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Benign neoplasm of oral cavity

MedGen UID:: 91119
•Concept ID:: C0347197
•: Neoplastic Process

Synonyms:	Benign Mouth Neoplasm; benign mouth neoplasm; Benign Mouth Tumor; benign mouth tumor; benign mouth tumour; Benign Neoplasm of Mouth; benign neoplasm of mouth; Benign Neoplasm of Oral Cavity; benign neoplasm of oral cavity; Benign Neoplasm of the Mouth; benign neoplasm of the mouth; Benign Neoplasm of the Oral Cavity; benign neoplasm of the oral cavity; Benign Oral Cavity Neoplasm; benign oral cavity neoplasm; Benign Oral Cavity Tumor; benign oral cavity tumor; benign oral cavity tumour; Benign Oral Neoplasm; Benign Oral Tumor; Benign Tumor of Mouth; benign tumor of mouth; Benign Tumor of Oral Cavity; Benign tumor of oral cavity; benign tumor of oral cavity; Benign Tumor of the Mouth; benign tumor of the mouth; Benign Tumor of the Oral Cavity; benign tumor of the oral cavity; benign tumour of mouth; benign tumour of oral cavity; benign tumour of the mouth; benign tumour of the oral cavity; Oral benign tumor; oral cavity benign neoplasm; Oral Neoplasm, Benign
SNOMED CT:	Benign neoplasm of oral cavity (419645003); Benign tumor of oral cavity (419645003); Oral benign tumor (419645003)

Monarch Initiative:	MONDO:0021445

Definition

A neoplasm that arises from the oral cavity and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include hemangioma, tongue lipoma, and buccal mucosa papilloma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign neoplasm of oral cavity

Pathological process
- Disease
  - Neoplasm
    - Neoplasm by Special Category
      - Benign neoplasm
        Benign Head and Neck Neoplasm
        Benign neoplasm of oral cavity
        Benign neoplasm of buccal mucosa
        Papilloma of buccal mucosa
        Benign neoplasm of floor of mouth
        Benign neoplasm of gum
        Gingival Angiofibroma
        Hemangioma of gingiva
        Benign neoplasm of hard palate
        Hard Palate Monomorphic Adenoma
        Hard Palate Pleomorphic Adenoma
        Benign neoplasm of lip
        Cherry Hemangioma of Lip
        Benign neoplasm of tongue
        Benign Anterior Tongue Neoplasm
        Benign Posterior Tongue Neoplasm
        Lipoma of the tongue
        Benign neoplasm of tonsil
        Tonsillar lipoma
        Benign Odontogenic Neoplasm
        Adenomatoid odontogenic tumor
        Ameloblastic Fibro-Odontoma
        Ameloblastic Fibrodentinoma
        Ameloblastic Fibroma
        Benign Ameloblastoma
        Calcifying Cystic Odontogenic Tumor
        Calcifying epithelial odontogenic tumor
        Cementoma
        Dentinogenic Ghost Cell Tumor
        Odontogenic Fibroma
        Peripheral Odontogenic Fibroma
        Odontogenic Myxofibroma
        Odontogenic Myxoma
        Ossifying fibroma
        Primordial Odontogenic Tumor
        Squamous Odontogenic Tumor
        Benign Oral Cavity Soft Tissue Neoplasm
        Oral Cavity Leiomyoma
        Oral Cavity Lipoma
        Pyogenic granuloma of oral mucosa
        Oral Cavity Adenoma
        Oral Cavity Monomorphic Adenoma
        Oral Cavity Pleomorphic Adenoma
        Soft Palate Pleomorphic Adenoma
        Oral Cavity Benign Granular Cell Tumor
        Soft Palate Benign Granular Cell Tumor

Professional guidelines

PubMed

Management of oral potentially malignant disorders.

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758

Management of Mucoceles, Sialoceles, and Ranulas.

Bowers EMR, Schaitkin B
Otolaryngol Clin North Am 2021 Jun;54(3):543-551. doi: 10.1016/j.otc.2021.03.002. PMID: 34024482

Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.

Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076

See all (2919)

Recent clinical studies

Etiology

Lip and Oral Cavity Squamous Cell Carcinoma.

Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176

Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.

Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325

Benign oral mucosal lesions: Clinical and pathological findings.

Maymone MBC, Greer RO, Burdine LK, Dao-Cheng A, Venkatesh S, Sahitya PC, Maymone AC, Kesecker J, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):43-56. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.061. PMID: 30447312

Cancer of the oral cavity.

Montero PH, Patel SG
Surg Oncol Clin N Am 2015 Jul;24(3):491-508. Epub 2015 Apr 15 doi: 10.1016/j.soc.2015.03.006. PMID: 25979396 Free PMC Article

HPV and cancer of the oral cavity.

Hübbers CU, Akgül B
Virulence 2015;6(3):244-8. doi: 10.1080/21505594.2014.999570. PMID: 25654476 Free PMC Article

See all (23433)

Diagnosis

Lip and Oral Cavity Squamous Cell Carcinoma.

Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176

Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.

Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325

Benign oral mucosal lesions: Clinical and pathological findings.

Role of Salivary Biomarkers in Oral Cancer Detection.

Khurshid Z, Zafar MS, Khan RS, Najeeb S, Slowey PD, Rehman IU
Adv Clin Chem 2018;86:23-70. Epub 2018 Jul 23 doi: 10.1016/bs.acc.2018.05.002. PMID: 30144841

Cancer of the oral cavity.

Montero PH, Patel SG
Surg Oncol Clin N Am 2015 Jul;24(3):491-508. Epub 2015 Apr 15 doi: 10.1016/j.soc.2015.03.006. PMID: 25979396 Free PMC Article

See all (21588)

Therapy

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment.

Worthington HV, Bulsara VM, Glenny AM, Clarkson JE, Conway DI, Macluskey M
Cochrane Database Syst Rev 2023 Aug 31;8(8):CD006205. doi: 10.1002/14651858.CD006205.pub5. PMID: 37650478 Free PMC Article

The potential role of Photodynamic therapy in oral premalignant and malignant lesions: A systematic review.

Romano A, Di Stasio D, Gentile E, Petruzzi M, Serpico R, Lucchese A
J Oral Pathol Med 2021 Apr;50(4):333-344. Epub 2021 Jan 5 doi: 10.1111/jop.13139. PMID: 33217059

Smokeless tobacco use and risk of oral cavity cancer.

Khan SZ, Farooq A, Masood M, Shahid A, Khan IU, Nisar H, Fatima I
Turk J Med Sci 2020 Apr 9;50(1):291-297. doi: 10.3906/sag-1809-11. PMID: 31655504 Free PMC Article

Role of Smoking-Mediated molecular events in the genesis of oral cancers.

Khowal S, Wajid S
Toxicol Mech Methods 2019 Nov;29(9):665-685. Epub 2019 Sep 3 doi: 10.1080/15376516.2019.1646372. PMID: 31345084

The role of oral flora in the development of chemotherapy-induced oral mucositis.

Stringer AM, Logan RM
J Oral Pathol Med 2015 Feb;44(2):81-7. Epub 2014 Feb 4 doi: 10.1111/jop.12152. PMID: 24494824

See all (12641)

Prognosis

Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190

Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.

Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325

Role of Salivary Biomarkers in Oral Cancer Detection.

Khurshid Z, Zafar MS, Khan RS, Najeeb S, Slowey PD, Rehman IU
Adv Clin Chem 2018;86:23-70. Epub 2018 Jul 23 doi: 10.1016/bs.acc.2018.05.002. PMID: 30144841

Cancer of the oral cavity.

Montero PH, Patel SG
Surg Oncol Clin N Am 2015 Jul;24(3):491-508. Epub 2015 Apr 15 doi: 10.1016/j.soc.2015.03.006. PMID: 25979396 Free PMC Article

HPV and cancer of the oral cavity.

Hübbers CU, Akgül B
Virulence 2015;6(3):244-8. doi: 10.1080/21505594.2014.999570. PMID: 25654476 Free PMC Article

See all (17660)

Clinical prediction guides

PET Imaging of Oral Cavity and Oropharyngeal Cancers.

Marcus C, Subramaniam RM
PET Clin 2022 Apr;17(2):223-234. Epub 2022 Mar 4 doi: 10.1016/j.cpet.2021.12.005. PMID: 35256303

Role of Hydrogen Sulfide in Oral Disease.

Wu DD, Ngowi EE, Zhai YK, Wang YZ, Khan NH, Kombo AF, Khattak S, Li T, Ji XY
Oxid Med Cell Longev 2022;2022:1886277. Epub 2022 Jan 25 doi: 10.1155/2022/1886277. PMID: 35116090 Free PMC Article

Towards better understanding of giant cell granulomas of the oral cavity.

Ahmed A, Naidu A
J Clin Pathol 2021 Aug;74(8):483-490. Epub 2021 Apr 15 doi: 10.1136/jclinpath-2020-206858. PMID: 33858937

MRI Dynamic Contrast Imaging of Oral Cavity and Oropharyngeal Tumors.

Sideras P, Singh G
Top Magn Reson Imaging 2021 Apr 1;30(2):97-104. doi: 10.1097/RMR.0000000000000283. PMID: 33828061

MR assessment of oral cavity carcinomas.

Hagiwara M, Nusbaum A, Schmidt BL
Magn Reson Imaging Clin N Am 2012 Aug;20(3):473-94. Epub 2012 Jul 3 doi: 10.1016/j.mric.2012.05.003. PMID: 22877952

See all (14702)

Recent systematic reviews

Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies.

Lawler T, Warren Andersen S
Nutrients 2023 Jan 13;15(2) doi: 10.3390/nu15020422. PMID: 36678292 Free PMC Article

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.

Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047 Free PMC Article

Yuwanati M, Gondivkar S, Sarode SC, Gadbail A, Desai A, Mhaske S, Pathak SK, N Khatib M
Future Oncol 2021 Mar;17(8):979-990. Epub 2021 Feb 5 doi: 10.2217/fon-2020-0881. PMID: 33541115

Diabetes mellitus and oral cancer/oral potentially malignant disorders: A systematic review and meta-analysis.

Ramos-Garcia P, Roca-Rodriguez MDM, Aguilar-Diosdado M, Gonzalez-Moles MA
Oral Dis 2021 Apr;27(3):404-421. Epub 2020 Feb 18 doi: 10.1111/odi.13289. PMID: 31994293

Optimal Perioperative Care in Major Head and Neck Cancer Surgery With Free Flap Reconstruction: A Consensus Review and Recommendations From the Enhanced Recovery After Surgery Society.

Dort JC, Farwell DG, Findlay M, Huber GF, Kerr P, Shea-Budgell MA, Simon C, Uppington J, Zygun D, Ljungqvist O, Harris J
JAMA Otolaryngol Head Neck Surg 2017 Mar 1;143(3):292-303. doi: 10.1001/jamaoto.2016.2981. PMID: 27737447

See all (860)

MedGen

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Benign neoplasm of oral cavity

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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