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Transient Primary Hypothyroidism

MedGen UID:
1388665
•Concept ID:
C4331427
•
Disease or Syndrome

Definition

Primary hypothyroidism that resolves spontaneously. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransient Primary Hypothyroidism

Professional guidelines

PubMed

Somatostatin treatment of congenital chylothorax may induce transient hypothyroidism in newborns.
Maayan-Metzger A, Sack J, Mazkereth R, Vardi A, Kuint J
Acta Paediatr 2005 Jun;94(6):785-9. doi: 10.1111/j.1651-2227.2005.tb01985.x. PMID: 16188789
Hypothyroxinemia in premature infants: is thyroxine treatment necessary?
Fisher DA
Thyroid 1999 Jul;9(7):715-20. doi: 10.1089/thy.1999.9.715. PMID: 10447019
Transient primary hypothyroidism in the newborn: experience of the Victorian Neonatal Thyroid Screening Programme.
Coakley JC, Francis I, Gold H, Mathur K, Connelly JF
Aust Paediatr J 1989 Feb;25(1):25-30. doi: 10.1111/j.1440-1754.1989.tb01408.x. PMID: 2567157

Recent clinical studies

Etiology

Congenital hypothyroidism and iodine status in Turkey: a comparison between the data obtained from an epidemiological study in school-aged children and neonatal screening for congenital hypothyroidism in Turkey.
Simşek E, Karabay M, Safak A, Kocabay K
Pediatr Endocrinol Rev 2003 Dec;1 Suppl 2:155-61. PMID: 16444153
Outcome in three siblings with antibody-mediated transient congenital hypothyroidism.
Pacaud D, Huot C, Gattereau A, Brown RS, Glorieux J, Dussault JH, Van Vliet G
J Pediatr 1995 Aug;127(2):275-7. doi: 10.1016/s0022-3476(95)70308-x. PMID: 7636655

Diagnosis

Hypothyroxinemia in premature infants: is thyroxine treatment necessary?
Fisher DA
Thyroid 1999 Jul;9(7):715-20. doi: 10.1089/thy.1999.9.715. PMID: 10447019
Screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency and of its control.
Delange F
Thyroid 1998 Dec;8(12):1185-92. doi: 10.1089/thy.1998.8.1185. PMID: 9920376
Transient primary hypothyroidism in the newborn: experience of the Victorian Neonatal Thyroid Screening Programme.
Coakley JC, Francis I, Gold H, Mathur K, Connelly JF
Aust Paediatr J 1989 Feb;25(1):25-30. doi: 10.1111/j.1440-1754.1989.tb01408.x. PMID: 2567157
Anorexia nervosa with elevated serum TSH.
Matsubayashi S, Tamai H, Uehata S, Kobayashi N, Mori K, Nakagawa T, Kumagai LF
Psychosom Med 1988 Nov-Dec;50(6):600-6. doi: 10.1097/00006842-198811000-00006. PMID: 3148959

Therapy

Hypothyroxinemia in premature infants: is thyroxine treatment necessary?
Fisher DA
Thyroid 1999 Jul;9(7):715-20. doi: 10.1089/thy.1999.9.715. PMID: 10447019
Recovery of thyroid function in primary hypothyroidism.
Nikolai TF
Am J Med Sci 1989 Jan;297(1):18-21. doi: 10.1097/00000441-198901000-00005. PMID: 2913797
Transient primary hypothyroidism in the newborn: experience of the Victorian Neonatal Thyroid Screening Programme.
Coakley JC, Francis I, Gold H, Mathur K, Connelly JF
Aust Paediatr J 1989 Feb;25(1):25-30. doi: 10.1111/j.1440-1754.1989.tb01408.x. PMID: 2567157
Primary hypothyroidism in an adult patient with protein-calorie malnutrition: a study of its mechanism and the effect of amino acid deficiency.
Tahara Y, Hirota M, Shima K, Kozu S, Ikegami H, Tanaka A, Kumahara Y, Amino N, Hayashizaki S, Miyai K
Metabolism 1988 Jan;37(1):9-14. doi: 10.1016/0026-0495(88)90022-4. PMID: 3121981
Transient primary hypothyroidism in prematures.
Kulaylat NA, Najjar SS
Clin Pediatr (Phila) 1987 Jul;26(7):339-42. doi: 10.1177/000992288702600703. PMID: 3595039

Prognosis

Hyperthyrotropinemia at 2 weeks of age indicates thyroid dysfunction and predicts the occurrence of delayed elevation of thyrotropin in very low birth weight infants.
Niwa F, Kawai M, Kanazawa H, Iwanaga K, Matsukura T, Hasegawa T, Heike T
Clin Endocrinol (Oxf) 2012 Aug;77(2):255-61. doi: 10.1111/j.1365-2265.2011.04323.x. PMID: 22168665
Screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency and of its control.
Delange F
Thyroid 1998 Dec;8(12):1185-92. doi: 10.1089/thy.1998.8.1185. PMID: 9920376
Outcome in three siblings with antibody-mediated transient congenital hypothyroidism.
Pacaud D, Huot C, Gattereau A, Brown RS, Glorieux J, Dussault JH, Van Vliet G
J Pediatr 1995 Aug;127(2):275-7. doi: 10.1016/s0022-3476(95)70308-x. PMID: 7636655

Clinical prediction guides

Hyperthyrotropinemia at 2 weeks of age indicates thyroid dysfunction and predicts the occurrence of delayed elevation of thyrotropin in very low birth weight infants.
Niwa F, Kawai M, Kanazawa H, Iwanaga K, Matsukura T, Hasegawa T, Heike T
Clin Endocrinol (Oxf) 2012 Aug;77(2):255-61. doi: 10.1111/j.1365-2265.2011.04323.x. PMID: 22168665
Screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency and of its control.
Delange F
Thyroid 1998 Dec;8(12):1185-92. doi: 10.1089/thy.1998.8.1185. PMID: 9920376

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