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Gastrointestinal Tract Adenoma, Intestinal-Type

MedGen UID:
1380693
•Concept ID:
C4511908
•
Neoplastic Process
Synonyms: Adenoma, Intestinal-Type; Digestive System Adenoma, Intestinal-Type; GI Adenoma, Intestinal-Type; GI Tract Adenoma, Intestinal-Type; Intestinal-type adenoma
SNOMED CT: Intestinal-type adenoma (726545001)

Definition

An adenoma that arises from the glandular epithelium of the gastrointestinal tract and is associated with intestinal-type differentiation. [from NCI]

Professional guidelines

PubMed

Indicative value of pathological classification of duodenal papillary adenomas in clinical diagnosis and treatment.
Lv Y, Wang P, Chen J, Zhao L, Chen L, Zhuang Y, Wang L, Zou X
Surg Endosc 2022 Jul;36(7):5183-5197. Epub 2022 Mar 14 doi: 10.1007/s00464-021-08894-0. PMID: 35286472

Recent clinical studies

Etiology

CEACAM5 and TROP2 define metaplastic and dysplastic transitions in human antral gastric precancerous lesions and tumors.
Jang B, Lee SH, Dovirak I, Kim H, Srivastava S, Teh M, Yeoh KG, So JB, Tsao SKK, Khor CJ, Ang TL, Goldenring JR
Gastric Cancer 2024 Mar;27(2):263-274. Epub 2024 Jan 14 doi: 10.1007/s10120-023-01458-2. PMID: 38221567Free PMC Article
YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration.
Loe AKH, Rao-Bhatia A, Wei Z, Kim JE, Guan B, Qin Y, Hong M, Kwak HS, Liu X, Zhang L, Wrana JL, Guo H, Kim TH
Cell Rep 2023 Dec 26;42(12):113497. Epub 2023 Nov 30 doi: 10.1016/j.celrep.2023.113497. PMID: 38041813
The pathology of gastric and duodenal polyps: current concepts.
Kővári B, Kim BH, Lauwers GY
Histopathology 2021 Jan;78(1):106-124. doi: 10.1111/his.14275. PMID: 33382489
Pathology of gastric cancer and its precursor lesions.
Yakirevich E, Resnick MB
Gastroenterol Clin North Am 2013 Jun;42(2):261-84. Epub 2013 Mar 1 doi: 10.1016/j.gtc.2013.01.004. PMID: 23639640
Primary intestinal-type adenoma of the vagina arising directly from endocervical-type adenosis: a case report.
Can B, Gün S, Aydin O, Kandemir B
J Reprod Med 2012 Jan-Feb;57(1-2):68-73. PMID: 22324273

Diagnosis

Gastric Intestinal Metaplasia: Real Culprit or Innocent Bystander as a Precancerous Condition for Gastric Cancer?
Sugano K, Moss SF, Kuipers EJ
Gastroenterology 2023 Dec;165(6):1352-1366.e1. Epub 2023 Aug 29 doi: 10.1053/j.gastro.2023.08.028. PMID: 37652306
Indicative value of pathological classification of duodenal papillary adenomas in clinical diagnosis and treatment.
Lv Y, Wang P, Chen J, Zhao L, Chen L, Zhuang Y, Wang L, Zou X
Surg Endosc 2022 Jul;36(7):5183-5197. Epub 2022 Mar 14 doi: 10.1007/s00464-021-08894-0. PMID: 35286472
Primary intestinal-type adenoma of the vagina arising directly from endocervical-type adenosis: a case report.
Can B, Gün S, Aydin O, Kandemir B
J Reprod Med 2012 Jan-Feb;57(1-2):68-73. PMID: 22324273
Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach.
Kushima R, Vieth M, Borchard F, Stolte M, Mukaisho K, Hattori T
Gastric Cancer 2006;9(3):177-84. doi: 10.1007/s10120-006-0381-8. PMID: 16952035
Pathogenesis of carcinoma of the papilla of Vater.
Fischer HP, Zhou H
J Hepatobiliary Pancreat Surg 2004;11(5):301-9. doi: 10.1007/s00534-004-0898-3. PMID: 15549428

Therapy

Distribution of LGR5+ cells and associated implications during the early stage of gastric tumorigenesis.
Jang BG, Lee BL, Kim WH
PLoS One 2013;8(12):e82390. Epub 2013 Dec 10 doi: 10.1371/journal.pone.0082390. PMID: 24340024Free PMC Article
Effect of Helicobacter pylori eradication on malignant transformation of gastric adenoma.
Saito K, Arai K, Mori M, Kobayashi R, Ohki I
Gastrointest Endosc 2000 Jul;52(1):27-32. doi: 10.1067/mge.2000.106112. PMID: 10882958

Prognosis

YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration.
Loe AKH, Rao-Bhatia A, Wei Z, Kim JE, Guan B, Qin Y, Hong M, Kwak HS, Liu X, Zhang L, Wrana JL, Guo H, Kim TH
Cell Rep 2023 Dec 26;42(12):113497. Epub 2023 Nov 30 doi: 10.1016/j.celrep.2023.113497. PMID: 38041813
Indicative value of pathological classification of duodenal papillary adenomas in clinical diagnosis and treatment.
Lv Y, Wang P, Chen J, Zhao L, Chen L, Zhuang Y, Wang L, Zou X
Surg Endosc 2022 Jul;36(7):5183-5197. Epub 2022 Mar 14 doi: 10.1007/s00464-021-08894-0. PMID: 35286472
Atrophic and Metaplastic Progression in the Background Mucosa of Patients with Gastric Adenoma.
Na HK, Cho CJ, Bae SE, Lee JH, Park YS, Ahn JY, Kim DH, Choi KD, Song HJ, Lee GH, Jang SJ, Jung HY
PLoS One 2017;12(1):e0169456. Epub 2017 Jan 10 doi: 10.1371/journal.pone.0169456. PMID: 28072871Free PMC Article
Expression and prognostic significance of human growth and transformation-dependent protein in gastric carcinoma and gastric adenoma.
Cho YE, Kim JY, Kim YW, Park JH, Lee S
Hum Pathol 2009 Jul;40(7):975-81. Epub 2009 Mar 9 doi: 10.1016/j.humpath.2008.12.007. PMID: 19269009
Pathogenesis of carcinoma of the papilla of Vater.
Fischer HP, Zhou H
J Hepatobiliary Pancreat Surg 2004;11(5):301-9. doi: 10.1007/s00534-004-0898-3. PMID: 15549428

Clinical prediction guides

CEACAM5 and TROP2 define metaplastic and dysplastic transitions in human antral gastric precancerous lesions and tumors.
Jang B, Lee SH, Dovirak I, Kim H, Srivastava S, Teh M, Yeoh KG, So JB, Tsao SKK, Khor CJ, Ang TL, Goldenring JR
Gastric Cancer 2024 Mar;27(2):263-274. Epub 2024 Jan 14 doi: 10.1007/s10120-023-01458-2. PMID: 38221567Free PMC Article
Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations.
Vanoli A, Grillo F, Furlan D, Arpa G, Grami O, Guerini C, Riboni R, Mastracci L, Di Sabatino A
Int J Mol Sci 2021 Apr 22;22(9) doi: 10.3390/ijms22094388. PMID: 33922305Free PMC Article
Clinicopathological characteristics of non-ampullary duodenal tumors and their phenotypic classification.
Yoshida M, Shimoda T, Abe M, Kakushima N, Kawata N, Takizawa K, Ono H, Sugino T
Pathol Int 2019 Jul;69(7):398-406. Epub 2019 Jul 21 doi: 10.1111/pin.12829. PMID: 31328367
The different pathogeneses of sporadic adenoma and adenocarcinoma in non-ampullary lesions of the proximal and distal duodenum.
Niwa A, Kuwano S, Tomita H, Kimura K, Orihara Y, Kanayama T, Noguchi K, Hisamatsu K, Nakashima T, Hatano Y, Hirata A, Miyazaki T, Kaneko K, Tanaka T, Hara A
Oncotarget 2017 Jun 20;8(25):41078-41090. doi: 10.18632/oncotarget.17051. PMID: 28467793Free PMC Article
Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum.
Matsubara A, Sekine S, Kushima R, Ogawa R, Taniguchi H, Tsuda H, Kanai Y
J Pathol 2013 Mar;229(4):579-87. Epub 2013 Feb 4 doi: 10.1002/path.4153. PMID: 23208952

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