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Hypoalphalipoproteinemia

MedGen UID:
96877
•Concept ID:
C0473527
•
Disease or Syndrome
Synonyms: alpha Lipoproteinemia, Hypo; HDL Cholesterol, Low Serum; Hypo alpha Lipoproteinemia; Hypo alpha Lipoproteinemias; Hypoalphalipoproteinemias; Lipoproteinemia, Hypo alpha; Lipoproteinemias, Hypo alpha
SNOMED CT: Hypoalphalipoproteinemia (190785000)

Definition

A metabolic disorder characterized by deficiency of high density (alpha) lipoprotein in the blood. [from NCI]

Professional guidelines

PubMed

Very low HDL levels: clinical assessment and management.
Bonilha I, Luchiari B, Nadruz W, Sposito AC
Arch Endocrinol Metab 2023 Jan 18;67(1):3-18. doi: 10.20945/2359-3997000000585. PMID: 36651718Free PMC Article
Dyslipidemia prevalence, awareness, treatment and control in Mexico: results of the Ensanut 2012.
Hernández-Alcaraz C, Aguilar-Salinas CA, Mendoza-Herrera K, Pedroza-Tobías A, Villalpando S, Shamah-Levy T, Rivera-Dommarco J, Hernández-Ávila M, Barquera S
Salud Publica Mex 2020 Mar-Apr;62(2):137-146. doi: 10.21149/10520. PMID: 32237556
Diagnosis and management of familial dyslipoproteinemia in children and adolescents.
Kwiterovich PO Jr
Pediatr Clin North Am 1990 Dec;37(6):1489-523. doi: 10.1016/s0031-3955(16)37021-3. PMID: 2259550

Recent clinical studies

Etiology

Very low HDL levels: clinical assessment and management.
Bonilha I, Luchiari B, Nadruz W, Sposito AC
Arch Endocrinol Metab 2023 Jan 18;67(1):3-18. doi: 10.20945/2359-3997000000585. PMID: 36651718Free PMC Article
Food Consumption and Metabolic Risks in Young University Students.
González-Torres S, González-Silva N, Pérez-Reyes Á, Anaya-Esparza LM, Sánchez-Enríquez S, Vargas-Becerra PN, Villagrán Z, García-García MR
Int J Environ Res Public Health 2021 Dec 31;19(1) doi: 10.3390/ijerph19010449. PMID: 35010709Free PMC Article
Rare Diseases Related with Lipoprotein Metabolism.
Zhou H, Gong Y, Wu Q, Ye X, Yu B, Lu C, Jiang W, Ye J, Fu Z
Adv Exp Med Biol 2020;1276:171-188. doi: 10.1007/978-981-15-6082-8_11. PMID: 32705600
High density lipoprotein cholesterol and cancer: Marker or causative?
Pirro M, Ricciuti B, Rader DJ, Catapano AL, Sahebkar A, Banach M
Prog Lipid Res 2018 Jul;71:54-69. Epub 2018 Jun 4 doi: 10.1016/j.plipres.2018.06.001. PMID: 29879431
Gene-based therapies in lipidology: current status and future challenges.
Gaudet D, Brisson D
Curr Opin Lipidol 2015 Dec;26(6):553-65. doi: 10.1097/MOL.0000000000000240. PMID: 26780008

Diagnosis

Progress in finding pathogenic DNA copy number variations in dyslipidemia.
Iacocca MA, Dron JS, Hegele RA
Curr Opin Lipidol 2019 Apr;30(2):63-70. doi: 10.1097/MOL.0000000000000581. PMID: 30664016
High density lipoprotein cholesterol and cancer: Marker or causative?
Pirro M, Ricciuti B, Rader DJ, Catapano AL, Sahebkar A, Banach M
Prog Lipid Res 2018 Jul;71:54-69. Epub 2018 Jun 4 doi: 10.1016/j.plipres.2018.06.001. PMID: 29879431
Familial lipoprotein disorders and premature coronary artery disease.
Schaefer EJ, Genest JJ Jr, Ordovas JM, Salem DN, Wilson PW
Atherosclerosis 1994 Aug;108 Suppl:S41-54. doi: 10.1016/0021-9150(94)90152-x. PMID: 7802728
Hypoalphalipoproteinemia.
Frohlich JJ
CMAJ 1992 Dec 15;147(12):1809. PMID: 1458423Free PMC Article
Diagnosis and management of familial dyslipoproteinemia in children and adolescents.
Kwiterovich PO Jr
Pediatr Clin North Am 1990 Dec;37(6):1489-523. doi: 10.1016/s0031-3955(16)37021-3. PMID: 2259550

Therapy

Very low HDL levels: clinical assessment and management.
Bonilha I, Luchiari B, Nadruz W, Sposito AC
Arch Endocrinol Metab 2023 Jan 18;67(1):3-18. doi: 10.20945/2359-3997000000585. PMID: 36651718Free PMC Article
Rare Diseases Related with Lipoprotein Metabolism.
Zhou H, Gong Y, Wu Q, Ye X, Yu B, Lu C, Jiang W, Ye J, Fu Z
Adv Exp Med Biol 2020;1276:171-188. doi: 10.1007/978-981-15-6082-8_11. PMID: 32705600
High density lipoprotein cholesterol and cancer: Marker or causative?
Pirro M, Ricciuti B, Rader DJ, Catapano AL, Sahebkar A, Banach M
Prog Lipid Res 2018 Jul;71:54-69. Epub 2018 Jun 4 doi: 10.1016/j.plipres.2018.06.001. PMID: 29879431
Gemfibrozil, nicotinic acid and combination therapy in patients with isolated hypoalphalipoproteinemia: a randomized, open-label, crossover study.
Zema MJ
J Am Coll Cardiol 2000 Mar 1;35(3):640-6. doi: 10.1016/s0735-1097(99)00585-9. PMID: 10716466
Familial hypoalphalipoproteinemia.
Glueck CJ, Melser MA, Borecki IB, Third JL, Rao DC, Laskarzewski PM
Adv Exp Med Biol 1986;201:83-92. doi: 10.1007/978-1-4684-1262-8_8. PMID: 3541525

Prognosis

Polygenic scores for dyslipidemia: the emerging genomic model of plasma lipoprotein trait inheritance.
Trinder M, Brunham LR
Curr Opin Lipidol 2021 Apr 1;32(2):103-111. doi: 10.1097/MOL.0000000000000737. PMID: 33395106
Hypoalphalipoproteinemia and BRAF(V600E) Mutation Are Major Predictors of Aortic Infiltration in the Erdheim-Chester Disease.
Cohen-Aubart F, Guerin M, Poupel L, Cluzel P, Saint-Charles F, Charlotte F, Arsafi Y, Emile JF, Frisdal E, Le Goff C, Donadieu J, Amoura Z, Lesnik P, Haroche J, Le Goff W
Arterioscler Thromb Vasc Biol 2018 Aug;38(8):1913-1925. doi: 10.1161/ATVBAHA.118.310803. PMID: 29930009
Vascular risk factors in sudden hearing loss.
Rudack C, Langer C, Stoll W, Rust S, Walter M
Thromb Haemost 2006 Mar;95(3):454-61. doi: 10.1160/TH05-08-0554. PMID: 16525573
Hypoalphalipoproteinemia (low high density lipoprotein) as a risk factor for coronary heart disease.
Vega GL, Grundy SM
Curr Opin Lipidol 1996 Aug;7(4):209-16. doi: 10.1097/00041433-199608000-00007. PMID: 8883496
Primary and familial hypoalphalipoproteinemia.
Third JL, Montag J, Flynn M, Freidel J, Laskarzewski P, Glueck CJ
Metabolism 1984 Feb;33(2):136-46. doi: 10.1016/0026-0495(84)90126-4. PMID: 6694557

Clinical prediction guides

Food Consumption and Metabolic Risks in Young University Students.
González-Torres S, González-Silva N, Pérez-Reyes Á, Anaya-Esparza LM, Sánchez-Enríquez S, Vargas-Becerra PN, Villagrán Z, García-García MR
Int J Environ Res Public Health 2021 Dec 31;19(1) doi: 10.3390/ijerph19010449. PMID: 35010709Free PMC Article
Polygenic scores for dyslipidemia: the emerging genomic model of plasma lipoprotein trait inheritance.
Trinder M, Brunham LR
Curr Opin Lipidol 2021 Apr 1;32(2):103-111. doi: 10.1097/MOL.0000000000000737. PMID: 33395106
Hypoalphalipoproteinemia and BRAF(V600E) Mutation Are Major Predictors of Aortic Infiltration in the Erdheim-Chester Disease.
Cohen-Aubart F, Guerin M, Poupel L, Cluzel P, Saint-Charles F, Charlotte F, Arsafi Y, Emile JF, Frisdal E, Le Goff C, Donadieu J, Amoura Z, Lesnik P, Haroche J, Le Goff W
Arterioscler Thromb Vasc Biol 2018 Aug;38(8):1913-1925. doi: 10.1161/ATVBAHA.118.310803. PMID: 29930009
Primary and familial hypoalphalipoproteinemia.
Third JL, Montag J, Flynn M, Freidel J, Laskarzewski P, Glueck CJ
Metabolism 1984 Feb;33(2):136-46. doi: 10.1016/0026-0495(84)90126-4. PMID: 6694557
Familial hypo-alpha-lipoproteinemia.
Vergani C, Bettale G
Clin Chim Acta 1981 Jul 18;114(1):45-52. doi: 10.1016/0009-8981(81)90226-6. PMID: 7249374

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