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Elevated natural killer cell count

MedGen UID:
1054022
•Concept ID:
CN377506
•
Finding
HPO: HP:6000677

Definition

The count of natural killer cells per volume of blood is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated natural killer cell count

Professional guidelines

PubMed

PD-1, PD-L1 and PD-L2 Gene Expression on T-Cells and Natural Killer Cells Declines in Conjunction with a Reduction in PD-1 Protein during the Intensive Phase of Tuberculosis Treatment.
Hassan SS, Akram M, King EC, Dockrell HM, Cliff JM
PLoS One 2015;10(9):e0137646. Epub 2015 Sep 11 doi: 10.1371/journal.pone.0137646. PMID: 26359860Free PMC Article
High circulating CD3+CD56+CD16+ natural killer-like T cell levels predict a better IVF treatment outcome.
Zhou J, Zhao X, Wang Z, Wang J, Sun H, Hu Y
J Reprod Immunol 2013 Apr;97(2):197-203. Epub 2013 Feb 27 doi: 10.1016/j.jri.2012.12.006. PMID: 23452704
The relationship of systemic TNF-alpha and IFN-gamma with IVF treatment outcome and peripheral blood NK cells.
Thum MY, Abdalla HI, Bhaskaran S, Harden EL, Ford B, Sumar N, Shehata H, Bansal A
Am J Reprod Immunol 2007 Mar;57(3):210-7. doi: 10.1111/j.1600-0897.2006.00465.x. PMID: 17295900

Recent clinical studies

Etiology

The central role of natural killer cells in preeclampsia.
Wei X, Yang X
Front Immunol 2023;14:1009867. Epub 2023 Feb 14 doi: 10.3389/fimmu.2023.1009867. PMID: 36865565Free PMC Article
Recipient T Cell Exhaustion and Successful Adoptive Transfer of Haploidentical Natural Killer Cells.
Williams RL, Cooley S, Bachanova V, Blazar BR, Weisdorf DJ, Miller JS, Verneris MR
Biol Blood Marrow Transplant 2018 Mar;24(3):618-622. Epub 2017 Nov 29 doi: 10.1016/j.bbmt.2017.11.022. PMID: 29197679Free PMC Article
Natural killer cells in female infertility and recurrent miscarriage: a systematic review and meta-analysis.
Seshadri S, Sunkara SK
Hum Reprod Update 2014 May-Jun;20(3):429-38. Epub 2013 Nov 27 doi: 10.1093/humupd/dmt056. PMID: 24285824
Changes in Natural Killer cell activation and function during primary HIV-1 Infection.
Naranbhai V, Altfeld M, Karim SS, Ndung'u T, Karim QA, Carr WH
PLoS One 2013;8(1):e53251. Epub 2013 Jan 9 doi: 10.1371/journal.pone.0053251. PMID: 23326405Free PMC Article
Exercise immunology: practical applications.
Nieman DC
Int J Sports Med 1997 Mar;18 Suppl 1:S91-100. doi: 10.1055/s-2007-972705. PMID: 9129268

Diagnosis

Uterine Natural Killer Cells in the Context of Implantation: Immunohistochemical Analysis of Endometrial Samples from Women with Habitual Abortion and Recurrent Implantation Failure.
Lapides L, Klein M, Belušáková V, Csöbönyeiová M, Varga I, Babál P
Physiol Res 2022 Dec 27;71(Suppl 1):S99-S105. doi: 10.33549/physiolres.935012. PMID: 36592445Free PMC Article
Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning.
McCurdy SR, Radojcic V, Tsai HL, Vulic A, Thompson E, Ivcevic S, Kanakry CG, Powell JD, Lohman B, Adom D, Paczesny S, Cooke KR, Jones RJ, Varadhan R, Symons HJ, Luznik L
Blood 2022 Jan 27;139(4):608-623. doi: 10.1182/blood.2021013054. PMID: 34657151Free PMC Article
Are uterine natural killer and plasma cells in infertility patients associated with endometriosis, repeated implantation failure, or recurrent pregnancy loss?
Freitag N, Pour SJ, Fehm TN, Toth B, Markert UR, Weber M, Togawa R, Kruessel JS, Baston-Buest DM, Bielfeld AP
Arch Gynecol Obstet 2020 Dec;302(6):1487-1494. Epub 2020 Jul 14 doi: 10.1007/s00404-020-05679-z. PMID: 32666129Free PMC Article
Natural killer cells in female infertility and recurrent miscarriage: a systematic review and meta-analysis.
Seshadri S, Sunkara SK
Hum Reprod Update 2014 May-Jun;20(3):429-38. Epub 2013 Nov 27 doi: 10.1093/humupd/dmt056. PMID: 24285824
Exercise immunology: practical applications.
Nieman DC
Int J Sports Med 1997 Mar;18 Suppl 1:S91-100. doi: 10.1055/s-2007-972705. PMID: 9129268

Therapy

The causal role of circulating immunity-inflammation in preeclampsia: A Mendelian randomization.
Xue X, Guo C, Fan C, Lei D
J Clin Hypertens (Greenwich) 2024 May;26(5):474-482. Epub 2024 Mar 12 doi: 10.1111/jch.14775. PMID: 38476059Free PMC Article
Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning.
McCurdy SR, Radojcic V, Tsai HL, Vulic A, Thompson E, Ivcevic S, Kanakry CG, Powell JD, Lohman B, Adom D, Paczesny S, Cooke KR, Jones RJ, Varadhan R, Symons HJ, Luznik L
Blood 2022 Jan 27;139(4):608-623. doi: 10.1182/blood.2021013054. PMID: 34657151Free PMC Article
Immunological Characteristics in Type 2 Diabetes Mellitus Among COVID-19 Patients.
Han M, Ma K, Wang X, Yan W, Wang H, You J, Wang Q, Chen H, Guo W, Chen T, Ning Q, Luo X
Front Endocrinol (Lausanne) 2021;12:596518. Epub 2021 Mar 11 doi: 10.3389/fendo.2021.596518. PMID: 33776910Free PMC Article
Recipient T Cell Exhaustion and Successful Adoptive Transfer of Haploidentical Natural Killer Cells.
Williams RL, Cooley S, Bachanova V, Blazar BR, Weisdorf DJ, Miller JS, Verneris MR
Biol Blood Marrow Transplant 2018 Mar;24(3):618-622. Epub 2017 Nov 29 doi: 10.1016/j.bbmt.2017.11.022. PMID: 29197679Free PMC Article
NK cell recruitment and exercise: Potential immunotherapeutic role of shear stress and endothelial health.
Evans W
Med Hypotheses 2017 Nov;109:170-173. Epub 2017 Oct 17 doi: 10.1016/j.mehy.2017.10.015. PMID: 29150280

Prognosis

Clinical and immunological characteristics and prognosis of patients with autoantibody negative dermatomyositis: a case control study.
Xing X, Gan Y, Mo W, Zhang J, Wang N, Zhang K, Ma K, Zhang L, Ma L, Lu D, Li Y, He J
Clin Rheumatol 2024 Mar;43(3):1145-1154. Epub 2024 Feb 7 doi: 10.1007/s10067-024-06873-z. PMID: 38326675
The Innate Immune System and Cardiovascular Disease in ESKD: Monocytes and Natural Killer Cells.
Dounousi E, Duni A, Naka KK, Vartholomatos G, Zoccali C
Curr Vasc Pharmacol 2021;19(1):63-76. doi: 10.2174/1570161118666200628024027. PMID: 32600233
Lymphocyte Subset Counts in COVID-19 Patients: A Meta-Analysis.
Huang W, Berube J, McNamara M, Saksena S, Hartman M, Arshad T, Bornheimer SJ, O'Gorman M
Cytometry A 2020 Aug;97(8):772-776. Epub 2020 Jul 18 doi: 10.1002/cyto.a.24172. PMID: 32542842Free PMC Article
Recipient T Cell Exhaustion and Successful Adoptive Transfer of Haploidentical Natural Killer Cells.
Williams RL, Cooley S, Bachanova V, Blazar BR, Weisdorf DJ, Miller JS, Verneris MR
Biol Blood Marrow Transplant 2018 Mar;24(3):618-622. Epub 2017 Nov 29 doi: 10.1016/j.bbmt.2017.11.022. PMID: 29197679Free PMC Article
Natural killer cells in female infertility and recurrent miscarriage: a systematic review and meta-analysis.
Seshadri S, Sunkara SK
Hum Reprod Update 2014 May-Jun;20(3):429-38. Epub 2013 Nov 27 doi: 10.1093/humupd/dmt056. PMID: 24285824

Clinical prediction guides

Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning.
McCurdy SR, Radojcic V, Tsai HL, Vulic A, Thompson E, Ivcevic S, Kanakry CG, Powell JD, Lohman B, Adom D, Paczesny S, Cooke KR, Jones RJ, Varadhan R, Symons HJ, Luznik L
Blood 2022 Jan 27;139(4):608-623. doi: 10.1182/blood.2021013054. PMID: 34657151Free PMC Article
The Innate Immune System and Cardiovascular Disease in ESKD: Monocytes and Natural Killer Cells.
Dounousi E, Duni A, Naka KK, Vartholomatos G, Zoccali C
Curr Vasc Pharmacol 2021;19(1):63-76. doi: 10.2174/1570161118666200628024027. PMID: 32600233
Impaired natural killer cell counts and cytolytic activity in patients with severe COVID-19.
Osman M, Faridi RM, Sligl W, Shabani-Rad MT, Dharmani-Khan P, Parker A, Kalra A, Tripathi MB, Storek J, Cohen Tervaert JW, Khan FM
Blood Adv 2020 Oct 27;4(20):5035-5039. doi: 10.1182/bloodadvances.2020002650. PMID: 33075136Free PMC Article
Lymphocyte Subset Counts in COVID-19 Patients: A Meta-Analysis.
Huang W, Berube J, McNamara M, Saksena S, Hartman M, Arshad T, Bornheimer SJ, O'Gorman M
Cytometry A 2020 Aug;97(8):772-776. Epub 2020 Jul 18 doi: 10.1002/cyto.a.24172. PMID: 32542842Free PMC Article
Recipient T Cell Exhaustion and Successful Adoptive Transfer of Haploidentical Natural Killer Cells.
Williams RL, Cooley S, Bachanova V, Blazar BR, Weisdorf DJ, Miller JS, Verneris MR
Biol Blood Marrow Transplant 2018 Mar;24(3):618-622. Epub 2017 Nov 29 doi: 10.1016/j.bbmt.2017.11.022. PMID: 29197679Free PMC Article

Recent systematic reviews

The Effect of Acute Physical Exercise on NK-Cell Cytolytic Activity: A Systematic Review and Meta-Analysis.
Rumpf C, Proschinger S, Schenk A, Bloch W, Lampit A, Javelle F, Zimmer P
Sports Med 2021 Mar;51(3):519-530. Epub 2021 Jan 4 doi: 10.1007/s40279-020-01402-9. PMID: 33398798Free PMC Article
The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.
Akbari H, Tabrizi R, Lankarani KB, Aria H, Vakili S, Asadian F, Noroozi S, Keshavarz P, Faramarz S
Life Sci 2020 Oct 1;258:118167. Epub 2020 Jul 29 doi: 10.1016/j.lfs.2020.118167. PMID: 32735885Free PMC Article
Natural killer cells in female infertility and recurrent miscarriage: a systematic review and meta-analysis.
Seshadri S, Sunkara SK
Hum Reprod Update 2014 May-Jun;20(3):429-38. Epub 2013 Nov 27 doi: 10.1093/humupd/dmt056. PMID: 24285824

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