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Extrahepatic bile duct adenocarcinoma

MedGen UID:
124642
•Concept ID:
C0279659
•
Neoplastic Process
Synonyms: Adenocarcinoma of Extrahepatic Bile Duct; adenocarcinoma of extrahepatic bile duct; Adenocarcinoma of the Extrahepatic Bile Duct; adenocarcinoma of the extrahepatic bile duct; Extrahepatic Bile Duct Adenocarcinoma; extrahepatic bile duct adenocarcinoma
 
Monarch Initiative: MONDO:0002665

Definition

An adenocarcinoma arising from the epithelium of the extrahepatic bile ducts. Signs and symptoms include abdominal pain, anorexia, jaundice, pruritus, nausea and vomiting, and weight loss. [from NCI]

Professional guidelines

PubMed

The utility of villin and mammaglobin in the differential diagnosis between intrahepatic cholangiocarcinoma and breast cancer.
Yang Z
Appl Immunohistochem Mol Morphol 2015 Jan;23(1):19-25. doi: 10.1097/PAI.0000000000000035. PMID: 25153498

Recent clinical studies

Etiology

Differentiation grade for extrahepatic bile duct adenocarcinoma: Assessed by diffusion-weighted imaging at 3.0-T MR.
Huang XQ, Shu J, Luo L, Jin ML, Lu XF, Yang SG
Eur J Radiol 2016 Nov;85(11):1980-1986. Epub 2016 Sep 9 doi: 10.1016/j.ejrad.2016.09.004. PMID: 27776649
Efficacy and safety of S-1 monotherapy in patients with advanced biliary tract adenocarcinoma: retrospective analysis of 162 patients.
Park I, Lee JL, Ryu MH, Kim TW, Chang HM, Lee SS, Sohn BS, Kim EK, Park DH, Lee SS, Suh DW, Lee SK, Kim MH, Lee J
Oncology 2009;76(2):126-32. Epub 2009 Jan 22 doi: 10.1159/000195538. PMID: 19158445
Extrahepatic bile duct adenocarcinoma: patients at high-risk for local recurrence treated with surgery and adjuvant chemoradiation have an equivalent overall survival to patients with standard-risk treated with surgery alone.
Borghero Y, Crane CH, Szklaruk J, Oyarzo M, Curley S, Pisters PW, Evans D, Abdalla EK, Thomas MB, Das P, Wistuba II, Krishnan S, Vauthey JN
Ann Surg Oncol 2008 Nov;15(11):3147-56. Epub 2008 Aug 27 doi: 10.1245/s10434-008-9998-7. PMID: 18754070
Comparison between pancreatoduodenectomy and hepatopancreatoduodenectomy for bile duct cancer.
Yoshimi F, Asato Y, Amemiya R, Shioyama Y, Itabashi M
Hepatogastroenterology 2001 Jul-Aug;48(40):994-8. PMID: 11490856

Diagnosis

Differentiation grade for extrahepatic bile duct adenocarcinoma: Assessed by diffusion-weighted imaging at 3.0-T MR.
Huang XQ, Shu J, Luo L, Jin ML, Lu XF, Yang SG
Eur J Radiol 2016 Nov;85(11):1980-1986. Epub 2016 Sep 9 doi: 10.1016/j.ejrad.2016.09.004. PMID: 27776649
The utility of villin and mammaglobin in the differential diagnosis between intrahepatic cholangiocarcinoma and breast cancer.
Yang Z
Appl Immunohistochem Mol Morphol 2015 Jan;23(1):19-25. doi: 10.1097/PAI.0000000000000035. PMID: 25153498
Extrahepatic bile duct adenocarcinoma: patients at high-risk for local recurrence treated with surgery and adjuvant chemoradiation have an equivalent overall survival to patients with standard-risk treated with surgery alone.
Borghero Y, Crane CH, Szklaruk J, Oyarzo M, Curley S, Pisters PW, Evans D, Abdalla EK, Thomas MB, Das P, Wistuba II, Krishnan S, Vauthey JN
Ann Surg Oncol 2008 Nov;15(11):3147-56. Epub 2008 Aug 27 doi: 10.1245/s10434-008-9998-7. PMID: 18754070
Radiochemotherapy followed by gemcitabine and capecitabine in extrahepatic bile duct cancer: a phase I/II trial.
Schoppmeyer K, Miethe S, Wiedmann M, Liebmann A, Hauss J, Mossner J, Caca K, Witzigmann H, Hildebrandt G
Am J Clin Oncol 2006 Dec;29(6):576-82. doi: 10.1097/01.coc.0000239167.17922.82. PMID: 17148994
Comparison between pancreatoduodenectomy and hepatopancreatoduodenectomy for bile duct cancer.
Yoshimi F, Asato Y, Amemiya R, Shioyama Y, Itabashi M
Hepatogastroenterology 2001 Jul-Aug;48(40):994-8. PMID: 11490856

Therapy

Efficacy and safety of S-1 monotherapy in patients with advanced biliary tract adenocarcinoma: retrospective analysis of 162 patients.
Park I, Lee JL, Ryu MH, Kim TW, Chang HM, Lee SS, Sohn BS, Kim EK, Park DH, Lee SS, Suh DW, Lee SK, Kim MH, Lee J
Oncology 2009;76(2):126-32. Epub 2009 Jan 22 doi: 10.1159/000195538. PMID: 19158445
Extrahepatic bile duct adenocarcinoma: patients at high-risk for local recurrence treated with surgery and adjuvant chemoradiation have an equivalent overall survival to patients with standard-risk treated with surgery alone.
Borghero Y, Crane CH, Szklaruk J, Oyarzo M, Curley S, Pisters PW, Evans D, Abdalla EK, Thomas MB, Das P, Wistuba II, Krishnan S, Vauthey JN
Ann Surg Oncol 2008 Nov;15(11):3147-56. Epub 2008 Aug 27 doi: 10.1245/s10434-008-9998-7. PMID: 18754070
Radiochemotherapy followed by gemcitabine and capecitabine in extrahepatic bile duct cancer: a phase I/II trial.
Schoppmeyer K, Miethe S, Wiedmann M, Liebmann A, Hauss J, Mossner J, Caca K, Witzigmann H, Hildebrandt G
Am J Clin Oncol 2006 Dec;29(6):576-82. doi: 10.1097/01.coc.0000239167.17922.82. PMID: 17148994
A fatal overdose of the ergot derivative cabergoline.
Johansen SS, Karkov J
Forensic Sci Int 2004 Nov 10;146(1):47-51. doi: 10.1016/j.forsciint.2004.03.013. PMID: 15485721

Prognosis

Differentiation grade for extrahepatic bile duct adenocarcinoma: Assessed by diffusion-weighted imaging at 3.0-T MR.
Huang XQ, Shu J, Luo L, Jin ML, Lu XF, Yang SG
Eur J Radiol 2016 Nov;85(11):1980-1986. Epub 2016 Sep 9 doi: 10.1016/j.ejrad.2016.09.004. PMID: 27776649
Adequate lymph node assessment for extrahepatic bile duct adenocarcinoma.
Ito K, Ito H, Allen PJ, Gonen M, Klimstra D, D'Angelica MI, Fong Y, DeMatteo RP, Brennan MF, Blumgart LH, Jarnagin WR
Ann Surg 2010 Apr;251(4):675-81. doi: 10.1097/SLA.0b013e3181d3d2b2. PMID: 20224368
Expression of syndecan-1 and E-cadherin is inversely correlated with poor patient's prognosis and recurrent status of extrahepatic bile duct carcinoma.
Ohashi M, Kusumi T, Sato F, Kudo Y, Jin H, Akasaka H, Miyamoto K, Toyoki Y, Hakamada K, Kijima H
Biomed Res 2009 Apr;30(2):79-86. doi: 10.2220/biomedres.30.79. PMID: 19420730
Efficacy and safety of S-1 monotherapy in patients with advanced biliary tract adenocarcinoma: retrospective analysis of 162 patients.
Park I, Lee JL, Ryu MH, Kim TW, Chang HM, Lee SS, Sohn BS, Kim EK, Park DH, Lee SS, Suh DW, Lee SK, Kim MH, Lee J
Oncology 2009;76(2):126-32. Epub 2009 Jan 22 doi: 10.1159/000195538. PMID: 19158445
Extrahepatic bile duct adenocarcinoma: patients at high-risk for local recurrence treated with surgery and adjuvant chemoradiation have an equivalent overall survival to patients with standard-risk treated with surgery alone.
Borghero Y, Crane CH, Szklaruk J, Oyarzo M, Curley S, Pisters PW, Evans D, Abdalla EK, Thomas MB, Das P, Wistuba II, Krishnan S, Vauthey JN
Ann Surg Oncol 2008 Nov;15(11):3147-56. Epub 2008 Aug 27 doi: 10.1245/s10434-008-9998-7. PMID: 18754070

Clinical prediction guides

Differentiation grade for extrahepatic bile duct adenocarcinoma: Assessed by diffusion-weighted imaging at 3.0-T MR.
Huang XQ, Shu J, Luo L, Jin ML, Lu XF, Yang SG
Eur J Radiol 2016 Nov;85(11):1980-1986. Epub 2016 Sep 9 doi: 10.1016/j.ejrad.2016.09.004. PMID: 27776649
Pathologic observations of the duodenum in 615 consecutive duodenal specimens in a single Japanese hospital: II. malignant lesions.
Terada T
Int J Clin Exp Pathol 2012;5(1):52-7. Epub 2012 Jan 1 PMID: 22295147Free PMC Article
Expression of syndecan-1 and E-cadherin is inversely correlated with poor patient's prognosis and recurrent status of extrahepatic bile duct carcinoma.
Ohashi M, Kusumi T, Sato F, Kudo Y, Jin H, Akasaka H, Miyamoto K, Toyoki Y, Hakamada K, Kijima H
Biomed Res 2009 Apr;30(2):79-86. doi: 10.2220/biomedres.30.79. PMID: 19420730
Radiochemotherapy followed by gemcitabine and capecitabine in extrahepatic bile duct cancer: a phase I/II trial.
Schoppmeyer K, Miethe S, Wiedmann M, Liebmann A, Hauss J, Mossner J, Caca K, Witzigmann H, Hildebrandt G
Am J Clin Oncol 2006 Dec;29(6):576-82. doi: 10.1097/01.coc.0000239167.17922.82. PMID: 17148994

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