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Microvascular complications of diabetes, susceptibility to, 6(MVCD6)

MedGen UID:
382533
•Concept ID:
C2675128
•
Finding
Synonym: Microvascular complications of diabetes 6
 
Gene (location): SOD2 (6q25.3)
 
Monarch Initiative: MONDO:0012970
OMIM®: 612634

Definition

Any microvascular complications of diabetes, susceptibility in which the cause of the disease is a mutation in the SOD2 gene. [from MONDO]

Professional guidelines

PubMed

Report of the Committee on the classification and diagnostic criteria of diabetes mellitus.
Kuzuya T, Nakagawa S, Satoh J, Kanazawa Y, Iwamoto Y, Kobayashi M, Nanjo K, Sasaki A, Seino Y, Ito C, Shima K, Nonaka K, Kadowaki T; Committee of the Japan Diabetes Society on the diagnostic criteria of diabetes mellitus
Diabetes Res Clin Pract 2002 Jan;55(1):65-85. doi: 10.1016/s0168-8227(01)00365-5. PMID: 11755481

Recent clinical studies

Etiology

Genetic risk score is associated with T2DM and diabetes complications risks.
Hubacek JA, Dlouha L, Adamkova V, Dlouha D, Pacal L, Kankova K, Galuska D, Lanska V, Veleba J, Pelikanova T
Gene 2023 Jan 15;849:146921. Epub 2022 Sep 26 doi: 10.1016/j.gene.2022.146921. PMID: 36174902
Do Long-Term Complications of Type 2 Diabetes Increase Susceptibility to Geriatric Syndromes in Older Adults?
Çakmak G, Ganidağlı S, Efendioğlu EM, Öztürk E, Öztürk ZA
Medicina (Kaunas) 2021 Sep 15;57(9) doi: 10.3390/medicina57090968. PMID: 34577891Free PMC Article
The association of interieukin-6 polymorphism (rs1800795) with microvascular complications in Type 2 diabetes mellitus.
Cui J, Zhang X, Guo C, Zhang L
Biosci Rep 2020 Oct 30;40(10) doi: 10.1042/BSR20201105. PMID: 33016995Free PMC Article
Microvascular Disease, Peripheral Artery Disease, and Amputation.
Beckman JA, Duncan MS, Damrauer SM, Wells QS, Barnett JV, Wasserman DH, Bedimo RJ, Butt AA, Marconi VC, Sico JJ, Tindle HA, Bonaca MP, Aday AW, Freiberg MS
Circulation 2019 Aug 6;140(6):449-458. Epub 2019 Jul 8 doi: 10.1161/CIRCULATIONAHA.119.040672. PMID: 31280589Free PMC Article
Genetic factors in diabetic nephropathy.
Freedman BI, Bostrom M, Daeihagh P, Bowden DW
Clin J Am Soc Nephrol 2007 Nov;2(6):1306-16. Epub 2007 Oct 17 doi: 10.2215/CJN.02560607. PMID: 17942768

Diagnosis

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Do Long-Term Complications of Type 2 Diabetes Increase Susceptibility to Geriatric Syndromes in Older Adults?
Çakmak G, Ganidağlı S, Efendioğlu EM, Öztürk E, Öztürk ZA
Medicina (Kaunas) 2021 Sep 15;57(9) doi: 10.3390/medicina57090968. PMID: 34577891Free PMC Article
The association of interieukin-6 polymorphism (rs1800795) with microvascular complications in Type 2 diabetes mellitus.
Cui J, Zhang X, Guo C, Zhang L
Biosci Rep 2020 Oct 30;40(10) doi: 10.1042/BSR20201105. PMID: 33016995Free PMC Article
Microvascular Disease, Peripheral Artery Disease, and Amputation.
Beckman JA, Duncan MS, Damrauer SM, Wells QS, Barnett JV, Wasserman DH, Bedimo RJ, Butt AA, Marconi VC, Sico JJ, Tindle HA, Bonaca MP, Aday AW, Freiberg MS
Circulation 2019 Aug 6;140(6):449-458. Epub 2019 Jul 8 doi: 10.1161/CIRCULATIONAHA.119.040672. PMID: 31280589Free PMC Article
Crossing family histories of diabetes and cardiovascular disease leads to unexpected outcomes in diabetic offspring.
Hermans MP, Ahn SA, Rousseau MF
J Diabetes 2019 Apr;11(4):301-308. Epub 2018 Sep 23 doi: 10.1111/1753-0407.12840. PMID: 30105804

Therapy

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Effects of intensive insulin therapy on the retinal microvasculature in patients with type 2 diabetes mellitus: a prospective observational study.
Yang N, Li MX, Peng XY
BMC Ophthalmol 2022 Apr 22;22(1):187. doi: 10.1186/s12886-022-02397-9. PMID: 35459162Free PMC Article
Crossing family histories of diabetes and cardiovascular disease leads to unexpected outcomes in diabetic offspring.
Hermans MP, Ahn SA, Rousseau MF
J Diabetes 2019 Apr;11(4):301-308. Epub 2018 Sep 23 doi: 10.1111/1753-0407.12840. PMID: 30105804
The role of inflammatory cytokines in diabetic nephropathy.
Navarro-González JF, Mora-Fernández C
J Am Soc Nephrol 2008 Mar;19(3):433-42. Epub 2008 Feb 6 doi: 10.1681/ASN.2007091048. PMID: 18256353
Chromosome 7q35 and susceptibility to diabetic microvascular complications.
Patel A, Hibberd ML, Millward BA, Demaine AG
J Diabetes Complications 1996 Mar-Apr;10(2):62-7. doi: 10.1016/1056-8727(95)00004-6. PMID: 8777332

Prognosis

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Genetic risk score is associated with T2DM and diabetes complications risks.
Hubacek JA, Dlouha L, Adamkova V, Dlouha D, Pacal L, Kankova K, Galuska D, Lanska V, Veleba J, Pelikanova T
Gene 2023 Jan 15;849:146921. Epub 2022 Sep 26 doi: 10.1016/j.gene.2022.146921. PMID: 36174902
Microvascular Disease, Peripheral Artery Disease, and Amputation.
Beckman JA, Duncan MS, Damrauer SM, Wells QS, Barnett JV, Wasserman DH, Bedimo RJ, Butt AA, Marconi VC, Sico JJ, Tindle HA, Bonaca MP, Aday AW, Freiberg MS
Circulation 2019 Aug 6;140(6):449-458. Epub 2019 Jul 8 doi: 10.1161/CIRCULATIONAHA.119.040672. PMID: 31280589Free PMC Article
Effect of family history of type-2 diabetes on coronary flow reserve and it's relationship with insulin resistance: an observational study.
Calişkan M, Pamuk BÖ, Güllü H, Çiftçi Ö, Çalişkan Z, Erdoğan D, Güven A, Polat E, Müderrisoğlu H
Anadolu Kardiyol Derg 2013 Feb;13(1):48-56. Epub 2012 Oct 19 doi: 10.5152/akd.2013.006. PMID: 23086803
Type II diabetes and its complications in Mexican Americans.
Stern MP, Haffner SM
Diabetes Metab Rev 1990 Feb;6(1):29-45. doi: 10.1002/dmr.5610060102. PMID: 2192854

Clinical prediction guides

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Genetic risk score is associated with T2DM and diabetes complications risks.
Hubacek JA, Dlouha L, Adamkova V, Dlouha D, Pacal L, Kankova K, Galuska D, Lanska V, Veleba J, Pelikanova T
Gene 2023 Jan 15;849:146921. Epub 2022 Sep 26 doi: 10.1016/j.gene.2022.146921. PMID: 36174902
Do Long-Term Complications of Type 2 Diabetes Increase Susceptibility to Geriatric Syndromes in Older Adults?
Çakmak G, Ganidağlı S, Efendioğlu EM, Öztürk E, Öztürk ZA
Medicina (Kaunas) 2021 Sep 15;57(9) doi: 10.3390/medicina57090968. PMID: 34577891Free PMC Article
Association of Combined TCF7L2 and KCNQ1 Gene Polymorphisms with Diabetic Micro- and Macrovascular Complications in Type 2 Diabetes Mellitus.
Rattanatham R, Settasatian N, Komanasin N, Kukongviriyapan U, Sawanyawisuth K, Intharaphet P, Senthong V, Settasatian C
Diabetes Metab J 2021 Jul;45(4):578-593. Epub 2021 Mar 22 doi: 10.4093/dmj.2020.0101. PMID: 33752320Free PMC Article
Crossing family histories of diabetes and cardiovascular disease leads to unexpected outcomes in diabetic offspring.
Hermans MP, Ahn SA, Rousseau MF
J Diabetes 2019 Apr;11(4):301-308. Epub 2018 Sep 23 doi: 10.1111/1753-0407.12840. PMID: 30105804

Recent systematic reviews

(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article

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