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Benign neoplasm of salivary gland

MedGen UID:: 83857
•Concept ID:: C0347206
•: Neoplastic Process

Synonyms:	Benign Neoplasm of Salivary Gland; benign neoplasm of salivary gland; Benign Neoplasm of the Salivary Gland; benign neoplasm of the salivary gland; Benign Salivary Gland Neoplasm; benign salivary gland neoplasm; Benign Salivary Gland Tumor; benign salivary gland tumor; benign salivary gland tumour; Benign tumor of salivary gland; Benign Tumor of Salivary Gland; benign tumor of salivary gland; Benign Tumor of the Salivary Gland; benign tumor of the salivary gland; benign tumour of salivary gland; benign tumour of the salivary gland; saliva-secreting gland benign neoplasm; Salivary Gland Neoplasm, Benign; salivary gland neoplasm, benign
SNOMED CT:	Benign neoplasm of salivary gland (255154009); Benign tumor of salivary gland (255154009)

Monarch Initiative:	MONDO:0021460

Definition

A neoplasm that arises from the major or minor salivary glands and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include Warthin tumor, monomorphic adenoma, and pleomorphic adenoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign neoplasm of salivary gland

Pathological process
- Disease
  - Neoplasm
    - Neoplasm by Special Category
      - Benign neoplasm
        Benign Head and Neck Neoplasm
        Benign neoplasm of salivary gland
        Benign neoplasm of major salivary gland
        Benign neoplasm of parotid gland
        Parotid Gland Hemangioma
        Parotid Gland Lipoma
        Parotid Gland Lymphangioma
        Parotid Gland Monomorphic Adenoma
        Parotid Gland Nodular Fasciitis
        Parotid Gland Pleomorphic Adenoma
        Parotid Gland Sebaceous Lymphadenoma
        Parotid Gland Sialolipoma
        Parotid Gland Warthin Tumor
        Benign neoplasm of sublingual gland
        Benign neoplasm of submandibular gland
        Benign neoplasm of minor salivary gland
        Pleomorphic adenoma of salivary gland
        Laryngeal Pleomorphic Adenoma
        Metastasizing Pleomorphic Adenoma of the Salivary Gland
        Oral Cavity Pleomorphic Adenoma
        Hard Palate Pleomorphic Adenoma
        Soft Palate Pleomorphic Adenoma
        Oropharyngeal Pleomorphic Adenoma
        Sinonasal Pleomorphic Adenoma
        Salivary Gland Cystadenoma
        Salivary Gland Ductal Papilloma
        Salivary Gland Intraductal Papilloma
        Salivary Gland Inverted Ductal Papilloma
        Salivary Gland Sialadenoma Papilliferum
        Salivary Gland Hemangioma
        Salivary Gland Lipoma
        Salivary Gland Lymphadenoma
        Salivary Gland Sebaceous Lymphadenoma
        Salivary Gland Monomorphic Adenoma
        Basal Cell Adenoma
        Oral Cavity Monomorphic Adenoma
        Hard Palate Monomorphic Adenoma
        Salivary Gland Canalicular Adenoma
        Salivary gland oncocytoma
        Salivary Gland Sebaceous Adenoma
        Salivary Gland Myoepithelioma
        Salivary Gland Nodular Fasciitis
        Sclerosing Polycystic Adenosis
        Sialolipoma
        Warthin tumor
        Lacrimal Gland Warthin Tumor

Professional guidelines

PubMed

The contemporary management of cancers of the sinonasal tract in adults.

Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666 Free PMC Article

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.

Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026

Management of Mucoceles, Sialoceles, and Ranulas.

Bowers EMR, Schaitkin B
Otolaryngol Clin North Am 2021 Jun;54(3):543-551. doi: 10.1016/j.otc.2021.03.002. PMID: 34024482

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Recent clinical studies

Etiology

Updated Salivary Gland Immunohistochemistry: A Review.

Swid MA, Li L, Drahnak EM, Idom H, Quinones W
Arch Pathol Lab Med 2023 Dec 1;147(12):1383-1389. doi: 10.5858/arpa.2022-0461-RA. PMID: 37074867

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.

Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980 Free PMC Article

The Evaluation and Management of Carcinoma of the Minor Salivary Glands.

Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489

Cytopathology and diagnostics of Warthin's tumour.

Sučić M, Ljubić N, Perković L, Ivanović D, Pažanin L, Sučić Radovanović T, Župnić-Krmek D, Knežević F
Cytopathology 2020 May;31(3):193-207. doi: 10.1111/cyt.12830. PMID: 32259367

Salivary gland carcinomas.

Ettl T, Schwarz-Furlan S, Gosau M, Reichert TE
Oral Maxillofac Surg 2012 Sep;16(3):267-83. Epub 2012 Jul 29 doi: 10.1007/s10006-012-0350-9. PMID: 22842859

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Diagnosis

Updated Salivary Gland Immunohistochemistry: A Review.

Swid MA, Li L, Drahnak EM, Idom H, Quinones W
Arch Pathol Lab Med 2023 Dec 1;147(12):1383-1389. doi: 10.5858/arpa.2022-0461-RA. PMID: 37074867

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.

Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.

Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980 Free PMC Article

Evaluation: Imaging Studies.

Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072

Salivary glands.

Silvers AR, Som PM
Radiol Clin North Am 1998 Sep;36(5):941-66, vi. doi: 10.1016/s0033-8389(05)70070-1. PMID: 9747195

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Therapy

Tubarial salivary gland sparing with proton therapy.

Wright CM, Lee DY, Kim M, Barsky AR, Teo BK, Lukens JN, Swisher-McClure S, Lin A
Med Dosim 2022 Autumn;47(3):222-226. Epub 2022 Apr 12 doi: 10.1016/j.meddos.2022.03.001. PMID: 35428548

Epithelial-immune cell interplay in primary Sjögren syndrome salivary gland pathogenesis.

Verstappen GM, Pringle S, Bootsma H, Kroese FGM
Nat Rev Rheumatol 2021 Jun;17(6):333-348. Epub 2021 Apr 28 doi: 10.1038/s41584-021-00605-2. PMID: 33911236 Free PMC Article

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK
Clin Cancer Res 2021 Feb 1;27(3):852-864. Epub 2020 Nov 10 doi: 10.1158/1078-0432.CCR-20-1192. PMID: 33172898 Free PMC Article

Alternative Clinical Indications of Botulinum Toxin.

Alster TS, Harrison IS
Am J Clin Dermatol 2020 Dec;21(6):855-880. doi: 10.1007/s40257-020-00532-0. PMID: 32651806

Advances in salivary gland gene therapy - oral and systemic implications.

Baum BJ, Alevizos I, Chiorini JA, Cotrim AP, Zheng C
Expert Opin Biol Ther 2015;15(10):1443-54. Epub 2015 Jul 6 doi: 10.1517/14712598.2015.1064894. PMID: 26149284 Free PMC Article

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Prognosis

Salivary Gland-like Tumors of the Breast.

Richardson ET, Jo VY, Schnitt SJ
Arch Pathol Lab Med 2023 Sep 1;147(9):1014-1024. doi: 10.5858/arpa.2023-0038-RA. PMID: 37651394

State-of-the-Art Imaging of Salivary Gland Tumors.

Abdel Razek AAK, Mukherji SK
Neuroimaging Clin N Am 2018 May;28(2):303-317. doi: 10.1016/j.nic.2018.01.009. PMID: 29622121

The morphological spectrum of salivary gland type tumours of the breast.

Foschini MP, Morandi L, Asioli S, Giove G, Corradini AG, Eusebi V
Pathology 2017 Feb;49(2):215-227. Epub 2016 Dec 30 doi: 10.1016/j.pathol.2016.10.011. PMID: 28043647

Mammary Analogue Secretory Carcinoma.

Parekh V, Stevens TM
Arch Pathol Lab Med 2016 Sep;140(9):997-1001. doi: 10.5858/arpa.2015-0075-RS. PMID: 27575269

Evaluation: Imaging Studies.

Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072

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Clinical prediction guides

Sjögren's syndrome: one year in review 2023.

Longhino S, Chatzis LG, Dal Pozzolo R, Peretti S, Fulvio G, La Rocca G, Navarro Garcia IC, Orlandi M, Quartuccio L, Baldini C, Bartoloni E
Clin Exp Rheumatol 2023 Dec;41(12):2343-2356. Epub 2023 Dec 23 doi: 10.55563/clinexprheumatol/255qsx. PMID: 38149515

Fusion-positive salivary gland carcinomas.

Skálová A, Hyrcza MD, Vaneček T, Baněčková M, Leivo I
Genes Chromosomes Cancer 2022 May;61(5):228-243. Epub 2022 Jan 6 doi: 10.1002/gcc.23020. PMID: 34913211

State-of-the-Art Imaging of Salivary Gland Tumors.

Abdel Razek AAK, Mukherji SK
Neuroimaging Clin N Am 2018 May;28(2):303-317. doi: 10.1016/j.nic.2018.01.009. PMID: 29622121

Margins for Benign Salivary Gland Neoplasms of the Head and Neck.

Carlson ER, McCoy JM
Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):325-340. doi: 10.1016/j.coms.2017.03.009. PMID: 28709532

Evaluation: Imaging Studies.

Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072

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Recent systematic reviews

Lymphomas of the salivary glands: a systematic review.

Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309

Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.

Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869 Free PMC Article

Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.

Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810

Feasibility and advantages of endoscope-assisted parotidectomy: a systematic review and meta-analysis.

Zou HW, Gao J, Liu JX, Qu ZL, Du ZS, Zhao H, Zhao M, Chen HY
Br J Oral Maxillofac Surg 2021 Jun;59(5):503-510. Epub 2020 Aug 19 doi: 10.1016/j.bjoms.2020.08.049. PMID: 33845989

Canalicular adenoma: A systematic review.

Peraza AJ, Wright J, Gómez R
J Craniomaxillofac Surg 2017 Oct;45(10):1754-1758. Epub 2017 Aug 3 doi: 10.1016/j.jcms.2017.07.020. PMID: 28890252

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MedGen

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Benign neoplasm of salivary gland

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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