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Small Cell Glioblastoma

MedGen UID:
696081
•Concept ID:
C1272516
•
Neoplastic Process
Synonyms: Small cell glioblastoma; Small-cell glioblastoma
SNOMED CT: Small cell glioblastoma (384992008); Small-cell glioblastoma (384992008)

Definition

A morphologic variant of glioblastoma characterized by the presence of a highly proliferative and monotonous population of malignant small glial cells. [from NCI]

Professional guidelines

PubMed

Glioblastoma Multiforme: The Latest Diagnostics and Treatment Techniques.
Czarnywojtek A, Borowska M, Dyrka K, Van Gool S, Sawicka-Gutaj N, Moskal J, Kościński J, Graczyk P, Hałas T, Lewandowska AM, Czepczyński R, Ruchała M
Pharmacology 2023;108(5):423-431. Epub 2023 Jul 17 doi: 10.1159/000531319. PMID: 37459849
Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook.
Garcia J, Hurwitz HI, Sandler AB, Miles D, Coleman RL, Deurloo R, Chinot OL
Cancer Treat Rev 2020 Jun;86:102017. Epub 2020 Mar 26 doi: 10.1016/j.ctrv.2020.102017. PMID: 32335505
Emerging treatment strategies for glioblastoma multiforme.
Carlsson SK, Brothers SP, Wahlestedt C
EMBO Mol Med 2014 Nov;6(11):1359-70. doi: 10.15252/emmm.201302627. PMID: 25312641Free PMC Article

Recent clinical studies

Etiology

Glioblastoma: Changing concepts in the WHO CNS5 classification.
Chen J, Han P, Dahiya S
Indian J Pathol Microbiol 2022 May;65(Supplement):S24-S32. doi: 10.4103/ijpm.ijpm_1109_21. PMID: 35562131
Cerebrospinal fluid dissemination of high-grade gliomas following boron neutron capture therapy occurs more frequently in the small cell subtype of IDH1(R132H) mutation-negative glioblastoma.
Kondo N, Barth RF, Miyatake SI, Kawabata S, Suzuki M, Ono K, Lehman NL
J Neurooncol 2017 May;133(1):107-118. Epub 2017 May 22 doi: 10.1007/s11060-017-2408-x. PMID: 28534152Free PMC Article
Clinicopathologic features of small cell glioblastomas.
Takeuchi H, Kitai R, Hosoda T, Yamada S, Hashimoto N, Kikuta K, Shimizu Y, Kimura H
J Neurooncol 2016 Apr;127(2):337-44. Epub 2016 Jan 2 doi: 10.1007/s11060-015-2038-0. PMID: 26725094

Diagnosis

Glioblastoma: Changing concepts in the WHO CNS5 classification.
Chen J, Han P, Dahiya S
Indian J Pathol Microbiol 2022 May;65(Supplement):S24-S32. doi: 10.4103/ijpm.ijpm_1109_21. PMID: 35562131
Small cell glioblastoma multiforme: a case series and clinicopathological update.
Yadav AK, Madan R, Chatterjee D, Dhiman S, Goyal S, Kumar N, Sahoo SK
CNS Oncol 2020 Dec 1;9(4):CNS63. Epub 2020 Dec 7 doi: 10.2217/cns-2020-0016. PMID: 33283529Free PMC Article
FNA Cytology in pediatric small cell glioblastoma.
Kalogerak A, Tamiolakis D, Zoi I, Karvela-Kalogeraki I, Karvelas-Kalogerakis M, Segredakis J, Datseri G
Acta Biomed 2018 Jun 7;89(2):265-268. doi: 10.23750/abm.v89i2.5436. PMID: 29957763Free PMC Article
Small Cell Glioblastoma of the Sella Turcica Region: Case Report and Review of the Literature.
Deng S, Liu L, Wang D, Tong D, Zhao G
World Neurosurg 2018 Feb;110:174-179. Epub 2017 Nov 15 doi: 10.1016/j.wneu.2017.11.038. PMID: 29155113
Small cell glioblastoma or small cell carcinoma: a case report and review of the literature.
Hilbrandt C, Sathyadas S, Dahlrot RH, Kristensen BW
Clin Neuropathol 2013 Jul-Aug;32(4):303-10. doi: 10.5414/np300480. PMID: 23806221

Therapy

Dramatic clinical response in the treatment of small cell glioblastoma multiforme.
Zaman FY, McLean C, Ameratunga M
J Clin Pharm Ther 2022 Jun;47(6):832-834. Epub 2022 Jan 11 doi: 10.1111/jcpt.13608. PMID: 35018664Free PMC Article

Prognosis

Dramatic clinical response in the treatment of small cell glioblastoma multiforme.
Zaman FY, McLean C, Ameratunga M
J Clin Pharm Ther 2022 Jun;47(6):832-834. Epub 2022 Jan 11 doi: 10.1111/jcpt.13608. PMID: 35018664Free PMC Article
Small cell glioblastoma multiforme: a case series and clinicopathological update.
Yadav AK, Madan R, Chatterjee D, Dhiman S, Goyal S, Kumar N, Sahoo SK
CNS Oncol 2020 Dec 1;9(4):CNS63. Epub 2020 Dec 7 doi: 10.2217/cns-2020-0016. PMID: 33283529Free PMC Article
Primary Spinal Cord Small-Cell Glioblastoma: Case Report and Literature Review.
Caro-Osorio E, Herrera-Castro JC, Barbosa-Quintana A, Benvenutti-Regato M
World Neurosurg 2018 Oct;118:69-70. Epub 2018 Jul 11 doi: 10.1016/j.wneu.2018.07.007. PMID: 30017760
Clinicopathologic features of small cell glioblastomas.
Takeuchi H, Kitai R, Hosoda T, Yamada S, Hashimoto N, Kikuta K, Shimizu Y, Kimura H
J Neurooncol 2016 Apr;127(2):337-44. Epub 2016 Jan 2 doi: 10.1007/s11060-015-2038-0. PMID: 26725094
Diagnostic implications of IDH1-R132H and OLIG2 expression patterns in rare and challenging glioblastoma variants.
Joseph NM, Phillips J, Dahiya S, M Felicella M, Tihan T, Brat DJ, Perry A
Mod Pathol 2013 Mar;26(3):315-26. Epub 2012 Oct 5 doi: 10.1038/modpathol.2012.173. PMID: 23041832

Clinical prediction guides

Cerebrospinal fluid dissemination of high-grade gliomas following boron neutron capture therapy occurs more frequently in the small cell subtype of IDH1(R132H) mutation-negative glioblastoma.
Kondo N, Barth RF, Miyatake SI, Kawabata S, Suzuki M, Ono K, Lehman NL
J Neurooncol 2017 May;133(1):107-118. Epub 2017 May 22 doi: 10.1007/s11060-017-2408-x. PMID: 28534152Free PMC Article
Diagnostic implications of IDH1-R132H and OLIG2 expression patterns in rare and challenging glioblastoma variants.
Joseph NM, Phillips J, Dahiya S, M Felicella M, Tihan T, Brat DJ, Perry A
Mod Pathol 2013 Mar;26(3):315-26. Epub 2012 Oct 5 doi: 10.1038/modpathol.2012.173. PMID: 23041832
Histopathological features of recurrent pleomorphic xanthoastrocytomas: further corroboration of the glial nature of this neoplasm. A study of 3 cases.
Kepes JJ, Rubinstein LJ, Ansbacher L, Schreiber DJ
Acta Neuropathol 1989;78(6):585-93. doi: 10.1007/BF00691285. PMID: 2816300

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