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Malignant Optic Nerve Neoplasm

MedGen UID:
87553
•Concept ID:
C0346323
•
Neoplastic Process
Synonyms: Malignant Optic Nerve Tumor; Optic Nerve Tumor, Malignant; Tumor, Malignant, Optic Nerve; Tumor, Optic Nerve, Malignant
SNOMED CT: Malignant tumor of optic nerve (363498002)

Definition

A primary or metastatic malignant neoplasm that affects the optic nerve. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Optic Nerve Neoplasm

Professional guidelines

PubMed

Current treatment of optic nerve gliomas.
Farazdaghi MK, Katowitz WR, Avery RA
Curr Opin Ophthalmol 2019 Sep;30(5):356-363. doi: 10.1097/ICU.0000000000000587. PMID: 31246635Free PMC Article
SIOPE - Brain tumor group consensus guideline on craniospinal target volume delineation for high-precision radiotherapy.
Ajithkumar T, Horan G, Padovani L, Thorp N, Timmermann B, Alapetite C, Gandola L, Ramos M, Van Beek K, Christiaens M, Lassen-Ramshad Y, Magelssen H, Nilsson K, Saran F, Rombi B, Kortmann R, Janssens GO; SIOPE BTG Radiotherapy Group
Radiother Oncol 2018 Aug;128(2):192-197. Epub 2018 May 2 doi: 10.1016/j.radonc.2018.04.016. PMID: 29729847
Pituitary incidentaloma: an endocrine society clinical practice guideline.
Freda PU, Beckers AM, Katznelson L, Molitch ME, Montori VM, Post KD, Vance ML; Endocrine Society
J Clin Endocrinol Metab 2011 Apr;96(4):894-904. doi: 10.1210/jc.2010-1048. PMID: 21474686Free PMC Article

Recent clinical studies

Etiology

Serum and Cerebrospinal Fluid Testing in Optic Neuropathy Patients with Malignant Tumors.
Sun CB, Liu GH, Xiao Q, Zhao YN, Ren Q
Dis Markers 2022;2022:7076385. Epub 2022 Feb 17 doi: 10.1155/2022/7076385. PMID: 35222744Free PMC Article
Neurological malignancies in neurofibromatosis type 1.
Eoli M, Saletti V, Finocchiaro G
Curr Opin Oncol 2019 Nov;31(6):554-561. doi: 10.1097/CCO.0000000000000576. PMID: 31436563
Hemangioblastoma of the optic nerve.
McGrath LA, Mudhar HS, Salvi SM
Surv Ophthalmol 2019 Mar-Apr;64(2):175-184. Epub 2018 Oct 13 doi: 10.1016/j.survophthal.2018.10.002. PMID: 30321570
Neurofibromatosis type 1.
Gutmann DH, Ferner RE, Listernick RH, Korf BR, Wolters PL, Johnson KJ
Nat Rev Dis Primers 2017 Feb 23;3:17004. doi: 10.1038/nrdp.2017.4. PMID: 28230061
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696

Diagnosis

Optic nerve sheath meningioma.
Douglas VP, Douglas KAA, Cestari DM
Curr Opin Ophthalmol 2020 Nov;31(6):455-461. doi: 10.1097/ICU.0000000000000700. PMID: 33009076
Diagnostic error and neuro-ophthalmology.
Stunkel L, Newman NJ, Biousse V
Curr Opin Neurol 2019 Feb;32(1):62-67. doi: 10.1097/WCO.0000000000000635. PMID: 30516641Free PMC Article
Hemangioblastoma of the optic nerve.
McGrath LA, Mudhar HS, Salvi SM
Surv Ophthalmol 2019 Mar-Apr;64(2):175-184. Epub 2018 Oct 13 doi: 10.1016/j.survophthal.2018.10.002. PMID: 30321570
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Second chances.
Nagia L, Doyle JI, Hackney JR, Vaphiades MS, Kline LB, Levin MH
Surv Ophthalmol 2015 Nov-Dec;60(6):596-9. Epub 2015 Jun 14 doi: 10.1016/j.survophthal.2015.06.002. PMID: 26079932

Therapy

A phase II trial of selumetinib in children with recurrent optic pathway and hypothalamic low-grade glioma without NF1: a Pediatric Brain Tumor Consortium study.
Fangusaro J, Onar-Thomas A, Poussaint TY, Wu S, Ligon AH, Lindeman N, Campagne O, Banerjee A, Gururangan S, Kilburn LB, Goldman S, Qaddoumi I, Baxter P, Vezina G, Bregman C, Patay Z, Jones JY, Stewart CF, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Neuro Oncol 2021 Oct 1;23(10):1777-1788. doi: 10.1093/neuonc/noab047. PMID: 33631016Free PMC Article
Current treatment of optic nerve gliomas.
Farazdaghi MK, Katowitz WR, Avery RA
Curr Opin Ophthalmol 2019 Sep;30(5):356-363. doi: 10.1097/ICU.0000000000000587. PMID: 31246635Free PMC Article
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591
Optic nerve glioma: an update.
Nair AG, Pathak RS, Iyer VR, Gandhi RA
Int Ophthalmol 2014 Aug;34(4):999-1005. Epub 2014 Apr 16 doi: 10.1007/s10792-014-9942-8. PMID: 24736941

Prognosis

A phase II trial of selumetinib in children with recurrent optic pathway and hypothalamic low-grade glioma without NF1: a Pediatric Brain Tumor Consortium study.
Fangusaro J, Onar-Thomas A, Poussaint TY, Wu S, Ligon AH, Lindeman N, Campagne O, Banerjee A, Gururangan S, Kilburn LB, Goldman S, Qaddoumi I, Baxter P, Vezina G, Bregman C, Patay Z, Jones JY, Stewart CF, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Neuro Oncol 2021 Oct 1;23(10):1777-1788. doi: 10.1093/neuonc/noab047. PMID: 33631016Free PMC Article
Optic nerve sheath meningioma.
Douglas VP, Douglas KAA, Cestari DM
Curr Opin Ophthalmol 2020 Nov;31(6):455-461. doi: 10.1097/ICU.0000000000000700. PMID: 33009076
Optic Nerve Hemangioblastoma: Review.
Darbari S, Meena RK, Sawarkar D, Doddamani RS
World Neurosurg 2019 Aug;128:211-215. Epub 2019 May 1 doi: 10.1016/j.wneu.2019.04.224. PMID: 31054346
Optic pathway glioma of childhood.
Rasool N, Odel JG, Kazim M
Curr Opin Ophthalmol 2017 May;28(3):289-295. doi: 10.1097/ICU.0000000000000370. PMID: 28257299
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696

Clinical prediction guides

Optic nerve motion and gaze direction: Their impact on intraorbital tumor radiotherapy.
Mesny E, Jacob J, Culot F, Calugaru V, Jenny C, Fonti B, Bourdais R, Courtault-Deslandes F, Boulle G, Meillan N, Simon JM, Maingon P, Feuvret L
Cancer Radiother 2022 Sep;26(5):678-683. Epub 2022 Feb 25 doi: 10.1016/j.canrad.2021.12.003. PMID: 35227595
Single- and Multi-Fraction Stereotactic Radiosurgery Dose Tolerances of the Optic Pathways.
Milano MT, Grimm J, Soltys SG, Yorke E, Moiseenko V, Tomé WA, Sahgal A, Xue J, Ma L, Solberg TD, Kirkpatrick JP, Constine LS, Flickinger JC, Marks LB, El Naqa I
Int J Radiat Oncol Biol Phys 2021 May 1;110(1):87-99. Epub 2018 Jan 31 doi: 10.1016/j.ijrobp.2018.01.053. PMID: 29534899Free PMC Article
Neurological malignancies in neurofibromatosis type 1.
Eoli M, Saletti V, Finocchiaro G
Curr Opin Oncol 2019 Nov;31(6):554-561. doi: 10.1097/CCO.0000000000000576. PMID: 31436563
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Primary optic nerve tumours.
Wilhelm H
Curr Opin Neurol 2009 Feb;22(1):11-8. doi: 10.1097/WCO.0b013e32831fd9f5. PMID: 19155759

Recent systematic reviews

Immune Checkpoint Inhibitors and Optic Neuropathy: A Systematic Review.
Pietris J, Santhosh S, Ferdinando Cirocco G, Lam A, Bacchi S, Tan Y, Gupta AK, Kovoor JG, Chan W
Semin Ophthalmol 2023 Aug;38(6):547-558. Epub 2023 Jan 22 doi: 10.1080/08820538.2023.2168494. PMID: 36683270
Treatment and prophylaxis of radiation optic neuropathy: A systematic review and meta-analysis.
Yu CW, Joarder I, Micieli JA
Eur J Ophthalmol 2022 Nov;32(6):3129-3141. Epub 2022 Mar 9 doi: 10.1177/11206721221085409. PMID: 35262423
Paraneoplastic ocular syndrome: a pandora's box of underlying malignancies.
Sarkar P, Mehtani A, Gandhi HC, Bhalla JS, Tapariya S
Eye (Lond) 2022 Jul;36(7):1355-1367. Epub 2021 Aug 3 doi: 10.1038/s41433-021-01676-x. PMID: 34345027Free PMC Article
Modern Management of Meningiomas Compressing the Optic Nerve: A Systematic Review.
Hénaux PL, Bretonnier M, Le Reste PJ, Morandi X
World Neurosurg 2018 Oct;118:e677-e686. Epub 2018 Aug 3 doi: 10.1016/j.wneu.2018.07.020. PMID: 30010062
Optical coherence tomography impacts the evaluation of visual pathway tumors.
Banc A, Stan C, Florian IS
Neurosurg Rev 2018 Apr;41(2):415-426. Epub 2016 Jul 28 doi: 10.1007/s10143-016-0772-1. PMID: 27465394

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