Testicular Seminoma with High Mitotic Index

MedGen UID:: 90797
•Concept ID:: C0334516
•: Neoplastic Process

Synonyms:	Anaplastic seminoma; Anaplastic Seminoma; Atypical Seminoma; Seminoma with high mitotic index; Seminoma, anaplastic
SNOMED CT:	Seminoma, anaplastic (72907003); Anaplastic seminoma (72907003); Seminoma with high mitotic index (72907003)

Definition

A seminoma of the testis characterized by increased cellular pleomorphism, high mitotic activity, and a non-prominent stromal lymphocytic infiltrate. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVTesticular Seminoma with High Mitotic Index

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Malignant neoplastic disease
        Anaplastic cancer
        Testicular Seminoma with High Mitotic Index

Recent clinical studies

Etiology

Contribution of cell proliferative activity to malignancy potential in testicular seminoma.

Hori K, Uematsu K, Yasoshima H, Sakurai K, Yamada A
Pathol Int 1997 May;47(5):282-7. doi: 10.1111/j.1440-1827.1997.tb04494.x. PMID: 9143022

Mitosis counting in seminoma: an exercise of questionable significance.

Zuckman MH, Williams G, Levin HS
Hum Pathol 1988 Mar;19(3):329-35. doi: 10.1016/s0046-8177(88)80528-8. PMID: 3346009

See all (2)

Diagnosis

Contribution of cell proliferative activity to malignancy potential in testicular seminoma.

Hori K, Uematsu K, Yasoshima H, Sakurai K, Yamada A
Pathol Int 1997 May;47(5):282-7. doi: 10.1111/j.1440-1827.1997.tb04494.x. PMID: 9143022

Globotriaosyl ceramide glycolipid in seminoma: its clinicopathological importance in differentiation from testicular malignant lymphoma.

Ohyama C, Orikasa S, Satoh M, Saito S, Ohtani H, Fukushi Y
J Urol 1992 Jul;148(1):72-5. doi: 10.1016/s0022-5347(17)36513-8. PMID: 1613886

Lectin histochemistry of human testicular germ cell tumors.

Kosmehl H, Langbein L, Katenkamp D
Neoplasma 1989;36(1):29-39. PMID: 2539568

Mitosis counting in seminoma: an exercise of questionable significance.

Zuckman MH, Williams G, Levin HS
Hum Pathol 1988 Mar;19(3):329-35. doi: 10.1016/s0046-8177(88)80528-8. PMID: 3346009

See all (4)

Prognosis

Contribution of cell proliferative activity to malignancy potential in testicular seminoma.

Hori K, Uematsu K, Yasoshima H, Sakurai K, Yamada A
Pathol Int 1997 May;47(5):282-7. doi: 10.1111/j.1440-1827.1997.tb04494.x. PMID: 9143022

Mitosis counting in seminoma: an exercise of questionable significance.

Zuckman MH, Williams G, Levin HS
Hum Pathol 1988 Mar;19(3):329-35. doi: 10.1016/s0046-8177(88)80528-8. PMID: 3346009

See all (2)

Clinical prediction guides

Immunohistochemical comparison between anaplastic seminoma and typical seminoma.

Suzuki T, Sasano H, Aoki H, Nagura H, Sasano N, Sano T, Saito M, Watanuki T, Kato H, Aizawa S
Acta Pathol Jpn 1993 Dec;43(12):751-7. doi: 10.1111/j.1440-1827.1993.tb02562.x. PMID: 7509106

Globotriaosyl ceramide glycolipid in seminoma: its clinicopathological importance in differentiation from testicular malignant lymphoma.

Ohyama C, Orikasa S, Satoh M, Saito S, Ohtani H, Fukushi Y
J Urol 1992 Jul;148(1):72-5. doi: 10.1016/s0022-5347(17)36513-8. PMID: 1613886

Nucleolar organizer regions in seminoma and intratubular malignant germ cells.

Delahunt B, Mostofi FK, Sesterhenn IA, Ribas JL, Avallone FA
Mod Pathol 1990 Mar;3(2):141-5. PMID: 2326249

Lectin histochemistry of human testicular germ cell tumors.

Kosmehl H, Langbein L, Katenkamp D
Neoplasma 1989;36(1):29-39. PMID: 2539568

Mitosis counting in seminoma: an exercise of questionable significance.

Zuckman MH, Williams G, Levin HS
Hum Pathol 1988 Mar;19(3):329-35. doi: 10.1016/s0046-8177(88)80528-8. PMID: 3346009

See all (5)