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Positive cold agglutinin test

MedGen UID:
1052765
•Concept ID:
CN376982
•
Finding
HPO: HP:6000386

Definition

Cold agglutinin are erythrocyte antibodies which possess the property of agglutinating red blood cells at temperatures of below 37 degrees C, this phenomenon is reversible after heating. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPositive cold agglutinin test

Professional guidelines

PubMed

Defining autoimmune hemolytic anemia: a systematic review of the terminology used for diagnosis and treatment.
Hill QA, Hill A, Berentsen S
Blood Adv 2019 Jun 25;3(12):1897-1906. doi: 10.1182/bloodadvances.2019000036. PMID: 31235526Free PMC Article
Immune Hemolysis: Diagnosis and Treatment Recommendations.
Barcellini W
Semin Hematol 2015 Oct;52(4):304-12. Epub 2015 May 19 doi: 10.1053/j.seminhematol.2015.05.001. PMID: 26404442
Diagnosis and treatment of autoimmune haemolytic anaemias in adults: a clinical review.
Valent P, Lechner K
Wien Klin Wochenschr 2008;120(5-6):136-51. doi: 10.1007/s00508-008-0945-1. PMID: 18365153

Recent clinical studies

Etiology

Cold Agglutinins and Cryoglobulins Associate With Clinical and Laboratory Parameters of Cold Urticaria.
Bizjak M, Košnik M, Terhorst-Molawi D, Dinevski D, Maurer M
Front Immunol 2021;12:665491. Epub 2021 Apr 29 doi: 10.3389/fimmu.2021.665491. PMID: 33995398Free PMC Article

Diagnosis

Acute respiratory distress syndrome in Mycoplasma pneumonia: a case report and review.
Chian CF, Chang FY
J Microbiol Immunol Infect 1999 Mar;32(1):52-6. PMID: 11561570

Prognosis

Cold Agglutinins and Cryoglobulins Associate With Clinical and Laboratory Parameters of Cold Urticaria.
Bizjak M, Košnik M, Terhorst-Molawi D, Dinevski D, Maurer M
Front Immunol 2021;12:665491. Epub 2021 Apr 29 doi: 10.3389/fimmu.2021.665491. PMID: 33995398Free PMC Article

Supplemental Content

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