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Rheumatoid nodule

MedGen UID:
1052555
Concept ID:
CN377014
Finding
HPO: HP:6000418

Definition

A well-demarcated, flesh colored, subcutaneous and usually freely movable lump or mass. Rheumatoid nodules can vary in size from small, pea sized lesions up to the size of a lemon and are most often round. The nodules usually are doughy or firm however and not tender. Typically rheumatoid nodules are distributed over areas of repeated trauma or pressure and occur adjacent to joints on extensor surfaces, such as the elbow, fingers and forearms. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRheumatoid nodule

Professional guidelines

PubMed

Chansakul T, Dellaripa PF, Doyle TJ, Madan R
Eur J Radiol 2015 Oct;84(10):1981-91. Epub 2015 Jul 17 doi: 10.1016/j.ejrad.2015.07.008. PMID: 26210094Free PMC Article

Recent clinical studies

Etiology

Zyluk A, Owczarska A
Handchir Mikrochir Plast Chir 2023 Sep;55(5):344-349. Epub 2023 Mar 9 doi: 10.1055/a-2008-0772. PMID: 36893786
Esposito AJ, Chu SG, Madan R, Doyle TJ, Dellaripa PF
Clin Chest Med 2019 Sep;40(3):545-560. Epub 2019 Jul 6 doi: 10.1016/j.ccm.2019.05.003. PMID: 31376890Free PMC Article
Ţăranu T, Grigorovici M, Constantin M, Toader MP
Acta Dermatovenerol Croat 2017 Dec;25(4):292-294. PMID: 30064602
Wick MR
Semin Diagn Pathol 2017 May;34(3):301-311. Epub 2016 Dec 14 doi: 10.1053/j.semdp.2016.12.003. PMID: 28094163
Dodiuk-Gad RP, Shear NH
Dermatol Clin 2015 Jul;33(3):525-39. doi: 10.1016/j.det.2015.03.015. PMID: 26143430

Diagnosis

Rosen Y
Arch Pathol Lab Med 2022 Jan 2;146(2):233-251. doi: 10.5858/arpa.2020-0543-RA. PMID: 33905479
Esposito AJ, Chu SG, Madan R, Doyle TJ, Dellaripa PF
Clin Chest Med 2019 Sep;40(3):545-560. Epub 2019 Jul 6 doi: 10.1016/j.ccm.2019.05.003. PMID: 31376890Free PMC Article
Errichetti E, Stinco G
Dermatol Clin 2018 Oct;36(4):369-375. Epub 2018 Aug 2 doi: 10.1016/j.det.2018.05.004. PMID: 30201146
Tilstra JS, Lienesch DW
Dermatol Clin 2015 Jul;33(3):361-71. doi: 10.1016/j.det.2015.03.004. PMID: 26143419
García-Patos V
Semin Cutan Med Surg 2007 Jun;26(2):100-7. doi: 10.1016/j.sder.2007.02.007. PMID: 17544962

Therapy

Roongta R, Mondal S
Rheumatology (Oxford) 2022 May 30;61(6):e161. doi: 10.1093/rheumatology/keab613. PMID: 34320645
Sharma A, Kasetty A, Kumar A
Clin Rheumatol 2021 Apr;40(4):1645-1647. Epub 2020 Aug 22 doi: 10.1007/s10067-020-05351-6. PMID: 32827281
Xue Y, Cohen JM, Wright NA, Merola JF
Am J Clin Dermatol 2016 Apr;17(2):147-62. doi: 10.1007/s40257-015-0167-z. PMID: 26649439
Dodiuk-Gad RP, Shear NH
Dermatol Clin 2015 Jul;33(3):525-39. doi: 10.1016/j.det.2015.03.015. PMID: 26143430
Tilstra JS, Lienesch DW
Dermatol Clin 2015 Jul;33(3):361-71. doi: 10.1016/j.det.2015.03.004. PMID: 26143419

Prognosis

Wang HF, Wang YY, Li ZY, He PJ, Liu S, Li QS
Ann Med 2024 Dec;56(1):2332406. Epub 2024 Mar 28 doi: 10.1080/07853890.2024.2332406. PMID: 38547537Free PMC Article
Ţăranu T, Grigorovici M, Constantin M, Toader MP
Acta Dermatovenerol Croat 2017 Dec;25(4):292-294. PMID: 30064602
Trăistaru MR, Kamal D, Traşcă DM, Foarfă MC, Gruia CL, Rogoveanu OC
Rom J Morphol Embryol 2016;57(1):215-25. PMID: 27151711
García-Patos V
Semin Cutan Med Surg 2007 Jun;26(2):100-7. doi: 10.1016/j.sder.2007.02.007. PMID: 17544962
Zvaifler NJ, Robinson CA
Dis Mon 1974 May:1-56. PMID: 4494538

Clinical prediction guides

Wang HF, Wang YY, Li ZY, He PJ, Liu S, Li QS
Ann Med 2024 Dec;56(1):2332406. Epub 2024 Mar 28 doi: 10.1080/07853890.2024.2332406. PMID: 38547537Free PMC Article
Bang S, Kim Y, Jang K, Paik SS, Shin SJ
Clin Rheumatol 2019 Nov;38(11):3041-3048. Epub 2019 Jul 4 doi: 10.1007/s10067-019-04668-1. PMID: 31273637
Ziemer M, Müller AK, Hein G, Oelzner P, Elsner P
J Dtsch Dermatol Ges 2016 Dec;14(12):1237-1246. Epub 2016 Nov 25 doi: 10.1111/ddg.12680. PMID: 27886444
Minetti G, Bartolini B, Garlaschi G, Silvestri E, Cimmino MA
Reumatismo 2015 Dec 30;67(3):123-4. doi: 10.4081/reumatismo.2015.852. PMID: 26876192
Galarza-Delgado DA, Esquivel-Valerio JA, Garza-Elizondo MA, Góngora-Rivera F, Muñoz-De Hoyos JL, Serna-Peña G
Reumatol Clin 2013 May-Jun;9(3):136-41. Epub 2012 Dec 28 doi: 10.1016/j.reuma.2012.07.006. PMID: 23273674

Recent systematic reviews

Wang HF, Wang YY, Li ZY, He PJ, Liu S, Li QS
Ann Med 2024 Dec;56(1):2332406. Epub 2024 Mar 28 doi: 10.1080/07853890.2024.2332406. PMID: 38547537Free PMC Article
Shah N, Shah M, Drucker AM, Shear NH, Ziv M, Dodiuk-Gad RP
Am J Clin Dermatol 2021 Jan;22(1):39-53. doi: 10.1007/s40257-020-00566-4. PMID: 33108647

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