Dwivedi2014 - Crohns IL6 Disease model - sgp130 activity
View the 2014-09 Model of the Month entry for this model-
[BIOMD0000000534]
Healthy Volunteer model
-
[BIOMD0000000535]
Crohn's Disease - IL-6 Antibody
- [BIOMD0000000536] Crohn's Disease - sgp130FC
-
[BIOMD0000000537]
Crohn's Disease - IL-6Ra Antibody
The figure referring to this Crohn's Disease model is 6b.
This model is described in the article:
Abstract:
In this study, we have developed a multiscale systems model of interleukin (IL)-6-mediated immune regulation in Crohn's disease, by integrating intracellular signaling with organ-level dynamics of pharmacological markers underlying the disease. This model was linked to a general pharmacokinetic model for therapeutic monoclonal antibodies and used to comparatively study various biotherapeutic strategies targeting IL-6-mediated signaling in Crohn's disease. Our work illustrates techniques to develop mechanistic models of disease biology to study drug-system interaction. Despite a sparse training data set, predictions of the model were qualitatively validated by clinical biomarker data from a pilot trial with tocilizumab. Model-based analysis suggests that strategies targeting IL-6, IL-6R?, or the IL-6/sIL-6R? complex are less effective at suppressing pharmacological markers of Crohn's than dual targeting the IL-6/sIL-6R? complex in addition to IL-6 or IL-6R?. The potential value of multiscale system pharmacology modeling in drug discovery and development is also discussed.CPT: Pharmacometrics & Systems Pharmacology (2014) 3, e89; doi:10.1038/psp.2013.64; advance online publication 8 January 2014.
This model is hosted on BioModels Database and identified by: BIOMD0000000536.
To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models.
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.
-
A multiscale model of interleukin-6-mediated immune regulation in Crohn's disease and its application in drug discovery and development.
- G Dwivedi, L Fitz, M Hegen, S W Martin, J Harrold, A Heatherington, C Li
- CPT: pharmacometrics & systems pharmacology , 1/ 2014 , Volume 3 , pages: e89 , PubMed ID: 24402116
Submitter of this revision: Lucian Smith
Curator: Lucian Smith
Modellers: administrator, Vincent Knight-Schrijver
Metadata information
isDescribedBy (1 statement)
hasTaxon (1 statement)
hasPart (1 statement)
isVersionOf (1 statement)
hasVersion (1 statement)
isPartOf (1 statement)
hasProperty (1 statement)
Connected external resources