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Abnormal leukocyte morphology

MedGen UID:
508852
•Concept ID:
C0152009
•
Finding
Synonym: Abnormal leukocyte function
SNOMED CT: Abnormal white blood cell (24827003); Abnormal leukocyte (24827003); White blood cell abnormality (134199001); White blood cell abnormality (24827003)
 
HPO: HP:0001881

Definition

An abnormality of leukocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal leukocyte morphology

Professional guidelines

PubMed

The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options.
Periman LM, Perez VL, Saban DR, Lin MC, Neri P
J Ocul Pharmacol Ther 2020 Apr;36(3):137-146. Epub 2020 Mar 12 doi: 10.1089/jop.2019.0060. PMID: 32175799Free PMC Article
Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome.
Tchirikov M, Schlabritz-Loutsevitch N, Maher J, Buchmann J, Naberezhnev Y, Winarno AS, Seliger G
J Perinat Med 2018 Jul 26;46(5):465-488. doi: 10.1515/jpm-2017-0027. PMID: 28710882
Hyperleukocytosis and leukostasis: management of a medical emergency.
Giammarco S, Chiusolo P, Piccirillo N, Di Giovanni A, Metafuni E, Laurenti L, Sica S, Pagano L
Expert Rev Hematol 2017 Feb;10(2):147-154. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270754. PMID: 27967252

Recent clinical studies

Etiology

Primary and secondary defects of the thymus.
Dinges SS, Amini K, Notarangelo LD, Delmonte OM
Immunol Rev 2024 Mar;322(1):178-211. Epub 2024 Jan 16 doi: 10.1111/imr.13306. PMID: 38228406Free PMC Article
Computational analysis of peripheral blood smears detects disease-associated cytomorphologies.
de Almeida JG, Gudgin E, Besser M, Dunn WG, Cooper J, Haferlach T, Vassiliou GS, Gerstung M
Nat Commun 2023 Jul 20;14(1):4378. doi: 10.1038/s41467-023-39676-y. PMID: 37474506Free PMC Article
Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Peripheral Mononuclear Cells in Patients With Ankylosing Spondylitis.
Xu H, Yu H, Liu L, Wu H, Zhang C, Cai W, Hong X, Liu D, Tang D, Dai Y
Front Immunol 2021;12:760381. Epub 2021 Nov 22 doi: 10.3389/fimmu.2021.760381. PMID: 34880858Free PMC Article
Histopathology of laryngomalacia.
Gan RWC, Moustafa A, Turner K, Knight L
Acta Otolaryngol 2021 Jan;141(1):85-88. Epub 2020 Oct 14 doi: 10.1080/00016489.2020.1821246. PMID: 33393421
Nuclear medicine imaging of bone infections.
Love C, Palestro CJ
Clin Radiol 2016 Jul;71(7):632-46. Epub 2016 Feb 17 doi: 10.1016/j.crad.2016.01.003. PMID: 26897336

Diagnosis

Primary and secondary defects of the thymus.
Dinges SS, Amini K, Notarangelo LD, Delmonte OM
Immunol Rev 2024 Mar;322(1):178-211. Epub 2024 Jan 16 doi: 10.1111/imr.13306. PMID: 38228406Free PMC Article
POEMS Syndrome: Diagnosis and Investigative Work-up.
Dispenzieri A, Kourelis T, Buadi F
Hematol Oncol Clin North Am 2018 Feb;32(1):119-139. doi: 10.1016/j.hoc.2017.09.010. PMID: 29157614
Nuclear medicine imaging of bone infections.
Love C, Palestro CJ
Clin Radiol 2016 Jul;71(7):632-46. Epub 2016 Feb 17 doi: 10.1016/j.crad.2016.01.003. PMID: 26897336
How to approach chronic anemia.
Koury MJ, Rhodes M
Hematology Am Soc Hematol Educ Program 2012;2012:183-90. doi: 10.1182/asheducation-2012.1.183. PMID: 23233579
Why does my patient have leukocytosis?
Cerny J, Rosmarin AG
Hematol Oncol Clin North Am 2012 Apr;26(2):303-19, viii. Epub 2012 Feb 17 doi: 10.1016/j.hoc.2012.01.001. PMID: 22463829

Therapy

NK cell-based cancer immunotherapy: from basic biology to clinical development.
Liu S, Galat V, Galat Y, Lee YKA, Wainwright D, Wu J
J Hematol Oncol 2021 Jan 6;14(1):7. doi: 10.1186/s13045-020-01014-w. PMID: 33407739Free PMC Article
Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia.
Wang J, Xu Y, Chen Z, Liang J, Lin Z, Liang H, Xu Y, Wu Q, Guo X, Nie J, Lu B, Huang B, Xian H, Wang X, Wu Q, Zeng J, Chai C, Zhang M, Lin Y, Zhang L, Zhao S, Tong Y, Zeng L, Gu X, Chen ZG, Yi S, Zhang T, Delfouneso D, Zhang Y, Nutt SL, Lew AM, Lu L, Bai F, Xia H, Wen Z, Zhang Y
Cell 2020 Dec 23;183(7):1867-1883.e26. Epub 2020 Nov 27 doi: 10.1016/j.cell.2020.10.048. PMID: 33248023
B Cell Abnormalities in Systemic Lupus Erythematosus and Lupus Nephritis-Role in Pathogenesis and Effect of Immunosuppressive Treatments.
Yap DYH, Chan TM
Int J Mol Sci 2019 Dec 10;20(24) doi: 10.3390/ijms20246231. PMID: 31835612Free PMC Article
Biliary atresia: A comprehensive review.
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Chediak-Higashi syndrome.
Barak Y, Nir E
Am J Pediatr Hematol Oncol 1987 Spring;9(1):42-55. doi: 10.1097/00043426-198721000-00008. PMID: 3296821

Prognosis

Neutropenia and leukemia development: genetic risk factors and prognosis.
Shahrabi S, Maleknia M, Tavakolifar Y, D Zayeri Z, Saki N
Leuk Lymphoma 2019 Dec;60(14):3363-3374. Epub 2019 Jun 19 doi: 10.1080/10428194.2019.1630622. PMID: 31213100
A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer.
Wagner J, Rapsomaniki MA, Chevrier S, Anzeneder T, Langwieder C, Dykgers A, Rees M, Ramaswamy A, Muenst S, Soysal SD, Jacobs A, Windhager J, Silina K, van den Broek M, Dedes KJ, Rodríguez Martínez M, Weber WP, Bodenmiller B
Cell 2019 May 16;177(5):1330-1345.e18. Epub 2019 Apr 11 doi: 10.1016/j.cell.2019.03.005. PMID: 30982598Free PMC Article
Biliary atresia: A comprehensive review.
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Nuclear medicine imaging of bone infections.
Love C, Palestro CJ
Clin Radiol 2016 Jul;71(7):632-46. Epub 2016 Feb 17 doi: 10.1016/j.crad.2016.01.003. PMID: 26897336
Malaria: a haematological disease.
Akinosoglou KS, Solomou EE, Gogos CA
Hematology 2012 Mar;17(2):106-14. doi: 10.1179/102453312X13221316477336. PMID: 22664049

Clinical prediction guides

Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Peripheral Mononuclear Cells in Patients With Ankylosing Spondylitis.
Xu H, Yu H, Liu L, Wu H, Zhang C, Cai W, Hong X, Liu D, Tang D, Dai Y
Front Immunol 2021;12:760381. Epub 2021 Nov 22 doi: 10.3389/fimmu.2021.760381. PMID: 34880858Free PMC Article
Telomere Length and Male Fertility.
Gentiluomo M, Luddi A, Cingolani A, Fornili M, Governini L, Lucenteforte E, Baglietto L, Piomboni P, Campa D
Int J Mol Sci 2021 Apr 12;22(8) doi: 10.3390/ijms22083959. PMID: 33921254Free PMC Article
Artificial intelligence and leukocyte epigenomics: Evaluation and prediction of late-onset Alzheimer's disease.
Bahado-Singh RO, Vishweswaraiah S, Aydas B, Yilmaz A, Metpally RP, Carey DJ, Crist RC, Berrettini WH, Wilson GD, Imam K, Maddens M, Bisgin H, Graham SF, Radhakrishna U
PLoS One 2021;16(3):e0248375. Epub 2021 Mar 31 doi: 10.1371/journal.pone.0248375. PMID: 33788842Free PMC Article
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.
Collins MH, Martin LJ, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE, Abonia JP, Mukkada VA, Franciosi JP, Rothenberg ME
Dis Esophagus 2017 Feb 1;30(3):1-8. doi: 10.1111/dote.12470. PMID: 26857345Free PMC Article
Nuclear medicine imaging of bone infections.
Love C, Palestro CJ
Clin Radiol 2016 Jul;71(7):632-46. Epub 2016 Feb 17 doi: 10.1016/j.crad.2016.01.003. PMID: 26897336

Recent systematic reviews

Mechanisms of Peritoneal Fibrosis: Focus on Immune Cells-Peritoneal Stroma Interactions.
Terri M, Trionfetti F, Montaldo C, Cordani M, Tripodi M, Lopez-Cabrera M, Strippoli R
Front Immunol 2021;12:607204. Epub 2021 Mar 29 doi: 10.3389/fimmu.2021.607204. PMID: 33854496Free PMC Article
Neutropenia in patients with hyperthyroidism: Systematic review and meta-analysis.
Scappaticcio L, Maiorino MI, Maio A, Esposito K, Bellastella G
Clin Endocrinol (Oxf) 2021 Mar;94(3):473-483. Epub 2020 Sep 1 doi: 10.1111/cen.14313. PMID: 32799342
Cellular models to study bipolar disorder: A systematic review.
Viswanath B, Jose SP, Squassina A, Thirthalli J, Purushottam M, Mukherjee O, Vladimirov V, Patrinos GP, Del Zompo M, Jain S
J Affect Disord 2015 Sep 15;184:36-50. Epub 2015 May 28 doi: 10.1016/j.jad.2015.05.037. PMID: 26070045
Variability in diagnostic criteria for eosinophilic esophagitis: a systematic review.
Dellon ES, Aderoju A, Woosley JT, Sandler RS, Shaheen NJ
Am J Gastroenterol 2007 Oct;102(10):2300-13. Epub 2007 Jul 7 doi: 10.1111/j.1572-0241.2007.01396.x. PMID: 17617209
The influence of diabetes on the periodontal tissues.
Ryan ME, Carnu O, Kamer A
J Am Dent Assoc 2003 Oct;134 Spec No:34S-40S. doi: 10.14219/jada.archive.2003.0370. PMID: 18196671

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