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Benign Eye Neoplasm

MedGen UID:
99224
•Concept ID:
C0496897
•
Neoplastic Process
Synonyms: Benign Eye Tumor; Benign neoplasm of eye; Benign Neoplasm of Eye; Benign Neoplasm of the Eye; Benign Ocular Neoplasm; Benign Ocular Tumor; Benign Tumor of Eye; Benign Tumor of the Eye
SNOMED CT: Benign neoplasm of eye (92097004)

Definition

A neoplasm that arises from the eye and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Dermoscopy in Primary Care.
Pokhrel PK, Helm MF, Greene A, Helm LA, Partin M
Prim Care 2022 Mar;49(1):99-118. Epub 2022 Jan 3 doi: 10.1016/j.pop.2021.10.004. PMID: 35125161
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article

Recent clinical studies

Etiology

Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Clinical and pathological diagnosis and comparison of benign and malignant eyelid tumors.
Sendul SY, Akpolat C, Yilmaz Z, Eryilmaz OT, Guven D, Kabukcuoglu F
J Fr Ophtalmol 2021 Apr;44(4):537-543. Epub 2021 Feb 18 doi: 10.1016/j.jfo.2020.07.019. PMID: 33610396
Orbital Paraganglioma.
Zhu B, Yan J
J Craniofac Surg 2019 Sep;30(6):e503-e506. doi: 10.1097/SCS.0000000000005408. PMID: 30896513
Pathology of eyelid tumors.
Pe'er J
Indian J Ophthalmol 2016 Mar;64(3):177-90. doi: 10.4103/0301-4738.181752. PMID: 27146927Free PMC Article
Ocular phototherapy.
Singh AD
Eye (Lond) 2013 Feb;27(2):190-8. Epub 2012 Dec 14 doi: 10.1038/eye.2012.258. PMID: 23238445Free PMC Article

Diagnosis

Orbital dermoid cyst.
Bansal R, Honavar SG, Talloju SS, Mulay K
Indian J Ophthalmol 2022 Feb;70(2):709. doi: 10.4103/ijo.IJO_145_22. PMID: 35086291Free PMC Article
Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Rare Diseases of the Orbit.
Kisser U, Heichel J, Glien A
Laryngorhinootologie 2021 Apr;100(S 01):S1-S79. Epub 2021 Apr 30 doi: 10.1055/a-1384-4641. PMID: 34352903Free PMC Article
PET/CT and PET/MRI in ophthalmic oncology (Review).
Kalemaki MS, Karantanas AH, Exarchos D, Detorakis ET, Zoras O, Marias K, Millo C, Bagci U, Pallikaris I, Stratis A, Karatzanis I, Perisinakis K, Koutentakis P, Kontadakis GA, Spandidos DA, Tsatsakis A, Papadakis GZ
Int J Oncol 2020 Feb;56(2):417-429. Epub 2020 Jan 3 doi: 10.3892/ijo.2020.4955. PMID: 31939615Free PMC Article
Dacryops - A review.
Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543

Therapy

PET/CT and PET/MRI in ophthalmic oncology (Review).
Kalemaki MS, Karantanas AH, Exarchos D, Detorakis ET, Zoras O, Marias K, Millo C, Bagci U, Pallikaris I, Stratis A, Karatzanis I, Perisinakis K, Koutentakis P, Kontadakis GA, Spandidos DA, Tsatsakis A, Papadakis GZ
Int J Oncol 2020 Feb;56(2):417-429. Epub 2020 Jan 3 doi: 10.3892/ijo.2020.4955. PMID: 31939615Free PMC Article
Conjunctival lymphoma.
Li JJ, Chen W, Sadeghi N
BMJ Case Rep 2019 Jul 10;12(7) doi: 10.1136/bcr-2019-229599. PMID: 31296640Free PMC Article
Pharmacotherapy and Immunotherapy of Conjunctival Tumors.
Midena E, Frizziero L, Parrozzani R
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):121-131. doi: 10.22608/APO.201751. PMID: 28399343
Orbital pseudotumor.
Mendenhall WM, Lessner AM
Am J Clin Oncol 2010 Jun;33(3):304-6. doi: 10.1097/COC.0b013e3181a07567. PMID: 19738455
Corneal myxoma.
Wollensak G, Green WR, Seiler T
Jpn J Ophthalmol 2002 Mar-Apr;46(2):193-7. doi: 10.1016/s0021-5155(01)00493-2. PMID: 12062226

Prognosis

Intramuscular Eyelid Myxoma.
Liu CK, Williamson JE 3rd, Milman T, Lally SE, Shields CL
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):e180-e183. Epub 2022 Jul 4 doi: 10.1097/IOP.0000000000002236. PMID: 35793663
Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Rare Diseases of the Orbit.
Kisser U, Heichel J, Glien A
Laryngorhinootologie 2021 Apr;100(S 01):S1-S79. Epub 2021 Apr 30 doi: 10.1055/a-1384-4641. PMID: 34352903Free PMC Article
Intraocular leiomyoma: Current concepts.
Tomar AS, Finger PT, Iacob CE
Surv Ophthalmol 2020 Jul-Aug;65(4):421-437. Epub 2020 Jan 7 doi: 10.1016/j.survophthal.2019.12.008. PMID: 31923479
An Update on Tumors of the Lacrimal Gland.
Andreasen S, Esmaeli B, Holstein SL, Mikkelsen LH, Rasmussen PK, Heegaard S
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172. doi: 10.22608/APO.201707. PMID: 28399336

Clinical prediction guides

Radiomics in breast cancer classification and prediction.
Conti A, Duggento A, Indovina I, Guerrisi M, Toschi N
Semin Cancer Biol 2021 Jul;72:238-250. Epub 2020 May 1 doi: 10.1016/j.semcancer.2020.04.002. PMID: 32371013
Dacryops - A review.
Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543
Orbital Paraganglioma.
Zhu B, Yan J
J Craniofac Surg 2019 Sep;30(6):e503-e506. doi: 10.1097/SCS.0000000000005408. PMID: 30896513
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article
Corneal myxoma.
Wollensak G, Green WR, Seiler T
Jpn J Ophthalmol 2002 Mar-Apr;46(2):193-7. doi: 10.1016/s0021-5155(01)00493-2. PMID: 12062226

Recent systematic reviews

Clinical features and therapeutic management of choroidal osteoma: A systematic review.
Zhang L, Ran QB, Lei CY, Zhang MX
Surv Ophthalmol 2023 Nov-Dec;68(6):1084-1092. Epub 2023 Jun 14 doi: 10.1016/j.survophthal.2023.06.002. PMID: 37321477
Conjunctival myxoma: A systematic review of a rare tumor.
Alvarado-Villacorta R, Torres Zavala NM, Marroquín Loayza L, Rodríguez-Reyes AA
Surv Ophthalmol 2022 May-Jun;67(3):729-740. Epub 2021 Aug 27 doi: 10.1016/j.survophthal.2021.08.007. PMID: 34461119
Exclusively endoscopic endonasal resection of benign orbital tumors: a systematic review and meta-analysis.
Jafari A, von Sneidern M, Lehmann AE, Shen SA, Shishido S, Freitag SK, Bleier BS
Int Forum Allergy Rhinol 2021 May;11(5):924-934. Epub 2020 Dec 22 doi: 10.1002/alr.22745. PMID: 33350602
Gamma knife radiosurgery for uveal melanomas and metastases: a systematic review and meta-analysis.
Parker T, Rigney G, Kallos J, Stefko ST, Kano H, Niranjan A, Green AL, Aziz T, Rath P, Lunsford LD
Lancet Oncol 2020 Nov;21(11):1526-1536. doi: 10.1016/S1470-2045(20)30459-9. PMID: 33152286
Interventions for infantile haemangiomas of the skin.
Novoa M, Baselga E, Beltran S, Giraldo L, Shahbaz A, Pardo-Hernandez H, Arevalo-Rodriguez I
Cochrane Database Syst Rev 2018 Apr 18;4(4):CD006545. doi: 10.1002/14651858.CD006545.pub3. PMID: 29667726Free PMC Article

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