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LH-Producing Pituitary Neuroendocrine Tumor

MedGen UID:
889619
•Concept ID:
C4054682
•
Neoplastic Process
Synonyms: LH-Producing Pituitary Gland Adenoma; Luteinizing Hormone-Producing Gonadotroph Adenoma

Definition

A pituitary neuroendocrine tumor that produces luteinizing hormone (LH). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLH-Producing Pituitary Neuroendocrine Tumor

Professional guidelines

PubMed

Molecular classification of pituitary adenomas: in search for criteria useful for high-throughput studies.
Żebracka-Gala J, Rudnik A, Hasse-Lazar K, Larysz D, Jarząb M, Krajewska J, Bażowski P, Jarząb B
Endokrynol Pol 2016;67(2):148-56. Epub 2016 Feb 17 doi: 10.5603/EP.a2016.0024. PMID: 26884293

Recent clinical studies

Etiology

Pituitary apoplexy developed in a patient with androgen insensitivity syndrome.
Watanobe H, Kawabe H
J Endocrinol Invest 1997 Sep;20(8):497-500. doi: 10.1007/BF03348008. PMID: 9364255
Prolactin receptor messenger ribonucleic acid in normal and neoplastic human pituitary tissues.
Jin L, Qian X, Kulig E, Scheithauer BW, Calle-Rodrigue R, Abboud C, Davis DH, Kovacs K, Lloyd RV
J Clin Endocrinol Metab 1997 Mar;82(3):963-8. doi: 10.1210/jcem.82.3.3815. PMID: 9062514
Somatostatin regulation of glycoprotein hormone and free subunit secretion in clinically nonfunctioning and somatotroph adenomas in vitro.
Klibanski A, Alexander JM, Bikkal HA, Hsu DW, Swearingen B, Zervas NT
J Clin Endocrinol Metab 1991 Dec;73(6):1248-55. doi: 10.1210/jcem-73-6-1248. PMID: 1720125

Diagnosis

Ectopic bioactive luteinizing hormone secretion by a pancreatic endocrine tumor, manifested as luteinized granulosa-thecal cell tumor of the ovaries.
Piaditis G, Angellou A, Kontogeorgos G, Mazarakis N, Kounadi T, Kaltsas G, Vamvakidis K, Lloyd RV, Horvath E, Kovacs K
J Clin Endocrinol Metab 2005 Apr;90(4):2097-103. Epub 2005 Feb 1 doi: 10.1210/jc.2003-032029. PMID: 15687346
Pituitary apoplexy developed in a patient with androgen insensitivity syndrome.
Watanobe H, Kawabe H
J Endocrinol Invest 1997 Sep;20(8):497-500. doi: 10.1007/BF03348008. PMID: 9364255

Therapy

Prolactin receptor messenger ribonucleic acid in normal and neoplastic human pituitary tissues.
Jin L, Qian X, Kulig E, Scheithauer BW, Calle-Rodrigue R, Abboud C, Davis DH, Kovacs K, Lloyd RV
J Clin Endocrinol Metab 1997 Mar;82(3):963-8. doi: 10.1210/jcem.82.3.3815. PMID: 9062514

Prognosis

Pituitary apoplexy developed in a patient with androgen insensitivity syndrome.
Watanobe H, Kawabe H
J Endocrinol Invest 1997 Sep;20(8):497-500. doi: 10.1007/BF03348008. PMID: 9364255

Clinical prediction guides

Molecular classification of pituitary adenomas: in search for criteria useful for high-throughput studies.
Żebracka-Gala J, Rudnik A, Hasse-Lazar K, Larysz D, Jarząb M, Krajewska J, Bażowski P, Jarząb B
Endokrynol Pol 2016;67(2):148-56. Epub 2016 Feb 17 doi: 10.5603/EP.a2016.0024. PMID: 26884293
High level expression of Prop-1 gene in gonadotropic cell lines.
Aikawa S, Sato T, Ono T, Kato T, Kato Y
J Reprod Dev 2006 Apr;52(2):195-201. Epub 2005 Dec 28 doi: 10.1262/jrd.17050. PMID: 16394624
Somatostatin regulation of glycoprotein hormone and free subunit secretion in clinically nonfunctioning and somatotroph adenomas in vitro.
Klibanski A, Alexander JM, Bikkal HA, Hsu DW, Swearingen B, Zervas NT
J Clin Endocrinol Metab 1991 Dec;73(6):1248-55. doi: 10.1210/jcem-73-6-1248. PMID: 1720125

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