U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Glottis neoplasm

MedGen UID:
138026
•Concept ID:
C0345713
•
Neoplastic Process
Synonyms: Glottis Neoplasm; glottis neoplasm; glottis neoplasm (disease); Glottis Tumor; glottis tumor; glottis tumour; Neoplasm of glottis; Neoplasm of Glottis; neoplasm of glottis; Neoplasm of the Glottis; neoplasm of the glottis; Tumor of glottis; Tumor of Glottis; tumor of glottis; Tumor of the Glottis; tumor of the glottis; tumour of glottis; tumour of the glottis
SNOMED CT: Neoplasm of glottis (126693009); Tumor of glottis (126693009)
 
Monarch Initiative: MONDO:0002353

Definition

A benign or malignant neoplasm that affects the glottic area of the larynx. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlottis neoplasm

Professional guidelines

PubMed

Surgical Treatment of Early Glottic Cancer.
Silver JA, Turkdogan S, Roy CF, Kost KM
Otolaryngol Clin North Am 2023 Apr;56(2):259-273. doi: 10.1016/j.otc.2022.12.009. PMID: 37030939
Diagnosis and Treatment of Benign Pediatric Lesions.
Hron TA, Kavanagh KR, Murray N
Otolaryngol Clin North Am 2019 Aug;52(4):657-668. Epub 2019 May 11 doi: 10.1016/j.otc.2019.03.010. PMID: 31088693
Treatment of early-stage laryngeal cancer: A comparison of treatment options.
Baird BJ, Sung CK, Beadle BM, Divi V
Oral Oncol 2018 Dec;87:8-16. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.09.012. PMID: 30527248

Recent clinical studies

Etiology

Surgical Management of Advanced Glottic Cancer.
Poonia SK, Nicolli E
Otolaryngol Clin North Am 2023 Apr;56(2):275-283. doi: 10.1016/j.otc.2022.12.007. PMID: 37030940
Surgical Treatment of Early Glottic Cancer.
Silver JA, Turkdogan S, Roy CF, Kost KM
Otolaryngol Clin North Am 2023 Apr;56(2):259-273. doi: 10.1016/j.otc.2022.12.009. PMID: 37030939
Prognostic and Treatment Differences Between T1a and T1b Glottic Cancer.
Syal A, Lott DG, Zhang N, Karle WE
Laryngoscope 2022 Nov;132(11):2187-2193. Epub 2022 Jan 21 doi: 10.1002/lary.30030. PMID: 35060629
Clinical Analysis of Laryngeal Spindle Cell Carcinoma.
Chen L, Chen Q, Li C, Zhou L, Wang S, Zhang M
ORL J Otorhinolaryngol Relat Spec 2020;82(6):310-317. Epub 2020 Sep 2 doi: 10.1159/000508134. PMID: 32877904
Subglottic cancer.
Hanna EY
Am J Otolaryngol 1994 Sep-Oct;15(5):322-8. doi: 10.1016/0196-0709(94)90130-9. PMID: 7978035

Diagnosis

Dysplastic Lesions of the Larynx.
Olson C, Alexander R, Stinnett S
Otolaryngol Clin North Am 2023 Apr;56(2):233-246. doi: 10.1016/j.otc.2023.01.001. PMID: 37030937
Prognostic and Treatment Differences Between T1a and T1b Glottic Cancer.
Syal A, Lott DG, Zhang N, Karle WE
Laryngoscope 2022 Nov;132(11):2187-2193. Epub 2022 Jan 21 doi: 10.1002/lary.30030. PMID: 35060629
Clinical Analysis of Laryngeal Spindle Cell Carcinoma.
Chen L, Chen Q, Li C, Zhou L, Wang S, Zhang M
ORL J Otorhinolaryngol Relat Spec 2020;82(6):310-317. Epub 2020 Sep 2 doi: 10.1159/000508134. PMID: 32877904
Laryngeal myxoma.
Nakamura A, Iguchi H, Kusuki M, Yamane H, Matsuda M, Osako S
Acta Otolaryngol 2008 Jan;128(1):110-2. doi: 10.1080/00016480701361970. PMID: 17851923
Subglottic paraganglioma.
Peterson KL, Fu YS, Calcaterra T
Head Neck 1997 Jan;19(1):54-6. doi: 10.1002/(sici)1097-0347(199701)19:1<54::aid-hed10>3.0.co;2-r. PMID: 9030946

Therapy

Treatment of early-stage laryngeal cancer: A comparison of treatment options.
Baird BJ, Sung CK, Beadle BM, Divi V
Oral Oncol 2018 Dec;87:8-16. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.09.012. PMID: 30527248
Management of Dysphonia After Radiation Therapy.
Villari CR, Courey MS
Otolaryngol Clin North Am 2015 Aug;48(4):601-9. Epub 2015 Jun 17 doi: 10.1016/j.otc.2015.04.006. PMID: 26092762
Evidence-based review of treatment options for patients with glottic cancer.
Hartl DM, Ferlito A, Brasnu DF, Langendijk JA, Rinaldo A, Silver CE, Wolf GT
Head Neck 2011 Nov;33(11):1638-48. Epub 2011 Jan 6 doi: 10.1002/hed.21528. PMID: 21990228
Therapy for recurrent respiratory papillomatosis.
Auborn KJ
Antivir Ther 2002 Mar;7(1):1-9. PMID: 12008782
Hypopharyngeal stenosis.
McConnel FM, Duck SW, Hester TR
Laryngoscope 1984 Sep;94(9):1162-4. doi: 10.1288/00005537-198409000-00006. PMID: 6472011

Prognosis

Prognostic and Treatment Differences Between T1a and T1b Glottic Cancer.
Syal A, Lott DG, Zhang N, Karle WE
Laryngoscope 2022 Nov;132(11):2187-2193. Epub 2022 Jan 21 doi: 10.1002/lary.30030. PMID: 35060629
Supracricoid Partial Laryngectomy With and Without Neoadjuvant Chemotherapy in Glottic Cancer.
Luna-Ortiz K, Reynoso-Noveron N, Zacarias-Ramon LC, Alvarez-Avitia M, Luna-Peteuil Z, Garcia-Ortega DY
Laryngoscope 2022 Jan;132(1):156-162. Epub 2021 Jun 26 doi: 10.1002/lary.29713. PMID: 34173978
Clinical Analysis of Laryngeal Spindle Cell Carcinoma.
Chen L, Chen Q, Li C, Zhou L, Wang S, Zhang M
ORL J Otorhinolaryngol Relat Spec 2020;82(6):310-317. Epub 2020 Sep 2 doi: 10.1159/000508134. PMID: 32877904
Prognosis of subglottic carcinoma: Is it really worse?
Coskun H, Mendenhall WM, Rinaldo A, Rodrigo JP, Suárez C, Strojan P, López F, Mondin V, Saba NF, Shaha AR, Smee R, Takes RP, Ferlito A
Head Neck 2019 Feb;41(2):511-521. Epub 2018 Jun 26 doi: 10.1002/hed.25172. PMID: 29947111
Treatment of early-stage laryngeal cancer: A comparison of treatment options.
Baird BJ, Sung CK, Beadle BM, Divi V
Oral Oncol 2018 Dec;87:8-16. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.09.012. PMID: 30527248

Clinical prediction guides

Difficult glottis: Diagnostic dilemma in viewof the clinical presentation.
Klimza H, Witkiewicz J, Jackowska J, Wierzbicka M
Otolaryngol Pol 2023 Jul 21;77(4):53-57. doi: 10.5604/01.3001.0053.7263. PMID: 37772377
Clinical Analysis of Laryngeal Spindle Cell Carcinoma.
Chen L, Chen Q, Li C, Zhou L, Wang S, Zhang M
ORL J Otorhinolaryngol Relat Spec 2020;82(6):310-317. Epub 2020 Sep 2 doi: 10.1159/000508134. PMID: 32877904
Distinct Biomarker Profiles and Clinical Characteristics in T1-T2 Glottic and Supraglottic Carcinomas.
Wachters JE, Kop E, Slagter-Menkema L, Mastik M, van der Wal JE, van der Vegt B, de Bock GH, van der Laan BFAM, Schuuring E
Laryngoscope 2020 Dec;130(12):2825-2832. Epub 2020 Feb 17 doi: 10.1002/lary.28532. PMID: 32065407Free PMC Article
Vocal fold leukoplakia: incidence, management, and prevention.
Parker NP
Curr Opin Otolaryngol Head Neck Surg 2017 Dec;25(6):464-468. doi: 10.1097/MOO.0000000000000406. PMID: 28857841
Lesions of the posterior glottis: clinical and pathologic considerations and treatment outcome.
Shoffel-Havakuk H, Halperin D, Yosef L, Feldberg E, Lahav Y
J Voice 2014 Mar;28(2):263.e1-263.e8. Epub 2013 Dec 2 doi: 10.1016/j.jvoice.2013.08.013. PMID: 24291442

Recent systematic reviews

Epidemiological, clinical and oncological outcomes of laryngeal verrucous carcinomas: a systematic review.
Lechien JR, Hans S
J Otolaryngol Head Neck Surg 2023 Dec 13;52(1):81. doi: 10.1186/s40463-023-00666-1. PMID: 38093339Free PMC Article
Treatment of early stage Supraglottic squamous cell carcinoma: meta-analysis comparing primary surgery versus primary radiotherapy.
Patel KB, Nichols AC, Fung K, Yoo J, MacNeil SD
J Otolaryngol Head Neck Surg 2018 Mar 5;47(1):19. doi: 10.1186/s40463-018-0262-2. PMID: 29506564Free PMC Article
Laryngeal Verrucous Carcinoma.
Echanique KA, Desai SV, Marchiano E, Spinazzi EF, Strojan P, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2017 Jan;156(1):38-45. Epub 2016 Aug 9 doi: 10.1177/0194599816662631. PMID: 27484231
Can videostroboscopy predict early glottic cancer? A systematic review and meta-analysis.
Mehlum CS, Rosenberg T, Groentved AM, Dyrvig AK, Godballe C
Laryngoscope 2016 Sep;126(9):2079-84. Epub 2015 Nov 3 doi: 10.1002/lary.25745. PMID: 26524997
Transoral laser surgery versus radiotherapy: systematic review and meta-analysis for treatment options of T1a glottic cancer.
Abdurehim Y, Hua Z, Yasin Y, Xukurhan A, Imam I, Yuqin F
Head Neck 2012 Jan;34(1):23-33. Epub 2011 Mar 3 doi: 10.1002/hed.21686. PMID: 21374753

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...