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Series GSE80970 Query DataSets for GSE80970
Status Public on Aug 01, 2016
Title Cortical hypermethylation across an extended region spanning the HOXA gene cluster on chromosome 7 is robustly associated with Alzheimer's disease neuropathology
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Alzheimer's disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. We undertook an epigenome-wide association study across three independent brain tissue cohorts (total n = 999) to identify differential DNA methylation associated with neuropathology in the superior temporal gyrus and prefrontal cortex. We present robust evidence for elevated DNA methylation associated with AD neuropathology across an extended region spanning the HOXA gene cluster on chromosome 7.
 
Overall design Prefrontal cortex and superior temporal gyrus tissue from 147 individuals with varying levels of AD pathology. DNA modifications for these samples were quantified using the Illumina Infinium Human 450K Methylation Array.
 
Contributor(s) Smith R, Hannon E, De Jager P, Chibnik L, Lott S, Condliffe D, Smith A, Haroutunian V, Troakes C, Bennett D, Powell J, Lovestone S, Schalkwyk L, Mill J, Lunnon K
Citation(s) 29550519
Submission date May 01, 2016
Last update date Mar 22, 2019
Contact name Rebecca Georgina Smith
E-mail(s) r.g.smith@exeter.ac.uk
Organization name University of Exeter
Department Medical School
Street address RILD, RD and E
City Exeter
State/province Devon
ZIP/Postal code EX2 5DW
Country United Kingdom
 
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (286)
GSM2139163 Prefrontal Cortex Male Alzheimer's Disease (MS66AC)
GSM2139164 Prefrontal Cortex Female Control (MS546AC)
GSM2139165 Prefrontal Cortex Female Alzheimer's Disease (MS709AC)
Relations
BioProject PRJNA320252

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE80970_MSACF_raw_beta.txt.gz 367.3 Mb (ftp)(http) TXT
GSE80970_MSACF_raw_methylated.txt.gz 285.6 Mb (ftp)(http) TXT
GSE80970_MSACF_raw_pvals.txt.gz 3.3 Mb (ftp)(http) TXT
GSE80970_MSACF_raw_unmethylated.txt.gz 288.2 Mb (ftp)(http) TXT
GSE80970_RAW.tar 183.1 Mb (http)(custom) TAR
Processed data included within Sample table
Processed data are available on Series record
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