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High Grade Salivary Gland Carcinoma

MedGen UID:
124649
•Concept ID:
C0279743
•
Neoplastic Process
Synonyms: High-Grade Carcinoma of Salivary Gland; High-Grade Carcinoma of the Salivary Gland

Definition

A usually aggressive salivary gland carcinoma with high grade histopathologic features. It includes the salivary duct carcinoma, salivary gland oncocytic carcinoma, and high grade salivary gland mucoepidermoid carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade Salivary Gland Carcinoma

Professional guidelines

PubMed

Pre-treatment metabolic tumor volume predicts tumor metastasis and progression in high-grade salivary gland carcinoma.
Almuhaimid TM, Lim WS, Roh JL, Oh JS, Kim JS, Kim SJ, Choi SH, Nam SY, Kim SY
J Cancer Res Clin Oncol 2018 Dec;144(12):2485-2493. Epub 2018 Oct 6 doi: 10.1007/s00432-018-2760-z. PMID: 30293119

Recent clinical studies

Etiology

Androgen receptor immunohistochemistry in salivary duct carcinoma: a retrospective study of 188 cases focusing on tumoral heterogeneity and temporal concordance.
Xu B, Dogan S, Haroon Al Rasheed MR, Ghossein R, Katabi N
Hum Pathol 2019 Nov;93:30-36. Epub 2019 Aug 17 doi: 10.1016/j.humpath.2019.08.007. PMID: 31430492Free PMC Article
Pre-treatment metabolic tumor volume predicts tumor metastasis and progression in high-grade salivary gland carcinoma.
Almuhaimid TM, Lim WS, Roh JL, Oh JS, Kim JS, Kim SJ, Choi SH, Nam SY, Kim SY
J Cancer Res Clin Oncol 2018 Dec;144(12):2485-2493. Epub 2018 Oct 6 doi: 10.1007/s00432-018-2760-z. PMID: 30293119
Elective neck management for high-grade salivary gland carcinoma.
Herman MP, Werning JW, Morris CG, Kirwan JM, Amdur RJ, Mendenhall WM
Am J Otolaryngol 2013 May-Jun;34(3):205-8. Epub 2013 Jan 14 doi: 10.1016/j.amjoto.2012.11.012. PMID: 23332405

Diagnosis

High-grade salivary gland carcinoma with the ETV6-NTRK3 gene fusion: A case report and literature review of secretory carcinoma with high-grade transformation.
Asai S, Sumiyoshi S, Yamada Y, Tateya I, Nagao T, Minamiguchi S, Haga H
Pathol Int 2021 Jun;71(6):427-434. Epub 2021 Apr 13 doi: 10.1111/pin.13100. PMID: 33848386
Androgen receptor immunohistochemistry in salivary duct carcinoma: a retrospective study of 188 cases focusing on tumoral heterogeneity and temporal concordance.
Xu B, Dogan S, Haroon Al Rasheed MR, Ghossein R, Katabi N
Hum Pathol 2019 Nov;93:30-36. Epub 2019 Aug 17 doi: 10.1016/j.humpath.2019.08.007. PMID: 31430492Free PMC Article
Pre-treatment metabolic tumor volume predicts tumor metastasis and progression in high-grade salivary gland carcinoma.
Almuhaimid TM, Lim WS, Roh JL, Oh JS, Kim JS, Kim SJ, Choi SH, Nam SY, Kim SY
J Cancer Res Clin Oncol 2018 Dec;144(12):2485-2493. Epub 2018 Oct 6 doi: 10.1007/s00432-018-2760-z. PMID: 30293119
Reproducibility of PD-L1 immunohistochemistry interpretation across various types of genitourinary and head/neck carcinomas, antibody clones, and tissue types.
Wang C, Hahn E, Slodkowska E, Eskander A, Enepekides D, Higgins K, Vesprini D, Liu SK, Downes MR, Xu B
Hum Pathol 2018 Dec;82:131-139. Epub 2018 Aug 1 doi: 10.1016/j.humpath.2018.07.024. PMID: 30075156

Prognosis

CDK12 alterations and ARID1A mutations are predictors of poor prognosis and therapeutic targets in high-grade salivary gland carcinoma: analysis of the National Genomic Profiling Database.
Kobayashi K, Saito Y, Kage H, Fukuoka O, Yamamura K, Mukai T, Oda K, Yamasoba T
Jpn J Clin Oncol 2023 Aug 30;53(9):798-807. doi: 10.1093/jjco/hyad066. PMID: 37357968
Androgen receptor immunohistochemistry in salivary duct carcinoma: a retrospective study of 188 cases focusing on tumoral heterogeneity and temporal concordance.
Xu B, Dogan S, Haroon Al Rasheed MR, Ghossein R, Katabi N
Hum Pathol 2019 Nov;93:30-36. Epub 2019 Aug 17 doi: 10.1016/j.humpath.2019.08.007. PMID: 31430492Free PMC Article
Pre-treatment metabolic tumor volume predicts tumor metastasis and progression in high-grade salivary gland carcinoma.
Almuhaimid TM, Lim WS, Roh JL, Oh JS, Kim JS, Kim SJ, Choi SH, Nam SY, Kim SY
J Cancer Res Clin Oncol 2018 Dec;144(12):2485-2493. Epub 2018 Oct 6 doi: 10.1007/s00432-018-2760-z. PMID: 30293119
Reproducibility of PD-L1 immunohistochemistry interpretation across various types of genitourinary and head/neck carcinomas, antibody clones, and tissue types.
Wang C, Hahn E, Slodkowska E, Eskander A, Enepekides D, Higgins K, Vesprini D, Liu SK, Downes MR, Xu B
Hum Pathol 2018 Dec;82:131-139. Epub 2018 Aug 1 doi: 10.1016/j.humpath.2018.07.024. PMID: 30075156
Hepatocyte growth factor and c-Met immunoreactivity are associated with metastasis in high grade salivary gland carcinoma.
Tsukinoki K, Yasuda M, Mori Y, Asano S, Naito H, Ota Y, Osamura RY, Watanabe Y
Oncol Rep 2004 Nov;12(5):1017-21. PMID: 15492787

Clinical prediction guides

CDK12 alterations and ARID1A mutations are predictors of poor prognosis and therapeutic targets in high-grade salivary gland carcinoma: analysis of the National Genomic Profiling Database.
Kobayashi K, Saito Y, Kage H, Fukuoka O, Yamamura K, Mukai T, Oda K, Yamasoba T
Jpn J Clin Oncol 2023 Aug 30;53(9):798-807. doi: 10.1093/jjco/hyad066. PMID: 37357968
Androgen receptor immunohistochemistry in salivary duct carcinoma: a retrospective study of 188 cases focusing on tumoral heterogeneity and temporal concordance.
Xu B, Dogan S, Haroon Al Rasheed MR, Ghossein R, Katabi N
Hum Pathol 2019 Nov;93:30-36. Epub 2019 Aug 17 doi: 10.1016/j.humpath.2019.08.007. PMID: 31430492Free PMC Article
Pre-treatment metabolic tumor volume predicts tumor metastasis and progression in high-grade salivary gland carcinoma.
Almuhaimid TM, Lim WS, Roh JL, Oh JS, Kim JS, Kim SJ, Choi SH, Nam SY, Kim SY
J Cancer Res Clin Oncol 2018 Dec;144(12):2485-2493. Epub 2018 Oct 6 doi: 10.1007/s00432-018-2760-z. PMID: 30293119
Reproducibility of PD-L1 immunohistochemistry interpretation across various types of genitourinary and head/neck carcinomas, antibody clones, and tissue types.
Wang C, Hahn E, Slodkowska E, Eskander A, Enepekides D, Higgins K, Vesprini D, Liu SK, Downes MR, Xu B
Hum Pathol 2018 Dec;82:131-139. Epub 2018 Aug 1 doi: 10.1016/j.humpath.2018.07.024. PMID: 30075156
Hepatocyte growth factor and c-Met immunoreactivity are associated with metastasis in high grade salivary gland carcinoma.
Tsukinoki K, Yasuda M, Mori Y, Asano S, Naito H, Ota Y, Osamura RY, Watanabe Y
Oncol Rep 2004 Nov;12(5):1017-21. PMID: 15492787

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