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Salivary gland carcinoma

MedGen UID:: 215302
•Concept ID:: C0948750
•: Neoplastic Process

Synonyms:	carcinoma of saliva-secreting gland; Carcinoma of Salivary Gland; carcinoma of salivary gland; Carcinoma of the Salivary Gland; carcinoma of the salivary gland; saliva-secreting gland carcinoma; salivary carcinoma; Salivary Gland Carcinoma; salivary gland carcinoma

Monarch Initiative:	MONDO:0000521

Definition

A carcinoma that arises from the major or minor salivary glands. Representative examples include carcinoma ex pleomorphic adenoma, adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSalivary gland carcinoma

Pathological process
- Disease
  - Neoplasm
    - Epithelial neoplasm
      - Carcinoma
        Head and neck carcinoma
        Salivary gland carcinoma
        Adult Salivary Gland Carcinoma
        Childhood Salivary Gland Carcinoma
        High Grade Salivary Gland Carcinoma
        High Grade Salivary Gland Mucoepidermoid Carcinoma
        Salivary duct carcinoma
        Recurrent Salivary Duct Carcinoma
        Salivary Gland Oncocytic Carcinoma
        Hybrid Salivary Gland Carcinoma
        Low Grade Salivary Gland Carcinoma
        Low Grade Salivary Gland Mucoepidermoid Carcinoma
        Salivary Gland Intraductal Carcinoma
        Salivary Gland Polymorphous Adenocarcinoma
        Oropharyngeal Polymorphous Adenocarcinoma
        Salivary Gland Secretory Carcinoma
        Major salivary gland carcinoma
        Carcinoma of parotid gland
        Mucoepidermoid carcinoma of parotid gland
        Parotid gland adenocarcinoma
        Parotid gland adenoid cystic carcinoma
        Parotid gland carcinoma ex pleomorphic adenoma
        Parotid gland squamous cell carcinoma
        Parotid Gland Undifferentiated Carcinoma
        Recurrent Parotid Gland Carcinoma
        Major Salivary Gland Adenocarcinoma
        Major Salivary Gland Acinic Cell Carcinoma
        Sublingual Gland Adenocarcinoma
        Submandibular gland adenocarcinoma
        Major salivary gland adenoid cystic carcinoma
        Submandibular gland adenoid cystic carcinoma
        Major Salivary Gland Cancer by AJCC v7 Stage
        Stage I Major Salivary Gland Cancer AJCC v7
        Stage II Major Salivary Gland Cancer AJCC v7
        Stage III Major Salivary Gland Cancer AJCC v7
        Stage IV Major Salivary Gland Cancer AJCC v7
        Major Salivary Gland Cancer by AJCC v8 Stage
        Stage 0 Major Salivary Gland Cancer AJCC v8
        Stage I Major Salivary Gland Cancer AJCC v8
        Stage II Major Salivary Gland Cancer AJCC v8
        Stage III Major Salivary Gland Cancer AJCC v8
        Stage IV Major Salivary Gland Cancer AJCC v8
        Major salivary gland carcinoma ex pleomorphic adenoma
        Submandibular Gland Carcinoma ex Pleomorphic Adenoma
        Major salivary gland mucoepidermoid carcinoma
        Mucoepidermoid carcinoma of submandibular gland
        Major Salivary Gland Squamous Cell Carcinoma
        Submandibular Gland Squamous Cell Carcinoma
        Sublingual gland carcinoma
        Submandibular Gland Carcinoma
        Recurrent Submandibular Gland Carcinoma
        Submandibular Gland Undifferentiated Carcinoma
        Metastatic Salivary Gland Carcinoma
        Advanced Salivary Gland Carcinoma
        Locally Advanced Salivary Gland Carcinoma
        Metastatic Salivary Gland Squamous Cell Carcinoma
        Stage IV Major Salivary Gland Carcinoma with Metastasis
        Minor salivary gland carcinoma
        Minor salivary gland adenocarcinoma
        Cribriform Adenocarcinoma of Minor Salivary Gland
        Minor Salivary Gland Acinic Cell Carcinoma
        Recurrent Minor Salivary Gland Adenocarcinoma
        Minor salivary gland adenoid cystic carcinoma
        Minor Salivary Gland Carcinoma ex Pleomorphic Adenoma
        Minor Salivary Gland Mucoepidermoid Carcinoma
        Minor Salivary Gland Small Cell Neuroendocrine Carcinoma
        Minor Salivary Gland Squamous Cell Carcinoma
        Minor Salivary Gland Undifferentiated Carcinoma
        Recurrent Salivary Gland Carcinoma
        Recurrent Salivary Gland Squamous Cell Carcinoma
        Recurrent Parotid Gland Squamous Cell Carcinoma
        Recurrent Submandibular Gland Squamous Cell Carcinoma
        Refractory Salivary Gland Carcinoma
        Salivary Gland Adenocarcinoma
        Salivary gland acinic cell carcinoma
        Salivary Gland Adenocarcinoma, Not Otherwise Specified
        Salivary gland basal cell adenocarcinoma
        Salivary Gland Cystadenocarcinoma
        Salivary gland mucinous adenocarcinoma
        Salivary Gland Sebaceous Carcinoma
        Salivary gland adenoid cystic carcinoma
        Salivary gland adenosquamous carcinoma
        Salivary gland carcinoma ex pleomorphic adenoma
        Salivary Gland Clear Cell Carcinoma
        Salivary gland epithelial myoepithelial carcinoma
        Salivary Gland Lymphoepithelial Carcinoma
        Salivary gland mucoepidermoid carcinoma
        Intermediate Grade Salivary Gland Mucoepidermoid Carcinoma
        Salivary Gland Myoepithelial Carcinoma
        Salivary Gland Poorly Differentiated Carcinoma
        Salivary gland large cell carcinoma
        Salivary Gland Large Cell Neuroendocrine Carcinoma
        Salivary gland squamous cell carcinoma
        Salivary Gland Poorly Differentiated Squamous Cell Carcinoma
        Unresectable Salivary Gland Squamous Cell Carcinoma
        Salivary Gland Undifferentiated Carcinoma
        Unresectable Salivary Gland Carcinoma

Professional guidelines

PubMed

The Evaluation and Management of Carcinoma of the Minor Salivary Glands.

Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489

Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.

Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944 Free PMC Article

Management of salivary gland carcinomas - a review.

Wang X, Luo Y, Li M, Yan H, Sun M, Fan T
Oncotarget 2017 Jan 17;8(3):3946-3956. doi: 10.18632/oncotarget.13952. PMID: 27992367 Free PMC Article

See all (29)

Recent clinical studies

Etiology

Fusion-positive salivary gland carcinomas.

Skálová A, Hyrcza MD, Vaneček T, Baněčková M, Leivo I
Genes Chromosomes Cancer 2022 May;61(5):228-243. Epub 2022 Jan 6 doi: 10.1002/gcc.23020. PMID: 34913211

Salivary Gland Cancers.

Tchekmedyian V
Hematol Oncol Clin North Am 2021 Oct;35(5):973-990. doi: 10.1016/j.hoc.2021.05.011. PMID: 34503735

Salivary gland carcinoma in children and adolescents: The EXPeRT/PARTNER diagnosis and treatment recommendations.

Surun A, Schneider DT, Ferrari A, Stachowicz-Stencel T, Rascon J, Synakiewicz A, Agaimy A, Martinova K, Kachanov D, Roganovic J, Bien E, Bisogno G, Brecht IB, Kolb F, Thariat J, Moya-Plana A, Orbach D
Pediatr Blood Cancer 2021 Jun;68 Suppl 4:e29058. doi: 10.1002/pbc.29058. PMID: 34174160

The Evaluation and Management of Carcinoma of the Minor Salivary Glands.

Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489

ALK alterations in salivary gland carcinomas.

Majewska H, Gorczyński A, Czapiewski P, Menon R, Mueller J, Lakis S, Heuckmann JM, Laco J, Gupta R, Andreasen S, Stodulski D, Iliszko M, Dziadziuszko R, Jassem J, Heukamp LC, Biernat W
Virchows Arch 2021 May;478(5):933-941. Epub 2020 Nov 25 doi: 10.1007/s00428-020-02971-w. PMID: 33237469 Free PMC Article

See all (210)

Diagnosis

Fusion-positive salivary gland carcinomas.

Skálová A, Hyrcza MD, Vaneček T, Baněčková M, Leivo I
Genes Chromosomes Cancer 2022 May;61(5):228-243. Epub 2022 Jan 6 doi: 10.1002/gcc.23020. PMID: 34913211

Salivary gland carcinoma in children and adolescents: The EXPeRT/PARTNER diagnosis and treatment recommendations.

The Evaluation and Management of Carcinoma of the Minor Salivary Glands.

Walvekar R, Phalke NP
Otolaryngol Clin North Am 2021 Jun;54(3):629-639. doi: 10.1016/j.otc.2021.02.011. PMID: 34024489

Epithelial-Myoepithelial Carcinoma.

Nakaguro M, Nagao T
Surg Pathol Clin 2021 Mar;14(1):97-109. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.10.002. PMID: 33526226

Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.

Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944 Free PMC Article

See all (166)

Therapy

Salivary gland carcinoma: Towards a more personalised approach.

Rached L, Saleh K, Casiraghi O, Even C
Cancer Treat Rev 2024 Mar;124:102697. Epub 2024 Feb 12 doi: 10.1016/j.ctrv.2024.102697. PMID: 38401478

Targeting human EGFR 2 (HER2) in salivary gland carcinoma.

Wotman M, El-Naggar A, Ferrarotto R
Expert Rev Anticancer Ther 2023 Jun;23(6):573-582. Epub 2023 May 16 doi: 10.1080/14737140.2023.2208350. PMID: 37114470

New approaches in salivary gland carcinoma.

Even C, Baste N, Classe M
Curr Opin Oncol 2019 May;31(3):169-174. doi: 10.1097/CCO.0000000000000527. PMID: 30844885

Systemic therapy in metastatic salivary gland carcinomas: A pathology-driven paradigm?

Alfieri S, Granata R, Bergamini C, Resteghini C, Bossi P, Licitra LF, Locati LD
Oral Oncol 2017 Mar;66:58-63. Epub 2017 Jan 19 doi: 10.1016/j.oraloncology.2016.12.016. PMID: 28249649

Adjuvant Therapy for Salivary Gland Carcinomas.

Sayan M, Vempati P, Miles B, Teng M, Genden E, Demicco EG, Misiukiewicz K, Posner M, Gupta V, Bakst RL
Anticancer Res 2016 Aug;36(8):4165-70. PMID: 27466526

See all (66)

Prognosis

Fusion-positive salivary gland carcinomas.

Skálová A, Hyrcza MD, Vaneček T, Baněčková M, Leivo I
Genes Chromosomes Cancer 2022 May;61(5):228-243. Epub 2022 Jan 6 doi: 10.1002/gcc.23020. PMID: 34913211

Prognosis and management of recurrent and/or metastatic head and neck adenoid cystic carcinoma.

Lorini L, Ardighieri L, Bozzola A, Romani C, Bignotti E, Buglione M, Guerini A, Lombardi D, Deganello A, Tomasoni M, Bonini SA, Sigala S, Farina D, Ravanelli M, Bossi P
Oral Oncol 2021 Apr;115:105213. Epub 2021 Feb 9 doi: 10.1016/j.oraloncology.2021.105213. PMID: 33578204

Epithelial-Myoepithelial Carcinoma.

Nakaguro M, Nagao T
Surg Pathol Clin 2021 Mar;14(1):97-109. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.10.002. PMID: 33526226

Expression of Mucins in Salivary Gland Mucoepidermoid Carcinoma.

Robinson L, van Heerden MB, Ker-Fox JG, Hunter KD, van Heerden WFP
Head Neck Pathol 2021 Jun;15(2):491-502. Epub 2020 Sep 21 doi: 10.1007/s12105-020-01226-z. PMID: 32959209 Free PMC Article

Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.

Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944 Free PMC Article

See all (218)

Clinical prediction guides

Targeting human EGFR 2 (HER2) in salivary gland carcinoma.

Wotman M, El-Naggar A, Ferrarotto R
Expert Rev Anticancer Ther 2023 Jun;23(6):573-582. Epub 2023 May 16 doi: 10.1080/14737140.2023.2208350. PMID: 37114470

Fusion-positive salivary gland carcinomas.

Skálová A, Hyrcza MD, Vaneček T, Baněčková M, Leivo I
Genes Chromosomes Cancer 2022 May;61(5):228-243. Epub 2022 Jan 6 doi: 10.1002/gcc.23020. PMID: 34913211

Expression of Mucins in Salivary Gland Mucoepidermoid Carcinoma.

Robinson L, van Heerden MB, Ker-Fox JG, Hunter KD, van Heerden WFP
Head Neck Pathol 2021 Jun;15(2):491-502. Epub 2020 Sep 21 doi: 10.1007/s12105-020-01226-z. PMID: 32959209 Free PMC Article

Survival Outcome of Intermediate-Grade Salivary Gland Carcinoma.

Park GC, Roh JL, Cho KJ, Jung YG, Lee HW, Kim TG, Choi SH, Nam SY, Kim SY
Oncology 2018;94(2):125-132. Epub 2017 Nov 18 doi: 10.1159/000484411. PMID: 29151106

Systemic therapy in metastatic salivary gland carcinomas: A pathology-driven paradigm?

Alfieri S, Granata R, Bergamini C, Resteghini C, Bossi P, Licitra LF, Locati LD
Oral Oncol 2017 Mar;66:58-63. Epub 2017 Jan 19 doi: 10.1016/j.oraloncology.2016.12.016. PMID: 28249649

See all (129)

Recent systematic reviews

Prognostic role of PD-L1 expression in patients with salivary gland carcinoma: A systematic review and meta-analysis.

Wu L, Jiang C, Zhu Z, Sun Y, Zhang T
PLoS One 2022;17(7):e0272080. Epub 2022 Jul 26 doi: 10.1371/journal.pone.0272080. PMID: 35881656 Free PMC Article

Elective neck dissection in patients with salivary gland carcinoma: A systematic review and meta-analysis.

Westergaard-Nielsen M, Rosenberg T, Gerke O, Dyrvig AK, Godballe C, Bjørndal K
J Oral Pathol Med 2020 Aug;49(7):606-616. Epub 2020 Jun 14 doi: 10.1111/jop.13034. PMID: 32430929

A systematic review including an additional pediatric case report: Pediatric cases of mammary analogue secretory carcinoma.

Ngouajio AL, Drejet SM, Phillips DR, Summerlin DJ, Dahl JP
Int J Pediatr Otorhinolaryngol 2017 Sep;100:187-193. Epub 2017 Jul 6 doi: 10.1016/j.ijporl.2017.07.004. PMID: 28802370

See all (3)

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Salivary gland carcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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