID: 32491169Free PMC Article
Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Arlt W, Bancos I, Dralle H, Newell-Price J, Sahdev A, Tabarin A, Terzolo M, Tsagarakis S, Dekkers OM
Eur J Endocrinol 2016 Aug;175(2):G1-G34. doi: 10.1530/EJE-16-0467. PMID: 27390021

Recent clinical studies

Etiology

The 5(th) edition of WHO classification of tumors of endocrine organs: changes in the diagnosis of follicular-derived thyroid carcinoma.
Basolo F, Macerola E, Poma AM, Torregrossa L
Endocrine 2023 Jun;80(3):470-476. Epub 2023 Mar 25 doi: 10.1007/s12020-023-03336-4. PMID: 36964880Free PMC Article
Oncocrinology.
Kalra S, Priya G, Bhattacharya S, Sahay R
J Pak Med Assoc 2020 Apr;70(4):757-761. PMID: 32296231
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE, Tolaney SM
JAMA Oncol 2018 Feb 1;4(2):173-182. doi: 10.1001/jamaoncol.2017.3064. PMID: 28973656Free PMC Article
The Treatment of Cushing's Disease.
Pivonello R, De Leo M, Cozzolino A, Colao A
Endocr Rev 2015 Aug;36(4):385-486. Epub 2015 Jun 11 doi: 10.1210/er.2013-1048. PMID: 26067718Free PMC Article
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Diagnosis

The 5(th) edition of WHO classification of tumors of endocrine organs: changes in the diagnosis of follicular-derived thyroid carcinoma.
Basolo F, Macerola E, Poma AM, Torregrossa L
Endocrine 2023 Jun;80(3):470-476. Epub 2023 Mar 25 doi: 10.1007/s12020-023-03336-4. PMID: 36964880Free PMC Article
Imaging of Adrenal-Related Endocrine Disorders.
Yalniz C, Morani AC, Waguespack SG, Elsayes KM
Radiol Clin North Am 2020 Nov;58(6):1099-1113. Epub 2020 Sep 17 doi: 10.1016/j.rcl.2020.07.010. PMID: 33040851
Parathyroid Imaging.
Itani M, Middleton WD
Radiol Clin North Am 2020 Nov;58(6):1071-1083. Epub 2020 Sep 17 doi: 10.1016/j.rcl.2020.07.006. PMID: 33040849
Adrenal Incidentaloma.
Sherlock M, Scarsbrook A, Abbas A, Fraser S, Limumpornpetch P, Dineen R, Stewart PM
Endocr Rev 2020 Dec 1;41(6):775-820. doi: 10.1210/endrev/bnaa008. PMID: 32266384Free PMC Article
Surgery for primary hyperparathyroidism.
Callender GG, Udelsman R
Cancer 2014 Dec 1;120(23):3602-16. Epub 2014 Jul 9 doi: 10.1002/cncr.28891. PMID: 25042934

Therapy

LIBRETTO-531: a phase III study of selpercatinib in multikinase inhibitor-naïve RET-mutant medullary thyroid cancer.
Wirth LJ, Brose MS, Elisei R, Capdevila J, Hoff AO, Hu MI, Tahara M, Robinson B, Gao M, Xia M, Maeda P, Sherman E
Future Oncol 2022 Sep;18(28):3143-3150. Epub 2022 Aug 15 doi: 10.2217/fon-2022-0657. PMID: 35969032Free PMC Article
Oncocrinology.
Kalra S, Priya G, Bhattacharya S, Sahay R
J Pak Med Assoc 2020 Apr;70(4):757-761. PMID: 32296231
Absolute Improvements in Freedom From Distant Recurrence to Tailor Adjuvant Endocrine Therapies for Premenopausal Women: Results From TEXT and SOFT.
Pagani O, Francis PA, Fleming GF, Walley BA, Viale G, Colleoni M, Láng I, Gómez HL, Tondini C, Pinotti G, Di Leo A, Coates AS, Goldhirsch A, Gelber RD, Regan MM; SOFT and TEXT Investigators and International Breast Cancer Study Group
J Clin Oncol 2020 Apr 20;38(12):1293-1303. Epub 2019 Oct 16 doi: 10.1200/JCO.18.01967. PMID: 31618131Free PMC Article
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE, Tolaney SM
JAMA Oncol 2018 Feb 1;4(2):173-182. doi: 10.1001/jamaoncol.2017.3064. PMID: 28973656Free PMC Article
Therapy of endocrine disease: treatment of malignant pheochromocytoma and paraganglioma.
Baudin E, Habra MA, Deschamps F, Cote G, Dumont F, Cabanillas M, Arfi-Roufe J, Berdelou A, Moon B, Al Ghuzlan A, Patel S, Leboulleux S, Jimenez C
Eur J Endocrinol 2014 Sep;171(3):R111-22. Epub 2014 Jun 2 doi: 10.1530/EJE-14-0113. PMID: 24891137

Prognosis

The 5(th) edition of WHO classification of tumors of endocrine organs: changes in the diagnosis of follicular-derived thyroid carcinoma.
Basolo F, Macerola E, Poma AM, Torregrossa L
Endocrine 2023 Jun;80(3):470-476. Epub 2023 Mar 25 doi: 10.1007/s12020-023-03336-4. PMID: 36964880Free PMC Article
Imaging of Adrenal-Related Endocrine Disorders.
Yalniz C, Morani AC, Waguespack SG, Elsayes KM
Radiol Clin North Am 2020 Nov;58(6):1099-1113. Epub 2020 Sep 17 doi: 10.1016/j.rcl.2020.07.010. PMID: 33040851
Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules.
Nikiforova MN, Mercurio S, Wald AI, Barbi de Moura M, Callenberg K, Santana-Santos L, Gooding WE, Yip L, Ferris RL, Nikiforov YE
Cancer 2018 Apr 15;124(8):1682-1690. Epub 2018 Jan 18 doi: 10.1002/cncr.31245. PMID: 29345728Free PMC Article
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE, Tolaney SM
JAMA Oncol 2018 Feb 1;4(2):173-182. doi: 10.1001/jamaoncol.2017.3064. PMID: 28973656Free PMC Article
Cryptorchidism.
Hutson JM, Balic A, Nation T, Southwell B
Semin Pediatr Surg 2010 Aug;19(3):215-24. doi: 10.1053/j.sempedsurg.2010.04.001. PMID: 20610195

Clinical prediction guides

Risks and prediction of postoperative hypoparathyroidism due to thyroid surgery.
Yazıcıoğlu MÖ, Yılmaz A, Kocaöz S, Özçağlayan R, Parlak Ö
Sci Rep 2021 Jun 4;11(1):11876. doi: 10.1038/s41598-021-91277-1. PMID: 34088943Free PMC Article
Serum Inflammation-based Scores in Endocrine Tumors.
Marques P, de Vries F, Dekkers OM, Korbonits M, Biermasz NR, Pereira AM
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3796-e3819. doi: 10.1210/clinem/dgab238. PMID: 33837783Free PMC Article
Updates in Thyroid Cytology.
Nishino M, Krane JF
Surg Pathol Clin 2018 Sep;11(3):467-487. doi: 10.1016/j.path.2018.05.002. PMID: 30190135
Adrenal myelolipoma: a comprehensive review.
Decmann Á, Perge P, Tóth M, Igaz P
Endocrine 2018 Jan;59(1):7-15. Epub 2017 Nov 21 doi: 10.1007/s12020-017-1473-4. PMID: 29164520
Clinicopathological correlates of hyperparathyroidism.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Oct;68(10):771-87. Epub 2015 Jul 10 doi: 10.1136/jclinpath-2015-203186. PMID: 26163537

Recent systematic reviews

Ovarian torsion in pediatric and adolescent patients: A systematic review.
Dasgupta R, Renaud E, Goldin AB, Baird R, Cameron DB, Arnold MA, Diefenbach KA, Gosain A, Grabowski J, Guner YS, Jancelewicz T, Kawaguchi A, Lal DR, Oyetunji TA, Ricca RL, Shelton J, Somme S, Williams RF, Downard CD
J Pediatr Surg 2018 Jul;53(7):1387-1391. Epub 2017 Nov 16 doi: 10.1016/j.jpedsurg.2017.10.053. PMID: 29153467
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE, Tolaney SM
JAMA Oncol 2018 Feb 1;4(2):173-182. doi: 10.1001/jamaoncol.2017.3064. PMID: 28973656Free PMC Article
The physiology and clinical utility of anti-Mullerian hormone in women.
Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, Griesinger G, Kelsey TW, La Marca A, Lambalk C, Mason H, Nelson SM, Visser JA, Wallace WH, Anderson RA
Hum Reprod Update 2014 May-Jun;20(3):370-85. Epub 2014 Jan 14 doi: 10.1093/humupd/dmt062. PMID: 24430863
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893
The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report.
Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF; Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society
Fertil Steril 2009 Feb;91(2):456-88. Epub 2008 Oct 23 doi: 10.1016/j.fertnstert.2008.06.035. PMID: 18950759

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...