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Pulmonary perfusion defect

MedGen UID:
1053610
•Concept ID:
CN377008
•
Finding
HPO: HP:6000412

Definition

Lack of blood perfusion in a specific area of the lung. Pulmonary ventilation (V) and Perfusion (Q) scan, also known as lung V/Q scan, is a nuclear test that uses the perfusion scan to delineate the blood flow distribution and the ventilation scan to measure airflow distribution in the lungs. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary perfusion defect

Professional guidelines

PubMed

Evaluation and Management of Chronic Thromboembolic Pulmonary Hypertension.
Yang J, Madani MM, Mahmud E, Kim NH
Chest 2023 Aug;164(2):490-502. Epub 2023 Mar 28 doi: 10.1016/j.chest.2023.03.029. PMID: 36990148Free PMC Article
Long-term treatment of venous thromboembolism.
Kearon C, Kahn SR
Blood 2020 Jan 30;135(5):317-325. doi: 10.1182/blood.2019002364. PMID: 31917402
Perfusion Scintigraphy in Diagnosis and Management of Thromboembolic Pulmonary Hypertension.
Moradi F, Morris TA, Hoh CK
Radiographics 2019 Jan-Feb;39(1):169-185. doi: 10.1148/rg.2019180074. PMID: 30620694

Recent clinical studies

Etiology

Evaluation of CT angiography obstruction score and pulmonary perfusion defect score using the third-generation dual-source CT for pulmonary embolism.
Hu H, Xie P, Li C, Ni S, Wang H, Li A, Wei H, Li W
Clin Radiol 2023 Sep;78(9):e627-e634. Epub 2023 Jun 2 doi: 10.1016/j.crad.2023.04.017. PMID: 37331850
Pulmonary perfusion defect volume on dual-energy CT: prognostic marker of adverse events in patients with suspected pulmonary embolism.
Foldyna B, Zangeneh FA, Wagner M, Doktorov K, Basmagi S, Matveeva A, Denecke T, Gohmann R, Gutberlet M, Lehmkuhl L
Int J Cardiovasc Imaging 2023 Jul;39(7):1333-1341. Epub 2023 Mar 20 doi: 10.1007/s10554-023-02836-8. PMID: 36939984
Clinical risk stratification of acute pulmonary embolism: comparing the usefulness of CTA obstruction score and pulmonary perfusion defect score with dual-energy CT.
Kong WF, Wang YT, Yin LL, Pu H, Tao KY
Int J Cardiovasc Imaging 2017 Dec;33(12):2039-2047. Epub 2017 Jun 13 doi: 10.1007/s10554-017-1188-x. PMID: 28612276
Assessment of correlation between CT angiographic clot load score, pulmonary perfusion defect score and global right ventricular function with dual-source CT for acute pulmonary embolism.
Zhou Y, Shi H, Wang Y, Kumar AR, Chi B, Han P
Br J Radiol 2012 Jul;85(1015):972-9. Epub 2011 Oct 5 doi: 10.1259/bjr/40850443. PMID: 21976633Free PMC Article
Dual-energy CT for assessment of the severity of acute pulmonary embolism: pulmonary perfusion defect score compared with CT angiographic obstruction score and right ventricular/left ventricular diameter ratio.
Chae EJ, Seo JB, Jang YM, Krauss B, Lee CW, Lee HJ, Song KS
AJR Am J Roentgenol 2010 Mar;194(3):604-10. doi: 10.2214/AJR.09.2681. PMID: 20173135

Diagnosis

Pulmonary perfusion defect volume on dual-energy CT: prognostic marker of adverse events in patients with suspected pulmonary embolism.
Foldyna B, Zangeneh FA, Wagner M, Doktorov K, Basmagi S, Matveeva A, Denecke T, Gohmann R, Gutberlet M, Lehmkuhl L
Int J Cardiovasc Imaging 2023 Jul;39(7):1333-1341. Epub 2023 Mar 20 doi: 10.1007/s10554-023-02836-8. PMID: 36939984
Quantitative lung perfusion blood volume using dual energy CT-based effective atomic number (Z(eff) ) imaging.
Li K, Li Y, Qi Z, Garrett JW, Grist TM, Chen GH
Med Phys 2021 Nov;48(11):6658-6672. Epub 2021 Oct 22 doi: 10.1002/mp.15227. PMID: 34520066Free PMC Article
Clinical risk stratification of acute pulmonary embolism: comparing the usefulness of CTA obstruction score and pulmonary perfusion defect score with dual-energy CT.
Kong WF, Wang YT, Yin LL, Pu H, Tao KY
Int J Cardiovasc Imaging 2017 Dec;33(12):2039-2047. Epub 2017 Jun 13 doi: 10.1007/s10554-017-1188-x. PMID: 28612276
Assessment of correlation between CT angiographic clot load score, pulmonary perfusion defect score and global right ventricular function with dual-source CT for acute pulmonary embolism.
Zhou Y, Shi H, Wang Y, Kumar AR, Chi B, Han P
Br J Radiol 2012 Jul;85(1015):972-9. Epub 2011 Oct 5 doi: 10.1259/bjr/40850443. PMID: 21976633Free PMC Article
Severity assessment of pulmonary embolism using dual energy CT - correlation of a pulmonary perfusion defect score with clinical and morphological parameters of blood oxygenation and right ventricular failure.
Thieme SF, Ashoori N, Bamberg F, Sommer WH, Johnson TR, Leuchte H, Becker A, Maxien D, Helck AD, Behr J, Reiser MF, Nikolaou K
Eur Radiol 2012 Feb;22(2):269-78. Epub 2011 Sep 14 doi: 10.1007/s00330-011-2267-3. PMID: 21913059

Therapy

Pulmonary thromboembolism following angioplasty for membranous occlusion of the vena cava: case report.
Nagata Y, Kumada K, Yamada R, Abe M, Ozawa K
Cardiovasc Intervent Radiol 1989 Nov-1990 Dec;12(6):304-6. doi: 10.1007/BF02575425. PMID: 2534059

Prognosis

Pulmonary perfusion defect volume on dual-energy CT: prognostic marker of adverse events in patients with suspected pulmonary embolism.
Foldyna B, Zangeneh FA, Wagner M, Doktorov K, Basmagi S, Matveeva A, Denecke T, Gohmann R, Gutberlet M, Lehmkuhl L
Int J Cardiovasc Imaging 2023 Jul;39(7):1333-1341. Epub 2023 Mar 20 doi: 10.1007/s10554-023-02836-8. PMID: 36939984
Right to Left Intrapulmonary Shunt in a Case with COVID-19-associated Pneumonia.
Siddique M, Nawaz MK, Khalid MB, Rai A
J Coll Physicians Surg Pak 2021 Jan;31(1):S23-S25. doi: 10.29271/jcpsp.2021.Supp1.S23. PMID: 34530541
Right to Left Intrapulmonary Shunt in a Case with COVID-19-associated Pneumonia.
Siddique M, Nawaz MK, Khalid MB, Rai A
J Coll Physicians Surg Pak 2021 Jan;31(1):S23-S25. doi: 10.29271/jcpsp.2021.01.S23. PMID: 33650419
Clinical risk stratification of acute pulmonary embolism: comparing the usefulness of CTA obstruction score and pulmonary perfusion defect score with dual-energy CT.
Kong WF, Wang YT, Yin LL, Pu H, Tao KY
Int J Cardiovasc Imaging 2017 Dec;33(12):2039-2047. Epub 2017 Jun 13 doi: 10.1007/s10554-017-1188-x. PMID: 28612276
Pulmonary perfusion defect and bronchial artery collateral blood flow.
Neches WH, Weiss FH, Park SC, Lenox CC, Zuberbuhler JR, Carroll RG
JAMA 1977 Oct 24;238(17):1842-4. PMID: 578541

Clinical prediction guides

Evaluation of CT angiography obstruction score and pulmonary perfusion defect score using the third-generation dual-source CT for pulmonary embolism.
Hu H, Xie P, Li C, Ni S, Wang H, Li A, Wei H, Li W
Clin Radiol 2023 Sep;78(9):e627-e634. Epub 2023 Jun 2 doi: 10.1016/j.crad.2023.04.017. PMID: 37331850
Pulmonary perfusion defect volume on dual-energy CT: prognostic marker of adverse events in patients with suspected pulmonary embolism.
Foldyna B, Zangeneh FA, Wagner M, Doktorov K, Basmagi S, Matveeva A, Denecke T, Gohmann R, Gutberlet M, Lehmkuhl L
Int J Cardiovasc Imaging 2023 Jul;39(7):1333-1341. Epub 2023 Mar 20 doi: 10.1007/s10554-023-02836-8. PMID: 36939984
Clinical risk stratification of acute pulmonary embolism: comparing the usefulness of CTA obstruction score and pulmonary perfusion defect score with dual-energy CT.
Kong WF, Wang YT, Yin LL, Pu H, Tao KY
Int J Cardiovasc Imaging 2017 Dec;33(12):2039-2047. Epub 2017 Jun 13 doi: 10.1007/s10554-017-1188-x. PMID: 28612276
Assessment of correlation between CT angiographic clot load score, pulmonary perfusion defect score and global right ventricular function with dual-source CT for acute pulmonary embolism.
Zhou Y, Shi H, Wang Y, Kumar AR, Chi B, Han P
Br J Radiol 2012 Jul;85(1015):972-9. Epub 2011 Oct 5 doi: 10.1259/bjr/40850443. PMID: 21976633Free PMC Article
Severity assessment of pulmonary embolism using dual energy CT - correlation of a pulmonary perfusion defect score with clinical and morphological parameters of blood oxygenation and right ventricular failure.
Thieme SF, Ashoori N, Bamberg F, Sommer WH, Johnson TR, Leuchte H, Becker A, Maxien D, Helck AD, Behr J, Reiser MF, Nikolaou K
Eur Radiol 2012 Feb;22(2):269-78. Epub 2011 Sep 14 doi: 10.1007/s00330-011-2267-3. PMID: 21913059

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