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Benign neoplasm of mediastinum

MedGen UID:
102298
•Concept ID:
C0153956
•
Neoplastic Process
Synonyms: Benign Mediastinal Neoplasm; benign mediastinal neoplasm; Benign Mediastinal Neoplasms NOS; Benign Mediastinal Tumor; benign mediastinal tumor; benign mediastinal tumour; Benign Neoplasm of Mediastinum; benign neoplasm of mediastinum; Benign Neoplasm of the Mediastinum; benign neoplasm of the mediastinum; Benign tumor of mediastinum; Benign Tumor of Mediastinum; benign tumor of mediastinum; Benign Tumor of the Mediastinum; benign tumor of the mediastinum; benign tumour of mediastinum; benign tumour of the mediastinum; mediastinum benign neoplasm
SNOMED CT: Benign tumor of mediastinum (92214000); Benign neoplasm of mediastinum (92214000)
 
Monarch Initiative: MONDO:0021521

Definition

A neoplasm that arises from the mediastinum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include lipoma, leiomyoma, and schwannoma. [from NCI]

Professional guidelines

PubMed

Primary Mediastinal B-Cell Lymphoma: A 2021 Update on Genetics, Diagnosis, and Novel Therapeutics.
Ahmed Z, Afridi SS, Shahid Z, Zamani Z, Rehman S, Aiman W, Khan M, Mir MA, Awan FT, Anwer F, Iftikhar R
Clin Lymphoma Myeloma Leuk 2021 Nov;21(11):e865-e875. Epub 2021 Jun 24 doi: 10.1016/j.clml.2021.06.012. PMID: 34330673
Lymphomas of the Mediastinum and Their Differential Diagnosis.
Zhang ML, Sohani AR
Semin Diagn Pathol 2020 Jul;37(4):156-165. Epub 2020 May 15 doi: 10.1053/j.semdp.2020.04.005. PMID: 32451144
Methods for staging non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.
Silvestri GA, Gonzalez AV, Jantz MA, Margolis ML, Gould MK, Tanoue LT, Harris LJ, Detterbeck FC
Chest 2013 May;143(5 Suppl):e211S-e250S. doi: 10.1378/chest.12-2355. PMID: 23649440

Recent clinical studies

Etiology

Benign lesions of the mediastinum.
Gerber TS, Porubsky S
Histopathology 2024 Jan;84(1):183-195. Epub 2023 Nov 21 doi: 10.1111/his.15088. PMID: 37988262
Is the diagnostic yield of mediastinal lymph node cryobiopsy (cryoEBUS) better for diagnosing mediastinal node involvement compared to endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)? A systematic review.
Botana-Rial M, Lojo-Rodríguez I, Leiro-Fernández V, Ramos-Hernández C, González-Montaos A, Pazos-Area L, Núñez-Delgado M, Fernández-Villar A
Respir Med 2023 Nov;218:107389. Epub 2023 Aug 12 doi: 10.1016/j.rmed.2023.107389. PMID: 37579981
Pediatric mediastinal masses.
Sreedher G, Tadros SS, Janitz E
Pediatr Radiol 2022 Sep;52(10):1935-1947. Epub 2022 Jun 8 doi: 10.1007/s00247-022-05409-4. PMID: 35674800
Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: Pathology review and diagnostic approach.
Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847
ITMIG Classification of Mediastinal Compartments and Multidisciplinary Approach to Mediastinal Masses.
Carter BW, Benveniste MF, Madan R, Godoy MC, de Groot PM, Truong MT, Rosado-de-Christenson ML, Marom EM
Radiographics 2017 Mar-Apr;37(2):413-436. Epub 2017 Jan 27 doi: 10.1148/rg.2017160095. PMID: 28129068

Diagnosis

Mediastinal Staging in Non-Small-Cell Lung Cancer: Saying Goodbye to Mediastinoscopy.
Dunne EG, Fick CN, Jones DR
J Clin Oncol 2023 Aug 1;41(22):3785-3790. Epub 2023 Jun 2 doi: 10.1200/JCO.23.00867. PMID: 37267507Free PMC Article
The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors?
Marx A, Chan JKC, Chalabreysse L, Dacic S, Detterbeck F, French CA, Hornick JL, Inagaki H, Jain D, Lazar AJ, Marino M, Marom EM, Moreira AL, Nicholson AG, Noguchi M, Nonaka D, Papotti MG, Porubsky S, Sholl LM, Tateyama H, Thomas de Montpréville V, Travis WD, Rajan A, Roden AC, Ströbel P
J Thorac Oncol 2022 Feb;17(2):200-213. Epub 2021 Oct 22 doi: 10.1016/j.jtho.2021.10.010. PMID: 34695605
Mediastinal Germ Cell Tumors: A Review and Update on Pathologic, Clinical, and Molecular Features.
El-Zaatari ZM, Ro JY
Adv Anat Pathol 2021 Sep 1;28(5):335-350. doi: 10.1097/PAP.0000000000000304. PMID: 34029275
ITMIG Classification of Mediastinal Compartments and Multidisciplinary Approach to Mediastinal Masses.
Carter BW, Benveniste MF, Madan R, Godoy MC, de Groot PM, Truong MT, Rosado-de-Christenson ML, Marom EM
Radiographics 2017 Mar-Apr;37(2):413-436. Epub 2017 Jan 27 doi: 10.1148/rg.2017160095. PMID: 28129068
Approaching the patient with an anterior mediastinal mass: a guide for clinicians.
Carter BW, Marom EM, Detterbeck FC
J Thorac Oncol 2014 Sep;9(9 Suppl 2):S102-9. doi: 10.1097/JTO.0000000000000294. PMID: 25396306

Therapy

Mediastinal Staging in Non-Small-Cell Lung Cancer: Saying Goodbye to Mediastinoscopy.
Dunne EG, Fick CN, Jones DR
J Clin Oncol 2023 Aug 1;41(22):3785-3790. Epub 2023 Jun 2 doi: 10.1200/JCO.23.00867. PMID: 37267507Free PMC Article
Postoperative radiotherapy versus no postoperative radiotherapy in patients with completely resected non-small-cell lung cancer and proven mediastinal N2 involvement (Lung ART): an open-label, randomised, phase 3 trial.
Le Pechoux C, Pourel N, Barlesi F, Lerouge D, Antoni D, Lamezec B, Nestle U, Boisselier P, Dansin E, Paumier A, Peignaux K, Thillays F, Zalcman G, Madelaine J, Pichon E, Larrouy A, Lavole A, Argo-Leignel D, Derollez M, Faivre-Finn C, Hatton MQ, Riesterer O, Bouvier-Morel E, Dunant A, Edwards JG, Thomas PA, Mercier O, Bardet A
Lancet Oncol 2022 Jan;23(1):104-114. Epub 2021 Dec 15 doi: 10.1016/S1470-2045(21)00606-9. PMID: 34919827
Primary mediastinal large B-cell lymphoma.
Savage KJ
Blood 2022 Sep 1;140(9):955-970. doi: 10.1182/blood.2020008376. PMID: 34496020
Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: a randomised trial.
Zhang J, Guo JR, Huang ZS, Fu WL, Wu XL, Wu N, Kuebler WM, Herth FJF, Fan Y
Eur Respir J 2021 Dec;58(6) Epub 2021 Dec 9 doi: 10.1183/13993003.00055-2021. PMID: 33958432
Lymphoblastic lymphoma.
Thomas DA, Kantarjian HM
Hematol Oncol Clin North Am 2001 Feb;15(1):51-95, vi. doi: 10.1016/s0889-8588(05)70200-8. PMID: 11253609

Prognosis

What is new in mediastinal staging?
Schwalk AJ, Niroula A, Schimmel M
Curr Opin Pulm Med 2024 Jan 1;30(1):25-34. Epub 2023 Oct 26 doi: 10.1097/MCP.0000000000001022. PMID: 37851368
Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach.
Choi JH, Ro JY
Adv Anat Pathol 2021 Sep 1;28(5):351-381. doi: 10.1097/PAP.0000000000000306. PMID: 34050062
Mediastinal staging: when and how?
D'Andrilli A, Maurizi G, Venuta F, Rendina EA
Gen Thorac Cardiovasc Surg 2020 Jul;68(7):725-732. Epub 2019 Dec 3 doi: 10.1007/s11748-019-01263-8. PMID: 31797211
Primary mediastinal germ cell tumors.
Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171
Mediastinal incidentalomas.
Stigt JA, Boers JE, Oostdijk AH, van den Berg JW, Groen HJ
J Thorac Oncol 2011 Aug;6(8):1345-9. doi: 10.1097/JTO.0b013e31821d41c8. PMID: 21587083

Clinical prediction guides

Efficacy and safety of EBUS-TBNA under conscious sedation with meperidine and midazolam.
Piro R, Casalini E, Fontana M, Galeone C, Ruggiero P, Taddei S, Ghidoni G, Patricelli G, Facciolongo N
Thorac Cancer 2022 Feb;13(4):533-538. Epub 2022 Jan 7 doi: 10.1111/1759-7714.14286. PMID: 34994092Free PMC Article
Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: a randomised trial.
Zhang J, Guo JR, Huang ZS, Fu WL, Wu XL, Wu N, Kuebler WM, Herth FJF, Fan Y
Eur Respir J 2021 Dec;58(6) Epub 2021 Dec 9 doi: 10.1183/13993003.00055-2021. PMID: 33958432
Competence in endosonographic techniques.
Candoli P, Ceron L, Trisolini R, Romagnoli M, Michieletto L, Scarlata S, Galasso T, Leoncini F, Pasini V, Dennetta D, Marchesani F, Zotti M, Corbetta L
Panminerva Med 2019 Sep;61(3):249-279. Epub 2018 Nov 9 doi: 10.23736/S0031-0808.18.03570-X. PMID: 30421897
Mediastinal incidentalomas.
Stigt JA, Boers JE, Oostdijk AH, van den Berg JW, Groen HJ
J Thorac Oncol 2011 Aug;6(8):1345-9. doi: 10.1097/JTO.0b013e31821d41c8. PMID: 21587083
Restaging of the mediastinum.
Herth FJ, Ernst A, Eberhardt R
Curr Opin Pulm Med 2009 Jul;15(4):308-12. doi: 10.1097/MCP.0b013e32832cbee6. PMID: 19436205

Recent systematic reviews

Is the diagnostic yield of mediastinal lymph node cryobiopsy (cryoEBUS) better for diagnosing mediastinal node involvement compared to endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)? A systematic review.
Botana-Rial M, Lojo-Rodríguez I, Leiro-Fernández V, Ramos-Hernández C, González-Montaos A, Pazos-Area L, Núñez-Delgado M, Fernández-Villar A
Respir Med 2023 Nov;218:107389. Epub 2023 Aug 12 doi: 10.1016/j.rmed.2023.107389. PMID: 37579981
A Systematic Review on Intensity Modulated Radiation Therapy for Mediastinal Hodgkin's Lymphoma.
Buglione M, Guerini AE, Filippi AR, Spiazzi L, Pasinetti N, Magli A, Toraci C, Borghetti P, Triggiani L, Alghisi A, Costantino G, Bertagna F, Giaj Levra N, Pegurri L, Magrini SM
Crit Rev Oncol Hematol 2021 Nov;167:103437. Epub 2021 Aug 3 doi: 10.1016/j.critrevonc.2021.103437. PMID: 34358649
Clinicopathological features of esophageal schwannomas in mainland China: systematic review of the literature.
Gao ZY, Liu XB, Pandey S, Gao B, Liu P, Zhang QH, Gao YJ, Li SB
Int J Clin Oncol 2021 Feb;26(2):284-295. Epub 2020 Nov 20 doi: 10.1007/s10147-020-01809-4. PMID: 33216242
Video-assisted thoracoscopic surgery node dissection for lung cancer treatment.
Watanabe A, Miyajima M, Mishina T, Tsuruta K, Takahashi Y, Maki R, Tada M
Surg Today 2017 Dec;47(12):1419-1428. Epub 2017 Mar 11 doi: 10.1007/s00595-017-1494-x. PMID: 28285463
Endosonography Versus Mediastinoscopy in Mediastinal Staging of Lung Cancer: Systematic Review and Meta-Analysis.
Sehgal IS, Dhooria S, Aggarwal AN, Behera D, Agarwal R
Ann Thorac Surg 2016 Nov;102(5):1747-1755. doi: 10.1016/j.athoracsur.2016.05.110. PMID: 27637288

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