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Choriocarcinoma Combined with Other Germ Cell Elements

MedGen UID:
90800
•Concept ID:
C0334527
•
Neoplastic Process
Synonyms: Choriocarcinoma combined with embryonal carcinoma; Choriocarcinoma combined with germ cell elements; Choriocarcinoma combined with other germ cell elements
SNOMED CT: Choriocarcinoma combined with germ cell elements (8734000); Choriocarcinoma combined with other germ cell elements (8734000); Choriocarcinoma combined with embryonal carcinoma (8734000)

Definition

A malignant mixed germ cell tumor characterized by the presence of a choriocarcinomatous component admixed with another germ cell component (e.g. embryonal carcinoma, teratoma, or seminoma). [from NCI]

Professional guidelines

PubMed

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

Recent clinical studies

Etiology

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Primary germ cell tumors of the mediastinum: III. Yolk sac tumor, embryonal carcinoma, choriocarcinoma, and combined nonteratomatous germ cell tumors of the mediastinum--a clinicopathologic and immunohistochemical study of 64 cases.
Moran CA, Suster S, Koss MN
Cancer 1997 Aug 15;80(4):699-707. PMID: 9264353
Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases.
Matsutani M, Sano K, Takakura K, Fujimaki T, Nakamura O, Funata N, Seto T
J Neurosurg 1997 Mar;86(3):446-55. doi: 10.3171/jns.1997.86.3.0446. PMID: 9046301
Unusual neoplasms detected in testis cancer patients undergoing post-chemotherapy retroperitoneal lymphadenectomy.
Little JS Jr, Foster RS, Ulbright TM, Donohue JP
J Urol 1994 Oct;152(4):1144-9. doi: 10.1016/s0022-5347(17)32524-7. PMID: 8072083
Germ cell neoplasms of the testis.
Ulbright TM
Am J Surg Pathol 1993 Nov;17(11):1075-91. doi: 10.1097/00000478-199311000-00001. PMID: 8214253

Diagnosis

ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Primary germ cell tumors of the mediastinum: III. Yolk sac tumor, embryonal carcinoma, choriocarcinoma, and combined nonteratomatous germ cell tumors of the mediastinum--a clinicopathologic and immunohistochemical study of 64 cases.
Moran CA, Suster S, Koss MN
Cancer 1997 Aug 15;80(4):699-707. PMID: 9264353
Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases.
Matsutani M, Sano K, Takakura K, Fujimaki T, Nakamura O, Funata N, Seto T
J Neurosurg 1997 Mar;86(3):446-55. doi: 10.3171/jns.1997.86.3.0446. PMID: 9046301
Expression of intermediate filaments and other special markers by testicular germ cell tumors. With reference to embryogenesis.
Hanai J, Lin M, Wada A, Ishiguro S, Miki T, Sakaguchi H, Kanda H
Histol Histopathol 1992 Oct;7(4):533-41. PMID: 1333851

Therapy

Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases.
Matsutani M, Sano K, Takakura K, Fujimaki T, Nakamura O, Funata N, Seto T
J Neurosurg 1997 Mar;86(3):446-55. doi: 10.3171/jns.1997.86.3.0446. PMID: 9046301
Malignant germ cell tumours in two siblings.
Blake KI, Gerrard MP
Med Pediatr Oncol 1993;21(4):299-300. doi: 10.1002/mpo.2950210413. PMID: 7682284

Prognosis

ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases.
Matsutani M, Sano K, Takakura K, Fujimaki T, Nakamura O, Funata N, Seto T
J Neurosurg 1997 Mar;86(3):446-55. doi: 10.3171/jns.1997.86.3.0446. PMID: 9046301
Expression of intermediate filaments and other special markers by testicular germ cell tumors. With reference to embryogenesis.
Hanai J, Lin M, Wada A, Ishiguro S, Miki T, Sakaguchi H, Kanda H
Histol Histopathol 1992 Oct;7(4):533-41. PMID: 1333851
Interrelationships of histopathology and other clinical variables in patients with germ cell tumors of the testis.
Bosl GJ, Geller N, Cirrincione C, Hajdu SI, Whitmore W Jr, Nisselbaum J, Vugrin D, Golbey RB
Cancer 1983 Jun 1;51(11):2121-5. doi: 10.1002/1097-0142(19830601)51:11<2121::aid-cncr2820511128>3.0.co;2-2. PMID: 6188528

Clinical prediction guides

ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Primary germ cell tumors of the mediastinum: III. Yolk sac tumor, embryonal carcinoma, choriocarcinoma, and combined nonteratomatous germ cell tumors of the mediastinum--a clinicopathologic and immunohistochemical study of 64 cases.
Moran CA, Suster S, Koss MN
Cancer 1997 Aug 15;80(4):699-707. PMID: 9264353
Unusual neoplasms detected in testis cancer patients undergoing post-chemotherapy retroperitoneal lymphadenectomy.
Little JS Jr, Foster RS, Ulbright TM, Donohue JP
J Urol 1994 Oct;152(4):1144-9. doi: 10.1016/s0022-5347(17)32524-7. PMID: 8072083
Expression of intermediate filaments and other special markers by testicular germ cell tumors. With reference to embryogenesis.
Hanai J, Lin M, Wada A, Ishiguro S, Miki T, Sakaguchi H, Kanda H
Histol Histopathol 1992 Oct;7(4):533-41. PMID: 1333851
Malignant germ cell tumors of the mediastinum.
Knapp RH, Hurt RD, Payne WS, Farrow GM, Lewis BD, Hahn RG, Muhm JR, Earle JD
J Thorac Cardiovasc Surg 1985 Jan;89(1):82-9. PMID: 2981374

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