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Recurrent Adult Soft Tissue Sarcoma

MedGen UID:
75850
•Concept ID:
C0278665
•
Neoplastic Process
Synonyms: Recurrent Adult Sarcoma of Soft Tissue; Recurrent Adult Sarcoma of the Soft Tissue; Relapsed Adult Sarcoma of Soft Tissue; Relapsed Adult Sarcoma of the Soft Tissue; Relapsed Adult Soft Tissue Sarcoma

Definition

A soft tissue sarcoma occurring in adults that has recurred after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Adult Soft Tissue Sarcoma

Professional guidelines

PubMed

Myxoid Liposarcomas: Systemic Treatment Options.
Nassif EF, Keung EZ, Thirasastr P, Somaiah N
Curr Treat Options Oncol 2023 Apr;24(4):274-291. Epub 2023 Feb 28 doi: 10.1007/s11864-023-01057-4. PMID: 36853469
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Radiation Therapy for Treatment of Soft Tissue Sarcoma in Adults: Executive Summary of an ASTRO Clinical Practice Guideline.
Salerno KE, Alektiar KM, Baldini EH, Bedi M, Bishop AJ, Bradfield L, Chung P, DeLaney TF, Folpe A, Kane JM, Li XA, Petersen I, Powell J, Stolten M, Thorpe S, Trent JC, Voermans M, Guadagnolo BA
Pract Radiat Oncol 2021 Sep-Oct;11(5):339-351. Epub 2021 Jul 26 doi: 10.1016/j.prro.2021.04.005. PMID: 34326023

Recent clinical studies

Etiology

Popliteal Fossa Sarcomas.
Erdogan O, Çeli K A, Yildirim ANT, Tekçe E, Altun G, Demi Röz S, Güler Y, Ozkan K, Gurkan V
Acta Chir Orthop Traumatol Cech 2023;90(3):181-187. PMID: 37395425
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Outcomes of soft-tissue sarcoma in nonagenarians.
Hartley LJ, AlAqeel M, Kurisunkal VJ, Evans S
Bone Joint J 2022 Jan;104-B(1):177-182. doi: 10.1302/0301-620X.104B1.BJJ-2021-0761.R1. PMID: 34969278
Radiation Therapy for Treatment of Soft Tissue Sarcoma in Adults: Executive Summary of an ASTRO Clinical Practice Guideline.
Salerno KE, Alektiar KM, Baldini EH, Bedi M, Bishop AJ, Bradfield L, Chung P, DeLaney TF, Folpe A, Kane JM, Li XA, Petersen I, Powell J, Stolten M, Thorpe S, Trent JC, Voermans M, Guadagnolo BA
Pract Radiat Oncol 2021 Sep-Oct;11(5):339-351. Epub 2021 Jul 26 doi: 10.1016/j.prro.2021.04.005. PMID: 34326023
Head and neck soft-tissue sarcoma in adults.
Galy-Bernadoy C, Garrel R
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Feb;133(1):37-42. Epub 2015 Sep 26 doi: 10.1016/j.anorl.2015.09.003. PMID: 26403655

Diagnosis

Popliteal Fossa Sarcomas.
Erdogan O, Çeli K A, Yildirim ANT, Tekçe E, Altun G, Demi Röz S, Güler Y, Ozkan K, Gurkan V
Acta Chir Orthop Traumatol Cech 2023;90(3):181-187. PMID: 37395425
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Outcomes of soft-tissue sarcoma in nonagenarians.
Hartley LJ, AlAqeel M, Kurisunkal VJ, Evans S
Bone Joint J 2022 Jan;104-B(1):177-182. doi: 10.1302/0301-620X.104B1.BJJ-2021-0761.R1. PMID: 34969278
Head and neck soft-tissue sarcoma in adults.
Galy-Bernadoy C, Garrel R
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Feb;133(1):37-42. Epub 2015 Sep 26 doi: 10.1016/j.anorl.2015.09.003. PMID: 26403655
A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma.
Pervaiz N, Colterjohn N, Farrokhyar F, Tozer R, Figueredo A, Ghert M
Cancer 2008 Aug 1;113(3):573-81. doi: 10.1002/cncr.23592. PMID: 18521899

Therapy

Molecular testing of rhabdomyosarcoma in clinical trials to improve risk stratification and outcome: A consensus view from European paediatric Soft tissue sarcoma Study Group, Children's Oncology Group and Cooperative Weichteilsarkom-Studiengruppe.
Hettmer S, Linardic CM, Kelsey A, Rudzinski ER, Vokuhl C, Selfe J, Ruhen O, Shern JF, Khan J, Kovach AR, Lupo PJ, Gatz SA, Schäfer BW, Volchenboum S, Minard-Colin V, Koscielniak E, Hawkins DS, Bisogno G, Sparber-Sauer M, Venkatramani R, Merks JHM, Shipley J
Eur J Cancer 2022 Sep;172:367-386. Epub 2022 Jul 12 doi: 10.1016/j.ejca.2022.05.036. PMID: 35839732
Non-rhabdomyosarcoma.
Dasgupta R, Rodeberg D
Semin Pediatr Surg 2016 Oct;25(5):284-289. Epub 2016 Sep 22 doi: 10.1053/j.sempedsurg.2016.09.012. PMID: 27955731
Significant Reduction of Late Toxicities in Patients With Extremity Sarcoma Treated With Image-Guided Radiation Therapy to a Reduced Target Volume: Results of Radiation Therapy Oncology Group RTOG-0630 Trial.
Wang D, Zhang Q, Eisenberg BL, Kane JM, Li XA, Lucas D, Petersen IA, DeLaney TF, Freeman CR, Finkelstein SE, Hitchcock YJ, Bedi M, Singh AK, Dundas G, Kirsch DG
J Clin Oncol 2015 Jul 10;33(20):2231-8. Epub 2015 Feb 9 doi: 10.1200/JCO.2014.58.5828. PMID: 25667281Free PMC Article
A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma.
Pervaiz N, Colterjohn N, Farrokhyar F, Tozer R, Figueredo A, Ghert M
Cancer 2008 Aug 1;113(3):573-81. doi: 10.1002/cncr.23592. PMID: 18521899
Neo-adjuvant chemotherapy for primary high-grade extremity soft tissue sarcoma.
Grobmyer SR, Maki RG, Demetri GD, Mazumdar M, Riedel E, Brennan MF, Singer S
Ann Oncol 2004 Nov;15(11):1667-72. doi: 10.1093/annonc/mdh431. PMID: 15520069

Prognosis

Outcome after surgical resection of multiple recurrent retroperitoneal soft tissue sarcoma.
Willis F, Musa J, Schimmack S, Hinz U, Mechtersheimer G, Uhl M, Schmidt T, Fröhling S, Büchler MW, Schneider M
Eur J Surg Oncol 2021 Aug;47(8):2189-2200. Epub 2021 May 4 doi: 10.1016/j.ejso.2021.04.040. PMID: 33980415
Prognosis and surgical outcome of soft tissue sarcoma with malignant fungating wounds.
Okajima K, Kobayashi H, Okuma T, Arai S, Zhang L, Hirai T, Ishibashi Y, Ikegami M, Shinoda Y, Akiyama T, Goto T, Tanaka S
Jpn J Clin Oncol 2021 Jan 1;51(1):78-84. doi: 10.1093/jjco/hyaa176. PMID: 33037437
Head and neck soft-tissue sarcoma in adults.
Galy-Bernadoy C, Garrel R
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Feb;133(1):37-42. Epub 2015 Sep 26 doi: 10.1016/j.anorl.2015.09.003. PMID: 26403655
Prognostic factors in soft tissue sarcoma.
Maretty-Nielsen K
Dan Med J 2014 Nov;61(11):B4957. PMID: 25370967
Adult soft tissue sarcoma.
Mann GB, Lewis JJ, Brennan MF
Aust N Z J Surg 1999 May;69(5):336-43. doi: 10.1046/j.1440-1622.1999.01568.x. PMID: 10353547

Clinical prediction guides

Popliteal Fossa Sarcomas.
Erdogan O, Çeli K A, Yildirim ANT, Tekçe E, Altun G, Demi Röz S, Güler Y, Ozkan K, Gurkan V
Acta Chir Orthop Traumatol Cech 2023;90(3):181-187. PMID: 37395425
Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Magnetic resonance imaging of soft tissue sarcoma: features related to prognosis.
Scalas G, Parmeggiani A, Martella C, Tuzzato G, Bianchi G, Facchini G, Clinca R, Spinnato P
Eur J Orthop Surg Traumatol 2021 Dec;31(8):1567-1575. Epub 2021 May 29 doi: 10.1007/s00590-021-03003-2. PMID: 34052920
Outcome after surgical resection of multiple recurrent retroperitoneal soft tissue sarcoma.
Willis F, Musa J, Schimmack S, Hinz U, Mechtersheimer G, Uhl M, Schmidt T, Fröhling S, Büchler MW, Schneider M
Eur J Surg Oncol 2021 Aug;47(8):2189-2200. Epub 2021 May 4 doi: 10.1016/j.ejso.2021.04.040. PMID: 33980415
BCOR-CCNB3 Fusion Positive Sarcomas: A Clinicopathologic and Molecular Analysis of 36 Cases With Comparison to Morphologic Spectrum and Clinical Behavior of Other Round Cell Sarcomas.
Kao YC, Owosho AA, Sung YS, Zhang L, Fujisawa Y, Lee JC, Wexler L, Argani P, Swanson D, Dickson BC, Fletcher CDM, Antonescu CR
Am J Surg Pathol 2018 May;42(5):604-615. doi: 10.1097/PAS.0000000000000965. PMID: 29300189Free PMC Article

Recent systematic reviews

Sarcomas of the sellar region: a systematic review.
Guerrero-Pérez F, Vidal N, López-Vázquez M, Sánchez-Barrera R, Sánchez-Fernández JJ, Torres-Díaz A, Vilarrasa N, Villabona C
Pituitary 2021 Feb;24(1):117-129. doi: 10.1007/s11102-020-01073-9. PMID: 32785833
Salvage Therapy in Advanced Adult Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis of Randomized Trials.
Comandone A, Petrelli F, Boglione A, Barni S
Oncologist 2017 Dec;22(12):1518-1527. Epub 2017 Aug 23 doi: 10.1634/theoncologist.2016-0474. PMID: 28835514Free PMC Article
Uterine sarcoma Part II-Uterine endometrial stromal sarcoma: The TAG systematic review.
Horng HC, Wen KC, Wang PH, Chen YJ, Yen MS, Ng HT; Taiwan Association of Gynecology Systematic Review Group
Taiwan J Obstet Gynecol 2016 Aug;55(4):472-9. doi: 10.1016/j.tjog.2016.04.034. PMID: 27590366
Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081
A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma.
Pervaiz N, Colterjohn N, Farrokhyar F, Tozer R, Figueredo A, Ghert M
Cancer 2008 Aug 1;113(3):573-81. doi: 10.1002/cncr.23592. PMID: 18521899

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