Ciliberto2003_Morphogenesis_Checkpoint

Model Identifier
BIOMD0000000297
Short description

This a model from the article:
Mathematical model of the morphogenesis checkpoint in budding yeast.
Ciliberto A, Novak B, Tyson JJ J. Cell Biol. [2003 Dec; Volume: 163 (Issue: 6 )] Page info: 1243-54 14691135 ,
Abstract:
The morphogenesis checkpoint in budding yeast delays progression through the cell cycle in response to stimuli that prevent bud formation. Central to the checkpoint mechanism is Swe1 kinase: normally inactive, its activation halts cell cycle progression in G2. We propose a molecular network for Swe1 control, based on published observations of budding yeast and analogous control signals in fission yeast. The proposed Swe1 network is merged with a model of cyclin-dependent kinase regulation, converted into a set of differential equations and studied by numerical simulation. The simulations accurately reproduce the phenotypes of a dozen checkpoint mutants. Among other predictions, the model attributes a new role to Hsl1, a kinase known to play a role in Swe1 degradation: Hsl1 must also be indirectly responsible for potent inhibition of Swe1 activity. The model supports the idea that the morphogenesis checkpoint, like other checkpoints, raises the cell size threshold for progression from one phase of the cell cycle to the next.

The model reproduces Fig 3 of the paper.

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Format
SBML (L2V4)
Related Publication
  • Mathematical model of the morphogenesis checkpoint in budding yeast.
  • Andrea Ciliberto, Béla Novák, John J Tyson
  • The Journal of cell biology , 12/ 2003 , Volume 163 , Issue 6 , pages: 1243-1254 , PubMed ID: 14691135
Contributors
Submitter of the first revision: Harish Dharuri
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modellers: Harish Dharuri, administrator

Metadata information

is (2 statements)
BioModels Database BIOMD0000000297
BioModels Database MODEL2504064544

isDescribedBy (1 statement)
PubMed 14691135

hasTaxon (1 statement)
isVersionOf (2 statements)
isPartOf (1 statement)
KEGG Pathway Cell cycle - yeast

hasProperty (1 statement)
Mathematical Modelling Ontology Ordinary differential equation model


Curation status
Curated


Connected external resources