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Juvenile aseptic necrosis

MedGen UID:: 892393
•Concept ID:: C4022146
•: Disease or Syndrome

Synonym:	Aseptic epiphyseal necrosis

HPO:	HP:0100323

Definition

Juvenile aseptic necrosis comprises a group of orthopedic diseases characterized by interruption of the blood supply of a bone, followed by localized bony necrosis most often of the epiphyses of bones of children or teenagers. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVJuvenile aseptic necrosis

Phenotypic abnormality
- Abnormality of the musculoskeletal system
  - Abnormal musculoskeletal physiology
    - Avascular necrosis
      - Juvenile aseptic necrosis
        Juvenile osteochondrosis of spine
        Scheuermann-like vertebral changes
        Legg-Calve-Perthes disease
        Morbus Kienboeck
        Morbus Osgood-Schlatter
        Osteochondrosis
        Familial osteoarthropathy of the fingers
        Freiberg disease
        Juvenile osteochondritis
        Medial condensing osteitis of the clavicle
        Osteochondritis dissecans
        Osteochondritis of tarsal/metatarsal bone
        Osteochondrosis of Spine
        Panner disease
        Sinding-Larsen-Johansson disease

Professional guidelines

PubMed

The Assessment of Steroid Injections as a Potential Risk Factor for Osteochondral Lesions in Children with Juvenile Idiopathic Arthritis.

Heidt C, Grueberger N, Grisch D, Righini-Grunder F, Rueger M, Ramseier L
Cartilage 2021 Dec;13(1_suppl):894S-899S. Epub 2020 Sep 27 doi: 10.1177/1947603520961173. PMID: 32985233 Free PMC Article

A classification-based treatment algorithm for Kienböck disease: current and future considerations.

Saunders BM, Lichtman D
Tech Hand Up Extrem Surg 2011 Mar;15(1):38-40. doi: 10.1097/BTH.0b013e31820e82d2. PMID: 21358524

Differential diagnosis and management of hip pain in childhood.

Hollingworth P
Br J Rheumatol 1995 Jan;34(1):78-82. doi: 10.1093/rheumatology/34.1.78. PMID: 7881844

See all (4)

Recent clinical studies

Etiology

The pediatric glucocorticoid toxicity index.

Brogan P, Naden R, Ardoin SP, Cooper JC, De Benedetti F, Dicaire JF, Eleftheriou D, Feldman B, Goldin J, Karol SE, Price-Kuehne F, Skuse D, Stratakis CA, Webb N, Stone JH
Semin Arthritis Rheum 2022 Oct;56:152068. Epub 2022 Jul 14 doi: 10.1016/j.semarthrit.2022.152068. PMID: 35917759

Implant degradation of low-alloyed Mg-Zn-Ca in osteoporotic, old and juvenile rats.

Sommer NG, Hirzberger D, Paar L, Berger L, Ćwieka H, Schwarze UY, Herber V, Okutan B, Bodey AJ, Willumeit-Römer R, Zeller-Plumhoff B, Löffler JF, Weinberg AM
Acta Biomater 2022 Jul 15;147:427-438. Epub 2022 May 27 doi: 10.1016/j.actbio.2022.05.041. PMID: 35644328

Kienböck Disease in the Skeletally Immature Patient.

Afshar A
J Hand Surg Am 2018 May;43(5):465-469. Epub 2018 Mar 21 doi: 10.1016/j.jhsa.2018.02.029. PMID: 29573896

Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease.

Kim HK
J Bone Joint Surg Am 2012 Apr 4;94(7):659-69. doi: 10.2106/JBJS.J.01834. PMID: 22488623

Evidence for using bisphosphonate to treat Legg-Calvé-Perthes disease.

Young ML, Little DG, Kim HK
Clin Orthop Relat Res 2012 Sep;470(9):2462-75. doi: 10.1007/s11999-011-2240-0. PMID: 22270467 Free PMC Article

See all (51)

Diagnosis

Osteochondritis Dissecans: Etiology, Pathology, and Imaging with a Special Focus on the Knee Joint.

Bruns J, Werner M, Habermann C
Cartilage 2018 Oct;9(4):346-362. Epub 2017 Jun 22 doi: 10.1177/1947603517715736. PMID: 28639852 Free PMC Article

Evaluating the Limping Child: A Rheumatology Perspective.

Syed R
Mo Med 2016 Mar-Apr;113(2):131-5. PMID: 27311224 Free PMC Article

Pediatric hip: pearls and pitfalls.

Gill KG
Semin Musculoskelet Radiol 2013 Jul;17(3):328-38. Epub 2013 Jun 20 doi: 10.1055/s-0033-1348099. PMID: 23787987

Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease.

Kim HK
J Bone Joint Surg Am 2012 Apr 4;94(7):659-69. doi: 10.2106/JBJS.J.01834. PMID: 22488623

Arthritis in children.

Wilkinson RH, Weissman BN
Radiol Clin North Am 1988 Nov;26(6):1247-65. PMID: 3051095

See all (41)

Therapy

The pediatric glucocorticoid toxicity index.

Implant degradation of low-alloyed Mg-Zn-Ca in osteoporotic, old and juvenile rats.

Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease.

Kim HK
J Bone Joint Surg Am 2012 Apr 4;94(7):659-69. doi: 10.2106/JBJS.J.01834. PMID: 22488623

Evidence for using bisphosphonate to treat Legg-Calvé-Perthes disease.

Young ML, Little DG, Kim HK
Clin Orthop Relat Res 2012 Sep;470(9):2462-75. doi: 10.1007/s11999-011-2240-0. PMID: 22270467 Free PMC Article

Bisphosphonate use in conditions other than osteoporosis.

Silverman SL
Ann N Y Acad Sci 2011 Feb;1218:33-7. Epub 2010 Sep 28 doi: 10.1111/j.1749-6632.2010.05769.x. PMID: 20946575

See all (31)

Prognosis

The pediatric glucocorticoid toxicity index.

High Satisfaction and Activity Levels After Total Hip Arthroplasty in Patients Under Age 21.

Kahlenberg CA, Garvey MD, Blevins JL, Sculco TP, Sculco PK, Figgie MP
J Arthroplasty 2021 Oct;36(10):3485-3489. Epub 2021 May 21 doi: 10.1016/j.arth.2021.05.020. PMID: 34092468

Medium-term outcomes of total hip arthroplasty in juvenile patients.

Luceri F, Morelli I, Sinicato CM, Della Grazia A, Verdoni F, Maffulli N, Peretti GM, Curci D
J Orthop Surg Res 2020 Oct 16;15(1):476. doi: 10.1186/s13018-020-01990-2. PMID: 33066797 Free PMC Article

Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease.

Kim HK
J Bone Joint Surg Am 2012 Apr 4;94(7):659-69. doi: 10.2106/JBJS.J.01834. PMID: 22488623

Infantile and juvenile lunatomalacia.

Irisarri C, Kalb K, Ribak S
J Hand Surg Eur Vol 2010 Sep;35(7):544-8. Epub 2010 Mar 17 doi: 10.1177/1753193410364913. PMID: 20237187

See all (25)

Clinical prediction guides

Outcome measures and survivorship following total hip arthroplasty in adolescent population.

Fernandez-Fernandez R, Moraleda-Novo L, De Armas JN, Cruz-Pardos A
Int Orthop 2022 Dec;46(12):2785-2791. Epub 2022 Aug 9 doi: 10.1007/s00264-022-05536-5. PMID: 35945465

The pediatric glucocorticoid toxicity index.

Implant degradation of low-alloyed Mg-Zn-Ca in osteoporotic, old and juvenile rats.

Ceramic-on-ceramic cementless total hip arthroplasty in patients aged 40 years or under: Do preoperative conditions affect long-term results?

Garcia-Rey E, Bizot P, Garcia-Cimbrelo E
Orthop Traumatol Surg Res 2021 Feb;107(1):102763. Epub 2020 Dec 13 doi: 10.1016/j.otsr.2020.102763. PMID: 33321234

Medium-term outcomes of total hip arthroplasty in juvenile patients.

Luceri F, Morelli I, Sinicato CM, Della Grazia A, Verdoni F, Maffulli N, Peretti GM, Curci D
J Orthop Surg Res 2020 Oct 16;15(1):476. doi: 10.1186/s13018-020-01990-2. PMID: 33066797 Free PMC Article

See all (25)

Recent systematic reviews

Do Bisphosphonates Alleviate Pain in Children? A Systematic Review.

Celin MR, Simon JC, Krzak JJ, Fial AV, Kruger KM, Smith PA, Harris GF
Curr Osteoporos Rep 2020 Oct;18(5):486-504. doi: 10.1007/s11914-020-00621-3. PMID: 32960409

Effects of the use of growth hormone in children and adolescents with juvenile idiopathic arthritis: a systematic review.

Frittoli RB, Longhi BS, Silva AM, Filho AAB, Monteiro MÂRG, Appenzeller S
Rev Bras Reumatol Engl Ed 2017 Mar-Apr;57(2):100-106. Epub 2016 Oct 24 doi: 10.1016/j.rbre.2016.07.009. PMID: 28343613

Evidence for using bisphosphonate to treat Legg-Calvé-Perthes disease.

Young ML, Little DG, Kim HK
Clin Orthop Relat Res 2012 Sep;470(9):2462-75. doi: 10.1007/s11999-011-2240-0. PMID: 22270467 Free PMC Article

See all (3)

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Juvenile aseptic necrosis

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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