U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lip and oral cavity squamous cell carcinoma

MedGen UID:
124714
•Concept ID:
C0280297
•
Neoplastic Process
Synonyms: lip and oral cavity squamous cell cancer; Lip and Oral Cavity Squamous Cell Carcinoma; lip and oral cavity squamous cell carcinoma; lip/oral cavity squam. cell car.; squamous cell carcinoma of oral cavity and lip; Squamous cell carcinoma of oral cavity and lip
 
Monarch Initiative: MONDO:0044710
Orphanet: ORPHA502369

Definition

A squamous cell carcinoma arising from the lip or the oral cavity. The oral cavity squamous cell carcinoma usually arises from the buccal mucosa, tongue, or gums. It occurs predominantly in adults who use tobacco and alcohol and has a tendency to metastasize early to lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLip and oral cavity squamous cell carcinoma

Professional guidelines

PubMed

Potential Alternative Therapeutic Modalities for Management Head and Neck Squamous Cell Carcinoma: A Review.
Afshari K, Sohal KS
Cancer Control 2023 Jan-Dec;30:10732748231185003. doi: 10.1177/10732748231185003. PMID: 37328298Free PMC Article
Management of high-risk squamous cell carcinoma of the skin.
Samarasinghe V, Madan V, Lear JT
Expert Rev Anticancer Ther 2011 May;11(5):763-9. doi: 10.1586/era.11.36. PMID: 21554051
Current treatment options in squamous cell carcinoma of the oral cavity.
Palme CE, Gullane PJ, Gilbert RW
Surg Oncol Clin N Am 2004 Jan;13(1):47-70. doi: 10.1016/S1055-3207(03)00123-6. PMID: 15062361

Recent clinical studies

Etiology

Sentinel lymph node biopsy for early squamous cell carcinoma of the lip and oral cavity: Real-world experience in Brazil.
Matos LL, Capuzzo RC, Pedruzzi PAG, Farias T, de Farias JWM, Chone CT, Köhler HF, Vartanian JG, Dias FL, Couto EV, Pinto FR, Carvalho AL, Kowalski LP
Head Neck 2022 Jul;44(7):1604-1615. Epub 2022 Apr 15 doi: 10.1002/hed.27061. PMID: 35427429
Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Oral squamous cell carcinoma resection and neck dissection mortality: a 10-year national audit study.
Ong YLR, Sambrook P, Maddern G
ANZ J Surg 2021 Jan;91(1-2):145-151. Epub 2020 Nov 27 doi: 10.1111/ans.16463. PMID: 33244898
Characterization of dendritic cells in lip and oral cavity squamous cell carcinoma.
Costa NL, Gonçalves AS, Martins AF, Arantes DA, Silva TA, Batista AC
J Oral Pathol Med 2016 Jul;45(6):418-24. Epub 2015 Oct 30 doi: 10.1111/jop.12380. PMID: 26514660
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013

Diagnosis

Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Aggressive squamous cell carcinoma of the lip.
Schnur J, Johnson Shaw ME, Carnio LR, Casadesus D
BMJ Case Rep 2020 Dec 17;13(12) doi: 10.1136/bcr-2020-239281. PMID: 33334769Free PMC Article
Oral Biopsy Techniques.
Shanti RM, Tanaka T, Stanton DC
Dermatol Clin 2020 Oct;38(4):421-427. Epub 2020 Aug 10 doi: 10.1016/j.det.2020.05.003. PMID: 32892851
Squamous cell carcinoma of the head and neck in children.
Dombrowski ND, Wolter NE, Irace AL, Robson CD, Perez-Atayde AR, Mack JW, Rahbar R
Int J Pediatr Otorhinolaryngol 2019 Feb;117:131-137. Epub 2018 Nov 20 doi: 10.1016/j.ijporl.2018.11.019. PMID: 30579067
Characterization of dendritic cells in lip and oral cavity squamous cell carcinoma.
Costa NL, Gonçalves AS, Martins AF, Arantes DA, Silva TA, Batista AC
J Oral Pathol Med 2016 Jul;45(6):418-24. Epub 2015 Oct 30 doi: 10.1111/jop.12380. PMID: 26514660

Therapy

5-Aminolevulinic acid photodynamic therapy for early-stage lip squamous cell carcinoma.
Wang P, Zhang G, Zhang L, Zhou Z, Shi L, Zeng Q, Zhu L, Wang X
Photodiagnosis Photodyn Ther 2021 Sep;35:102321. Epub 2021 May 17 doi: 10.1016/j.pdpdt.2021.102321. PMID: 34015543
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Squamous cell carcinoma of the head and neck in children.
Dombrowski ND, Wolter NE, Irace AL, Robson CD, Perez-Atayde AR, Mack JW, Rahbar R
Int J Pediatr Otorhinolaryngol 2019 Feb;117:131-137. Epub 2018 Nov 20 doi: 10.1016/j.ijporl.2018.11.019. PMID: 30579067
A Review of Photodynamic Therapy for Neoplasms of the Head and Neck.
Civantos FJ, Karakullukcu B, Biel M, Silver CE, Rinaldo A, Saba NF, Takes RP, Vander Poorten V, Ferlito A
Adv Ther 2018 Mar;35(3):324-340. Epub 2018 Feb 7 doi: 10.1007/s12325-018-0659-3. PMID: 29417455
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects.
Vieira RA, Minicucci EM, Marques ME, Marques SA
An Bras Dermatol 2012 Jan-Feb;87(1):105-14. doi: 10.1590/s0365-05962012000100013. PMID: 22481658

Prognosis

Sentinel lymph node biopsy for early squamous cell carcinoma of the lip and oral cavity: Real-world experience in Brazil.
Matos LL, Capuzzo RC, Pedruzzi PAG, Farias T, de Farias JWM, Chone CT, Köhler HF, Vartanian JG, Dias FL, Couto EV, Pinto FR, Carvalho AL, Kowalski LP
Head Neck 2022 Jul;44(7):1604-1615. Epub 2022 Apr 15 doi: 10.1002/hed.27061. PMID: 35427429
Epidemiology and survival outcomes of lip, oral cavity, and oropharyngeal squamous cell carcinoma in a southeast Brazilian population.
Louredo BV, Vargas PA, Pérez-de-Oliveira ME, Lopes MA, Kowalski LP, Curado MP
Med Oral Patol Oral Cir Bucal 2022 May 1;27(3):e274-e284. doi: 10.4317/medoral.25147. PMID: 35368013Free PMC Article
Aggressive squamous cell carcinoma of the lip.
Schnur J, Johnson Shaw ME, Carnio LR, Casadesus D
BMJ Case Rep 2020 Dec 17;13(12) doi: 10.1136/bcr-2020-239281. PMID: 33334769Free PMC Article
Characterization of dendritic cells in lip and oral cavity squamous cell carcinoma.
Costa NL, Gonçalves AS, Martins AF, Arantes DA, Silva TA, Batista AC
J Oral Pathol Med 2016 Jul;45(6):418-24. Epub 2015 Oct 30 doi: 10.1111/jop.12380. PMID: 26514660
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013

Clinical prediction guides

Nodal Metastasis in Surgically Treated Oral Cavity Squamous Cell Carcinoma.
Carey RM, Anagnos VJ, Prasad A, Sangal NR, Rajasekaran K, Shanti RM, Cannady SB, Newman JG, Brant JA, Brody RM
ORL J Otorhinolaryngol Relat Spec 2023;85(6):348-359. Epub 2023 Nov 15 doi: 10.1159/000534491. PMID: 37967536Free PMC Article
Effects of racial residential segregation on oral squamous cell carcinoma prognosis and survival.
Harris JA, Hunter WP, Ji YD, Hanna GJ
Oral Oncol 2021 Aug;119:105364. Epub 2021 Jun 3 doi: 10.1016/j.oraloncology.2021.105364. PMID: 34091188
Opium use and the risk of head and neck squamous cell carcinoma.
Mohebbi E, Hadji M, Rashidian H, Rezaianzadeh A, Marzban M, Haghdoost AA, Naghibzadeh Tahami A, Moradi A, Gholipour M, Najafi F, Safari-Faramani R, Alizadeh-Navaei R, Ansari-Moghaddam A, Bakhshi M, Nejatizadeh A, Mahmoudi M, Shahidsales S, Ahmadi-Simab S, Arabi Mianroodi AA, Seyyedsalehi MS, Hosseini B, Peyghambari V, Shirkhoda M, Shirkoohi R, Ebrahimi E, Manifar S, Mohagheghi MA, Rozek L, Brennan P, Poustchi H, Etemadi A, Pukkala E, Schüz J, Malekzadeh R, Weiderpass E, Rahimi-Movaghar A, Boffetta P, Kamanagar F, Zendehdel K
Int J Cancer 2021 Mar 1;148(5):1066-1076. Epub 2020 Oct 9 doi: 10.1002/ijc.33289. PMID: 32895947
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013

Recent systematic reviews

Risk of head and neck cancer among opium users.
Mohebbi E, Alimoradi Z, Rozek LS, Mohebbi A, Jafari E
Arch Oral Biol 2024 Jan;157:105846. Epub 2023 Nov 8 doi: 10.1016/j.archoralbio.2023.105846. PMID: 37980840
Hydrochlorothiazide use is associated with the risk of cutaneous and lip squamous cell carcinoma: A systematic review and meta-analysis.
de Macedo Andrade AC, Felix FA, França GM, Ribeiro ILA, Barboza CAG, de Castro RD, de Lisboa Lopes Costa A
Eur J Clin Pharmacol 2022 Jun;78(6):919-930. Epub 2022 Mar 8 doi: 10.1007/s00228-022-03299-x. PMID: 35258665
Primary Intraosseous Squamous Cell Carcinoma Involving the Jaw Bones: A Systematic Review and Update.
de Morais EF, Carlan LM, de Farias Morais HG, Pinheiro JC, Martins HDD, Barboza CAG, de Almeida Freitas R
Head Neck Pathol 2021 Jun;15(2):608-616. Epub 2020 Oct 12 doi: 10.1007/s12105-020-01234-z. PMID: 33044723Free PMC Article
Identifying risk factors for the prognosis of head and neck cutaneous squamous cell carcinoma: A systematic review and meta-analysis.
Zeng S, Fu L, Zhou P, Ling H
PLoS One 2020;15(9):e0239586. Epub 2020 Sep 29 doi: 10.1371/journal.pone.0239586. PMID: 32991600Free PMC Article
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...