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Extrahepatic Bile Duct Adenocarcinoma, Biliary Type

MedGen UID:
474759
•Concept ID:
C3273126
•
Neoplastic Process

Definition

A well or moderately differentiated adenocarcinoma that arises from the extrahepatic bile ducts. It is characterized by the presence of malignant tubular glands. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtrahepatic Bile Duct Adenocarcinoma, Biliary Type

Professional guidelines

PubMed

A statement by the Japan-Korea expert pathologists for future clinicopathological and molecular analyses toward consensus building of intraductal papillary neoplasm of the bile duct through several opinions at the present stage.
Nakanuma Y, Jang KT, Fukushima N, Furukawa T, Hong SM, Kim H, Lee KB, Zen Y, Jang JY, Kubota K
J Hepatobiliary Pancreat Sci 2018 Mar;25(3):181-187. Epub 2018 Feb 12 doi: 10.1002/jhbp.532. PMID: 29272078
Surgical Treatment of Ampullary Adenocarcinoma - Single Center Experience and a Review of Literature.
Kunovský L, Kala Z, Procházka V, Potrusil M, Dastych M, Novotný I, Andrasina T, Pavlovský Z, Eid M, Moravcik P
Klin Onkol 2017 Winter;31(1):46-52. doi: 10.14735/amko201846. PMID: 29488778
Asia-Pacific consensus recommendations for endoscopic and interventional management of hilar cholangiocarcinoma.
Rerknimitr R, Angsuwatcharakon P, Ratanachu-ek T, Khor CJ, Ponnudurai R, Moon JH, Seo DW, Pantongrag-Brown L, Sangchan A, Pisespongsa P, Akaraviputh T, Reddy ND, Maydeo A, Itoi T, Pausawasdi N, Punamiya S, Attasaranya S, Devereaux B, Ramchandani M, Goh KL; Asia-Pacific Working Group on Hepatobiliary Cancers
J Gastroenterol Hepatol 2013 Apr;28(4):593-607. doi: 10.1111/jgh.12128. PMID: 23350673

Recent clinical studies

Etiology

Cholangiocarcinoma: Pathologic and Molecular Classification in the Era of Precision Medicine.
Gopal P, Robert ME, Zhang X
Arch Pathol Lab Med 2024 Mar 1;148(3):359-370. doi: 10.5858/arpa.2022-0537-RA. PMID: 37327187
Imaging Features of Premalignant Biliary Lesions and Predisposing Conditions with Pathologic Correlation.
Zulfiqar M, Chatterjee D, Yoneda N, Hoegger MJ, Ronot M, Hecht EM, Bastati N, Ba-Ssalamah A, Bashir MR, Fowler K
Radiographics 2022 Sep-Oct;42(5):1320-1337. Epub 2022 Aug 5 doi: 10.1148/rg.210194. PMID: 35930475
Menopausal hormone therapy and risk of biliary tract cancers.
Jackson SS, Pfeiffer RM, Gabbi C, Anderson L, Gadalla SM, Koshiol J
Hepatology 2022 Feb;75(2):309-321. doi: 10.1002/hep.32198. PMID: 34766362Free PMC Article
Comparison of Clinicopathological Features of Biliary Neuroendocrine Carcinoma with Adenocarcinoma.
Shiihara M, Higuchi R, Furukawa T, Yazawa T, Uemura S, Izumo W, Yamamoto M
Dig Surg 2021;38(1):30-37. Epub 2020 Jun 22 doi: 10.1159/000508443. PMID: 32570243
Helicobacter Species are Possible Risk Factors of Cholangiocarcinoma.
Kaewpitoon SJ, Loyd RA, Rujirakul R, Panpimanmas S, Matrakool L, Tongtawee T, Kootanavanichpong N, Pengsaa P, Kompor P, Chavengkun W, Kujapun J, Norkaew J, Ponphimai S, Padchasuwan N, Polsripradist P, Eksanti T, Phatisena T, Kaewpitoon N
Asian Pac J Cancer Prev 2016;17(1):37-44. doi: 10.7314/apjcp.2016.17.1.37. PMID: 26838240

Diagnosis

Imaging Features of Premalignant Biliary Lesions and Predisposing Conditions with Pathologic Correlation.
Zulfiqar M, Chatterjee D, Yoneda N, Hoegger MJ, Ronot M, Hecht EM, Bastati N, Ba-Ssalamah A, Bashir MR, Fowler K
Radiographics 2022 Sep-Oct;42(5):1320-1337. Epub 2022 Aug 5 doi: 10.1148/rg.210194. PMID: 35930475
Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct.
Sakai Y, Ohtsuka M, Sugiyama H, Mikata R, Yasui S, Ohno I, Iino Y, Kato J, Tsuyuguchi T, Kato N
World J Gastroenterol 2021 Apr 21;27(15):1569-1577. doi: 10.3748/wjg.v27.i15.1569. PMID: 33958844Free PMC Article
Intrahepatic cholangiocarcinoma.
Nakano M, Ariizumi SI, Yamamoto M
Semin Diagn Pathol 2017 Mar;34(2):160-166. Epub 2017 Jan 5 doi: 10.1053/j.semdp.2016.12.012. PMID: 28094162
"Biliary Diseases with Pancreatic Counterparts": Cross-sectional Imaging Findings.
Katabathina VS, Flaherty EM, Dasyam AK, Menias CO, Riddle ND, Lath N, Kozaka K, Matsui O, Nakanuma Y, Prasad SR
Radiographics 2016 Mar-Apr;36(2):374-92. Epub 2016 Feb 1 doi: 10.1148/rg.2016150071. PMID: 26824512
Cholangiocarcinoma.
Khan SA, Thomas HC, Davidson BR, Taylor-Robinson SD
Lancet 2005 Oct 8;366(9493):1303-14. doi: 10.1016/S0140-6736(05)67530-7. PMID: 16214602

Therapy

Menopausal hormone therapy and risk of biliary tract cancers.
Jackson SS, Pfeiffer RM, Gabbi C, Anderson L, Gadalla SM, Koshiol J
Hepatology 2022 Feb;75(2):309-321. doi: 10.1002/hep.32198. PMID: 34766362Free PMC Article
The role of minimally invasive surgery in the treatment of cholangiocarcinoma.
Levi Sandri GB, Spoletini G, Mascianà G, Colasanti M, Lepiane P, Vennarecci G, D'Andrea V, Ettorre GM
Eur J Surg Oncol 2017 Sep;43(9):1617-1621. Epub 2017 Mar 3 doi: 10.1016/j.ejso.2017.02.012. PMID: 28292628
Adenocarcinoma of the ampulla of Vater: what treatment options are available?
Senatore FJ, Ynson ML, Dasanu CA
J Oncol Pharm Pract 2015 Oct;21(5):364-9. Epub 2014 Jun 5 doi: 10.1177/1078155214538086. PMID: 24906539
Hepatobiliary cancers, version 2.2014.
Benson AB 3rd, D'Angelica MI, Abrams TA, Are C, Bloomston PM, Chang DT, Clary BM, Covey AM, Ensminger WD, Iyer R, Kelley RK, Linehan D, Malafa MP, Meranze SG, Park JO, Pawlik T, Posey JA, Scaife C, Schefter T, Sigurdson ER, Tian GG, Vauthey JN, Venook AP, Yen Y, Zhu AX, Hoffmann KG, McMillian NR, Sundar H
J Natl Compr Canc Netw 2014 Aug;12(8):1152-82. doi: 10.6004/jnccn.2014.0112. PMID: 25099447
Treatment and Prognosis for Patients With Intrahepatic Cholangiocarcinoma: Systematic Review and Meta-analysis.
Mavros MN, Economopoulos KP, Alexiou VG, Pawlik TM
JAMA Surg 2014 Jun;149(6):565-74. doi: 10.1001/jamasurg.2013.5137. PMID: 24718873

Prognosis

Imaging Features of Premalignant Biliary Lesions and Predisposing Conditions with Pathologic Correlation.
Zulfiqar M, Chatterjee D, Yoneda N, Hoegger MJ, Ronot M, Hecht EM, Bastati N, Ba-Ssalamah A, Bashir MR, Fowler K
Radiographics 2022 Sep-Oct;42(5):1320-1337. Epub 2022 Aug 5 doi: 10.1148/rg.210194. PMID: 35930475
Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct.
Sakai Y, Ohtsuka M, Sugiyama H, Mikata R, Yasui S, Ohno I, Iino Y, Kato J, Tsuyuguchi T, Kato N
World J Gastroenterol 2021 Apr 21;27(15):1569-1577. doi: 10.3748/wjg.v27.i15.1569. PMID: 33958844Free PMC Article
Functions of FGFR2 corrupted by translocations in intrahepatic cholangiocarcinoma.
Li F, Peiris MN, Donoghue DJ
Cytokine Growth Factor Rev 2020 Apr;52:56-67. Epub 2019 Dec 19 doi: 10.1016/j.cytogfr.2019.12.005. PMID: 31899106
Intrahepatic cholangiocarcinoma.
Nakano M, Ariizumi SI, Yamamoto M
Semin Diagn Pathol 2017 Mar;34(2):160-166. Epub 2017 Jan 5 doi: 10.1053/j.semdp.2016.12.012. PMID: 28094162
Precancerous lesions of the biliary tree.
Klöppel G, Adsay V, Konukiewitz B, Kleeff J, Schlitter AM, Esposito I
Best Pract Res Clin Gastroenterol 2013 Apr;27(2):285-97. doi: 10.1016/j.bpg.2013.04.002. PMID: 23809246

Clinical prediction guides

Reappraisal of pathological features of intraductal papillary neoplasm of bile duct with respect to the type 1 and 2 subclassifications.
Nakanuma Y, Uesaka K, Okamura Y, Terada T, Fukumura Y, Kakuda Y, Sugino T, Sato Y, Taek JK, Park YN
Hum Pathol 2021 May;111:21-35. Epub 2021 Jan 27 doi: 10.1016/j.humpath.2021.01.002. PMID: 33508254
"Biliary Diseases with Pancreatic Counterparts": Cross-sectional Imaging Findings.
Katabathina VS, Flaherty EM, Dasyam AK, Menias CO, Riddle ND, Lath N, Kozaka K, Matsui O, Nakanuma Y, Prasad SR
Radiographics 2016 Mar-Apr;36(2):374-92. Epub 2016 Feb 1 doi: 10.1148/rg.2016150071. PMID: 26824512
Adenocarcinoma of the ampulla of Vater: what treatment options are available?
Senatore FJ, Ynson ML, Dasanu CA
J Oncol Pharm Pract 2015 Oct;21(5):364-9. Epub 2014 Jun 5 doi: 10.1177/1078155214538086. PMID: 24906539
Treatment and Prognosis for Patients With Intrahepatic Cholangiocarcinoma: Systematic Review and Meta-analysis.
Mavros MN, Economopoulos KP, Alexiou VG, Pawlik TM
JAMA Surg 2014 Jun;149(6):565-74. doi: 10.1001/jamasurg.2013.5137. PMID: 24718873
Significance of mucin expression in pancreatobiliary neoplasms.
Yonezawa S, Higashi M, Yamada N, Yokoyama S, Goto M
J Hepatobiliary Pancreat Sci 2010 Mar;17(2):108-24. Epub 2009 Sep 29 doi: 10.1007/s00534-009-0174-7. PMID: 19787286

Recent systematic reviews

Characteristics and malignancy rates of adult patients diagnosed with choledochal cyst in the West: a systematic review.
Bloomfield GC, Nigam A, Calvo IG, Dorris CS, Fishbein TM, Radkani P, Winslow ER
J Gastrointest Surg 2024 Jan;28(1):77-87. doi: 10.1016/j.gassur.2023.11.007. PMID: 38353080
Defining an optimal surveillance strategy for patients following choledochal cyst resection: results of a systematic review.
Koea J, O'Grady M, Agraval J, Srinivasa S
ANZ J Surg 2022 Jun;92(6):1356-1364. Epub 2022 May 17 doi: 10.1111/ans.17775. PMID: 35579057
Treatment and Prognosis for Patients With Intrahepatic Cholangiocarcinoma: Systematic Review and Meta-analysis.
Mavros MN, Economopoulos KP, Alexiou VG, Pawlik TM
JAMA Surg 2014 Jun;149(6):565-74. doi: 10.1001/jamasurg.2013.5137. PMID: 24718873

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